Effects of dietary supplementation of chitosan on immune and antioxidative function in beef cattle

https://doi.org/10.17221/7910-CJASCitation:Li T., Na R., Yu P., Shi B., Yan S., Zhao Y., Xu Y. (2015): Effects of dietary supplementation of chitosan on immune and antioxidative function in beef cattle. Czech J. Anim. Sci., 60: 38-44.
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The present experiment was conducted to study the effects of chitosan (CHI) on immune and antioxidative function in beef cattle. A total of 24 fattening Simmental cattle with similar body weight and age were divided randomly into three dietary groups, and the three diets contained 0, 500, and 1000 mg/kg CHI, respectively. The feeding trial lasted for 84 days. It was found that: (1) the addition of CHI in diets improved (P < 0.05) the levels of IgA and interleukin-1, and decreased (P < 0.1) the levels of soluble cluster of differentiation 4 receptor in serum at middle stage except that IgA remained unchanged in 1000 mg/kg CHI group. The levels of IgM and IgA tended to be increased (P < 0.1) by dietary CHI at later stage of the experiment; (2) the addition of 500 mg/kg CHI in diets increased (P < 0.1) total superoxide dismutase activity and decreased (< 0.05) malondialdehyde content in serum at early and later stages, respectively. In conclusion, these results indicated that addition of 500 mg/kg CHI affected humoral and cellular immune responses, and improved the antioxidative function of beef cattle.
Afonso Valéry, Champy Romuald, Mitrovic Dragoslav, Collin Pascal, Lomri Abderrahim (2007): Reactive oxygen species and superoxide dismutases: Role in joint diseases. Joint Bone Spine, 74, 324-329  https://doi.org/10.1016/j.jbspin.2007.02.002
Anandan R., Ganesan B., Obulesu T., Mathew S., Asha K. K., Lakshmanan P. T., Zynudheen A. A. (2013): Antiaging effect of dietary chitosan supplementation on glutathione-dependent antioxidant system in young and aged rats. Cell Stress and Chaperones, 18, 121-125  https://doi.org/10.1007/s12192-012-0354-2
Cui Jun-Jian, Yuan Jiang-Feng, Zhang Zhi-Qi (2010): Anti-oxidation activity of the crude polysaccharides isolated from Polygonum Cillinerve (Nakai) Ohwi in immunosuppressed mice. Journal of Ethnopharmacology, 132, 512-517  https://doi.org/10.1016/j.jep.2010.08.052
David A.Z., Connie J.R., Kenneth W.H., Jeffrey S., John W.G. (2007): Chitosan solution enhances both humoral and cell-mediated immune responses to subcutaneous vaccination. Vaccine, 11, 2085–2094.
Esumi Kunio, Takei Naoko, Yoshimura Tomokazu (2003): Antioxidant-potentiality of gold–chitosan nanocomposites. Colloids and Surfaces B: Biointerfaces, 32, 117-123  https://doi.org/10.1016/S0927-7765(03)00151-6
Frey Andreas, Di Canzio James, Zurakowski David (1998): A statistically defined endpoint titer determination method for immunoassays. Journal of Immunological Methods, 221, 35-41  https://doi.org/10.1016/S0022-1759(98)00170-7
Guo Zhanyong, Xing Ronge, Liu Song, Zhong Zhimei, Li Pengcheng (2008): Synthesis and hydroxyl radicals scavenging activity of quaternized carboxymethyl chitosan. Carbohydrate Polymers, 73, 173-177  https://doi.org/10.1016/j.carbpol.2007.10.021
Johnson R.W. (1997): Inhibition of growth by pro-inflammatory cytokines: an integrated view. Journal of Animal Science, 75, 1244–1255.
Kong X.F., Zhou X.L., Lian G.Q., Blachier F., Liu G., Tan B.E, Nyachoti C.M., Yin Y.L. (2014): Dietary supplementation with chitooligosaccharides alters gut microbiota and modifies intestinal luminal metabolites in weaned Huanjiang mini-piglets. Livestock Science, 160, 97-101  https://doi.org/10.1016/j.livsci.2013.11.023
Li H.Y. (2009): Effects of chitosan on immune function in broilers and the underlying mechanisms. Ph.D. Thesis. Hohhot, Inner Mongolia Agricultural University. (in Chinese)
Li H. Y., Yan S. M., Shi B. L., Guo X. Y. (2009): Effect of Chitosan on Nitric Oxide Content and Inducible Nitric Oxide Synthase Activity in Serum and Expression of Inducible Nitric Oxide Synthase mRNA in Small Intestine of Broiler Chickens. Asian-Australasian Journal of Animal Sciences, 22, 1048-1053  https://doi.org/10.5713/ajas.2009.80708
Li Junliang, Shi Binlin, Yan Sumei, Jin Lu, Guo Yiwei, Xu Yuanqing, Li Tiyu, Guo Xiaoyu (2013): Effects of dietary supplementation of chitosan on humoral and cellular immune function in weaned piglets. Animal Feed Science and Technology, 186, 204-208  https://doi.org/10.1016/j.anifeedsci.2013.10.007
Lim B.O., Yamada K., Nonaka M., Kuramoto Y., Hung P., Sugano M. (1997): Dietary fibers modulate indices of intestinal immune function in rats. Journal of Nutrition, 127, 663–667.
Liu M., Shi T., Liu J.Q. (2011): Effects of chitosan on anti-oxidative function and immune organ index in broilers. Journal of Chinese Feed, 15, 22–25. (in Chinese)
Liu Q.H., Liang X.W., Wang G.L. (2007): Effects of dietary supplementation of chitosan on dry matter intake and blood parameters for dry dairy cows. Journal of Animal and Feed Sciences, 16, 430–435.
