Template-Type: ReDIF-Article 1.0 Author-Name: P Rauser Author-Workplace-Name: Department of Surgery and Orthopedics, Small Animal Clinic, Faculty of Veterinary Medicine, University of Veterinary Sciences, Brno, Czech Republic Author-Name: M Mrazova Author-Workplace-Name: Department of Surgery and Orthopedics, Small Animal Clinic, Faculty of Veterinary Medicine, University of Veterinary Sciences, Brno, Czech Republic Author-Name: A Sabatova Author-Workplace-Name: Department of Surgery and Orthopedics, Small Animal Clinic, Faculty of Veterinary Medicine, University of Veterinary Sciences, Brno, Czech Republic Author-Name: K Jiraskova Author-Workplace-Name: Department of Surgery and Orthopedics, Small Animal Clinic, Faculty of Veterinary Medicine, University of Veterinary Sciences, Brno, Czech Republic Title: Effect of vatinoxan co-administered with medetomidine on intraocular pressure and pupil diameter in healthy dogs Abstract: Medetomidine, an alpha-2 adrenoreceptor agonist, is used for sedation. This study aimed to determine the influence of the alpha-2 adrenoreceptor antagonist vatinoxan, co-administered with medetomidine, on healthy dogs' intraocular pressure (IOP) and pupil diameter (PD). A prospective, randomised, masked clinical study was performed. A total of 40 conscious dogs were allocated to one of two groups: medetomidine 0.01 mg/kg with vatinoxan 0.2 mg/kg intravenously (MV-group, n = 20) or medetomidine 0.01 mg/kg intravenously (M-group, n = 20). The IOP, PD, heart rate, and mean arterial pressure were measured prior to baseline and 5, 10, and 20 min after drug administration. Data were analysed using one- and two-way repeated measures ANOVA or their non-parametric equivalents (P < 0.05). No significant differences in IOP within or between groups were recorded. In the MV-group, PD remained unchanged compared to baseline. In the M-group, PD significantly (P = 0.007, P < 0.001, P < 0.001) decreased compared to baseline at all observation times. PD was significantly (P = 0.010, P < 0.001, P < 0.001) smaller in the M-group at all observation times compared to the MV-group. Vatinoxan co-administered with medetomidine, as well as medetomidine alone, did not significantly influence IOP. Vatinoxan with medetomidine did not affect PD, while medetomidine alone significantly reduced it. Keywords: alpha-2 adrenoreceptor agonist, alpha-2 adrenoreceptor antagonist, MK-467, L-659, 066, pupil size Journal: Veterinární medicína Pages: 427-431 Volume: 70 Issue: 12 Year: 2025 DOI: 10.17221/47/2025-VETMED File-URL: http://vetmed.agriculturejournals.cz/doi/10.17221/47/2025-VETMED.html File-Format: text/html X-File-Ref: http://agriculturejournals.cz/RePEc/caa/references/vet-202512-0001.txt Handle: RePEc:caa:jnlvet:v:70:y:2025:i:12:id:47-2025-VETMED Template-Type: ReDIF-Article 1.0 Author-Name: JH Han Author-Workplace-Name: Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, Republic of Korea Author-Name: JS Oh Author-Workplace-Name: Department of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea Author-Name: SY Ahn Author-Workplace-Name: Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, Republic of Korea Author-Name: J Kim Author-Workplace-Name: Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, Republic of Korea Author-Name: DN Lee Author-Workplace-Name: Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, Republic of Korea Author-Name: YD Suh Author-Workplace-Name: Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, Republic of Korea Author-Name: DY Kim Author-Workplace-Name: Department of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea Author-Name: J Yoon Author-Workplace-Name: Department of Veterinary Medical Imaging, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea Author-Name: SC Yeon Author-Workplace-Name: Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, Republic of Korea Title: Cerebellar hypoplasia in an Amur leopard cat (Prionailurus bengalensis euptilura) with feline panleukopenia virus infection Abstract: Cerebellar hypoplasia caused by feline panleukopenia virus (FPV) is well documented in domestic cats. Still, it remains unreported in wild felid species, including the Amur leopard cat (Prionailurus bengalensis euptilura). Understanding the impact of such viral diseases on wild populations is crucial for advancing conservation efforts and protecting