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A traceability system is an effective tool to guarantee safety in horticultural products and to improve supply chain transparency. A direct data matrix (DM) code created with carbon dioxide laser (wavelength 10.6 µm) can be used as a trust mark on bananas. In this study, green bananas were marked with the above-mentioned CO₂ laser. Subsequently, the samples were held under storage conditions. Images of the codes on bananas were captured by using two different cameras; i.e. hyperspectral imaging camera and charge-couple device (CCD) camera. Image processing was used for evaluating print quality of 2D codes based on the ISO/IEC 15415 standard. The quality of the codes on bananas mainly depends on some parameters: laser power, laser energy, marking time per module and storage time. The best readability results were achieved by using laser power of 1.8 W and marking time of 0.09 s per data matrix module, whereby an 80-100% readability of DM codes after the storage was obtained.

Farming is treated as one of the riskiest businesses. Political decisions, especially these related to the agricultural sector, may be treated as of a great importance. As a consequence, farm owners seek to diversify their sources of income and run other strategies aiming to stabilize their earnings i.e. by off-farm activities. The paper selected key groups of the determinants of the off-farm income with the aim to evaluate the current state and to propose further steps of the detailed analysis. The authors identified the mechanisms how the particular instruments influence farmers' decisions on generating the off-farm income. It may be concluded that the significance of direct payments is still very high. Subsidies generally discourage farmers from the non-agriculture employment. The influence of socio-demographic characteristics is significant, however, the strength of this impact is determined by the additional factors like the situation in the labour market. In case of environmental determinants, it should be noted that there is a limited group of factors that may be out of control by the farm operators. The value added of the article is an attempt to identify the mechanisms how the particular instruments may influence farmers' decisions on generating the off-farm income. The article finishes with the authors' recommendations for further empirical studies.

In the past decade, next-generation sequencing (NGS) platforms have changed the impact of sequencing on our knowledge of crop genomes and gene regulation. These techniques are today acquiring a great potential in metagenomic and agrigenomic research while showing prospects for their utilization in plant breeding. We can now obtain new and beneficial information about gene regulation on the cellular as well as whole-plant level through RNA-sequencing and subsequent expression analyses of genes participating in plant defence reactions to pathogens and in abiotic stress tolerance. NGS has facilitated the development of methods to genotype very large numbers of single-nucleotide polymorphisms. Genotyping- by-sequencing and whole-genome resequencing can lead to the development of molecular markers suited to studies of genetic relationships among breeding materials, creation of detailed genetic mapping of targeted genes and genome-wide association studies. Plant genotyping can benefit plant breeding through selection of individuals resistant to climatic stress and to pathogens causing substantial losses in agriculture.

This case report describes an episode of acute ataxia, tremor, vertical nystagmus and progressive weakness in a mixed breed dog treated with high doses of metronidazole. Complete blood cell count, serum biochemistry, coagulation profile, blood pressure measurement, urinalysis, computed tomography of the brain and cerebrospinal fluid examination were unremarkable. Metronidazole had been administered at a dose of 65 mg/kg/day and neurotoxicity was, therefore, suspected. Drug concentrations in the patient's serum and cerebrospinal fluid were measured using high-performance liquid chromatography and compared to control dogs. Metronidazole administration was immediately discontinued; supportive care consisted of fluid therapy and diazepam treatment. The neurological status of the patient improved rapidly within 72 h. The aim of this case report is to describe the clinical presentation of metronidazole intoxication in a mixed breed dog and to interpret the chromatographic analysis which can be a beneficial diagnostic and screening tool in dogs intoxicated with metronidazole.

In this research, laser-induced fluorescence (LIF) technique combined with back-propagation neural network (BPNN) was employed to analyse different nitrogen (N) fertilization levels in paddy rice. Leaf fluorescence characteristics (FLCs) were measured by using the LIF system built in our laboratory and exhibited different FLCs with different nitrogen fertilization levels. The correlation between fluorescence intensity ratios (F685/F460, F735/F460 and F735/F685) and the dose of N fertilization was established and analysed. Then, the BPNN algorithm was utilized to validate that the different N fertilization levels can be classified based on the three FLCs. The overall identification accuracies of 2014 and 2015 were 90% and 92.5%, respectively. Experimental results demonstrated that the three FLCs with the help of multivariate analysis can be served as a helpful tool in the evaluation of paddy rice N fertilization levels. Besides, this study can also provide guidance for the selection of LIF Lidar channels in the following research.

