Bisphenol S instead of bisphenol A: a story of reproductive disruption by regretable substitution – a reviewŽalmanová T., Hošková K., Nevoral J., Prokešová Š., Zámostná K., Kott T., Petr J. (2016): Bisphenol S instead of bisphenol A: a story of reproductive disruption by regretable substitution – a review. Czech J. Anim. Sci., 61: 433-449.
download PDF
A range of substances that are released into the environment, foodstuffs and drinking water as a result of human activity were originally considered relatively harmless, and it was only later that their adverse effects were discovered. In general the use of such substances is currently restricted, and they are often replaced by other substances. This applies also in the case of a range of endocrine disruptors. These substances have the capacity to disturb the balance of physiological functions of the organism on the level of hormonal regulation, and their pleiotropic spectrum of effects is very difficult to predict. Endocrine disruptors include the currently intensively studied bisphenol A (BPA), a prevalent environmental pollutant and contaminant of both water and foodstuffs. BPA has a significantly negative impact on human health, particularly on the regulation mechanisms of reproduction, and influences fertility. The ever increasingly stringent restriction of the industrial production of BPA is leading to its replacement with analogues, primarily with bisphenol S (BPS), which is not subject to these restrictions and whose impacts on the regulation of reproduction have not yet been exhaustively studied. However, the limited number of studies at disposal indicates that BPS may be at least as harmful as BPA. There is therefore a potential danger that the replacement of BPA with BPS will become one of the cases of regrettable substitution, in which the newly used substances manifest similar or even worse negative effects than the substances which they have replaced. The objective of this review is to draw attention to ill-advised replacements of endocrine disruptors with substances whose effects are not yet tested, and which may represent the same risks for the environment, for the reproduction of males and females, and for human health as have been demonstrated in the case of the originally used substances.
Akingbemi Benson T., Sottas Chantal M., Koulova Anna I., Klinefelter Gary R., Hardy Matthew P. (2004): Inhibition of Testicular Steroidogenesis by the Xenoestrogen Bisphenol A Is Associated with Reduced Pituitary Luteinizing Hormone Secretion and Decreased Steroidogenic Enzyme Gene Expression in Rat Leydig Cells. Endocrinology, 145, 592-603
Aluru Neelakanteswar, Leatherland John F., Vijayan Mathilakath M., Iwaniuk Andrew (2010): Bisphenol A in Oocytes Leads to Growth Suppression and Altered Stress Performance in Juvenile Rainbow Trout. PLoS ONE, 5, e10741-
Barrett Julia R. (2013): Assessing the Safety of a Replacement Chemical: Nongenomic Activity of Bisphenol S. Environmental Health Perspectives, 121, a97-a97
Bergman Åke, Rydén Andreas, Law Robin J., de Boer Jacob, Covaci Adrian, Alaee Mehran, Birnbaum Linda, Petreas Myrto, Rose Martin, Sakai Shinichi, Van den Eede Nele, van der Veen Ike (2012): A novel abbreviation standard for organobromine, organochlorine and organophosphorus flame retardants and some characteristics of the chemicals. Environment International, 49, 57-82
Bergman A., Heindel J.J., Jobling S., Kidd K.A., Zoeller R.T. (eds) (2013): State of the Science of Endocrine Disrupting Chemicals – 2012. World Health Organization, Geneva, Switzerland/United Nations Environment Programme, Nairobi, Kenya.
Birnbaum Linda S. (2012): Environmental Chemicals: Evaluating Low-Dose Effects. Environmental Health Perspectives, 120, a143-a144
Blacquière Tjeerd, Smagghe Guy, Gestel Cornelis A. M., Mommaerts Veerle (2012): Neonicotinoids in bees: a review on concentrations, side-effects and risk assessment. Ecotoxicology, 21, 973-992
Bloom Michael S., vom Saal Frederick S., Kim Dongsul, Taylor Julia A., Lamb Julie D., Fujimoto Victor Y. (2011): Serum unconjugated bisphenol A concentrations in men may influence embryo quality indicators during in vitro fertilization. Environmental Toxicology and Pharmacology, 32, 319-323
Bonefeld-Jørgensen Eva C., Long Manhai, Hofmeister Marlene V., Vinggaard Anne Marie (2007): Endocrine-Disrupting Potential of Bisphenol A, Bisphenol A Dimethacrylate, 4-n-Nonylphenol, and 4-n-Octylphenol in Vitro: New Data and a Brief Review. Environmental Health Perspectives, 115, 69-76
Borman Evan D., Foster Warren G., Greenacre Matthew K.E., Muir Cameron C., deCatanzaro Denys (2015): Stress lowers the threshold dose at which bisphenol A disrupts blastocyst implantation, in conjunction with decreased uterine closure and e-cadherin. Chemico-Biological Interactions, 237, 87-95
Brieno-Enriquez M. A., Robles P., Camats-Tarruella N., Garcia-Cruz R., Roig I., Cabero L., Martinez F., Caldes M. G. (): Human meiotic progression and recombination are affected by Bisphenol A exposure during in vitro human oocyte development. Human Reproduction, 26, 2807-2818
Brieno-Enriquez M. A., Reig-Viader R., Cabero L., Toran N., Martinez F., Roig I., Garcia Caldes M. (): Gene expression is altered after bisphenol A exposure in human fetal oocytes in vitro. Molecular Human Reproduction, 18, 171-183
Bromer J. G., Zhou Y., Taylor M. B., Doherty L., Taylor H. S. (): Bisphenol-A exposure in utero leads to epigenetic alterations in the developmental programming of uterine estrogen response. The FASEB Journal, 24, 2273-2280
Bushnik T., Haines D., Levallois P., Levesque J., van Oostdam J., Viau C. (2010): Lead and bisphenol A concentrations in the Canadian population. Health Reports, 21, 7–18.