wildlife. An orphaned Amur leopard cat exhibiting idiopathic ataxia was rescued. Initial diagnostics, including physical examination, radiography, and blood analysis, yielded no remarkable findings, though its clinical signs indicated an underlying neurological problem. Subsequent real-time polymerase chain reaction tests detected FPV. Magnetic resonance imaging (MRI) revealed brain lesions, including reduced cerebellar parenchyma and cerebrospinal fluid occupying the space where the cerebellum should be located. These findings suggested cerebellar hypoplasia caused by in utero FPV infection. The Amur leopard cat was euthanised owing to its permanent disability, and the necropsy confirmed a markedly shrunken cerebellum. At the same time, histopathology identified decreased cellularity of the molecular and granular layers of the cerebellar cortex. These results coincided with the MRI findings. This report suggests that cerebellar hypoplasia caused by FPV can occur in wild felid species. Keywords: cerebellar malformation, conservation medicine, in utero infection, viral disease, wildlife Journal: Veterinární medicína Pages: 452-459 Volume: 70 Issue: 12 Year: 2025 DOI: 10.17221/29/2025-VETMED File-URL: http://vetmed.agriculturejournals.cz/doi/10.17221/29/2025-VETMED.html File-Format: text/html X-File-Ref: http://agriculturejournals.cz/RePEc/caa/references/vet-202512-0002.txt Handle: RePEc:caa:jnlvet:v:70:y:2025:i:12:id:29-2025-VETMED Template-Type: ReDIF-Article 1.0 Author-Name: M Mansouri Author-Workplace-Name: Institute of Veterinary Sciences, SAAD Dahlab University Blida 1, Blida, Algeria Author-Workplace-Name: Laboratory of Protection and Valorization of Agrobiological Resources, Faculty of Natural Sciences and Life - Department of Biotechnology and Agroecology, SAAD Dahlab University Blida 1, Blida, Algeria Author-Name: N Hammami Author-Workplace-Name: Institute of Veterinary Sciences, SAAD Dahlab University Blida 1, Blida, Algeria Author-Workplace-Name: Biotechnologies Laboratory Related to Animal Reproduction (LBRA), Institute of Veterinary Sciences, SAAD Dahlab University Blida 1, Blida, Algeria Author-Name: A Yahia Author-Workplace-Name: Institute of Veterinary Sciences, SAAD Dahlab University Blida 1, Blida, Algeria Author-Workplace-Name: Biotechnologies Laboratory Related to Animal Reproduction (LBRA), Institute of Veterinary Sciences, SAAD Dahlab University Blida 1, Blida, Algeria Author-Name: K Saidani Author-Workplace-Name: Institute of Veterinary Sciences, SAAD Dahlab University Blida 1, Blida, Algeria Author-Name: Z Boumahdi Author-Workplace-Name: Biotechnologies Laboratory Related to Animal Reproduction (LBRA), Institute of Veterinary Sciences, SAAD Dahlab University Blida 1, Blida, Algeria Author-Name: D Tarzaali Author-Workplace-Name: Biotechnologies Laboratory Related to Animal Reproduction (LBRA), Institute of Veterinary Sciences, SAAD Dahlab University Blida 1, Blida, Algeria Author-Name: N Mimoune Author-Workplace-Name: Biotechnologies Laboratory Related to Animal Reproduction (LBRA), Institute of Veterinary Sciences, SAAD Dahlab University Blida 1, Blida, Algeria Author-Workplace-Name: Biotechnologies Platform for Animal Medicine & Reproduction, SAAD Dahlab University Blida 1, Blida, Algeria Author-Workplace-Name: Animal Health & Production (SPA) Laboratory, Higher National Veterinary School (ENSV), Algiers, Algeria Title: Impact of prebiotic supplementation on the zootechnical and health performance in broiler chickens Abstract: This study aimed to evaluate the effectiveness of mannan-oligosaccharides (MOSs) in broiler chicken feed throughout the complete rearing cycle, focusing on zootechnical performance and lactic acid bacteria. Over a period of 49 days, a total of one thousand and eighty (1 080) day-old ISA 15 chicks were divided into two (control and experimental) groups of 540 subjects each (9 replicates of 60 chicks per treatment). They were fed the same basic diet, but only the experimental group received a yeast cell wall extract-based prebiotic (AGRIMOS®, France), administered continuously at a dose of 2 g/kg throughout the different rearing phases. Under our local conditions, the prebiotic supplementation resulted in a significant increase in body weight gain (P < 0.01), reaching 1 559.82 ± 41.47 g during the growth phase and 913.20 ± 72.58 g during the