Extreme differences in agricultural holding size, existing not only among the countries within the EU as a whole but also within the farm structures of the individual countries, create a considerable uncertainty for establishing the optimal political and economic instruments to support sustainable rural development. The study explores the determinants influencing the spatial volatility of agricultural holding size at both the EU scale and the national scale of the Czech Republic, the latter of which has the largest mean agricultural holding size in the EU. While some factors are identical for both the EU and the Czech Republic, other effects can only be evaluated at the European or international scale, and still others can be evaluated only at the national scale. The only factor found in this study to be significantly associated with the agricultural holding size on the European scale was the wheat production. On the Czech national scale, land consolidation, unemployment rate, and soil fertility were significantly associated with the agricultural holding size. The study found that in the Czech Republic, the number of farms was increasing, while at the same time the agricultural holding sizes were decreasing. This is an opposite trend in comparison to the EU as a whole, where the number of farms is diminishing and the sizes increasing.

Using reverse transcription polymerase chain reaction, 160 sweet and sour cherry trees from a germplasm collection, orchards, and wild trees in the Czech Republic were screened for the presence of Cherry necrotic rusty mottle virus (CNRMV) and Cherry green ring mottle virus (CGRMV). The viruses were detected exclusively in sweet cherry trees in the germplasm collection, with CNRMV determined in two trees and CGRMV in four trees. Using next-generation sequencing, nearly complete genomic sequences (complete ORFs) were obtained for one CNRMV and three CGRMV isolates. Their relatedness to GenBank sequences of isolates from different countries together with negative results from screening outside of the germplasm collection suggests that the viruses had been imported with accessions.

The purpose of this study was to evaluate the feasibility of dental panoramic radiography for dental arch evaluation in small animals. The dental arches of four Beagles, one Shih Tzu dog, and three Korean short-haired cats were radiographed using human panoramic X-rays. All animals were under general anaesthesia during the examination. The animals' heads were placed horizontal to the panoramic device, just as a human's head is placed in panoramic dental assessments. All animals were evaluated with an open and closed mouth view (human view). In the closed mouth view, the animal was provided a bite blocker for proper placement of the oral cavity. The open mouth view angle was approximately 30-45°. The maxilla and mandible were held in position with radiolucent 3M tape. The standard scoring measurement was performed based on visibility of the tooth root and the sharpness of the dento-alveolar margin. No significant differences in scoring were noticed between the two positions. The visibility of teeth roots in Beagles was far better than that in the Shih Tzu dogs and two Korean short-haired cats. In addition, the Beagle series showed sharp dento-alveolar margin scores. These results suggest that human panoramic dental X-rays represent a possible dental evaluation tool for animals with large skulls.

Two cases of granulomatous colitis in two French bulldogs were found to be unresponsive to fluoroquinolones. The granulomatous colitis diagnosis was made on the basis of PAS-positive histiocytes in the lamina propria of the colonic mucosa in biopsy samples taken at colonoscopy. Remission of granulomatous colitis has been reported using fluoroquinolones leading to the idea that invasive Escherichia coli strains in the colonic mucosa are involved. Oral enrofloxacin (Baytril 150 mg, Bayer, Spain) at 10 mg/kg per day for eight weeks was prescribed to both dogs in this study. A first course of therapy resolved the problem in dog No. 1, which, however, was followed by relapse three months later without enrofloxacin response. No clinical remission was seen in dog No. 2 and 4.4 mg/kg marbofloxacin (Marbocyl P 20 mg, Vetoquinol, Spain) per day for 10 weeks was administered but without any response. From both dogs, biopsy samples from the colonic mucosa were taken during colonoscopy. Samples were homogenised for microbial culture in different agar media to identify invasive microbes. Escherichia coli were largely isolated and antibiotic sensitivity testing (MIC of E. coli to selected antimicrobials, CLSI 2013) was carried out. In both cases, E. coli was resistant to fluoroquinolones. In dog No. 1 E. coli was susceptible to amoxicillin-clavulanate, cefazolin, amikacin and gentamicin whereas in dog No. 2 it was susceptible to doxycycline and amoxicillin-clavulanate. Clinical remission was achieved in dog No. 1 with amoxicillin-clavulanate (Synulox 250 mg, Pfizer, Spain) therapy for eight weeks. No response was found in dog No. 2 with any of the antimicrobials alone or combined with metronidazole.

