Sodium butyrate enhances growth performance and intestinal development in broilers

https://doi.org/10.17221/190/2019-CJASCitation:Lan R., Li S., Chang Q., An L., Zhao Z. (2020): Sodium butyrate enhances growth performance and intestinal development in broilers. Czech J. Anim. Sci., 65: 1-12.
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The aim of this study was to evaluate the effects of sodium butyrate (SB) on growth performance and development of digestive and immune organs in broilers. Dietary treatments had similar compositions but with 0%, 0.03%, 0.06%, and 0.12% SB substituted (weight/weight) for identical amounts of the basal diet. SB supplementation linearly increased (P < 0.05) average daily gain for each period, except for days 15–21. SB supplementation linearly increased (P < 0.05) the relative weight of proventriculus (day 7), gizzard (days 7 and 14), duodenum (days 21 and 28), jejunum (day 21), ileum (day 21), small intestine (day 21), rectum (day 14), pancreas (days 7 and 21), liver (days 21 and 28), and thymus (days 7, 14, and 21). SB supplementation linearly increased (P < 0.05) the relative length of duodenum (day 21), jejunum (days 14 and 21), ileum (days 14 and 21) and small intestine (days 14 and 21), caeca (day 21) and rectum (day 21), as well as it improved intestinal structure by increasing the villus height in jejunum and ileum, and increasing goblet cell counts in duodenum, jejunum, and ileum. Collectively, dietary SB supplementation improved the growth performance of broilers by improving the development and morphological structure of the broilers’ intestinal organs.

References:
Adil S, Banday T, Bhat GA, Salahuddin M, Raquib M, Shanaz S. Response of broiler chicken to dietary supplementation of organic acids. J. Cent. Eur. Agric. 2011;12:498-508.
 
Aghazadeh AM, Yazdi MT. Effect of butyric acid supplementation and whole wheat inclusion on the performance and carcass traits of broilers. S. Afr. J. Anim. Sci. 2012;42:241-248.
 
Antongiovanni M, Buccioni A, Petacchi F, Leeson S, Minieri S, Martini A, Cecchi R. Butyric acid glycerides in the diet of broiler chickens: effects on gut histology and carcass composition. Ital. J. Anim. Sci. 2007;6:19-25.
 
Cerisuelo A, Marin C, Vizcaino FS, Gomez EA, de la Fuente JM, Duran R, Fernandez C. The impact of a specific blend of essential oil components and sodium butyrate in feed on growth performance and Salmonella counts in experimentally challenged broilers. Poult. Sci. 2014;93:599-606.
 
Chamba F, Puyalto M, Ortiz A, Torrealba H, Mallo J, Riboty R. Effect of partially protected sodium butyrate on performance, digestive organs, intestinal villi and E. coli development in broilers chickens. Int. J. Poult. Sci. 2014;13:390-396.
 
Choct M. Managing gut health through nutrition. Br. Poult. Sci. 2009;50:9-15.  https://doi.org/10.1080/00071660802538632
 
Corfield A, Myerscough N, Longman R, Sylvester P, Arul S, Pignatelli M. Mucins and mucosal protection in the gastrointestinal tract: new prospects for mucins in the pathology of gastrointestinal disease. Gut 2000;47:589-594.  https://doi.org/10.1136/gut.47.4.589
 
Ferket PR, van Heugten E, van Kempen TATG, Angel R. Nutritional strategies to reduce environmental emissions from nonruminants. J. Anim. Sci. 2002;80:E168-E182.  https://doi.org/10.2527/animalsci2002.80E-Suppl_2E168x
 
Fernandez-Rubio C, Ordonez C, Abad-Gonzalez J, Garcia-Gallero A, Pilar Honrubia M, Jose Mallo J, Balana-Fouce R. Butyric acid-based feed additives help protect broiler chickens from Salmonella Enteritidis infection. Poult. Sci. 2009;88:943-948.
 
Gonzalez-Ortiz G, dos Santos TT, Vienola K, Vartiainen S, Apajalahti J, Bedford MR. Response of broiler chickens to xylanase and butyrate supplementation. Poult. Sci. 2019;98:3914-3925.
 
Guilloteau P, Martin L, Eeckhaut V, Ducatelle R, Zabielski R, Immerseel FV. From the gut to the peripheral tissues: the multiple effects of butyrate. Nutr. Res. Rev. 2010;23:366-384.
 
AOAC International. Official Methods of Analysis. 18th Edn. Gaithersburg, USA: Association of Official Analytical Chemists International; 2006.
 
Islam K. Use of citric acid in broiler diets. Worlds. Poult. Sci. J. 2012;68:104-118.  https://doi.org/10.1017/S0043933912000116
 
Jozefiak D, Rutkowski A, Martin S. Carbohydrate fermentation in the avian ceca: a review. Anim. Feed Sci. Technol. 2004;113:1-15.
 
Kwak H, Austic R, Dietert R. Influence of dietary arginine concentration on lymphoid organ growth in chickens. Poult. Sci. 1999;78:1536-1541.
 