finishing phase. Moreover, a significant reduction in the feed conversion ratio was observed throughout the rearing cycle (P < 0.05). Across all segments of the analysed intestinal tract (duodenum, ileum, and caecum), the data showed that chickens supplemented with the prebiotic had a significantly higher number of lactic acid bacteria than the control group at the start, growth, and finishing phases (P < 0.01). Our findings demonstrated a clear impact of the prebiotic on the feed utilisation under our rearing conditions, which required further studies to elucidate the underlying mechanisms of action. Keywords: chicken,  lactic acid bacteria,  mannan-oligosaccharide, prebiotic, zootechnical performance Journal: Veterinární medicína Pages: 442-451 Volume: 70 Issue: 12 Year: 2025 DOI: 10.17221/37/2025-VETMED File-URL: http://vetmed.agriculturejournals.cz/doi/10.17221/37/2025-VETMED.html File-Format: text/html X-File-Ref: http://agriculturejournals.cz/RePEc/caa/references/vet-202512-0003.txt Handle: RePEc:caa:jnlvet:v:70:y:2025:i:12:id:37-2025-VETMED Template-Type: ReDIF-Article 1.0 Author-Name: M Ahmadi Author-Workplace-Name: Department of Veterinary Clinical Sciences,Shk.C., Islamic Azad University, Shahrekord, Iran Author-Name: I Nowrouzian Author-Workplace-Name: Department of Veterinary Clinical Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran Author-Name: M Norbakhsh Author-Workplace-Name: Department of Veterinary Clinical Sciences,Shk.C., Islamic Azad University, Shahrekord, Iran Author-Name: M Yadegari Author-Workplace-Name: Department of Veterinary Clinical Sciences,Shk.C., Islamic Azad University, Shahrekord, Iran Author-Name: M Jafarian Dehkordi Author-Workplace-Name: Department of Clinical Pathology, Shk.C., Islamic Azad University, Shahrekord, Iran Title: Evaluation of hydroalcoholic extract of Licorice (Glycyrrhiza glabra L.) root on treatment of experimentally induced peritonitis in New Zealand male rabbits Abstract: This experimental study evaluated the therapeutic potential of a liquorice-derived hydroalcoholic extract in managing experimentally induced peritonitis in New Zealand rabbits. The animals were randomly divided into six groups (n = 6): one control group, one negative control group (infected but untreated), three treatment groups that received the liquorice-derived extract at 0.5, 1, and 2 g/kg, and one positive control group treated with enrofloxacin. The confirmation of peritoneal infection relied on histopathological and radiographic tests. The effect of the liquorice extract on the peritoneal infection was evaluated using biochemical, haematological, and ultrasound analyses across the groups. The ultrasound examination, along with the haematological and biochemical evaluation on the 20th day after induction, showed significant differences between the groups. The results demonstrated that higher doses of 1 g/kg and 2 g/kg were more effective than the lower dose of 0.5 g/kg. The haematological and biochemical analyses revealed significant differences in several variables (including WBC, neutrophils, fibrinogen, and liver enzymes) between the treated and control groups, with the most pronounced improvements observed in the group receiving 2 g/kg of liquorice extract, suggesting a dose-dependent therapeutic effect. The administration of a hydroalcoholic extract of liquorice at different doses, along with the standard treatment with enrofloxacin, affected various haematological and biochemical variables in the context of peritoneal infection management. In conclusion, the effectiveness of the liquorice-derived extract is dose-dependent and could be used as an effective therapeutic agent in peritoneal infections in New Zealand rabbits. These findings showed that the liquorice-derived extract effectively improves the local inflammatory and structural changes associated with peritoneal infection without adversely affecting systemic biochemical homeostasis. Keywords: liquorice extract, peritonitis, rabbits, treatment Journal: Veterinární medicína Pages: 432-441 Volume: 70 Issue: 12 Year: 2025 DOI: 10.17221/31/2025-VETMED File-URL: http://vetmed.agriculturejournals.cz/doi/10.17221/31/2025-VETMED.html File-Format: text/html X-File-Ref: http://agriculturejournals.cz/RePEc/caa/references/vet-202512-0004.txt Handle: RePEc:caa:jnlvet:v:70:y:2025:i:12:id:31-2025-VETMED