An experiment was established in the spring of 2006 in the Experimental Orchard in Dąbrowice (central Poland). The plum cultivars under assessment included: 'Avalon', 'Edda', 'Excalibur', 'Jubileum', 'Mallard' and 'Reeves'. Trees of the cv. 'Victoria' were the control combination. On the basis of the eight-year study it was found that the most vigorously growing were trees of the cultivar 'Excalibur'. The most susceptible to frost damage and infection by Chondrostereum purpureum (silver leaf) were trees of the cultivars 'Edda' and 'Excalibur'. In addition, the cv. 'Excalibur' was characterized by high susceptibility to the Plum pox virus (sharka). The highest cumulative fruit yield was shown by the cultivar 'Jubileum'. The worst fruiting were trees of the cultivar 'Mallard'. Fruits of the cv. 'Excalibur' had the highest weight. The smallest were fruits of the cv. 'Edda' characterized by early ripening time. The highest amounts of soluble solids were contained in fruits of the cultivar 'Avalon'. The cvs 'Edda', 'Reeves' and 'Avalon' proved suitable for cultivation in Polish climatic conditions.

Agricultural land represents a country's natural heritage. Therefore, land protection is an issue that is the subject of various legislative measures, also including those that affect land fragmentation. Land fragmentation is a problem that hinders the effective use of land. In 1995, Slovak lawmakers adopted Law 180/1995 Coll., which prevents the fragmentation of land under a minimum size. The aim of this paper was to determine whether Slovak legislation concerning land fragmentation is effective and prevents this phenomenon. We compare the Slovak legislation with the legislations of other countries, and, further, we describe the existing situation with respect to land fragmentation in the individual regions of the country according to the requirements of Slovak legal regulations. The results include proposals for the potential amendment of the legal regulation to ensure the effective prevention of land fragmentation.

Sugar beet yield loss was predicted from early observations of weed density, relative weed cover, and weed biomass using non-linear regression models. Six field experiments were conducted in Germany and in the Russian Federation in 2012, 2013 and 2014. Average weed densities varied from 20 to 131 with typical weed species compositions for sugar beet fields at both locations. Sugar beet yielded higher in Germany and relative yield losses were lower than in Russia. Data of weed density, relative weed cover, weed biomass and relative yield loss fitted well to the non-linear regression models. Competitive weed species such as Chenopodium album and Amaranthus retroflexus caused more than 80% yield loss. Relative weed cover regression models provided more accurate predictions of sugar beet yield losses than weed biomass and weed density.

A reliable, qualitative PCR-based detection method for the traceability and authentication of common and Tartary buckwheat was developed. Five InDel markers developed from chloroplast genome variation between the two species were applied for 96 buckwheat accessions and all accessions were easily differentiated as Tartary and common buckwheat using these markers. We also determined the sample detection limit by PCR and qPCR as 0.001 and 0.02 ng/µl, respectively. InDel markers could detect the mixture of two species flour up to 10% contamination. InDel markers were also applied to processed foods such as noodles and tea, and we found that species-specific PCR bands could be used to identify buckwheat even after processing. Hence, these InDel markers are simple with higher specificity and sensitivity and are reliable for the authentication of buckwheat processed foods.

Most Salmonella enterica serovar Typhimurium strains are capable of infecting multiple hosts. In this report, an abdominal cavity abscess associated with the Salmonella enterica serovar Typhimurium phage type DT2 is described in a dog. A dead male dog was admitted to the Department of Pathology at the Faculty of Veterinary Medicine at Erciyes University for necropsy. Anorexia, weight loss and lethargy were the clinical symptoms that were reported by the owner of the dog. The diagnosis was made by histopathological and bacteriological examinations of the lungs, spleen, liver and heart. In addition, the content of the abdominal cavity mass was evaluated in bacteriological analysis. The serotyping, phage typing and antibiotic susceptibility of the isolated bacteria were performed at the Danish Institute for Food and Veterinary Research. To the best of the authors' knowledge, this is the first study reporting an abscess associated with S. enterica serovar Typhimurium phage type DT2 in a dog.

