Template-Type: ReDIF-Article 1.0 Author-Name: L Landa Author-Workplace-Name: Department of Pharmacology, Faculty of Medicine, Masaryk University, Brno, Czech Republic Author-Workplace-Name: Clinical Pharmacology Unit, Centre for Translational Medicine, International Clinical Research Centre, St. Anne's University Hospital, Brno, Czech Republic Author-Name: V Trojan Author-Workplace-Name: Clinical Pharmacology Unit, Centre for Translational Medicine, International Clinical Research Centre, St. Anne's University Hospital, Brno, Czech Republic Author-Name: R Demlova Author-Workplace-Name: Department of Pharmacology, Faculty of Medicine, Masaryk University, Brno, Czech Republic Author-Workplace-Name: Masaryk Memorial Cancer Institute, Brno, Czech Republic Author-Name: J Jurica Author-Workplace-Name: Department of Pharmacology, Faculty of Medicine, Masaryk University, Brno, Czech Republic Author-Workplace-Name: Masaryk Memorial Cancer Institute, Brno, Czech Republic Author-Name: R Hrib Author-Workplace-Name: Clinical Pharmacology Unit, Centre for Translational Medicine, International Clinical Research Centre, St. Anne's University Hospital, Brno, Czech Republic Author-Workplace-Name: Centre for Pain Management, Department of Anesthesiology and Intensive Care, St. Anne's University Hospital, Brno, Czech Republic Title: Cannabidiol and the possibilities of its use in veterinary medicine of dogs and horses: A brief review Abstract: In connection with the use of cannabinoids for therapeutic purposes in human medicine, there is increased attention for their use in veterinary medicine, particularly by the owners of companion animals and horses. Therefore, veterinarians are expected to face this interest and have the corresponding knowledge on these substances. Presently, it is not possible to use medical marijuana (in terms of the dried cannabis flowers) for veterinary purposes in many countries, but there is increasing evidence that isolated cannabinoids also have beneficial effects (namely cannabidiol - CBD). Thus, this review summarises the possible therapeutic implications of CBD within the scope of evidence-based medicine, particularly in dogs and horses in association with the treatment of pain, epilepsy and anxiety in order to provide veterinarians with a concise overview of scientific findings in this field. Keywords: cannabidiol, cannabinoids, dogs, horses, pain treatment Journal: Veterinární medicína Pages: 455-462 Volume: 67 Issue: 9 Year: 2022 DOI: 10.17221/127/2021-VETMED File-URL: http://vetmed.agriculturejournals.cz/doi/10.17221/127/2021-VETMED.html File-Format: text/html X-File-Ref: http://agriculturejournals.cz/RePEc/caa/references/vet-202209-0001.txt Handle: RePEc:caa:jnlvet:v:67:y:2022:i:9:id:127-2021-VETMED Template-Type: ReDIF-Article 1.0 Author-Name: Kim YS Author-Workplace-Name: T-stem Co., Ltd., Changwon, Gyeongsangnam-do, Republic of Korea Author-Name: SE Ha Author-Workplace-Name: Research Institute of Life Science and College of Veterinary Medicine, Gyeongsang National University, Jinju-daero, Jinju, Republic of Korea Author-Name: H Bae Author-Workplace-Name: College of Veterinary Medicine, Gyeongsang National University, Jinju-daero, Jinju, Republic of Korea Author-Name: D Lee Author-Workplace-Name: College of Veterinary Medicine, Gyeongsang National University, Jinju-daero, Jinju, Republic of Korea Author-Name: DH Yu Author-Workplace-Name: College of Veterinary Medicine, Gyeongsang National University, Jinju-daero, Jinju, Republic of Korea Author-Name: GS Kim Author-Workplace-Name: Research Institute of Life Science and College of Veterinary Medicine, Gyeongsang National University, Jinju-daero, Jinju, Republic of Korea Title: Clinical efficacy of membrane-free stem cell extracts for the treatment of canine atopic dermatitis Abstract: Despite various treatment options for canine atopic dermatitis (cAD), therapeutic limitations still exist, including adverse effects and low absorption ratios. This study evaluated the effects of a membrane-free stem cell extract (MFSCE) on