Calabrese Edward J. (2005): Toxicological awakenings: the rebirth of hormesis as a central pillar of toxicology. Toxicology and Applied Pharmacology, 204, 1-8
Calabrese E. J. (): The Frequency of U-Shaped Dose Responses in the Toxicological Literature. Toxicological Sciences, 62, 330-338
Can A. (2005): Bisphenol-A induces cell cycle delay and alters centrosome and spindle microtubular organization in oocytes during meiosis. Molecular Human Reproduction, 11, 389-396
Cao Xu-Liang, Zhang Jie, Goodyer Cynthia G., Hayward Stephen, Cooke Gerard M., Curran Ivan H.A. (2012): Bisphenol A in human placental and fetal liver tissues collected from Greater Montreal area (Quebec) during 1998–2008. Chemosphere, 89, 505-511
Casas Maribel, Valvi Damaskini, Luque Noelia, Ballesteros-Gomez Ana, Carsin Anne-Elie, Fernandez Marieta F., Koch Holger M., Mendez Michelle A., Sunyer Jordi, Rubio Soledad, Vrijheid Martine (2013): Dietary and sociodemographic determinants of bisphenol A urine concentrations in pregnant women and children. Environment International, 56, 10-18
Chan Winson K., Chan King Ming (2012): Disruption of the hypothalamic-pituitary-thyroid axis in zebrafish embryo–larvae following waterborne exposure to BDE-47, TBBPA and BPA. Aquatic Toxicology, 108, 106-111
Chen Min-Yu, Ike Michihiko, Fujita Masanori (2002): Acute toxicity, mutagenicity, and estrogenicity of bisphenol-A and other bisphenols. Environmental Toxicology, 17, 80-86
Chen S., Zhou D., Hsin L.-Y., Kanaya N., Wong C., Yip R., Sakamuru S., Xia M., Yuan Y.-C., Witt K., Teng C. (): AroER Tri-Screen Is a Biologically Relevant Assay for Endocrine Disrupting Chemicals Modulating the Activity of Aromatase and/or the Estrogen Receptor. Toxicological Sciences, 139, 198-209
Clayton R. (ed.) (2011): Endocrine Disrupters in the Environment. Foundation for Water Research, Marlow, UK, 3–22.
Coggon D. (): Work with pesticides and organophosphate sheep dips. Occupational Medicine, 52, 467-470
Colborn T, vom Saal F S, Soto A M (1993): Developmental effects of endocrine-disrupting chemicals in wildlife and humans. Environmental Health Perspectives, 101, 378-384
Corbel T., Gayrard V., Puel S., Lacroix M.Z., Berrebi A., Gil S., Viguié C., Toutain P.-L., Picard-Hagen N. (2014): Bidirectional placental transfer of Bisphenol A and its main metabolite, Bisphenol A-Glucuronide, in the isolated perfused human placenta. Reproductive Toxicology, 47, 51-58
Damstra T., Barlow S., Bergman A., Kavlock R., Van Der Kraak G. (eds) (2002): Global assessment of the state-of-the-science of endocrine disruptors. International Programme on Chemical Safety, World Health Organization. Available from (accessed Aug 1, 2002).
Danzl Erica, Sei Kazunari, Soda Satoshi, Ike Michihiko, Fujita Masanori (2009): Biodegradation of Bisphenol A, Bisphenol F and Bisphenol S in Seawater. International Journal of Environmental Research and Public Health, 6, 1472-1484
Delfosse V., Grimaldi M., Pons J.-L., Boulahtouf A., le Maire A., Cavailles V., Labesse G., Bourguet W., Balaguer P. (): Structural and mechanistic insights into bisphenols action provide guidelines for risk assessment and discovery of bisphenol A substitutes. Proceedings of the National Academy of Sciences, 109, 14930-14935
Diamanti-Kandarakis Evanthia, Bourguignon Jean-Pierre, Giudice Linda C., Hauser Russ, Prins Gail S., Soto Ana M., Zoeller R. Thomas, Gore Andrea C. (2009): Endocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement. Endocrine Reviews, 30, 293-342
Dietrich D.R., Hengstler J.G. (2016): From bisphenol A to bisphenol F and a ban of mustard due to chronic low-dose exposures? Archives of Toxicology, 90, 489–491.
DODDS E. C., LAWSON WILFRID (1936): Synthetic Œstrogenic Agents without the Phenanthrene Nucleus. Nature, 137, 996-996
Dolinoy D. C., Huang D., Jirtle R. L. (): Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development. Proceedings of the National Academy of Sciences, 104, 13056-13061
Drastichová J., Svobodová Z., Groenland M., Dobšíková R., Žlábek V., Weissová D., Szotkowská M. (): Effect of Exposure to Bisphenol A on the Sex Differentiation in Zebrafish (Danio rerio). Acta Veterinaria Brno, 74, 287-291
Edlow Andrea G., Chen Mei, Smith Nicole A., Lu Chensheng, McElrath Thomas F. (2012): Fetal bisphenol A exposure: Concentration of conjugated and unconjugated bisphenol A in amniotic fluid in the second and third trimesters. Reproductive Toxicology, 34, 1-7
Ehrlich S., Williams P. L., Missmer S. A., Flaws J. A., Ye X., Calafat A. M., Petrozza J. C., Wright D., Hauser R. (): Urinary bisphenol A concentrations and early reproductive health outcomes among women undergoing IVF. Human Reproduction, 27, 3583-3592
Ehrlich Shelley, Calafat Antonia M., Humblet Olivier, Smith Thomas, Hauser Russ (2014): Handling of Thermal Receipts as a Source of Exposure to Bisphenol A. JAMA, 311, 859-
Eichenlaub-Ritter Ursula, Vogt Edgar, Cukurcam Suna, Sun Fengyun, Pacchierotti Francesca, Parry Jim (2008): Exposure of mouse oocytes to bisphenol A causes meiotic arrest but not aneuploidy. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 651, 82-92
Commission Directive (2011): Commission Directive 2011/8/EU of 28 January 2011 amending Directive 2002/72/EC as regards the restriction of use of Bisphenol A in plastic infant feeding bottles. Official Journal of the European Union, L 26, 11–14.
EFSA (2014): Bisphenol A: EFSA consults on assessment of risks to human health. European Food Safety Authority. Available from (accessed Jan 17, 2014).
Fahrenkamp-Uppenbrink J. (): Using chemical design to avoid regrets. Science, 347, 1213-1213
FDA (2011): Bisphenol A (BPA). US Food and Drug Administration. Available from (accessed March 24, 2011).
