Template-Type: ReDIF-Article 1.0 Author-Name: M Svoboda Author-Workplace-Name: Ruminant and Swine Clinic, Faculty of Veterinary Medicine, University of Veterinary Sciences Brno, Brno, Czech Republic Author-Name: J Blahova Author-Workplace-Name: Department of Animal Protection and Welfare and Veterinary Public Health, Faculty of Veterinary Hygiene and Ecology, University of Veterinary Sciences Brno, Brno, Czech Republic Author-Name: M Hostovsky Author-Workplace-Name: Department of Animal Protection and Welfare and Veterinary Public Health, Faculty of Veterinary Hygiene and Ecology, University of Veterinary Sciences Brno, Brno, Czech Republic Author-Name: J Jarkovsky Author-Workplace-Name: Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University Brno, Brno, Czech Republic Author-Name: J Netolicky Author-Workplace-Name: Faculty of Veterinary Hygiene and Ecology, University of Veterinary Sciences Brno, Brno, Czech Republic Author-Name: P Predny Author-Workplace-Name: Faculty of Veterinary Medicine, University of Veterinary Sciences Brno, Brno, Czech Republic Author-Name: I Simkova Author-Workplace-Name: Ruminant and Swine Clinic, Faculty of Veterinary Medicine, University of Veterinary Sciences Brno, Brno, Czech Republic Author-Name: J Vanhara Author-Workplace-Name: Ruminant and Swine Clinic, Faculty of Veterinary Medicine, University of Veterinary Sciences Brno, Brno, Czech Republic Author-Name: J Vasek Author-Workplace-Name: Ruminant and Swine Clinic, Faculty of Veterinary Medicine, University of Veterinary Sciences Brno, Brno, Czech Republic Title: Efficacy and safety of higher oral doses of azaperone to achieve sedation in pigs Abstract: The aim of this study is to evaluate the possibility of achieving more effective and prolonged sedation in pigs by the oral administration of increased doses of azaperone and to evaluate its safety. This was performed through a prospective randomised and double blinded study. A total of 32 weaned piglets were divided into 4 groups (8 in each group). Group A was given 1 ml of saline orally and served as the control group. Group B received azaperone orally at a dose of 4 mg/kg b.w. Group C received azaperone orally at a dose of 8 mg/kg b.w. Group D was given azaperone orally at a dose of 12 mg/kg b.w. The response to the defined stimulus, movement level, degree of salivation, body temperature, respiratory frequency, blood plasma azaperone concentration and biochemical variables were included in the trial. We found that by increasing the dose of the orally administered azaperone, the onset of the sedation is faster, the end of the sedation starts later and the sedation time is longer. However, the use of higher doses of oral azaperone is not suitable for piglets because the doses negatively affect the respiratory rate, body temperature, some biochemical parameters and cause the immobility of the piglets. Keywords: behaviour, biochemical indicators, pharmacodynamics Journal: Veterinární medicína Pages: 553-561 Volume: 67 Issue: 11 Year: 2022 DOI: 10.17221/56/2022-VETMED File-URL: http://vetmed.agriculturejournals.cz/doi/10.17221/56/2022-VETMED.html File-Format: text/html X-File-Ref: http://agriculturejournals.cz/RePEc/caa/references/vet-202211-0001.txt Handle: RePEc:caa:jnlvet:v:67:y:2022:i:11:id:56-2022-VETMED Template-Type: ReDIF-Article 1.0 Author-Name: S Sureshkumar Author-Workplace-Name: Department of Animal Resource and Science, Dankook University, Cheonan, Republic of Korea Author-Name: JH Park Author-Workplace-Name: Department of Animal Resource and Science, Dankook University, Cheonan, Republic of Korea Author-Name: IH Kim Author-Workplace-Name: Department of Animal Resource and Science, Dankook University, Cheonan, Republic of Korea Title: Effects of Enterococcus faecium SLB 130 probiotic on the performance of weaning pigs Abstract: This study aims to analyse the effect of an Enterococcus faecium SLB 130 probiotic on the growth performance, nutrient digestibility, and blood profile in weaning pigs. A total of 200 weaning pigs were taken and assigned to 1 of 5 dietary treatments according to