Genetic diversity within and gene flow between three draught horse breeds using genealogical information

https://doi.org/10.17221/91/2015-CJASCitation:Vostrá-Vydrová H., Vostrý L., Hofmanová B., Krupa E., Veselá Z., Schmidová J. (2016): Genetic diversity within and gene flow between three draught horse breeds using genealogical information. Czech J. Anim. Sci., 61: 462-472.
download PDF
Three draught horse breeds are maintained in the Czech Republic: the Silesian Noriker (SN), the Noriker (N), and the Czech-Moravian Belgian (CMB). Because the SN and CMB populations are currently closed to outside breeding and are endangered (Genetic Resources), the loss of the genetic variation these horses represent is concerning. Genetic diversity within and between these three breeds and their population structures was analyzed based on pedigree information. Our goal was to identify and quantify factors that affected their genetic variability. The effective population size was analyzed in each breed. The numbers of generations were 22, 32, and 32 for the SN, N, and CMB breeds, respectively, with average equivalent known generations of 9.81, 8.45, and 8.91, respectively. The effective numbers of founders and ancestors contributing to the current genetic pool were, respectively, 69.42 and 22.32 for the SN breed, 98.48 and 42.20 for the N breed, and 43.33 and 23.32 for the CMB breed. The average inbreeding coefficients were 4.6%, 2%, and 4% for the SN, N, and CMB breeds, respectively, and the average inbreeding rate was 0.5% for the SN and CMB breeds and 0.2% for the N breed. The corresponding estimates of effective population size were 95, 195, and 101 for the SN, N, and CMB breeds, respectively. These statistics suggest that the genetic variability has decreased, and without changes in breeding strategy the genetic variability might continue to decline. Using genealogical F-statistics, small genetic differences were identified between the analyzed populations (FST = 0.02).
References:
Álvarez I., Royo L.J., Gutiérrez J.P., Fernández I., Arranz J.J., Goyache F. (2008): Relationship between genealogical and microsatellite information characterizing losses of genetic variability: Empirical evidence from the rare Xalda sheep breed. Livestock Science, 115, 80-88  https://doi.org/10.1016/j.livsci.2007.06.009
 
Bartolomé E., Goyache F., Molina A., Cervantes I., Valera M., Gutiérrez J. P. (2010): Pedigree estimation of the (sub) population contribution to the total gene diversity: the horse coat colour case. animal, 4, 867-  https://doi.org/10.1017/S1751731110000182
 
Boichard D, Maignel L, Verrier É (1997): The value of using probabilities of gene origin to measure genetic variability in a population. Genetics Selection Evolution, 29, 5-  https://doi.org/10.1186/1297-9686-29-1-5
 
CABALLERO ARMANDO, TORO MIGUEL A. (): Interrelations between effective population size and other pedigree tools for the management of conserved populations. Genetical Research, 75, 331-343  https://doi.org/10.1017/S0016672399004449
 
Caballero A., Toro M.A. (2002): Analysis of genetic diversity for the management of conserved subdivide populations. Conservation Genetics, 3, 289–299. https://doi.org/10.1023/A:1019956205473
 
Cervantes I., Goyache F., Molina A., Valera M., Gutiérrez J. P. (2008): Application of individual increase in inbreeding to estimate realized effective sizes from real pedigrees. Journal of Animal Breeding and Genetics, 125, 301-310  https://doi.org/10.1111/j.1439-0388.2008.00755.x
 
Cervantes I., Gutiérrez J.P., Molina A., Goyache F., Valera M. (2009): Genealogical analyses in open populations: the case of three Arab-derived Spanish horse breeds. Journal of Animal Breeding and Genetics, 126, 335-347  https://doi.org/10.1111/j.1439-0388.2008.00797.x
 
Druml T., Baumung R., Sölkner J. (2009): Pedigree analysis in the Austrian Noriker draught horse: genetic diversity and the impact of breeding for coat colour on population structure. Journal of Animal Breeding and Genetics, 126, 348-356  https://doi.org/10.1111/j.1439-0388.2008.00790.x
 
Falconer D.S., Mackay T.F.C. (1996): Introduction into Quantitative Genetics. Longman House, Harlow, UK.
 
FAO (1998): Secondary guidelines for development of farm animal genetic resources management plans. Management of small populations at risk. FAO, Rome, Italy.
 