Fernández Mariana F., Román Marta, Arrebola Juan Pedro, Olea Nicolás (2014): Endocrine Disruptors: Time to Act. Current Environmental Health Reports, 1, 325-332
Ferris Jacqueline, Favetta Laura A., King W. Allan (): Bisphenol A Exposure during Oocyte Maturation in vitro Results in Spindle Abnormalities and Chromosome Misalignment in <b><i>Bos taurus</i></b>. Cytogenetic and Genome Research, 145, 50-58
Fic Anja, Žegura Bojana, Sollner Dolenc Marija, Filipič Metka, Peterlin Mašič Lucija (2013): Mutagenicity and DNA Damage of Bisphenol a and its Structural Analogues in Hepg2 Cells. Archives of Industrial Hygiene and Toxicology, 64, -
Glausiusz Josie (2014): Toxicology: The plastics puzzle. Nature, 508, 306-308
Goodson A., Summerfield W., Cooper I. (2002): Survey of bisphenol A and bisphenol F in canned foods. Food Additives and Contaminants, 19, 796-802
Grasselli F., Baratta L., Baioni L., Bussolati S., Ramoni R., Grolli S., Basini G. (2010): Bisphenol A disrupts granulosa cell function. Domestic Animal Endocrinology, 39, 34-39
Grignard Elise, Lapenna Silvia, Bremer Susanne (2012): Weak estrogenic transcriptional activities of Bisphenol A and Bisphenol S. Toxicology in Vitro, 26, 727-731
Héliès-Toussaint Cécile, Peyre Ludovic, Costanzo Claudia, Chagnon Marie-Christine, Rahmani Roger (2014): Is bisphenol S a safe substitute for bisphenol A in terms of metabolic function? An in vitro study. Toxicology and Applied Pharmacology, , -
Howard Gregory J. (2014): Chemical alternatives assessment: The case of flame retardants. Chemosphere, , -
Huang Y.Q., Wong C.K.C., Zheng J.S., Bouwman H., Barra R., Wahlström B., Neretin L., Wong M.H. (2012): Bisphenol A (BPA) in China: A review of sources, environmental levels, and potential human health impacts. Environment International, 42, 91-99
Hubbs Ann F., Cumpston Amy M., Goldsmith W. Travis, Battelli Lori A., Kashon Michael L., Jackson Mark C., Frazer David G., Fedan Jeffrey S., Goravanahally Madhusudan P., Castranova Vincent, Kreiss Kathleen, Willard Patsy A., Friend Sherri, Schwegler-Berry Diane, Fluharty Kara L., Sriram Krishnan (2012): Respiratory and Olfactory Cytotoxicity of Inhaled 2,3-Pentanedione in Sprague-Dawley Rats. The American Journal of Pathology, 181, 829-844
Hunt Patricia A., Koehler Kara E., Susiarjo Martha, Hodges Craig A., Ilagan Arlene, Voigt Robert C., Thomas Sally, Thomas Brian F., Hassold Terry J. (2003): Bisphenol A Exposure Causes Meiotic Aneuploidy in the Female Mouse. Current Biology, 13, 546-553
Hunt P. A., Lawson C., Gieske M., Murdoch B., Smith H., Marre A., Hassold T., VandeVoort C. A. (): Bisphenol A alters early oogenesis and follicle formation in the fetal ovary of the rhesus monkey. Proceedings of the National Academy of Sciences, 109, 17525-17530
Ike M., Chen M.Y., Danzl E., Sei K., Fujita M. (): Biodegradation of a variety of bisphenols under aerobic and anaerobic conditions. Water Science & Technology, 53, 153-
Ikezuki Y., Tsutsumi O., Takai Y., Kamei Y., Taketani Y. (2002): Determination of bisphenol A concentrations in human biological fluids reveals significant early prenatal exposure. Human Reproduction, 17, 2839-2841
Jasarevic E., Sieli P. T., Twellman E. E., Welsh T. H., Schachtman T. R., Roberts R. M., Geary D. C., Rosenfeld C. S. (): Disruption of adult expression of sexually selected traits by developmental exposure to bisphenol A. Proceedings of the National Academy of Sciences, 108, 11715-11720
Jenkins Sarah, Wang Jun, Eltoum Isam, Desmond Renee, Lamartiniere Coral A. (2011): Chronic Oral Exposure to Bisphenol A Results in a Nonmonotonic Dose Response in Mammary Carcinogenesis and Metastasis in MMTV-erbB2 Mice. Environmental Health Perspectives, 119, 1604-1609
Ji Kyunghee, Hong Seongjin, Kho Younglim, Choi Kyungho (2013): Effects of Bisphenol S Exposure on Endocrine Functions and Reproduction of Zebrafish. Environmental Science & Technology, 47, 8793-8800
Jiménez-Díaz I., Zafra-Gómez A., Ballesteros O., Navea N., Navalón A., Fernández M.F., Olea N., Vílchez J.L. (2010): Determination of Bisphenol A and its chlorinated derivatives in placental tissue samples by liquid chromatography–tandem mass spectrometry. Journal of Chromatography B, 878, 3363-3369
Joskow R., Barr D. B., Barr J. R., Calafat A. M., Needham L. L., Rubin C. (): Exposure to bisphenol A from bis-glycidyl dimethacrylate-based dental sealants. Journal of the American Dental Association, 137, 353-362
Khan Deena, Ahmed S. Ansar (2015): Epigenetic Regulation of Non-Lymphoid Cells by Bisphenol A, a Model Endocrine Disrupter: Potential Implications for Immunoregulation. Frontiers in Endocrinology, 6, -
Kinch Cassandra D., Ibhazehiebo Kingsley, Jeong Joo-Hyun, Habibi Hamid R., Kurrasch Deborah M. (): Low-dose exposure to bisphenol A and replacement bisphenol S induces precocious hypothalamic neurogenesis in embryonic zebrafish. Proceedings of the National Academy of Sciences, 112, 1475-1480
Kitamura S. (2005): Comparative Study of the Endocrine-Disrupting Activity of Bisphenol A and 19 Related Compounds. Toxicological Sciences, 84, 249-259
Kloas Werner, Lutz Ilka, Einspanier Ralf (1999): Amphibians as a model to study endocrine disruptors: II. Estrogenic activity of environmental chemicals in vitro and in vivo. Science of The Total Environment, 225, 59-68
Knez J., Kranvogl R., Breznik B.P., Voncina E., Vlaisavljevic V. (2014): Are urinary bisphenol A levels in men related to semen quality and embryo development after medically assisted reproduction? Fertility and Sterility, 101, 215–221.