their average initial body weight and sex in a complete randomised block design. The experimental diets were as follows: CON - basal diet, and the basal diet supplemented with 2.5 × 105 cfu/g (TRT1), 1.29 × 106 cfu/g (TRT2), 1.15 × 107 cfu/g (TRT3), and 1.1 × 108 cfu/g (TRT4) of E. faecium for 6 weeks. Pigs fed a diet containing an E. faecium SLB 130 probiotic supplement significantly increased (P < 0.05) the body weight, average daily gain, and average daily feed intake at weeks 1, 3, 6, and the overall period. In addition, the E. faecium SLB 130 (P < 0.05) supplement group pigs showed an increased gain to feed ratio at week 6 and the overall experimental period. Moreover, the dietary inclusion of the E. faecium SLB 130 probiotic supplement linearly increased (P < 0.05) the nutrient digestibility of the dry matter and nitrogen, however, there were no improvements observed on weanling pigs' blood profile. In summary, the inclusion of an E. faecium SLB 130 probiotic additive in the weanling pigs' diet would be beneficial to enhance their growth performance and nutrient digestibility. Keywords: blood profile, growth performance, nutrient digestibility, weanling pigs Journal: Veterinární medicína Pages: 562-568 Volume: 67 Issue: 11 Year: 2022 DOI: 10.17221/41/2022-VETMED File-URL: http://vetmed.agriculturejournals.cz/doi/10.17221/41/2022-VETMED.html File-Format: text/html X-File-Ref: http://agriculturejournals.cz/RePEc/caa/references/vet-202211-0002.txt Handle: RePEc:caa:jnlvet:v:67:y:2022:i:11:id:41-2022-VETMED Template-Type: ReDIF-Article 1.0 Author-Name: TE Arotolu Author-Workplace-Name: Center of Conservation Medicine & Ecological Safety, Northeast Forestry University, Harbin, Heilongjiang Province, P.R. China Author-Workplace-Name: Key Laboratory of Wildlife Diseases and Biosecurity Management, Harbin, Heilongjiang Province, P.R. China Author-Workplace-Name: College of Wildlife and Protected Area, Northeast Forestry University, Harbin, Heilongjiang Province, P.R. China Author-Name: HN Wang Author-Workplace-Name: School of Geography and Tourism, Harbin University, Harbin, Heilongjiang Province, P.R. China Author-Name: JN Lv Author-Workplace-Name: College of Wildlife and Protected Area, Northeast Forestry University, Harbin, Heilongjiang Province, P.R. China Author-Name: S Kun Author-Workplace-Name: Wildlife Institute, Beijing Forestry University, Beijing, P.R. China Author-Name: LY Huang Author-Workplace-Name: Changbai Mountain Academy of Sciences, Antu, Jilin Province, P.R. China Author-Name: XL Wang Author-Workplace-Name: Center of Conservation Medicine & Ecological Safety, Northeast Forestry University, Harbin, Heilongjiang Province, P.R. China Author-Workplace-Name: Key Laboratory of Wildlife Diseases and Biosecurity Management, Harbin, Heilongjiang Province, P.R. China Author-Workplace-Name: College of Wildlife and Protected Area, Northeast Forestry University, Harbin, Heilongjiang Province, P.R. China Title: Environmental suitability of Yersinia pestis and the spatial dynamics of plague in the Qinghai Lake region, China Abstract: Plague, a highly infectious disease caused by Yersinia pestis, has killed millions of people in history and is still active in the natural foci of the world nowadays. Understanding the spatiotemporal patterns of plague outbreaks in history is critically important, as it may help facilitate the prevention and control for potential future outbreaks. This study's objective was to estimate the effect of the topography, vegetation, climate, and other environmental factors on the Y. pestis ecological niche. A maximum entropy algorithm spatially modelled plague occurrence data from 2004-2018 and the environmental variables to evaluate the contribution of the variables to the distribution of Y. pestis. Our results found that the average minimum temperature in September (-8 °C to +5 °C) and the sheep population density (250 sheep per km2) were influential in characterising the niche. The rim of Qinghai Lake showed more favourable conditions for Y. pestis presence than other areas within the study area. Identifying