the clinical signs of atopic dogs. Thirty client-owned dogs previously diagnosed with cAD were separated into placebo (n = 10) and MFSCE-treated groups (n = 20). The dogs were treated with a cream (MFSCE and placebo) via dermal administration twice daily for 14 days, and the clinical response was recorded on days 0, 7, and 14. The MFSCE-treated group showed significantly decreased severity of pruritus on day 14 compared to that on day 0. In addition, the erythema, pigmentation, skin dryness, and thickness were remarkably decreased in the MFSCE-treated group on day 14 compared to those on day 0 whereas no significant changes were observed in the placebo-treated group. No general clinical signs or adverse effects were observed in this study. These results suggest that MFSCE could be a surrogate treatment option for cAD. Keywords: atopic dermatitis, canine, clinical trial, membrane-free stem cell extract (MFSCE), veterinary medicine Journal: Veterinární medicína Pages: 463-470 Volume: 67 Issue: 9 Year: 2022 DOI: 10.17221/136/2021-VETMED File-URL: http://vetmed.agriculturejournals.cz/doi/10.17221/136/2021-VETMED.html File-Format: text/html X-File-Ref: http://agriculturejournals.cz/RePEc/caa/references/vet-202209-0002.txt Handle: RePEc:caa:jnlvet:v:67:y:2022:i:9:id:136-2021-VETMED Template-Type: ReDIF-Article 1.0 Author-Name: C Garcia Bover Author-Workplace-Name: Center for Poultry Quality and Animal Feed of the Community Valenciana (CECAV), Castellón, Spain Author-Name: Soriano JM del Castillo Author-Workplace-Name: Faculty of Pharmacy, University of Valencia, Burjassot, Spain Author-Name: V Cortes Moniz Author-Workplace-Name: Center for Poultry Quality and Animal Feed of the Community Valenciana (CECAV), Castellón, Spain Author-Name: Sa Sevilla-Navarro Author-Workplace-Name: Center for Poultry Quality and Animal Feed of the Community Valenciana (CECAV), Castellón, Spain Author-Name: C Marin Orenga Author-Workplace-Name: Department of Animal Production and Health, Veterinary Public Health and Food Science and Technology, Institute of Biomedical Sciences, Faculty of Veterinary Medicine, Cardenal Herrera-CEU University, CEU Universities, Moncada, Spain Author-Name: P Catala-Gregori Author-Workplace-Name: Center for Poultry Quality and Animal Feed of the Community Valenciana (CECAV), Castellón, Spain Title: Dynamic paramyxovirus type 1 seroprevalence maps in broilers in the Valencian Community (eastern Spain) during a five-year period (2008-2012) Abstract: Newcastle disease is a devasting disease in poultry production worldwide, thus it is important to implement control measures to avoid entrance of the disease and its spread in the field. In this context, the aim of this study was to design and implement a seroprevalence map based on business intelligence for avian paramyxovirus type 1 (APMV-1) in broilers in the Valencia Community (eastern Spain). This tool consists in software mapping based on data collection, data analysis and data representation. In order to obtain the serological data, 12 495 sera from 131 broiler farms over 5 years were analysed (2008-2012). The data were represented on a map of the Valencian Community including geographical information of flock locations to facilitate disease monitoring. No clinical signs of APMV-1 were reported in the studied flocks. The data from this study showed no evidence contact with APMV-1 in broiler flocks and the novel software mapping tool as a valuable method for easily monitoring the serological response to avian paramyxovirus type 1 (APMV-1) including geographical information. Keywords: geographical information system (GIS), mapping, haemagglutination inhibition, Newcastle disease (ND), poultry Journal: Veterinární medicína Pages: 471-478 Volume: 67 Issue: 9 Year: 2022 DOI: 10.17221/145/2020-VETMED File-URL: http://vetmed.agriculturejournals.cz/doi/10.17221/145/2020-VETMED.html File-Format: text/html X-File-Ref: http://agriculturejournals.cz/RePEc/caa/references/vet-202209-0003.txt Handle: RePEc:caa:jnlvet:v:67:y:2022:i:9:id:145-2020-VETMED