Effect of supplemental lactic acid bacteria on growth performance, glutathione turnover and aflatoxin B1 removal in lambs

https://doi.org/10.17221/5/2019-CJASCitation:Wang J., Lin L., Jiang Q., Huang W. (2019): Effect of supplemental lactic acid bacteria on growth performance, glutathione turnover and aflatoxin B1 removal in lambs. Czech J. Anim. Sci., 64: 272-278.
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This study investigated the effect of lactic acid bacteria (LAB) on growth performance, glutathione turnover, aflatoxin B1 (AFB1) residue and AFB1-DNA adduct in growing lambs. Diets were a 2 × 2 factorial design, including AFB1 at 0 or 100 µg/kg and LAB at 0 or 3 × 109 cfu/kg. Results showed that AFB1 decreased (P < 0.05) feed intake (FI), body weight gain (BWG), and activities of glutathione (GSH), glutathione s-transferases (GSTs) and glutathione reductase (GR) in liver and duodenal mucosa, whereas these parameters were increased (P < 0.05) by supplemental LAB. AFB1 increased and LAB decreased the feed conversion ratio (P < 0.05). Interactions (P < 0.05) were found on BWG, liver GSTs and mucosal GSH. LAB decreased (P ≤ 0.001) AFB1 residue in liver, kidney, plasma and faeces and AFB1-DNA adduct in kidney, plasma and faeces. It can be concluded that LAB can partially protect against AFB1 toxicity by facilitating glutathione turnover and reducing AFB1 toxicity in lambs.

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