Krishnan A V, Stathis P, Permuth S F, Tokes L, Feldman D (1993): Bisphenol-A: an estrogenic substance is released from polycarbonate flasks during autoclaving.. Endocrinology, 132, 2279-2286
Kundakovic M., Gudsnuk K., Franks B., Madrid J., Miller R. L., Perera F. P., Champagne F. A. (): Sex-specific epigenetic disruption and behavioral changes following low-dose in utero bisphenol A exposure. Proceedings of the National Academy of Sciences, 110, 9956-9961
KUROSAWA TAKAKO, HIROI HISAHIKO, TSUTSUMI OSAMU, ISHIKAWA TOMOKO, OSUGA YUTAKA, FUJIWARA TOSHIHIRO, INOUE SATOSHI, MURAMATSU MASAMI, MOMOEDA MIKIO, TAKETANI YUJI (2002): The Activity of Bisphenol A Depends on Both the Estrogen Receptor Subtype and the Cell Type.. Endocrine Journal, 49, 465-471
Kuruto-Niwa Ryoko, Tateoka Yumiko, Usuki Yasuteru, Nozawa Ryushi (2007): Measurement of bisphenol A concentrations in human colostrum. Chemosphere, 66, 1160-1164
Kuruto-Niwa Ryoko, Nozawa Ryushi, Miyakoshi Takashi, Shiozawa Tatsushi, Terao Yoshiyasu (2005): Estrogenic activity of alkylphenols, bisphenol S, and their chlorinated derivatives using a GFP expression system. Environmental Toxicology and Pharmacology, 19, 121-130
Kwintkiewicz Jakub, Nishi Yoshihiro, Yanase Toshihiko, Giudice Linda C. (2009): Peroxisome ProliferatorActivated Receptor-γ Mediates Bisphenol A Inhibition of FSH-Stimulated IGF-1, Aromatase, and Estradiol in Human Granulosa Cells. Environmental Health Perspectives, 118, 400-406
Lahnsteiner Franz, Berger Beate, Kletzl Manfred, Weismann Thomas (2005): Effect of bisphenol A on maturation and quality of semen and eggs in the brown trout, Salmo trutta f. fario. Aquatic Toxicology, 75, 213-224
Landrigan Philip J., Kimmel Carole A., Correa Adolfo, Eskenazi Brenda (2003): Children's Health and the Environment: Public Health Issues and Challenges for Risk Assessment. Environmental Health Perspectives, 112, 257-265
Lang Iain A. (2008): Association of Urinary Bisphenol A Concentration With Medical Disorders and Laboratory Abnormalities in Adults. JAMA, 300, 1303-
Lassen Tina Harmer, Frederiksen Hanne, Jensen Tina Kold, Petersen Jørgen Holm, Joensen Ulla N., Main Katharina M., Skakkebaek Niels E., Juul Anders, Jørgensen Niels, Andersson Anna-Maria (2014): Urinary Bisphenol A Levels in Young Men: Association with Reproductive Hormones and Semen Quality. Environmental Health Perspectives, , 478-484
Lee Sangwoo, Liu Xiaoshan, Takeda Shunichi, Choi Kyungho (2013): Genotoxic potentials and related mechanisms of bisphenol A and other bisphenol compounds: A comparison study employing chicken DT40 cells. Chemosphere, 93, 434-440
Le Fol Vincent, Aït-Aïssa Selim, Cabaton Nicolas, Dolo Laurence, Grimaldi Marina, Balaguer Patrick, Perdu Elisabeth, Debrauwer Laurent, Brion François, Zalko Daniel (2015): Cell-Specific Biotransformation of Benzophenone-2 and Bisphenol-S in Zebrafish and Human in Vitro Models Used for Toxicity and Estrogenicity Screening. Environmental Science & Technology, 49, 3860-3868
Li De-Kun, Zhou ZhiJun, Miao Maohua, He Yonghua, Wang JinTao, Ferber Jeannette, Herrinton Lisa J., Gao ErSheng, Yuan Wei (2011): Urine bisphenol-A (BPA) level in relation to semen quality. Fertility and Sterility, 95, 625-630.e4
Liao C., Liu F., Alomirah H., Loi V.D., Mohd M.A., Moon H.B. (2012a): Bisphenol S in urine from the United States and seven Asian countries: occurrence and human exposures. Environmental Science and Technology, 46, 6860–6866.
Liao C., Liu F., Guo Y., Moon H.B., Nakata H., Wu Q. (2012b): Occurrence of eight bisphenol analogues in indoor dust from the United States and several Asian countries: implications for human exposure. Environmental Science and Technology, 46, 9138–9145.
Liao C., Liu F., Kannan K. (2012c): Bisphenol S, a new bisphenol analogue, in paper products and currency bills and its association with bisphenol A residues. Environmental Science and Technology, 46, 6515–6522.
Maamar Millissia Ben, Lesné Laurianne, Desdoits-Lethimonier Christèle, Coiffec Isabelle, Lassurguère Julie, Lavoué Vincent, Deceuninck Yoann, Antignac Jean-Philippe, Le Bizec Bruno, Perdu Elisabeth, Zalko Daniel, Pineau Charles, Chevrier Cécile, Dejucq-Rainsford Nathalie, Mazaud-Guittot Séverine, Jégou Bernard, Nadal Angel (2015): An Investigation of the Endocrine-Disruptive Effects of Bisphenol A in Human and Rat Fetal Testes. PLOS ONE, 10, e0117226-
Machtinger Ronit, Orvieto Raoul (2014): Bisphenol A, oocyte maturation, implantation, and IVF outcome: review of animal and human data. Reproductive BioMedicine Online, , -
Machtinger R., Combelles C. M. H., Missmer S. A., Correia K. F., Williams P., Hauser R., Racowsky C. (): Bisphenol-A and human oocyte maturation in vitro. Human Reproduction, 28, 2735-2745
Manfo F.P., Jubendradass R., Nantia E.A., Moundipa P.F., Mathur P.P. (2014): Adverse effects of bisphenol A on male reproductive function. Reviews of Environmental Contamination and Toxicology, 228, 57–82.
