Effects of dietary Astragalus mongholicus, Astragalus polysaccharides and Lactobacillus on growth performance, immunity and antioxidant status in Qingjiaoma finishing broilers

https://doi.org/10.17221/12/2022-CJASCitation:

Wei F., Abulahaiti D., Tian C.C., Chen Y., Jiang S.S., Lu J.X., Zhang G.H. (2022): Effects of dietary Astragalus mongholicus, Astragalus polysaccharides and Lactobacillus on growth performance, immunity and antioxidant status in Qingjiaoma finishing broilers. Czech J. Anim. Sci., 67: 275–285.

download PDF

Three hundred 21-day-old male Qingjiaoma broilers were randomly assigned to six groups to investigate the effect of dietary stems and leaves of Astragalus mongholicus (AMSLs), Astragalus polysaccharides (APSs), Lactobacillus (Lac) and their combinations on finishing broilers in a 42-day feeding experiment. Supplementary 1% AMSLs, 1 000 mg/kg APSs and 4.5 × 1010 CFU/kg Lac improved significantly growth performance. Dietary AMSLs, APSs and Lac increased the serum concentrations of immunoglobulins IgA, IgG and complements C3 and C4. Furthermore, AMSLs increased glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) activities and total antioxidation capacity (T-AOC) and decreased the malondialdehyde (MDA) content in both serum and liver tissue. Compared with individual supplementation, the combination of Lac and AMSLs or APSs increased serum IgA, IgG, C3 and C4 concentrations. The combination of AMSLs and Lac increased serum GSH-Px activity and reduced the MDA content in the serum and liver tissue. These results suggested that AMSLs, APSs and Lac are beneficial feed additives, and the applications of combined Lac and AMSLs or APSs could synergistically improve immunity in broilers.

References:
Abdullahi AY, Kallon S, Yu X, Zhang Y, Li G. Vaccination with astragalus and ginseng polysaccharides improves immune response of chickens against H5N1 avian influenza virus. Biomed Res Int. 2016 Aug 15;2016: 8 p. https://doi.org/10.1155/2016/1510264
 
Amerah AM, Quiles A, Medel P, Sanchez J, Lehtinen MJ, Gracia MI. Effect of pelleting temperature and probiotic supplementation on growth performance and immune function of broilers fed maize/soy-based diets. Anim Feed Sci Tech. 2013 Mar;180(1):55-63. https://doi.org/10.1016/j.anifeedsci.2013.01.002
 
Bai K, Huang Q, Zhang J, He J, Zhang L, Wang T. Supplemental effects of probiotic Bacillus subtilis fmbJ on growth performance, antioxidant capacity, and meat quality of broiler chickens. Poult Sci. 2017 Jan 1;96(1):74-82. https://doi.org/10.3382/ps/pew246
 
Che D, Adams S, Wei C, Gui-Xin Q, Atiba EM, Hailong J. Effects of Astragalus membranaceus fiber on growth performance, nutrient digestibility, microbial composition, VFA production, gut pH, and immunity of weaned pigs. Microbiologyopen. 2019 May;8(5): 12 p. https://doi.org/10.1002/mbo3.712
 
Chen HL, Li DF, Chang BY, Gong LM, Dai JG, Yi GF. Effects of Chinese herbal polysaccharides on the immunity and growth performance of young broilers. Poult Sci. 2003 Mar;82(3):364-70. https://doi.org/10.1093/ps/82.3.364
 
Cheng K, Song ZH, Zheng XC, Zhang H, Zhang JF, Zhang LL, Zhou YM, Wang T. Effects of dietary vitamin E type on the growth performance and antioxidant capacity in cyclophosphamide immunosuppressed broilers. Poult Sci. 2017 May 1;96(5):1159-66. https://doi.org/10.3382/ps/pew336
 
de Souza M, Baptista AAS, Valdiviezo MJJ, Justino L, Menck-Costa MF, Ferraz CR, da Gloria EM, Verri WA Jr, Bracarense A. Lactobacillus spp. reduces morphological changes and oxidative stress induced by deoxynivalenol on the intestine and liver of broilers. Toxicon. 2020 Oct 15;185:203-12. https://doi.org/10.1016/j.toxicon.2020.07.002
 
Delanghe JR, Speeckaert R, Speeckaert MM. Complement C3 and its polymorphism: Biological and clinical consequences. Pathology. 2014 Jan 1;46(1):1-10. https://doi.org/10.1097/PAT.0000000000000042
 