various factors will assist any future modelling efforts. Our suitability map identifies hotspots and will help public health officials in resource allocation in their quest to abate future plague outbreaks. Keywords: infectious diseases, MaxEnt, niche modelling, zoonosis Journal: Veterinární medicína Pages: 569-578 Volume: 67 Issue: 11 Year: 2022 DOI: 10.17221/81/2021-VETMED File-URL: http://vetmed.agriculturejournals.cz/doi/10.17221/81/2021-VETMED.html File-Format: text/html X-File-Ref: http://agriculturejournals.cz/RePEc/caa/references/vet-202211-0003.txt Handle: RePEc:caa:jnlvet:v:67:y:2022:i:11:id:81-2021-VETMED Template-Type: ReDIF-Article 1.0 Author-Name: E Zuskova Author-Workplace-Name: South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Faculty of Fisheries and Protection of Waters, University of South Bohemia in Ceske Budejovice, Ceske Budejovice, Czech Republic Author-Name: V Piackova Author-Workplace-Name: South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Faculty of Fisheries and Protection of Waters, University of South Bohemia in Ceske Budejovice, Ceske Budejovice, Czech Republic Author-Name: O Valentova Author-Workplace-Name: South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Faculty of Fisheries and Protection of Waters, University of South Bohemia in Ceske Budejovice, Ceske Budejovice, Czech Republic Author-Name: K Zalohova Author-Workplace-Name: South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Faculty of Fisheries and Protection of Waters, University of South Bohemia in Ceske Budejovice, Ceske Budejovice, Czech Republic Author-Name: J Velisek Author-Workplace-Name: South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Faculty of Fisheries and Protection of Waters, University of South Bohemia in Ceske Budejovice, Ceske Budejovice, Czech Republic Title: Acute toxicity of praziquantel to fish Danio rerio and planktonic crustacean Daphnia magna Abstract: This study evaluated the toxicity of the pyrazino isoquinoline anthelmintic praziquantel (PZQ) to the Danio rerio zebrafish and Daphnia magna water flea. The estimated 24 h and 96 h LC50 of PZQ to the zebrafish was 39.9 mg/l and 30.4 mg/l, respectively. The highest 24 h and 96 h non-lethal concentration (LC0) was 21.7 mg/l and 21.2 mg/l, respectively. The mobility inhibition test of the juvenile Daphnia magna revealed a 48 h EC50 of 42.7 mg/l. Keywords: 96 h LC50, antiparasitic, bath treatment, water flea, zebrafish Journal: Veterinární medicína Pages: 579-584 Volume: 67 Issue: 11 Year: 2022 DOI: 10.17221/7/2022-VETMED File-URL: http://vetmed.agriculturejournals.cz/doi/10.17221/7/2022-VETMED.html File-Format: text/html X-File-Ref: http://agriculturejournals.cz/RePEc/caa/references/vet-202211-0004.txt Handle: RePEc:caa:jnlvet:v:67:y:2022:i:11:id:7-2022-VETMED Template-Type: ReDIF-Article 1.0 Author-Name: K Jelinkova Author-Workplace-Name: Department of Reproduction, Small Animal Clinic, Faculty of Veterinary Medicine, University of Veterinary Sciences Brno, Brno, Czech Republic Author-Name: E Cigankova Author-Workplace-Name: Department of Reproduction, Small Animal Clinic, Faculty of Veterinary Medicine, University of Veterinary Sciences Brno, Brno, Czech Republic Author-Name: R Vitasek Author-Workplace-Name: Department of Reproduction, Small Animal Clinic, Faculty of Veterinary Medicine, University of Veterinary Sciences Brno, Brno, Czech Republic Title: Repeated pregnancy in a bitch, with a diagnosis of extensive cystic endometrial hyperplasia, after the exact determination of the optimal time for breeding Abstract: A 6-year-old bitch was presented to the clinical examination with the aim of determining the optimal time for intrauterine insemination by frozen-thawed semen. The bitch had already had two litters in the past. Extensive cystic endometrial hyperplasia was diagnosed by an ultrasound examination in the bitch. The timing of the endoscopic transcervical insemination by a combination of ultrasonographic examination of the ovaries and determining the progesterone concentrations contributed to the successful conception in the bitch. The