Liu WS, Yang YN, Zhang JL, Gatlin DM, Ringø E, Zhou ZG. Effects of dietary microencapsulated sodium butyrate on growth, intestinal mucosal morphology, immune response and adhesive bacteria in juvenile common carp (Cyprinus carpio) pre-fed with or without oxidised oil. Br. J. Nutr. 2014;112:15-29.  https://doi.org/10.1017/S0007114514000610
 
Mahdzvi R, Torki M. Study on usage period of dietary protected butyic acid on performance carcass characteristics, serum metabolite levels and humoral immune response of broiler chickens. J. Anim. Vet. Adv. 2009;8:1702-1709.
 
NRC. Nutrient Requirements of Poultry. 9th Revised Edn. Washington, DC, USA: National Academies Press; 1994.
 
Ochoa JB, Strange J, Kearney P, Gellin G, Endean E, Fitzpatrick E. Effects of L-arginine on the proliferation of T lymphocyte subpopulations. J. Parenter. Enteral Nutr. 2001;25:23-29.  https://doi.org/10.1177/014860710102500123
 
Olukosi O, Dono N. Modification of digesta pH and intestinal morphology with the use of benzoic acid or phytobiotics and the effects on broiler chicken growth performance and energy and nutrient utilization. J. Anim. Sci. 2014;92:3945-3953.
 
Panda A, Rao S, Raju M, Sunder GS. Effect of butyric acid on performance, gastrointestinal tract health and carcass characteristics in broiler chickens. Asian-Australas. J. Anim. Sci. 2009;22:1026-1031.
 
Qaisrani S, Van Krimpen M, Kwakkel R, Verstegen M, Hendriks W. Diet structure, butyric acid, and fermentable carbohydrates influence growth performance, gut morphology, and cecal fermentation characteristics in broilers. Poult. Sci. 2015;94:2152-2164.
 
Sengupta S, Muir JG, Gibson PR. Does butyrate protect from colorectal cancer? J. Gastroenterol. Hepatol. 2006;21: https://doi.org/10.1111/j.1440-1746.2006.04213.x
 
209-218.
 
Sikandar A, Zaneb H, Younus M, Masood S, Aslam A, Khattak F, Ashraf S, Yousaf MS, Rehman H. Effect of sodium butyrate on performance, immune status, microarchitecture of small intestinal mucosa and lymphoid organs in broiler chickens. Asian-Australas. J. Anim. Sci. 2017;30:690-699.
 
Smulikowska S, Czerwinski J, Mieczkowska A, Jankowiak J. The effect of fat-coated organic acid salts and a feed enzyme on growth performance, nutrient utilization, microflora activity, and morphology of the small intestine in broiler chickens. J. Anim. Feed Sci. 2009;8:478-489.  https://doi.org/10.22358/jafs/66422/2009
 
Song B, Li H, Wu Y, Zhen W, Wang Z, Xia Z, Guo Y. Effect of microencapsulated sodium butyrate dietary supplementation on growth performance and intestinal barrier function of broiler chickens infected with necrotic enteritis. Anim. Feed Sci. Tech. 2017;232:6-15.
 
Strous GJ, Dekker J. Mucin-type glycoproteins. Crit. Rev. Biochem. Mol. Biol. 1992;27:57-92.
 
Svihus B, Hetland H. Ileal starch digestibility in growing broiler chickens fed on a wheat-based diet is improved by mash feeding, dilution with cellulose or whole wheat inclusion. Br. Poult. Sci. 2001;42:633-637.
 
Uni Z, Smirnov A, Sklan D. Pre- and posthatch development of goblet cells in the broiler small intestine: effect of delayed access to feed. Poult. Sci. 2003;82:320-327.
 
Wu G, Bazer FW, Davis TA, Kim SW, Li P, Rhoads JM, Yin Y. Arginine metabolism and nutrition in growth, health and disease. Amino Acids 2009;37:153-168.  https://doi.org/10.1007/s00726-008-0210-y
 
Wu W, Xiao ZB, An WY, Dong YY, Zhang BK. Dietary sodium butyrate improves intestinal development and function by modulating the microbial community in broilers. PLoS ONE 2018;13:e0197762.  https://doi.org/10.1371/journal.pone.0197762
 
Wu Y, Zhou Y, Lu C, Ahmad H, Zhang H, He J, Wang T. Influence of butyrate loaded clinoptilolite dietary supplementation on growth performance, development of intestine and antioxidant capacity in broiler chickens. PLoS ONE 2016;11:e0154410.  https://doi.org/10.1371/journal.pone.0154410
 
Zhang W, Jiang Y, Zhu Q, Gao F, Dai S, Chen J, Zhou G. Sodium butyrate maintains growth performance by regulating the immune response in broiler chickens. Br. Poult. Sci. 2011;52:292-301.
 
Zou X, Ji J, Qu H, Wang J, Shu DM, Wang Y, Liu TF, Li Y, Luo CL. Effects of sodium butyrate on intestinal health and gut microbiota composition during intestinal inflammation progression in broilers. Poult. Sci. 2019;98:4449-4456.
 
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