This study was undertaken to obtain and analyse, on the basis of sex, three-dimensional (3D) reconstructions obtained by a 3D computer program from two-dimensional (2D) vertebral column sections taken by multidetector computed tomography (MDCT) images, in the chinchilla. A total of 16 adult chinchillas (Chinchilla lanigera) of both sexes were used. The MDCT images were taken under general anaesthesia, and were then transferred to a personal computer on which 3D reconstructions were carried out using a 3D modelling program (Mimics 13.1). The volume, surface area and vertebral body length of each vertebra (except caudal region) forming the vertebral column were measured from the 3D models created. The ratios (in percentage) of the measurements of each vertebra (except the sacral ones) forming the vertebral column region (cervical part, thoracic part, lumbar part) were determined for statistical analysis. We detected significant differences (P < 0.05) between sexes in all vertebrae forming the vertebral column of the chinchilla with respect to volume, surface area and vertebral body length, except for C6 and L1. This study is the first to carry out 3D reconstructions of data obtained from CT images in the chinchilla and the obtained results contribute to a more detailed understanding of the anatomy of this species. Our strategy may also be useful for the design of experiments exploring the vertebral column in domestic mammals and humans.

The paper presents the results of a laboratory experiment aimed at the assessment of N₂O emissions, NO₃^-, NH₄⁺ and carbon (C) leaching from agricultural soils subjected to long-term mineral and organic fertilization. Our results show that long-term treatment impacts the N₂O emissions from loamy-sand Luvisols to a greater extent than the recent single application of mineral or organic fertilizers. The N₂O fluxes from soils with higher C_org content that results from long-term organic fertilization exceed those from soils with lower C_org content subsequent to long-term mineral fertilization. Our research confirms previous reports that the intensity of N₂O emission is related to soil moisture. The NO₃^- leaching depended on the recent application of fertilizers with a stronger influence of single application of NH₄NO₃ than farmyard manure. Long-term fertilization did not impact the NO₃^- leaching.

An important factor in hop growing is the process of drying. For this purpose belt dryers with follow-up conditioning are the most widespread but they are not ideal. In this respect, an analysis of the drying process was carried out in the belt dryer of Agrospol Velká Bystřice Co., Ltd. for the 'Saaz' hop variety. Drying parameters were monitored by means of fixed sensors, continuously sensing data loggers and samples taken for laboratory analysis (hop moisture, alpha and beta bitter acids, Hop Storage Index (HIS). The process of drying showed that hops are practically dry (10 ± 2.0% of moisture) already at the end of the second belt or possibly at the beginning of the third belt. It was also proved that hops are over-dried (moisture of 4 to 8%) and then they are adjusted by conditioning to the final moisture content of 8-10%. Excessive drying leads to cone disintegration, which makes any manipulation with hops for purposes of further processing difficult and results in greater losses of lupulin.

In the agricultural industry, many brokers exploit the benefits between farmers and customers and decrease the farmers' income. As the technology has developed, the internet has become the best advertising medium for many industries. In light of this, this study based on the Google Earth has designed an on-line Agricultural Products Navigation System operated by mobile devices which can easily exclude brokers, and build the bridge between farmers and customers in order to increase the farmers income and customer benefits. Moreover, based on the IS success model of DeLone and McLean, by using the qualitative methodology, it is expected that this model will be able to provide system developers with the knowledge to improve the success of their systems.

In 2012-2015 the virulence of the wheat leaf rust (Puccinia triticina Eriks.) population was studied on Thatcher near-isogenic lines with Lr1, Lr2a, Lr2b, Lr2c, Lr3a, Lr9, Lr10, Lr11, Lr13, Lr15, Lr17, Lr19, Lr21, Lr23, Lr24, Lr26 and Lr28. Samples of leaf rust were obtained from different parts of the Czech Republic. A total of 163 wheat leaf rust isolates were analysed. No virulence for the resistance gene Lr9 was found. Virulence for Lr19 was found only in one isolate in 2015. A lower frequency of virulence to Lr24, Lr2a, 2b, 2c and Lr28 was also observed. The presence of Lr10, Lr24, Lr26, Lr28 and Lr37 in registered cultivars was detected by polymerase chain reaction (PCR) molecular markers.

