Allele frequencies in loci controlling coat colour in Polish Coldblood horses

https://doi.org/10.17221/107/2018-CJASCitation:Stachurska A., Brodacki A., Liss M. (2018): Allele frequencies in loci controlling coat colour in Polish Coldblood horses. Czech J. Anim. Sci., 63: 462-472.
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The objective of this study was to estimate the frequencies of alleles which produce coat colour in Polish Coldblood horse population, and to verify the hypothesis that coat colour is not considered in its selection. The analysis included 35 928 horses and their parents having been registered in the studbook over a half-century. Allele frequencies in Agouti (A), Extension (E), Dun (D), Roan (Rn), and Grey (G) loci, in parental and offspring generations, were estimated according to test matings and the square root of recessive phenotype frequency. The population structure is in Hardy–Weinberg equilibrium only at E locus and coat colour is regarded by breeders. Black horses are favoured. Higher E locus homozygosity in blacks than in bays makes it easier to obtain black foals. Dun-diluted, roan and grey coat colours are undesirable and the population has come to consist almost uniformly of basic coat colours. These results show the importance of studies on population genetic structure, which despite no formal criteria for breeding for colour, can considerably change through generations.

References:
ADALSTEINSSON STEFÁN (1974): Inheritance of the Palomino Color in Icelandic Horses. Journal of Heredity, 65, 15-20  https://doi.org/10.1093/oxfordjournals.jhered.a108448
 
ADALSTEINSSON STEFÁN (1978): Inheritance of yellow dun and blue dun in the Icelandic toelter horse. Journal of Heredity, 69, 146-148  https://doi.org/10.1093/oxfordjournals.jhered.a108913
 
Andersson Lisa S., Wilbe Maria, Viluma Agnese, Cothran Gus, Ekesten Björn, Ewart Susan, Lindgren Gabriella, Wade Claire (2013): Equine Multiple Congenital Ocular Anomalies and Silver Coat Colour Result from the Pleiotropic Effects of Mutant PMEL. PLoS ONE, 8, e75639-  https://doi.org/10.1371/journal.pone.0075639
 
Bellone Rebecca R., Holl Heather, Setaluri Vijayasaradhi, Devi Sulochana, Maddodi Nityanand, Archer Sheila, Sandmeyer Lynne, Ludwig Arne, Foerster Daniel, Pruvost Melanie, Reissmann Monika, Bortfeldt Ralf, Adelson David L., Lim Sim Lin, Nelson Janelle, Haase Bianca, Engensteiner Martina, Leeb Tosso, Forsyth George, Mienaltowski Michael J., Mahadevan Padmanabhan, Hofreiter Michael, Paijmans Johanna L. A., Gonzalez-Fortes Gloria, Grahn Bruce, Brooks Samantha A., Anderson Michael G (2013): Evidence for a Retroviral Insertion in TRPM1 as the Cause of Congenital Stationary Night Blindness and Leopard Complex Spotting in the Horse. PLoS ONE, 8, e78280-  https://doi.org/10.1371/journal.pone.0078280
 
Blackburn H.D. (2004): Development of national animal genetic resource programs. Reproduction, Fertility and Developement, 16, 27–32. https://doi.org/10.1071/RD03075
 
Brooks Samantha A., Gabreski Nicole, Miller Donald, Brisbin Abra, Brown Helen E., Streeter Cassandra, Mezey Jason, Cook Deborah, Antczak Douglas F., Barsh Gregory S. (2010): Whole-Genome SNP Association in the Horse: Identification of a Deletion in Myosin Va Responsible for Lavender Foal Syndrome. PLoS Genetics, 6, e1000909-  https://doi.org/10.1371/journal.pgen.1000909
 
Brunberg E., Andersson L., Cothran G., Sandberg K., Mikko S., Lindgren G. (2006): A missense mutation in PMEL17 is associated with the silver coat color in the horse. BMC Genetics, 7: 46. https://doi.org/10.1186/1471-2156-7-46
 
Cieslak J., Cholewinski G., Mackowski M. (2013): Genotyping of coat color genes (MC1R, ASIP, PMEL17 and MATP) polymorphisms in cold-blooded horses bred in Poland reveals sporadic mistakes in phenotypic descriptions. Animal Science Papers and Reports, 31, 159–164.
 