Template-Type: ReDIF-Article 1.0 Author-Name: A Mustari Author-Workplace-Name: Department of Physiology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensigh, Bangladesh Author-Name: M Alam Author-Workplace-Name: Department of Physiology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensigh, Bangladesh Author-Name: MA Miah Author-Workplace-Name: Department of Physiology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensigh, Bangladesh Author-Name: M Nooruzzaman Author-Workplace-Name: Department of Pathology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensigh, Bangladesh Author-Name: KM Sujan Author-Workplace-Name: Department of Physiology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensigh, Bangladesh Author-Name: EH Chowdhury Author-Workplace-Name: Department of Pathology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensigh, Bangladesh Title: Retrieval action of zinc and folic acid for the restoration of normal reproductive function in bisphenol-A exposed male albino mice Abstract: Bisphenol-A (BPA) has become a great concern due to its toxic effects. The present study investigated the retrieval action of zinc (Zn) and folic acid (FA) supplementation against BPA-induced reproductive toxicities in male albino mice. A total of seventy-five 25-28 day-old mice were divided into five equal groups (group A-E, 15 mice in each group). The mice were given normal rations (control, group A) or administered with daily doses of BPA at 50 mg/kg body weight (b.w.) (group B-E). The mice from groups C, D and E were supplemented with Zn (10 mg/kg b.w.), FA (3 mg/kg b.w.) and both in the feed, respectively, daily for 12 weeks. Blood samples were collected, and the sera were separated for biochemical and hormonal analyses. The standard method was followed to test the sperm motility and sperm count. The testis samples were processed for a routine histopathological study using haematoxylin and eosin staining. The sperm counts, motility, and serum testosterone significantly declined in the BPA-exposed animals, but dramatically increased after the Zn and FA supplementation. There was significant degeneration of the seminiferous tubules in the testes of the BPA-exposed mice, which was recovered moderately by the Zn and FA supplementation. The study shows the retrieval action of zinc and folic acid in the restoration of normal reproductive function in bisphenol-A exposed male mice. Keywords: BPA, biochemical, histopathology, hormone, reproduction Journal: Veterinární medicína Pages: 479-486 Volume: 67 Issue: 9 Year: 2022 DOI: 10.17221/13/2022-VETMED File-URL: http://vetmed.agriculturejournals.cz/doi/10.17221/13/2022-VETMED.html File-Format: text/html X-File-Ref: http://agriculturejournals.cz/RePEc/caa/references/vet-202209-0004.txt Handle: RePEc:caa:jnlvet:v:67:y:2022:i:9:id:13-2022-VETMED Template-Type: ReDIF-Article 1.0 Author-Name: J Jang Author-Workplace-Name: Institute of Veterinary Science, College of Veterinary Medicine, Kangwon National University, Chuncheon, Republic of Korea Author-Name: H Choi Author-Workplace-Name: Department of Veterinary Medicine, College of Veterinary Medicine, Chungnam National University, Daejeon, Republic of Korea Author-Name: Y Lee Author-Workplace-Name: Department of Veterinary Medicine, College of Veterinary Medicine, Chungnam National University, Daejeon, Republic of Korea Author-Name: K Lee Author-Workplace-Name: Department of Veterinary Medicine, College of Veterinary Medicine, Kyumgpook National University, Daegu, Republic of Korea Author-Name: Y Choi Author-Workplace-Name: Yong Animal CTMRI Medical Center, Changwon, Republic of Korea Author-Name: I Park Author-Workplace-Name: Institute of Veterinary Science, College of Veterinary Medicine, Kangwon National University, Chuncheon, Republic of Korea Author-Name: S Choi Author-Workplace-Name: Institute of Veterinary Science, College of Veterinary Medicine, Kangwon National University, Chuncheon, Republic of Korea Title: Pancreatic adenocarcinoma with atypical imaging features