Deng Q, Shi H, Luo Y, Zhao H, Liu N. Effect of dietary Lactobacilli mixture on Listeria monocytogenes infection and virulence property in broilers. Poult Sci. 2020 Jul 1;99(7):3655-62. https://doi.org/10.1016/j.psj.2020.03.058
 
Ding S, Wang Y, Yan W, Li A, Jiang H, Fang J. Effects of Lactobacillus plantarum 15-1 and fructooligosaccharides on the response of broilers to pathogenic Escherichia coli O78 challenge. PLoS One. 2019 Jun 13;14(6): 14 p. https://doi.org/10.1371/journal.pone.0212079
 
Dong N, Li X, Xue C, Wang C, Xu X, Bi C, Shan A, Li D. Astragalus polysaccharides attenuated inflammation and balanced the gut microflora in mice challenged with Salmonella typhimurium. Int Immunopharmacol. 2019 Sep 1;74: 105681. https://doi.org/10.1016/j.intimp.2019.105681
 
Dong N, Li X, Xue C, Zhang L,Wang C, Xu X, Shan A. Astragalus polysaccharides alleviates LPS-induced inflammation via the NF-κB/MAPK signaling pathway. J Cell Physiol. 2020 Feb 9;235(7-8):5525-40. https://doi.org/10.1002/jcp.29452
 
Dong Q, Li Z, Zhang Q, Hu Y, Liang H, Xiong L. Astragalus mongholicus Bunge (Fabaceae): Bioactive compounds and potential therapeutic mechanisms against Alzheimer’s disease. Front Pharmacol. 2022 Jun 28;13: 14 p. https://doi.org/10.3389/fphar.2022.924429
 
Fassbinder-Orth CA, Wilcoxen TE, Tran T, Boughton RK, Fair JM, Hofmeister EK, Grindstaff JL, Owen JC. Immunoglobulin detection in wild birds: Effectiveness of three secondary anti-avian IgY antibodies in direct ELISAs in 41 avian species. Methods Ecol Evol. 2016 Oct;7(10):1174-81. https://doi.org/10.1111/2041-210X.12583
 
Guo L, Hua J, Luan Z, Xue P, Zhou S, Wang X, Qin N. Effects of the stems and leaves of Astragalus membranaceus on growth performance, immunological parameters, antioxidant status, and intestinal bacteria of quail. Anim Sci J. 2019 Jun;90(6):747-56. https://doi.org/10.1111/asj.13213
 
Humam AM, Loh TC, Foo HL, Samsudin AA, Mustapha NM, Zulkifli I, Izuddin WI. Effects of feeding different postbiotics produced by Lactobacillus plantarum on growth performance, carcass yield, intestinal morphology, gut microbiota composition, immune status, and growth gene expression in broilers under heat stress. Animal. 2019 Sep 2;9(9):644-64. https://doi.org/10.3390/ani9090644
 
Kalavathy R, Abdullah N, Jalaludin S, Ho YW. Effects of Lactobacillus cultures on growth performance, abdominal fat deposition, serum lipids and weight of organs of broiler chickens. Brit Poult Sci. 2003 Mar;44(1):139-44. https://doi.org/10.1080/0007166031000085445
 
Khan AZ, Kumbhar S, Liu Y, Hamid M, Pan C, Nido SA, Parveen F, Huang K. Dietary supplementation of selenium-enriched probiotics enhances meat quality of broiler chickens (Gallus gallus domesticus) raised under high ambient temperature. Biol Trace Elem Res. 2018 Apr;182(2):328-38. https://doi.org/10.1007/s12011-017-1094-z
 
Kim HW, Yan FF, Hu JY, Cheng HW, Kim YH. Effects of probiotics feeding on meat quality of chicken breast during postmortem storage. Poult Sci. 2016 Jun 1;95(6):1457-64. https://doi.org/10.3382/ps/pew055
 
Li SP, Zhao XJ, Wang JY. Synergy of Astragalus polysaccharides and probiotics (Lactobacillus and Bacillus cereus) on immunity and intestinal microbiota in chicks. Poult Sci. 2009 Mar 1;88(3):519-25. https://doi.org/10.3382/ps.2008-00365
 
Li W, Hu X, Wang S, Jiao Z, Sun T, Liu T, Song K. Characterization and anti-tumor bioactivity of astragalus polysaccharides by immunomodulation. Int J Biol Macromol. 2020 Feb15;145:985-97. https://doi.org/10.1016/j.ijbiomac.2019.09.189
 