Druml T., Baumung R., Sölkner J. (2009): Pedigree analysis in the Austrian Noriker draught horse: genetic diversity and the impact of breeding for coat colour on population structure. Journal of Animal Breeding and Genetics, 126, 348-356  https://doi.org/10.1111/j.1439-0388.2008.00790.x
 
Finn Jessica L., Haase Bianca, Willet Cali E., van Rooy Diane, Chew Tracy, Wade Claire M., Hamilton Natasha A., Velie Brandon D. (2016): The relationship between coat colour phenotype and equine behaviour: A pilot study. Applied Animal Behaviour Science, 174, 66-69  https://doi.org/10.1016/j.applanim.2015.11.004
 
Golebiewska K., Martyniuk E., Polak G. (2013): Study on Sztumski mares enrolled in the Genetic Resources Conservation Programme in 2008. Annals of Animal Science, 13, 687–700.
 
Haase B., Jude R., Brooks S. A., Leeb T. (2008): An equine chromosome 3 inversion is associated with the tobiano spotting pattern in German horse breeds. Animal Genetics, 39, 306-309  https://doi.org/10.1111/j.1365-2052.2008.01715.x
 
Hartl D.L., Clark A.G. (2007): Principles of Population Genetics. Sinauer Associates, Inc., Sunderland, USA.
 
HINTZ H. F., VAN VLECK L. D. (1979): Lethal dominant roan in horses. Journal of Heredity, 70, 145-146  https://doi.org/10.1093/oxfordjournals.jhered.a109213
 
Imsland Freyja, McGowan Kelly, Rubin Carl-Johan, Henegar Corneliu, Sundström Elisabeth, Berglund Jonas, Schwochow Doreen, Gustafson Ulla, Imsland Páll, Lindblad-Toh Kerstin, Lindgren Gabriella, Mikko Sofia, Millon Lee, Wade Claire, Schubert Mikkel, Orlando Ludovic, Penedo Maria Cecilia T, Barsh Gregory S, Andersson Leif (2016): Regulatory mutations in TBX3 disrupt asymmetric hair pigmentation that underlies Dun camouflage color in horses. Nature Genetics, 48, 152-158  https://doi.org/10.1038/ng.3475
 
Jacobs Lauren N., Staiger Elizabeth A., Albright Julia D., Brooks Samantha A. (2016): The MC1R and ASIP Coat Color Loci May Impact Behavior in the Horse. Journal of Heredity, 107, 214-219  https://doi.org/10.1093/jhered/esw007
 
Mariat Denis, Taourit Sead, Guérin Gérard (2003): A mutation in the MATP gene causes the cream coat colour in the horse. Genetics Selection Evolution, 35, 119-  https://doi.org/10.1186/1297-9686-35-1-119
 
Marklund L., Moller M. Johansson, Sandberg K., Andersson L. (1996): A missense mutation in the gene for melanocyte-stimulating hormone receptor (MCIR) is associated with the chestnut coat color in horses. Mammalian Genome, 7, 895-899  https://doi.org/10.1007/s003359900264
 
Marklund S., Moller M., Sandberg K., Andersson L. (1999): Close association between sequence polymorphism in the KIT gene and the roan coat color in horses KIT sequences: AJ224642–AJ224645.-->. Mammalian Genome, 10, 283-288  https://doi.org/10.1007/s003359900987
 
Metallinos *, † , A.T. Bowling D.L., Rine J. (1998): A missense mutation in the endothelin-B receptor gene is associated with Lethal White Foal Syndrome: an equine version of Hirschsprung Disease. Mammalian Genome, 9, 426-431  https://doi.org/10.1007/s003359900790
 
Munckel H. (1929): Research on horse coat colours and markings and their inheritance. Zeitschrift für Tierzüchtung und Züchtungsbiologie, 16, 1–200. (in German)
 
