Effect of missense mutation Asp298Asn in MC4R on growth and fatness traits in commercial pig crosses in the Czech Republic

https://doi.org/10.17221/1305-CJASCitation:Dvořáková V., Stupka R., Šprysl M., Čítek J., Okrouhlá M., Kluzáková E., Kratochvílová H. (2011): Effect of missense mutation Asp298Asn in MC4R on growth and fatness traits in commercial pig crosses in the Czech Republic. Czech J. Anim. Sci., 56: 176-180.
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The current knowledge of factors regulating voluntary feed intake in pigs is quite limited. The objective of this study was to test the influence of the missense mutation p.Asp298Asn (AF087937:c.746G>A) of the MC4R gene on selected production traits in pig crosses. These crosses are commonly used on commercial farms in the Czech Republic. The allele frequencies of c.746G>A were as follows: G allele – 0.59 and A allele – 0.41. We detected statistically significant differences in the content of intramuscular fat in the musculus longissimus lumborum et thoracis, and a similar trend was observed in shoulder and neck. A allele correlated with higher values of fatness and G allele with a higher percentage of lean meat. However, we did not find any significant influence on either feed intake or growth rate in this study. For another mutation, p.Arg236His (NM_214173.1:c.707G>A), frequencies of alleles were disproportional (A allele – 0.02 and G allele – 0.98), only two genotypes were observed (AG and GG) and linkage disequilibrium was not detected. Therefore, we assume that the effect of this polymorphism on growth rate and fatness in the Czech population of pigs is negligible.
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