Manikkam Mohan, Tracey Rebecca, Guerrero-Bosagna Carlos, Skinner Michael K., Shioda Toshi (2013): Plastics Derived Endocrine Disruptors (BPA, DEHP and DBP) Induce Epigenetic Transgenerational Inheritance of Obesity, Reproductive Disease and Sperm Epimutations. PLoS ONE, 8, e55387-
Mathew M., Sreedhanya S., Manoj P., Aravindakumar C.T., Aravind U.K. (2014): Exploring the interaction of bisphenol-S with serum albumins: a better or worse alternative for bisphenol A? The Journal of Physical Chemistry B, 118, 3832–3843.
Matsushima A., Kakuta Y., Teramoto T., Koshiba T., Liu X., Okada H., Tokunaga T., Kawabata S.-i., Kimura M., Shimohigashi Y. (2007): Structural Evidence for Endocrine Disruptor Bisphenol A Binding to Human Nuclear Receptor ERR . Journal of Biochemistry, 142, 517-524
Mcbride W.G. (1961): THALIDOMIDE AND CONGENITAL ABNORMALITIES. The Lancet, 278, 1358-
Mendiola J., Jorgensen N., Andersson A.M., Calafat A.M., Ye X., Redmon J.B. (2010): Are environmental levels of bisphenol A associated with reproductive function in fertile men? Environmental Health Perspectives, 118, 1286–1291.
Mendonca K., Hauser R., Calafat A. M., Arbuckle T. E., Duty S. M. (2014): Bisphenol A concentrations in maternal breast milk and infant urine. International Archives of Occupational and Environmental Health, 87, 13-20
Mendoza-Rodríguez C. Adriana, García-Guzmán Montserrat, Baranda-Avila Noemí, Morimoto Sumiko, Perrot-Applanat Martine, Cerbón Marco (2011): Administration of bisphenol A to dams during perinatal period modifies molecular and morphological reproductive parameters of the offspring. Reproductive Toxicology, 31, 177-183
Mileva Guergana, Baker Stephanie, Konkle Anne, Bielajew Catherine (2014): Bisphenol-A: Epigenetic Reprogramming and Effects on Reproduction and Behavior. International Journal of Environmental Research and Public Health, 11, 7537-7561
Miyamoto K.I., Kotake M. (2005): Estimation of daily bisphenol A intake of Japanese individuals with emphasis on uncertainty and variability. Environmental Sciences: an International Journal of Environmental Physiology and Toxicology, 13, 15–29.
Mok-Lin E., Ehrlich S., Williams P. L., Petrozza J., Wright D. L., Calafat A. M., Ye X., Hauser R. (2010): Urinary bisphenol A concentrations and ovarian response among women undergoing IVF. International Journal of Andrology, 33, 385-393
Molina-Molina José-Manuel, Amaya Esperanza, Grimaldi Marina, Sáenz José-María, Real Macarena, Fernández Mariana F., Balaguer Patrick, Olea Nicolás (2013): In vitro study on the agonistic and antagonistic activities of bisphenol-S and other bisphenol-A congeners and derivatives via nuclear receptors. Toxicology and Applied Pharmacology, 272, 127-136
Naderi Mohammad, Wong Marian Y.L., Gholami Fatemeh (2014): Developmental exposure of zebrafish (Danio rerio) to bisphenol-S impairs subsequent reproduction potential and hormonal balance in adults. Aquatic Toxicology, 148, 195-203
Nakagawa Yoshio, Tayama Sumiko (2000): Metabolism and cytotoxicity of bisphenol A and other bisphenols in isolated rat hepatocytes. Archives of Toxicology, 74, 99-105
Navarro V. M., Sánchez-Garrido M. A., Castellano J. M., Roa J., García-Galiano D., Pineda R., Aguilar E., Pinilla L., Tena-Sempere M. (2009): Persistent Impairment of Hypothalamic KiSS-1 System after Exposures to Estrogenic Compounds at Critical Periods of Brain Sex Differentiation. Endocrinology, 150, 2359-2367
Nevoral J., Krejcova T., Petr J., Melicharova P., Vyskocilova A., Dvorakova M., Sedmikova M. (2013): The role of nitric oxide synthase isoforms in aged porcine oocytes. Czech Journal of Animal Science, 58, 453–459.
Newbold Retha R., Jefferson Wendy N., Padilla-Banks Elizabeth (2009): Prenatal Exposure to Bisphenol A at Environmentally Relevant Doses Adversely Affects the Murine Female Reproductive Tract Later in Life. Environmental Health Perspectives, 117, 879-885
N’Tumba-Byn Thierry, Moison Delphine, Lacroix Marlène, Lecureuil Charlotte, Lesage Laëtitia, Prud’homme Sophie M., Pozzi-Gaudin Stéphanie, Frydman René, Benachi Alexandra, Livera Gabriel, Rouiller-Fabre Virginie, Habert René, Drevet Joel R. (2012): Differential Effects of Bisphenol A and Diethylstilbestrol on Human, Rat and Mouse Fetal Leydig Cell Function. PLoS ONE, 7, e51579-
Owens J. William, Ashby John (2008): Critical Review and Evaluation of the Uterotrophic Bioassay for the Identification of Possible Estrogen Agonists and Antagonists: In Support of the Validation of the OECD Uterotrophic Protocols for the Laboratory Rodent. Critical Reviews in Toxicology, 32, 445-520
Pacchierotti F., Ranaldi R., Eichenlaub-Ritter U., Attia S., Adler I.-D. (2008): Evaluation of aneugenic effects of bisphenol A in somatic and germ cells of the mouse. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 651, 64-70
Patisaul Heather B., Todd Karina L., Mickens Jillian A., Adewale Heather B. (2009): Impact of neonatal exposure to the ERα agonist PPT, bisphenol-A or phytoestrogens on hypothalamic kisspeptin fiber density in male and female rats. NeuroToxicology, 30, 350-357
Peretz J., Vrooman L., Ricke W.A., Hunt P.A., Ehrlich S., Hauser R., Padmanabhan V., Taylor H.S., Swan S.H., VandeVoort C.A., Flaws J.A. (2014): Bisphenol A and reproductive health: update of experimental and human evidence. Environmental Health Perspectives, 122, 775–786.
