Veterinární medicína, 2013 (vol. 58), issue 3

Antiviral agents targeting the influenza virus: a review and publication analysisReview

L. Eyer, K. Hruska

Vet Med - Czech, 2013, 58(3):113-185 | DOI: 10.17221/6746-VETMED  

Influenza is a serious infectious disease, which is life-threatening especially in children, seniors and immunocompromised patients. In addition to vaccination, the development of new anti-influenza agents represents a crucial defence strategy to combat seasonal and pandemic influenza strains. At present most attention is paid to the development of inhibitors of influenza neuraminidase, which has been established as a key drug target for the prophylaxis and treatment of influenza infections. However, the emergence of drug-resistant influenza variants highlights the need of continuously innovative strategies for the development of new drugs with improved...