Neveling DP, Dicks LMT. Probiotics: An antibiotic replacement strategy for healthy broilers and productive rearing. Probiotics Antimicrob Proteins. 2021 Feb;13(1):1-11. https://doi.org/10.1007/s12602-020-09640-z
 
Peng Q, Zeng XF, Zhu JL, Wang S, Liu XT, Hou CL, Thacker PA, Qiao SY. Effects of dietary Lactobacillus plantarum B1 on growth performance, intestinal microbiota, and short chain fatty acid profiles in broiler chickens. Poult Sci. 2016 Apr 1;95(4):893-900. https://doi.org/10.3382/ps/pev435
 
Qiu C, Cheng Y. Effect of Astragalus membranaceus polysaccharide on the serum cytokine levels and spermatogenesis of mice. Int J Biol Macromol. 2019 Nov 1;140:771-4. https://doi.org/10.1016/j.ijbiomac.2019.08.191
 
Saint-Cyr MJ, Haddad N, Taminiau B, Poezevara T, Quesne S, Amelot M, Daube G, Chemaly M, Dousset X, Guyard-Nicodeme M. Use of the potential probiotic strain Lactobacillus salivarius SMXD51 to control Campylobacter jejuni in broilers. Int J Food Microbiol. 2017 Apr 17;247:9-17. https://doi.org/10.1016/j.ijfoodmicro.2016.07.003
 
Shan C, Sun B, Dalloul RA, Zhai Z, Sun P, Li M, Yang S, Luan W. Effect of the oral administration of astragalus polysaccharides on jejunum mucosal immunity in chickens vaccinated against Newcastle disease. Microb Pathog. 2019 Oct 1;135: 103621. https://doi.org/10.1016/j.micpath.2019.103621
 
Shen X, Yi D, Ni X, Zeng D, Jing B, Lei M, Bian Z, Zeng Y, Li T, Xin J. Effects of Lactobacillus plantarum on production performance, immune characteristics, antioxidant status, and intestinal microflora of bursin-immunized broilers. Can J Microbiol. 2014 Feb 13;60(4):193-202. https://doi.org/10.1139/cjm-2013-0680
 
Shokryazdan P, Faseleh Jahromi M, Liang JB, Ramasamy K, Sieo CC, Ho YW. Effects of a Lactobacillus salivarius mixture on performance, intestinal health and serum lipids of broiler chickens. PLoS One. 2017 May 1;12(5): 20 p. https://doi.org/10.1371/journal.pone.0175959
 
Song X, Lin Z, Yu C, Qiu M, Peng H, Jiang X, Du H, Li Q, Liu Y, Zhang Z, Ren P, Yang C. Effects of Lactobacillus plantarum on growth traits, slaughter performance, serum markers and intestinal bacterial community of Daheng broilers. J Anim Physiol Anim Nutr (Berl). 2022a May;106(3):575-85. https://doi.org/10.1111/jpn.13621
 
Song D, Li A, Wang Y, Song G, Cheng J, Wang L, Liu K, Min Y, Wang W. Effects of synbiotic on growth, digestibility, immune and antioxidant performance in broilers. Animal. 2022b Apr 1;16(4): 7 p. https://doi.org/10.1016/j.animal.2022.100497
 
Tang Z, Huang G. Extraction, structure, and activity of polysaccharide from Radix astragali. Biomed Pharmacother. 2022 Jun 1;150: 15 p. https://doi.org/10.1016/j.biopha.2022.113015
 
Wang ZX, Lv M, Qi X, Ding JH. Effects of Astragalus extractive on growth, immune allelotaxy and antioxidant function in broiler chickens. Chin J Anim Sci. 2006 Aug;42(17):30-1.
 