Perez P, Pulgar R, Olea-Serrano F, Villalobos M, Rivas A, Metzler M, Pedraza V, Olea N (1998): The estrogenicity of bisphenol A-related diphenylalkanes with various substituents at the central carbon and the hydroxy groups. Environmental Health Perspectives, 106, 167-174
Petr J., Chmelíková E., Žalmanová T., Tůmová L., Kheilová K., Kučerová-Chrpová V., Jílek F. (2013): Pyrethroids cypermethrin, deltamethrin and fenvalerate have different effects on in vitro maturation of pig oocytes at different stages of growth. animal, 7, 134-142
Peyre Ludovic, Rouimi Patrick, de Sousa Georges, Héliès-Toussaint Cécile, Carré Benjamin, Barcellini Sylvie, Chagnon Marie-Christine, Rahmani Roger (2014): Comparative study of bisphenol A and its analogue bisphenol S on human hepatic cells: A focus on their potential involvement in nonalcoholic fatty liver disease. Food and Chemical Toxicology, 70, 9-18
Qiu Wenhui, Zhao Yali, Yang Ming, Farajzadeh Matthew, Pan Chenyuan, Wayne Nancy L. (2016): Actions of Bisphenol A and Bisphenol S on the Reproductive Neuroendocrine System During Early Development in Zebrafish. Endocrinology, 157, 636-647
Raju GA Rama, Prakash GJ, Krishna KM, Madan K (2007): Meiotic spindle and zona pellucida characteristics as predictors of embryonic development: a preliminary study using PolScope imaging. Reproductive BioMedicine Online, 14, 166-174
Richter Catherine A., Birnbaum Linda S., Farabollini Francesca, Newbold Retha R., Rubin Beverly S., Talsness Chris E., Vandenbergh John G., Walser-Kuntz Debby R., vom Saal Frederick S. (2007): In vivo effects of bisphenol A in laboratory rodent studies. Reproductive Toxicology, 24, 199-224
Rochester Johanna R. (2013): Bisphenol A and human health: A review of the literature. Reproductive Toxicology, 42, 132-155
Rochester Johanna Ruth, Bolden Ashley Louise (2015): Bisphenol S and F: A Systematic Review and Comparison of the Hormonal Activity of Bisphenol A Substitutes. Environmental Health Perspectives, , -
Rosenmai A.K., Dybdahl M., Pedersen M., van Vugt-Lussenburg B.M.A., Wedebye E.B., Taxvig C., Vinggaard A.M. (2014): Are structural analogues to bisphenol a safe alternatives? Toxicological Sciences, 139, 3–47.
Salgueiro-González N., Turnes-Carou I., Viñas-Diéguez L., Muniategui-Lorenzo S., López-Mahía P., Prada-Rodríguez D. (2015): Occurrence of endocrine disrupting compounds in five estuaries of the northwest coast of Spain: Ecological and human health impact. Chemosphere, 131, 241-247
Salvesen Guy S., Walsh Craig M. (2014): Functions of caspase 8: The identified and the mysterious. Seminars in Immunology, 26, 246-252
Santamaría Clarisa, Durando Milena, Muñoz de Toro Mónica, Luque Enrique H., Rodriguez Horacio A. (2016): Ovarian dysfunctions in adult female rat offspring born to mothers perinatally exposed to low doses of bisphenol A. The Journal of Steroid Biochemistry and Molecular Biology, 158, 220-230
Schönfelder Gilbert, Wittfoht Werner, Hopp Hartmut, Talsness Chris E., Paul Martin, Chahoud Ibrahim (2002): Parent Bisphenol A Accumulation in the Human Maternal-Fetal-Placental Unit. Environmental Health Perspectives, 110, a703-a707
Sedmikova M., Petr J., Dorflerova A., Nevoral J., Novotna B. (2013): Inhibition of c-Jun N-terminal kinase (JNK) suppresses porcine oocyte aging in vitro. Czech Journal of Animal Science, 58, 535–545.
Sohoni P., Tyler C. R., Hurd K., Caunter J., Hetheridge M., Williams T., Woods C., Evans M., Toy R., Gargas M., Sumpter J. P. (2001): Reproductive Effects of Long-Term Exposure to Bisphenol A in the Fathead Minnow ( Pimephales promelas ). Environmental Science & Technology, 35, 2917-2925
Song Shanjun, Song Maoyong, Zeng Luzhe, Wang Thanh, Liu Runzeng, Ruan Ting, Jiang Guibin (2014): Occurrence and profiles of bisphenol analogues in municipal sewage sludge in China. Environmental Pollution, 186, 14-19
Sui Yipeng, Ai Ni, Park Se-Hyung, Rios-Pilier Jennifer, Perkins Jordan T., Welsh William J., Zhou Changcheng (2012): Bisphenol A and Its Analogues Activate Human Pregnane X Receptor. Environmental Health Perspectives, 120, 399-405
Susiarjo M., Hassold T.J., Freeman E., Hunt P.A. (2007): Bisphenol A exposure in utero disrupts early oogenesis in the mouse. PLoS Genetics, 3, e5.