The aim of this study was to investigate the influence of storage time at +4 °C on haematological indicators in rainbow trout Oncorhynchus mykiss (Walbaum, 1792). For this purpose, 60 Italian trout were evaluated and red blood cells, white blood cells, thrombocyte count, haematocrit, haemoglobin concentration, mean corpuscular volume, mean corpuscular haemoglobin and mean corpuscular haemoglobin concentration were determined. After blood collection (T₀), all samples were immediately analysed using an automatic method to assess the haematological parameters and then divided into two different aliquots and stored at +4 °C. The first aliquot was refrigerated for 168 h (T₁), the second one for 336 h (T₂). Statistical analysis (one-way repeated-measures ANOVA) showed a significant effect of storage time (P < 0.05) on red blood cells, thrombocyte count, haematocrit, haemoglobin concentration, mean corpuscular haemoglobin and mean corpuscular haemoglobin concentration. The obtained data expand our knowledge of haematological evaluation techniques and could contribute to the development of an appropriate method for haematological analysis that is suitable for the evaluation of the health status of wild and farmed fish.

For the purposes of assessment of long-term changes, two sets of Chernozems soil samples were analysed and compared in parallel: 'old' file samples obtained during the Soil Survey 1960-1970 in the former Czechoslovakia and a 'present' (2013) set of samples from exactly the same sites as the archive samples. The recently collected samples revealed worse qualitative parameters (lower humic acid to fulvic acid (HA/FA) ratios and higher colour quotient Q4/6 values) than the file samples, for all the localities. On the other side, the quantitative soil organic matter (SOM) parameters (oxidizable carbon (C_ox) and all its determined components) showed contrary results. The amount of total SOM at the same sites is higher now than it was about 50 years ago. It can be concluded that the current decline in SOM quality in Chernozems is partly compensated for by higher accumulation of SOM in the soils. All the analysed Chernozem samples were found to have much worse qualitative SOM parameters than the values mentioned for this soil type in the older literature. However, a comparison of the current data and the file data of Chernozem SOM quality can still be considered an open issue and require more complex research.

Soil organic carbon (SOC) plays a critical role in rice production, but its feedback to the fate of fertilizer nitrogen (N) is not clear. In this study, a pot experiment was conducted to investigate the responses of rice yield and the fate of fertilizer N to different SOC levels using ¹⁵N-labelled urea. The results showed that rice biomass, yield and the total N uptake increased significantly with increasing SOC content. Both rice N uptake from soil and urea increased significantly with increasing SOC content. The recovery rate and residual rate of fertilizer N improved significantly with increasing SOC content, leading to a reduced rate of not-specified fertilizer N. Therefore, it was concluded that high SOC could not only improve rice yield and fertilizer N recovery, but also could increase the retention of fertilizer N and decrease the not-specified N in the paddy soil.

The reaction of IR 50, TRY 3, and IR 36 cultivars of rice to R. solani challenge, the causal agent of sheath blight, and its toxic metabolite was studied. Differential response of these cultivars to the pathogen and/or toxin inoculation was observed in detached leaf sheaths and greenhouse-grown plants. The observations were based on disease scoring, electrolyte leakage, and also microscopic views of infection cushions. The Osmyb4 gene expression was studied in the tissues from all these experiments and a correlation between the level of expression and disease response of the varieties was found at least in some experiments. The mechanisms regulated by Osmyb4 might have a lower but significant contribution to the tolerance of rice cultivars to sheath blight.

The purpose of this investigation was the identification of chicken, beef and sheep meat in pork sausages using PCR-RFLP and PCR with pecies-specific primers. Six dry fermented pork sausages were produced by adding beef, sheep and chicken meat to each in the amount of 1 and 5%. DNA was extracted from five regions of each sausage and PCR-RFLP together with PCR using species-specific primers was performed. PCR-RFLP analysis was successful only for chicken meat, while species-specific PCR was effective for identification of chicken, eef and sheep meat in all ratios and from all regions of the sausages. The results of our study show that discovering adulteration using PCR-RFLP is suitable only for chicken meat in the investigated products, while for detection of beef and sheep meat use of species-specific oligonucleotides is more effective.

Ruzrok, the first sorghum cultivar of Czech provenance, was selected as a multiline cultivar from sorghum collected in the Bílé Karpaty region in Moravia, Czech Republic. In the present paper, basic plant morphological and yield-related characteristics as well as characteristics related to plant resistance to major abiotic and biotic stress factors are described. The major advantages of Ruzrok consists in its earliness, plant height and high growth rate of plants leading to high biomass production. Ruzrok was registered for its high biomass yield; however, its grains can also be used for flour production and food purposes after the technological removal of tannin-rich outer layers of grains. Recommendations for basic cultural practices such as sowing date, fertilization and protection against pests and diseases are given. In conclusion, potential utilization of the novel sorghum variety as both biomass and fodder crop is discussed.