Wang HF, Yang WR, Yang HW, Wang Y, Yang ZB, Jiang SZ, Zhang GG. Effects of Astragalus membranaceus on growth performance, carcass characteristics, and antioxidant status of broiler chickens. Acta Agr Scand A Anim Sci. 2010 Oct 20;60(3):151-8. https://doi.org/10.1080/09064702.2010.511255
 
Wang S, Peng Q, Jia HM, Zeng XF, Zhu JL, Hou CL, Liu XT, Yang FJ, Qiao SY. Prevention of Escherichia coli infection in broiler chickens with Lactobacillus plantarum B1. Poult Sci. 2017 Aug;96(8):2576-86. https://doi.org/10.3382/ps/pex061
 
Wu S. Effect of dietary Astragalus membranaceus polysaccharide on the growth performance and immunity of juvenile broilers. Poult Sci. 2018 Oct 1;97(10):3489-93. https://doi.org/10.3382/ps/pey220
 
Wu XZ, Wen ZG, Hua JL. Effects of dietary inclusion of Lactobacillus and inulin on growth performance, gut microbiota, nutrient utilization, and immune parameters in broilers. Poult Sci. 2019a Oct 1;98(10):4656-63. https://doi.org/10.3382/ps/pez166
 
Wu Y, Wang B, Zeng Z, Liu R, Tang L, Gong L, Li W. Effects of probiotics Lactobacillus plantarum 16 and Paenibacillus polymyxa 10 on intestinal barrier function, antioxidative capacity, apoptosis, immune response, and biochemical parameters in broilers. Poult Sci. 2019b Oct 1;98(10):5028-39. https://doi.org/10.3382/ps/pez226
 
Xi N, Kang J, Hao L, Li R, Bao Y, Shi W. Effects of ultrafine powder of the stem and leaf of Astragalus on immunity in chickens. Ital J Anim Sci. 2014 Jan 1;13(1):142-6. https://doi.org/10.4081/ijas.2014.3022
 
Xu S, Wusiman A, Liu Z, Gu P, Ni H, Zhang Y, Hu Y, Liu J, Wu Y, Wang D. pH-responsive Astragalus polysaccharides-loaded poly (lactic-co-glycolic acid) nanoparticles and their in vitro immunogenicity. Int J Biol Macromol. 2019 Mar 15;125:865-75. https://doi.org/10.1016/j.ijbiomac.2018.12.156
 
Yang X, Liang S, Guo F, Ren Z, Yang X, Long F. Gut microbiota mediates the protective role of Lactobacillus plantarum in ameliorating deoxynivalenol-induced apoptosis and intestinal inflammation of broiler chickens. Poult Sci. 2020 May 1;99(5):2395-406. https://doi.org/10.1016/j.psj.2019.10.034
 
Yin FG, Liu YL, Yin YL, Kong XF, Huang RL, Li TJ, Wu GY, Hou Y. Dietary supplementation with Astragalus polysaccharide enhances ileal digestibilities and serum concentrations of amino acids in early weaned piglets. Amino Acids. 2009 Jul;37(2):263-70. https://doi.org/10.1007/s00726-008-0142-6
 
Yu DH, Bao YM, An LJ, Yang M. Protection of PC12 cells against superoxide-induced damage by isoflavonoids from Astragalus mongholicus. Biomed Environ Sci. 2009 Feb 1;22(1):50-4. https://doi.org/10.1016/S0895-3988(09)60022-2
 
Yu Y, Li Q, Zeng X, Xu Y, Jin K, Liu J, Cao G. Effects of probiotics on the growth performance, antioxidant functions, immune responses, and caecal microbiota of broilers challenged by lipopolysaccharide. Front Vet Sci. 2022 Feb 21;9: 12 p. https://doi.org/10.3389/fvets.2022.846649
 
Yulianto AB, Lokapirnasari WP, Najwan R, Wardhani HCP, Rahman NFN, Huda K, Ulfah N. Influence of Lactobacillus casei WB 315 and crude fish oil (CFO) on growth performance, EPA, DHA, HDL, LDL, cholesterol of meat broiler chickens. Iran J Microbiol. 2020 Apr;12(2):148-55. https://doi.org/10.18502/ijm.v12i2.2620
 
Zhang Y, Zhou QM, Xu X, Feng WY, Huang J, Wang LL, Ning XY. Detection of the medicinal and nutritional components in stems and leaves of Astragalus embranaceus. China Herbivore Sci. 2016 Oct;36:32-5.
 
Zhao L, Wu H, Zhao A, Lu H, Sun W, Ma C, Yang Y, Xin X, Zou H, Qiu M. The in vivo and in vitro study of polysaccharides from a two-herb formula on ulcerative colitis and potential mechanism of action. J Ethnopharmacol. 2014 Apr 11;153(1):151-9. https://doi.org/10.1016/j.jep.2014.02.008
 
download PDF

© 2022 Czech Academy of Agricultural Sciences | Prohlášení o přístupnosti