Fernandez J. (2005): Efficiency of the Use of Pedigree and Molecular Marker Information in Conservation Programs. Genetics, 170, 1313-1321  https://doi.org/10.1534/genetics.104.037325
 
Goyache F., Gutierrez J. P., Fernandez I., Gomez E., Alvarez I., Diez J., Royo L. J. (2003): Using pedigree information to monitor genetic variability of endangered populations: the Xalda sheep breed of Asturias as an example. Journal of Animal Breeding and Genetics, 120, 95-105  https://doi.org/10.1046/j.1439-0388.2003.00378.x
 
Gutierrez J.P., Marmi J., Goyache F., Jordana J. (2005): Pedigree information reveals moderate to high levels of inbreeding and a weak population structure in the endangered Catalonian donkey breed. Journal of Animal Breeding and Genetics, 122, 378-386  https://doi.org/10.1111/j.1439-0388.2005.00546.x
 
Gutiérrez Juan, Cervantes Isabel, Molina Antonio, Valera Mercedes, Goyache Félix (2008): Individual increase in inbreeding allows estimating effective sizes from pedigrees. Genetics Selection Evolution, 40, 359-  https://doi.org/10.1186/1297-9686-40-4-359
 
Hofmanova B., Pribanova M., Majzlik I., Vostry L., Vostra-Vydrova H. (2014): Population study of three breeds of cold blooded horses in the Czech Republic. In: Proc. 65th Annu. Mtg., European Association for Animal Production (EAAP), Copenhagen, Denmark, 379.
 
James J.W. (1972): Computation of genetic contribution from pedigrees. Theoretical and Applied Genetics, 42, 272–273.
 
Lacy Robert C. (1989): Analysis of founder representation in pedigrees: Founder equivalents and founder genome equivalents. Zoo Biology, 8, 111-123  https://doi.org/10.1002/zoo.1430080203
 
Lacy Robert C. (1995): Clarification of genetic terms and their use in the management of captive populations. Zoo Biology, 14, 565-577  https://doi.org/10.1002/zoo.1430140609
 
MacCluer Jean W., Boyce Anthony J., Dyke Bennett, Weitkamp Lowell R., Pfenning David W., Parsons Cindy J. (1983): Inbreeding and pedigree structure in Standardbred horses. Journal of Heredity, 74, 394-399  https://doi.org/10.1093/oxfordjournals.jhered.a109824
 
Maignel L., Boichard D., Verrier E. (1996): Genetic variability of French dairy breeds estimated from pedigree information. Interbull Bulletin, 14, 49–54.
 
Meuwissen T.H.E., Woolliams J.A. (1994): Effective sizes of livestock populations to prevent a decline in fitness. Theoretical and Applied Genetics, 89-89, -  https://doi.org/10.1007/BF00224533
 
Nagy I., Curik I., Radnai I., Cervantes I., Gyovai P., Baumung R., Farkas J., Szendro Z. (): Genetic diversity and population structure of the synthetic Pannon White rabbit revealed by pedigree analyses. Journal of Animal Science, 88, 1267-1275  https://doi.org/10.2527/jas.2009-2273
 
Nei M. (1987): Molecular Evolutionary Genetics. Columbia University Press, New York, USA.
 
Pjontek J., Kadlecik O., Kasarda R., Horny M. (2012): Pedigree analysis in four Slovak endangered horse breeds. Czech Journal of Animal Science, 57, 54–64.
 
Rodrigáñez J., Toro M. A., Rodriguez M. C., Silió L. (1998): Effect of founder allele survival and inbreeding depression on litter size in a closed line of Large White pigs. Animal Science, 67, 573-582  https://doi.org/10.1017/S1357729800033014
 
Toro Miguel A., Fernández Jesús, Caballero Armando (2009): Molecular characterization of breeds and its use in conservation. Livestock Science, 120, 174-195  https://doi.org/10.1016/j.livsci.2008.07.003
 
Valera M., Molina A., Gutiérrez J.P., Gómez J., Goyache F. (2005): Pedigree analysis in the Andalusian horse: population structure, genetic variability and influence of the Carthusian strain. Livestock Production Science, 95, 57-66  https://doi.org/10.1016/j.livprodsci.2004.12.004
 
VanRaden P.M. (1992): Accounting for Inbreeding and Crossbreeding in Genetic Evaluation of Large Populations. Journal of Dairy Science, 75, 3136-3144  https://doi.org/10.3168/jds.S0022-0302(92)78077-1
 
Vicente A.A., Carolino N., Gama L.T. (2012): Genetic diversity in the Lusitano horse breed assessed by pedigree analysis. Livestock Science, 148, 16-25  https://doi.org/10.1016/j.livsci.2012.05.002
 
Vostrá-Vydrová H., Vostrý L., Hofmanová B., Krupa E., Zavadilová L. (2016): Pedigree analysis of the endangered Old Kladruber horse population. Livestock Science, 185, 17-23  https://doi.org/10.1016/j.livsci.2016.01.001
 
Wright S. (1969): The Theory of Gene Frequencies: Evolution and the Genetics of Populations, Vol. 2. Chicago University Press, Chicago, USA.
 
Zechner P, Sölkner J, Bodo I, Druml T, Baumung R, Achmann R, Marti E, Habe F, Brem G (2002): Analysis of diversity and population structure in the Lipizzan horse breed based on pedigree information. Livestock Production Science, 77, 137-146  https://doi.org/10.1016/S0301-6226(02)00079-9
 
download PDF

© 2021 Czech Academy of Agricultural Sciences | Prohlášení o přístupnosti