Czech J. Food Sci., 2009, 27(10):S66-S69 | DOI: 10.17221/624-CJFS

Dietary Maillard Reaction Products: Implications for Human Health and Disease

J. M. AMES
School of Applied Sciences, Northumbria University at Newcastle, Newcastle upon Tyne, NE1 8ST, United Kingdom, E-mail: jenny.ames@northumbria.ac.uk

When foods are heat processed, the sugars and lipids react with the proteins they contain via the Maillard and related reactions to form a wide range of products. As a result, the sensory, safety, nutritional and health-promoting attributes of the foods are affected. Reaction products include advanced glycation/lipoxidation endproducts (AGE/ALEs), acrylamide and heterocyclic amines (HAA), all of which may impact on human health and disease. Furthermore, some Maillard reaction products affect the growth of colonic bacteria and thermally-induced modification of dietary protein can affect allergenicity. This paper briefly reviews aspects of the Maillard reaction in food related to human health.

Keywords: Maillard reaction; advanced glycation endproducts (AGEs); advanced lipoxidation endproducts (ALEs); heterocyclic amines; acrylamide; allergenicity; colonic health

Published: June 30, 2009  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
AMES JM. Dietary Maillard Reaction Products: Implications for Human Health and Disease. Czech J. Food Sci. 2009;27(Special Issue 1):S66-69. doi: 10.17221/624-CJFS.
Download citation

References

  1. Alaejos M.S., Pino V., Afonso A.M. (2008): Metabolism and toxicology of heterocyclic aromatic amines when consumed in diet: Influence of the genetic susceptibility to develop human cancer. A review. Food Research International, 41: 327-340. Go to original source...
  2. Ames J.M. (2007): Evidence against dietary advanced glycation endproducts being a risk to human health. Mololecular Nutrition and Food Research, 51: 1085- 1090. Go to original source... Go to PubMed...
  3. Cheng K.-W., Chen F., Wang M. (2006): Heterocyclic amines. Chemistry and health. Molecular Nutrition and Food Research, 50: 1150-1170. Go to original source... Go to PubMed...
  4. Dybing E., Farmer P.B., Andersen M., Fennell T.R., Lallje S.P.D:, Muller D.J.G., Olin S., Peterson B.J., Schlatter J., Scholz G., Scimeca J.A., Slimani N., Tornqvist M., Tuijtelaars S., Verger P, (2005): Human exposure and internal does assessments of acrylamide in food. Food Chemistry and Toxicology, 43: 365-410. Go to original source... Go to PubMed...
  5. Hodge J.E. (1953): Chemistry of browning reactions in model systems. Journal of Agricultural and Food Chemistry, 1: 928-943. Go to original source...
  6. Hogervorst J.G., Schouten L.J., Konings E.J., Goldvohm R.A., Van den Brandt P.A. (2007): A prospective study of dietary acrylamide intake and the risk of endometrial ovarian, and breast cancer. Cancer Epidemiology Biomarkers & Prevention, 16: 2304-2313. Go to original source... Go to PubMed...
  7. Maleki S.J., Chung S.Y., Champagne E.T., Raufman J.P. (2000): The effects of roasting on the allergenic properties of peanut proteins. Journal of Allergy and Clinical Immunology, 106: 763-768. Go to original source... Go to PubMed...
  8. Mills D.J.S., Tuohy K.M., Davies S.J., Booth J., Buck M., Crabbe M.J.C., Gibson G.R., Ames J.M. (2008): Dietary glycated protein modulates the colonic microbiota in healthy persons and in ulcerative colitis to a more detrimental composition. Journal of Applied Microbiology, 105: 706-714. Go to original source... Go to PubMed...
  9. Nakamura S., Suzuki Y., Ishikawa E., Yakushi T., Jing H., Miyamoto T., Hashizume K. (2008): Reduction of in vitro allergenicity of buckwheat Fag e 1 through the Maillard-type glycosylation with polysaccharides. Food Chemistry, 109: 538-545. Go to original source...
  10. Seal C.J., De Mul A., Eisenbrand G., Haverkort A.J., Franke K., Lalljie S.P.D., Mykkanen H., Reimerdes E., Scholz G., Somoza V., Tuijtelaars S., Van Boekel M., Van Klaveren J., Wilcockson S.J., Wilms L. (2008): Risk-benefit considerations of mitigation measures on acrylamide content of foods - A case study on potatoes, cereals and coffee. British Journal of Nutrition, 99: S1-S47. Go to original source... Go to PubMed...
  11. Seiquer I., Diaz-Alguacil J., Delgado-Andrade C., LopezFraos M., Hoyos A.M., Galdo G., Navarro M.P. (2006): Diets rich in Maillard reaction products affect protein digestibility in adolescent males aged 11-14 y. American Journal of Clinical Nutrition, 83: 1082-1088. Go to original source... Go to PubMed...
  12. Seiquer I., Ruiz-Roca B., Mesias M., Munoz-Hoyos A.,Galdo G., Ochoa J.J., Navarro M.P. (2008): The antioxidant effect of a diet rich in Maillard reaction products is attenuated after consumption by healthy male adolescents. In vitro and in vivo comparative study. Journal of the Science of Food and Agriculture, 88: 1245-1252. Go to original source...
  13. Stadler R.H., Scholz G. (2004): Acrylamide: An update on current knowledge in analysis, levels in foods, mechanisms of formation and potential strategies of control. Nutrition Reviews, 62: 449-467. Go to original source... Go to PubMed...
  14. van de Lagemaat J.V., Silvan J.M., Moreno F.J., Olano A., De Castillo M.D. (2007): In vitro glycation and antigenicity of soy proteins Food Research International, 40: 153-160. Go to original source...
  15. Zhang Y., Zhang Y. (2007): Formation and reduction of acrylamide in Maillard reaction: a review based on the current state of knowledge. Critical Reviews in Food Science and Nutrition, 47: 521-542. Go to original source... Go to PubMed...
  16. Zhang Q., Ames J.M., Smith R.D., Baynes J.W., Metz T.O. (2009): A perspective of the Maillard reaction and the analysis of protein glycation by mass spectrometry: probing the pathogenesis of chronic disease. Journal of Proteome Research, 8: 754-769. Go to original source... Go to PubMed...

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY NC 4.0), which permits non-comercial use, distribution, and reproduction in any medium, provided the original publication is properly cited. No use, distribution or reproduction is permitted which does not comply with these terms.