Susiarjo Martha, Sasson Isaac, Mesaros Clementina, Bartolomei Marisa S., Kelsey Gavin (2013): Bisphenol A Exposure Disrupts Genomic Imprinting in the Mouse. PLoS Genetics, 9, e1003401-
Susiarjo Martha, Xin Frances, Bansal Amita, Stefaniak Martha, Li Changhong, Simmons Rebecca A., Bartolomei Marisa S. (2015): Bisphenol A Exposure Disrupts Metabolic Health Across Multiple Generations in the Mouse. Endocrinology, 156, 2049-2058
Suzuki Atsuko, Sugihara Akika, Uchida Kaoru, Sato Tomomi, Ohta Yasuhiko, Katsu Yoshinao, Watanabe Hajime, Iguchi Taisen (2002): Developmental effects of perinatal exposure to bisphenol-A and diethylstilbestrol on reproductive organs in female mice. Reproductive Toxicology, 16, 107-116
Takayanagi Sayaka, Tokunaga Takatoshi, Liu Xiaohui, Okada Hiroyuki, Matsushima Ayami, Shimohigashi Yasuyuki (2006): Endocrine disruptor bisphenol A strongly binds to human estrogen-related receptor γ (ERRγ) with high constitutive activity. Toxicology Letters, 167, 95-105
Teng Christina, Goodwin Bonnie, Shockley Keith, Xia Menghang, Huang Ruili, Norris John, Merrick B. Alex, Jetten Anton M., Austin Christopher P., Tice Raymond R. (2013): Bisphenol A affects androgen receptor function via multiple mechanisms. Chemico-Biological Interactions, 203, 556-564
Tomari Hiroyuki, Honjou Kou, Nagata Yumi, Horiuchi Toshitaka (2011): Relationship between meiotic spindle characteristics in human oocytes and the timing of the first zygotic cleavage after intracytoplasmic sperm injection. Journal of Assisted Reproduction and Genetics, 28, 1099-1104
Trapphoff Tom, Heiligentag Martyna, El Hajj Nady, Haaf Thomas, Eichenlaub-Ritter Ursula (2013): Chronic exposure to a low concentration of bisphenol A during follicle culture affects the epigenetic status of germinal vesicles and metaphase II oocytes. Fertility and Sterility, 100, 1758-1767.e1
Trasande Leonardo, Attina Teresa M., Blustein Jan (2012): Association Between Urinary Bisphenol A Concentration and Obesity Prevalence in Children and Adolescents. JAMA, 308, 1113-
Vandenberg Laura N. (2013): Non-Monotonic Dose Responses in Studies of Endocrine Disrupting Chemicals: Bisphenol a as a Case Study. Dose-Response, 12, dose-response.1-
Vandenberg Laura N., Maffini Maricel V., Sonnenschein Carlos, Rubin Beverly S., Soto Ana M. (2009): Bisphenol-A and the Great Divide: A Review of Controversies in the Field of Endocrine Disruption. Endocrine Reviews, 30, 75-95
Vandenberg Laura N., Colborn Theo, Hayes Tyrone B., Heindel Jerrold J., Jacobs David R., Lee Duk-Hee, Shioda Toshi, Soto Ana M., vom Saal Frederick S., Welshons Wade V., Zoeller R. Thomas, Myers John Peterson (2012): Hormones and Endocrine-Disrupting Chemicals: Low-Dose Effects and Nonmonotonic Dose Responses. Endocrine Reviews, 33, 378-455
Vandenberg Laura N., Colborn Theo, Hayes Tyrone B., Heindel Jerrold J., Jacobs David R., Lee Duk-Hee, Myers John Peterson, Shioda Toshi, Soto Ana M., vom Saal Frederick S., Welshons Wade V., Zoeller R. Thomas (2013): Regulatory decisions on endocrine disrupting chemicals should be based on the principles of endocrinology. Reproductive Toxicology, 38, 1-15
Viñas P., Campillo N., Martínez-Castillo N., Hernández-Córdoba M. (2010): Comparison of two derivatization-based methods for solid-phase microextraction–gas chromatography–mass spectrometric determination of bisphenol A, bisphenol S and biphenol migrated from food cans. Analytical and Bioanalytical Chemistry, 397, 115-125
Vinas R., Watson C.S. (2013a): Bisphenol S disrupts estradiol-induced nongenomic signaling in a rat pituitary cell line: effects on cell functions. Environmental Health Perspectives, 121, 352–358.
Vinas R., Watson C.S. (2013b): Mixtures of xenoestrogens disrupt estradiol-induced non-genomic signaling and downstream functions in pituitary cells. Environmental Health, 12, 26.
Vinggaard Anne Marie, Niemelä Jay, Wedebye Eva Bay, Jensen Gunde Egeskov (2008): Screening of 397 Chemicals and Development of a Quantitative Structure−Activity Relationship Model for Androgen Receptor Antagonism. Chemical Research in Toxicology, 21, 813-823
Vitku J., Sosvorova L., Chlupacova T., Hampl R., Hill M., Sobotka V., Heracek J., Bicikova M., Starka L. (2015): Differences in bisphenol A and estrogen levels in the plasma and seminal plasma of men with different degrees of infertility. Physiological Research, 64, 303–311.