mimicking chronic pancreatitis in a dog Abstract: An 11-year-old intact female Pomeranian dog was referred for jaundice, anorexia, and vomiting. The blood analysis revealed increased alanine aminotransferase, alkaline phosphatase, and gamma-glutamyl transpeptidase. The serum canine pancreatic lipase immunoreactivity was within the normal reference range. The radiography revealed no significant findings. On ultrasound, the gallbladder was enlarged with a markedly distended common bile duct (CBD) measuring up to 6 mm in diameter. The pancreas had an irregular contour, a hypoechoic peripheral rim, multiple hyperechoic foci with acoustic shadowing, and showed increased echogenicity of the adjacent mesentery. Based on these results, an extrahepatic biliary obstruction secondary to the presumed chronic pancreatitis was diagnosed. The computed tomography (CT) images showed a hypoattenuating pancreatic parenchyma compared to the liver in the early phase, as well as multiple calcifications. A laparotomy was performed to reserve the patency of the CBD. The histopathological examination of the pancreas revealed exocrine pancreatic adenocarcinoma. While various appearances of exocrine pancreatic adenocarcinoma on CT have been reported in humans, CT features of pancreatic adenocarcinoma have not been well-established in dogs. The purpose of this report is to describe the atypical imaging features of pancreatic adenocarcinoma that are similar to those of chronic pancreatitis in a dog. Keywords: computed tomography, exocrine pancreatic adenocarcinoma, pancreatitis, ultrasound Journal: Veterinární medicína Pages: 487-491 Volume: 67 Issue: 9 Year: 2022 DOI: 10.17221/132/2021-VETMED File-URL: http://vetmed.agriculturejournals.cz/doi/10.17221/132/2021-VETMED.html File-Format: text/html X-File-Ref: http://agriculturejournals.cz/RePEc/caa/references/vet-202209-0005.txt Handle: RePEc:caa:jnlvet:v:67:y:2022:i:9:id:132-2021-VETMED Template-Type: ReDIF-Article 1.0 Author-Name: Y Jin Author-Workplace-Name: Department of Veterinary Internal Medicine, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea Author-Name: Y Son Author-Workplace-Name: Department of Veterinary Internal Medicine, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea Author-Name: T Oh Author-Workplace-Name: Department of Veterinary Internal Medicine, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea Author-Name: S Bae Author-Workplace-Name: Department of Veterinary Internal Medicine, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea Title: Combination of immunosuppressive drugs and allogeneic stem cell treatment in a dog with suspected nephrotic syndrome Abstract: The case study aims to describe the nephrotic syndrome (NS) in a castrated 3-year-old male Cocker Spaniel dog. The patient arrived at the hospital with a loss of appetite and weakness. Skin oedema with ascites was observed along with hypoalbuminaemia, hypoproteinaemia, hyperlipidaemia, hypercholesterolaemia, and proteinuria (urine protein to creatinine ratio = 22.4). Based on these findings, the patient was diagnosed with NS, although a renal biopsy was not conducted. Prednisolone (1 mg/kg, p.o. q12 h) and mycophenolate mofetil (10 mg/kg, p.o. q12 h) were prescribed as the immunosuppressive drugs, and previously cryopreserved allogeneic adipose tissue-derived mesenchymal stem cells (2 × 107 cells/kg) were injected intravenously. After several weeks of treatment, the patient recovered from NS. This is the first case report on immunosuppressive drugs and allogeneic mesenchymal stem cells being used to treat a dog with NS. Keywords: dog, glomerular disease, immunosuppressive drug, mesenchymal stem cell, nephrotic syndrome Journal: Veterinární medicína Pages: 492-496 Volume: 67 Issue: 9 Year: 2022 DOI: 10.17221/115/2021-VETMED File-URL: http://vetmed.agriculturejournals.cz/doi/10.17221/115/2021-VETMED.html File-Format: text/html X-File-Ref: http://agriculturejournals.cz/RePEc/caa/references/vet-202209-0006.txt Handle: RePEc:caa:jnlvet:v:67:y:2022:i:9:id:115-2021-VETMED