The purpose of the present studies was to determine the antagonistic effect of bacteria Bacillus spp. and Pseudomonas spp. towards selected fungi from the soil environment of carrot. Oats (Avena sativa L.), tansy phacelia (Phacelia tanacetifolia Bentham) and vetch (Vicia satica L.) were used as cover crops in the cultivation of this plant. In the traditional cultivation of carrot the population of bacteria was the smallest, while after the application of oats it was the largest. Laboratory tests showed that cover crops promoted the development of antagonistic Bacillus spp. and Pseudomonas spp. Irrespective of the experimental treatment, those bacteria were the most effective in limiting the growth and development of Fusarium oxysporum and Thanatephorus cucumeris (syn. Rhizoctonia solani), while being less effective towards Altenaria dauci and Alternaria radicina, and the least towards Sclerotinia sclerotiorum. The best total antagonistic effect of Pseudomonas spp. and Bacillus spp. towards the tested fungi was found after using oats and vetch, while the worst - in the traditional cultivation of carrot.

This paper follows up the landscape changes of Prague outskirts from 1990 to 2012 using the CORINE land cover data. It quantifies these changes by observing the acreage decrease and increase of individual types of land cover. The results confirm the frequently emerging trend in Europe, namely the increase of the urban area at the expense of arable land. Another significant change is the increase of pastures in the areas farther from the city. These changes are further analysed to find regularities relating to the relief, to the distance from the city and to the transport and settlement infrastructure. On the bases of the analyses there are defined the types of changes. The most significant change is a decrease of arable land at the expense of discontinuous urban fabric and pastures. The results show that there were changes made to the land cover on an area of 17,429 ha which is equivalent to 7.3% of the evaluated area.

Prociphilus (Meliarhizophagus) fraxinifolii (Riley, 1879) (Hemiptera: Eriosomatidae) is an alien species in Europe that has been spreading quickly there. This paper presents the origin and current occurrence, classification, description, identification, and biology of this species. It also discusses the harmfulness and threats, especially the impact on host- plants and ecosystem, invasion rate and facilitating factors.

We present a successful use of the plasmid inhibition detection and DNA isolation protocol optimisation for four food/feed samples in qPCR analysis of the sequence coding for chloroplast tRNA-Leu: two meat meal samples and two samples made of cranberries (jam and dried fruit). The quantitative real-time polymerase chain reaction (qPCR) can be inhibited by various substances and the DNA content in the sample can be underestimated. It is necessary to identify the PCR inhibition and choose an optimal DNA isolation protocol to correctly evaluate the sample. In a previous study, we have developed an assay using plasmid DNA carrying a non-homologous random sequence identifying possible inhibitors in qPCR in food/feed samples. The plasmid assay allowed to effectively reveal the PCR inhibition in all of the different sample matrices and to choose an optimal DNA isolation protocol.

Influenza is a serious infectious disease, which is life-threatening especially in children, seniors and immunocompromised patients. In addition to vaccination, the development of new anti-influenza agents represents a crucial defence strategy to combat seasonal and pandemic influenza strains. At present most attention is paid to the development of inhibitors of influenza neuraminidase, which has been established as a key drug target for the prophylaxis and treatment of influenza infections. However, the emergence of drug-resistant influenza variants highlights the need of continuously innovative strategies for the development of new drugs with improved antiviral effects, higher safety and increased tolerability. In this review article, an analysis of publications describing anti-influenza agents indexed in the Web of Science^® database has been carried out. The most important publications are presented in tables and are characterised by several key words, abstracts and references. The presented publications have been sorted according to five basic criteria: (i) review articles, (ii) design, synthesis and evaluation of new anti-influenza drugs, (iii) major classes of anti-influenza drugs, (iv) combination therapy of influenza infections and (v) influenza drug resistance. The design of this review article allows us to offer a complex overview of known antiviral agents targeting influenza viruses, facilitates easy and rapid orientation in numerous publications written on this subject, and aids the gathering of required data.