vom Saal Frederick S., Hughes Claude (2005): An Extensive New Literature Concerning Low-Dose Effects of Bisphenol A Shows the Need for a New Risk Assessment. Environmental Health Perspectives, 113, 926-933
vom Saal Frederick S., Welshons Wade V. (2006): Large effects from small exposures. II. The importance of positive controls in low-dose research on bisphenol A. Environmental Research, 100, 50-76
vom Saal Frederick S., Akingbemi Benson T., Belcher Scott M., Birnbaum Linda S., Crain D. Andrew, Eriksen Marcus, Farabollini Francesca, Guillette Louis J., Hauser Russ, Heindel Jerrold J., Ho Shuk-Mei, Hunt Patricia A., Iguchi Taisen, Jobling Susan, Kanno Jun, Keri Ruth A., Knudsen Karen E., Laufer Hans, LeBlanc Gerald A., Marcus Michele, McLachlan John A., Myers John Peterson, Nadal Angel, Newbold Retha R., Olea Nicolas, Prins Gail S., Richter Catherine A., Rubin Beverly S., Sonnenschein Carlos, Soto Ana M., Talsness Chris E., Vandenbergh John G., Vandenberg Laura N., Walser-Kuntz Debby R., Watson Cheryl S., Welshons Wade V., Wetherill Yelena, Zoeller R. Thomas (2007): Chapel Hill bisphenol A expert panel consensus statement: Integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure. Reproductive Toxicology, 24, 131-138
Vrooman Lisa A., Oatley Jon M., Griswold Jodi E., Hassold Terry J., Hunt Patricia A., Hawley R. Scott (2015): Estrogenic Exposure Alters the Spermatogonial Stem Cells in the Developing Testis, Permanently Reducing Crossover Levels in the Adult. PLOS Genetics, 11, e1004949-
Wang Feng, Hua Jing, Chen Minjian, Xia Yankai, Zhang Qi, Zhao Renzheng, Zhou Weixin, Zhang Zhengdong, Wang Bingling (2012): High urinary bisphenol A concentrations in workers and possible laboratory abnormalities. Occupational and Environmental Medicine, 69, 679-684
Wang Tiange, Lu Jieli, Xu Min, Xu Yu, Li Mian, Liu Yu, Tian Xiaoguang, Chen Yuhong, Dai Meng, Wang Weiqing, Lai Shenghan, Bi Yufang, Ning Guang (2013): Urinary Bisphenol A Concentration and Thyroid Function in Chinese Adults. Epidemiology, 24, 295-302
Warita Katsuhiko, Mitsuhashi Tomoko, Ohta Ken-ichi, Suzuki Shingo, Hoshi Nobuhiko, Miki Takanori, Takeuchi Yoshiki (2013): Gene expression of epigenetic regulatory factors related to primary silencing mechanism is less susceptible to lower doses of bisphenol A in embryonic hypothalamic cells. The Journal of Toxicological Sciences, 38, 285-289
Wetherill Yelena B., Akingbemi Benson T., Kanno Jun, McLachlan John A., Nadal Angel, Sonnenschein Carlos, Watson Cheryl S., Zoeller R. Thomas, Belcher Scott M. (2007): In vitro molecular mechanisms of bisphenol A action. Reproductive Toxicology, 24, 178-198
Wilson Melinda E., Sengoku Tomoko (2013): Developmental regulation of neuronal genes by DNA methylation: Environmental influences. International Journal of Developmental Neuroscience, 31, 448-451
Xi Wei, Lee C.K.F., Yeung W.S.B., Giesy John P., Wong M.H., Zhang Xiaowei, Hecker Markus, Wong Chris K.C. (2011): Effect of perinatal and postnatal bisphenol A exposure to the regulatory circuits at the hypothalamus–pituitary–gonadal axis of CD-1 mice. Reproductive Toxicology, 31, 409-417
Xiao Shuo, Diao Honglu, Smith Mary Alice, Song Xiao, Ye Xiaoqin (2011): Preimplantation exposure to bisphenol A (BPA) affects embryo transport, preimplantation embryo development, and uterine receptivity in mice. Reproductive Toxicology, , -
Xu Li-Chun, Sun Hong, Chen Jian-Feng, Bian Qian, Qian Jie, Song Ling, Wang Xin-Ru (2005): Evaluation of androgen receptor transcriptional activities of bisphenol A, octylphenol and nonylphenol in vitro. Toxicology, 216, 197-203
Yamada Hideto, Furuta Itsuko, Kato Emi H, Kataoka Soromon, Usuki Yasuteru, Kobashi Gen, Sata Fumihiro, Kishi Reiko, Fujimoto Seiichiro (2002): Maternal serum and amniotic fluid bisphenol A concentrations in the early second trimester. Reproductive Toxicology, 16, 735-739
Yamasaki K (2004): Comparative study of the uterotrophic potency of 14 chemicals in a uterotrophic assay and their receptor-binding affinity. Toxicology Letters, 146, 111-120
Yang Oneyeol, Kim Hye Lim, Weon Jong-Il, Seo Young Rok (2015): Endocrine-disrupting Chemicals: Review of Toxicological Mechanisms Using Molecular Pathway Analysis. Journal of Cancer Prevention, 20, 12-24
Yang Yunjia, Lu Libin, Zhang Jing, Yang Yi, Wu Yongning, Shao Bing (2014): Simultaneous determination of seven bisphenols in environmental water and solid samples by liquid chromatography–electrospray tandem mass spectrometry. Journal of Chromatography A, 1328, 26-34
Ye J, Coleman J, Hunter M G, Craigon J, Campbell K H S, Luck M R (2007): Physiological temperature variants and culture media modify meiotic progression and developmental potential of pig oocytes in vitro. Reproduction, 133, 877-886
Zhang Han-Qiong, Zhang Xi-Feng, Zhang Lian-Jun, Chao Hu-He, Pan Bo, Feng Yan-Min, Li Lan, Sun Xiao-Feng, Shen Wei (2012): Fetal exposure to bisphenol A affects the primordial follicle formation by inhibiting the meiotic progression of oocytes. Molecular Biology Reports, 39, 5651-5657
Zhang Teng, Li Lan, Qin Xun-Si, Zhou Yang, Zhang Xi-Feng, Wang Lin-Qing, De Felici Massimo, Chen Hong, Qin Guo-Qing, Shen Wei (2014): Di-(2-ethylhexyl) phthalate and bisphenol A exposure impairs mouse primordial follicle assembly in vitro. Environmental and Molecular Mutagenesis, 55, 343-353
Zhang Xiaowei, Chang Hong, Wiseman Steve, He Yuhe, Higley Eric, Jones Paul, Wong Chris K.C., Al-Khedhairy Abdulaziz, Giesy John P., Hecker Markus (2011): Bisphenol A Disrupts Steroidogenesis in Human H295R Cells. Toxicological Sciences, 121, 320-327
Zimmerman J. B., Anastas P. T. (2015): Toward designing safer chemicals. Science, 347, 215-215
Ziv-Gal Ayelet, Wang Wei, Zhou Changqing, Flaws Jodi A. (2015): The effects of in utero bisphenol A exposure on reproductive capacity in several generations of mice. Toxicology and Applied Pharmacology, 284, 354-362
Zoeller R. Thomas, Brown T. R., Doan L. L., Gore A. C., Skakkebaek N. E., Soto A. M., Woodruff T. J., Vom Saal F. S. (2012): Endocrine-Disrupting Chemicals and Public Health Protection: A Statement of Principles from The Endocrine Society. Endocrinology, 153, 4097-4110
Zoller O., Bruschweiler B.J., Magnin R., Reinhard H., Rhyn P., Rupp H., Zelter S., Felleisen R. (2016): Natural occurrence of bisphenol F in mustard. Food Additives and Contaminants: Part A, 33, 137–146.
download PDF

© 2021 Czech Academy of Agricultural Sciences | Prohlášení o přístupnosti