Rieder Stefan, Taourit Sead, Mariat Denis, Langlois Bertrand, Guérin Gérard (2001): Mutations in the agouti (ASIP), the extension (MC1R), and the brown (TYRP1) loci and their association to coat color phenotypes in horses (Equus caballus). Mammalian Genome, 12, 450-455  https://doi.org/10.1007/s003350020017
 
Rosengren Pielberg Gerli, Golovko Anna, Sundström Elisabeth, Curik Ino, Lennartsson Johan, Seltenhammer Monika H, Druml Thomas, Binns Matthew, Fitzsimmons Carolyn, Lindgren Gabriella, Sandberg Kaj, Baumung Roswitha, Vetterlein Monika, Strömberg Sara, Grabherr Manfred, Wade Claire, Lindblad-Toh Kerstin, Pontén Fredrik, Heldin Carl-Henrik, Sölkner Johann, Andersson Leif (2008): A cis-acting regulatory mutation causes premature hair graying and susceptibility to melanoma in the horse. Nature Genetics, 40, 1004-1009  https://doi.org/10.1038/ng.185
 
Sponenberg D.P. (2003): Equine Color Genetics. Wiley-Blackwell Publishing, USA.
 
Sponenberg DP, Weise MC (1997): Dominant black in horses. Genetics Selection Evolution, 29, 403-  https://doi.org/10.1186/1297-9686-29-3-403
 
Sponenberg D. Phillip, Harper Henry T., Harpar Anne L. (1984): Direct evidence for linkage of roan and extension loci in Belgian horses. Journal of Heredity, 75, 413-414  https://doi.org/10.1093/oxfordjournals.jhered.a109968
 
Stachurska A., Brodacki A. (2003): Selection of Polish Konik horses for coat colour and the ways to improve its effectiveness. Electronic Journal of Polish Agricultural Universities, Series Animal Husbandry, 6, 1. Available at http://www.ejpau.media.pl/volume6/issue1/animal/art-04.html (accessed March 1, 2018).
 
Stachurska Anna, Brodacki Antoni (2008): Variation of gene frequencies in ASIP, MC1R and GREY loci in Thoroughbred horses. Livestock Science, 113, 163-168  https://doi.org/10.1016/j.livsci.2007.03.007
 
Stachurska A., Pięta M., Łojek J., Szulowska J. (2007): Performance in racehorses of various colours. Livestock Science, 106, 282-286  https://doi.org/10.1016/j.livsci.2006.07.017
 
Stachurska A., Brodacki A., Grabowska J. (2012):  Allele frequency in loci which control coat colours in Hucul horse population. Czech Journal of Animal Science, 57, 178-186  https://doi.org/10.17221/5893-CJAS
 
Stachurska A., Nogaj A., Brodacki A., Nogaj J., Batkowska J. (2014): Genetic distances between horse breeds in Poland estimated according to blood protein polymorphism. Czech Journal of Animal Science, 59, 257-267  https://doi.org/10.17221/7496-CJAS
 
Stefaniuk-Szmukier Monika, Ropka-Molik Katarzyna, Piórkowska Katarzyna, Szmatoła Tomasz, Długosz Bogusława, Pisarczyk Weronika, Bugno-Poniewierska Monika (2017): Variation in TBX3 Gene Region in Dun Coat Color Polish Konik Horses. Journal of Equine Veterinary Science, 49, 60-62  https://doi.org/10.1016/j.jevs.2016.10.003
 
Swinburne J. E., Hopkins A., Binns M. M. (2002): Assignment of the horse grey coat colour gene to ECA25 using whole genome scanning. Animal Genetics, 33, 338-342  https://doi.org/10.1046/j.1365-2052.2002.00895.x
 
Thiruvenkadan A.K., Kandasamy N., Panneerselvam S. (2008): Coat colour inheritance in horses. Livestock Science, 117, 109-129  https://doi.org/10.1016/j.livsci.2008.05.008
 
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