ultrasonographic examination of the ovaries represents a non-invasive method which allowed us to view the changes on the ovaries in real time and, thus, is a very suitable method for the specification of the ovulation time in bitches. Cystic endometrial hyperplasia is considered to be a possible cause of infertility. Nevertheless, the bitch repeatedly conceived and had larger litter sizes. Moreover, a considerable reduction in the number of endometrial cysts was observed after the third pregnancy of the bitch. In the described clinical case, the influence of the cystic endometrial hyperplasia on the conception was not demonstrated. Keywords: cystic endometrial hyperplasia, dog, pregnancy, ultrasonography Journal: Veterinární medicína Pages: 585-589 Volume: 67 Issue: 11 Year: 2022 DOI: 10.17221/104/2021-VETMED File-URL: http://vetmed.agriculturejournals.cz/doi/10.17221/104/2021-VETMED.html File-Format: text/html X-File-Ref: http://agriculturejournals.cz/RePEc/caa/references/vet-202211-0005.txt Handle: RePEc:caa:jnlvet:v:67:y:2022:i:11:id:104-2021-VETMED Template-Type: ReDIF-Article 1.0 Author-Name: SH Lee Author-Workplace-Name: Department of Veterinary Surgery, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea Author-Name: DH Kim Author-Workplace-Name: Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea Author-Name: K Bae Author-Workplace-Name: Department of Veterinary Biochemistry, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea Author-Name: SW Jeong Author-Workplace-Name: Department of Veterinary Surgery, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea Author-Name: KA Yoon Author-Workplace-Name: Department of Veterinary Biochemistry, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea Author-Name: HY Yoon Author-Workplace-Name: Department of Veterinary Surgery, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea Author-Name: SH Do Author-Workplace-Name: Department of Veterinary Clinical Pathology, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea Author-Name: B Kim Author-Workplace-Name: Department of Physiology, School of Medicine, Konkuk University, Seoul, Republic of Korea Author-Name: JH Kim Author-Workplace-Name: Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea Title: Adjuvant therapy with imatinib for an incompletely resected multilobular tumour of bone in a dog Abstract: A 5-year-old neutered male Shiba Inu dog presented with a history of oral bleeding, dysphagia, and depression for 3 weeks. The physical examination revealed a firm mass in the right caudal palatal region along the level of PM4-M2. On the computed tomography, the mass was round-to-oval in shape and 22 mm × 30 mm × 15 mm in size. The mass contained multiple bone attenuated materials with a palatal bone lysis of 4 mm × 6 mm. A complete resection of the mass was proposed; however, the owner declined due to the risk of complications associated with the radical surgery. Therefore, a palliative resection and biopsy of the mass were performed. On the histological examination, the mass was diagnosed as grade 2 multilobular tumour of bone (MTB). Since the mass was incompletely resected, adjuvant therapy was pursued along with targeted therapy using a tyrosine kinase inhibitor. The tumour cells showed overexpression of the receptor of tyrosine kinase for c-KIT, PDGFR-α, PDGFR-β, and FGFR1 compared to normal tissue cells. Additionally, the cytotoxic effect of imatinib on the MTB cells was confirmed in vitro. Four weeks postoperatively, the administration of imatinib and carprofen was initiated and continued for 259 days. The patient maintained a good functional outcome for 306 days after the initial presentation. Keywords: canine, carprofen, sarcoma, target therapy, tyrosine kinase inhibitor Journal: Veterinární medicína Pages: 590-597 Volume: 67 Issue: 11 Year: 2022 DOI: 10.17221/85/2021-VETMED File-URL: http://vetmed.agriculturejournals.cz/doi/10.17221/85/2021-VETMED.html File-Format: text/html X-File-Ref: http://agriculturejournals.cz/RePEc/caa/references/vet-202211-0006.txt Handle: RePEc:caa:jnlvet:v:67:y:2022:i:11:id:85-2021-VETMED