McKee Amy S., Munks Michael W., Marrack Philippa (2007): How Do Adjuvants Work? Important Considerations for New Generation Adjuvants. Immunity, 27, 687-690  https://doi.org/10.1016/j.immuni.2007.11.003
Metcalfe Dean D. (1991): Food allergy. Current Opinion in Immunology, 3, 881-886  https://doi.org/10.1016/S0952-7915(05)80007-X
NRC (2000): Nutrient Requirements of Beef Cattle. 7th Ed. The National Academies Press, Washington, USA.
Ouali Ahmed, Herrera-Mendez Carlos Hernan, Coulis Gerald, Becila Samira, Boudjellal Abdelghani, Aubry Laurent, Sentandreu Miguel Angel (2006): Revisiting the conversion of muscle into meat and the underlying mechanisms. Meat Science, 74, 44-58  https://doi.org/10.1016/j.meatsci.2006.05.010
Ren H.J. (2008): Effects of chitosan on production performance and immune function in dairy cattle. Ph.D. Thesis. Hohhot, Inner Mongolia Agricultural University. (in Chinese)
Renckens Rosemarijn, Roelofs Joris J. T. H., Knapp Sylvia, de Vos Alex F., Florquin Sandrine, van der Poll Tom (2006): The Acute‐Phase Response and Serum Amyloid A Inhibit the Inflammatory Response to Acinetobacter baumannii Pneumonia. The Journal of Infectious Diseases, 193, 187-195  https://doi.org/10.1086/498876
Schley P.D., Field C.J. (2002): The immune-enhancing effects of dietary fibres and prebiotics. British Journal of Nutrition, 87, S221–S230.
Siwicki Andrzej K., Anderson Douglas P., Rumsey Gary L. (1994): Dietary intake of immunostimulants by rainbow trout affects non-specific immunity and protection against furunculosis. Veterinary Immunology and Immunopathology, 41, 125-139  https://doi.org/10.1016/0165-2427(94)90062-0
Song C.Y., Jiang J.Y., Han X.J., Shi J.S., Wei S.D. (2010): Effects of immunological stress on interleukin-1β, cortisol and growth hormone in different breed piglets. Reproduction and Physiology, 46, 19–22. (in Chinese)
Sun T., Yao Q., Zhou D., Mao F. (2008): Antioxidant activity of N-carboxymethyl chitosan oligosaccharides. Bioorganic & Medicinal Chemistry Letters, 18, 5774–5776.
Tokura S., Tamura H., Azuma I. (1999): Immunological aspects of chitin and chitin derivatives administered to animals. EXS, 87, 279–292.
Tomida Hisao, Fujii Takeshi, Furutani Nobuko, Michihara Akihiro, Yasufuku Taira, Akasaki Kenji, Maruyama Toru, Otagiri Masaki, Gebicki Janusz M., Anraku Makoto (2009): Antioxidant properties of some different molecular weight chitosans. Carbohydrate Research, 344, 1690-1696  https://doi.org/10.1016/j.carres.2009.05.006
UEHARA SOICHIRO, GOTHOH KATSUHIRO, HANDA HIROSHI, TOMITA HIROSHI, TOMITA YOSHIMURA (2003): Immune function in patients with acute pancreatitis. Journal of Gastroenterology and Hepatology, 18, 363-370  https://doi.org/10.1046/j.1440-1746.2003.02979.x
Xiao Dingfu, Tang Zhiru, Yin Yulong, Zhang Bin, Hu Xionggui, Feng Zemeng, Wang Jinquan (2013): Effects of dietary administering chitosan on growth performance, jejunal morphology, jejunal mucosal sIgA, occluding, claudin-1 and TLR4 expression in weaned piglets challenged by enterotoxigenic Escherichia coli. International Immunopharmacology, 17, 670-676  https://doi.org/10.1016/j.intimp.2013.07.023
Xu Y., Shi B., Yan S., Li J., Li T., Guo Y., Guo X. (2014): Effects of chitosan supplementation on the growth performance, nutrient digestibility, and digestive enzyme activity in weaned pigs. Czech Journal of Animal Science, 59, 156–163.
Yin J., Wu M. M., Xiao H., Ren W. K., Duan J. L., Yang G., Li T. J., Yin Y. L. (): Development of an antioxidant system after early weaning in piglets. Journal of Animal Science, 92, 612-619  https://doi.org/10.2527/jas.2013-6986
Yin Y.-L., Tang Z. R., Sun Z. H., Liu Z. Q., Li T. J., Huang R. L., Ruan Z., Deng Z. Y., Gao B., Chen L. X., Wu G. Y., Kim S. W. (2008): Effect of Galacto-mannan-oligosaccharides or Chitosan Supplementation on Cytoimmunity and Humoral Immunity in Early-weaned Piglets. Asian-Australasian Journal of Animal Sciences, 21, 723-731  https://doi.org/10.5713/ajas.2008.70408
Yoon Hyun Joong, Moon Myoung E., Park Haeng Soon, Kim Hyun Woo, Im Shun Young, Lee Jun Haeng, Kim Young Ho (2008): Effects of chitosan oligosaccharide (COS) on the glycerol-induced acute renal failure in vitro and in vivo. Food and Chemical Toxicology, 46, 710-716  https://doi.org/10.1016/j.fct.2007.09.111
Yu P., Zhao Y.G., Shi B.L., Yan S.M., Hong L., Xu Y.Q., Guo Y.W., Tian L.X. (2012): Effects of dietary supplementation of chitosan on growth performance and nutrient digestibility in beef cattle. Journal of Feed Industry, 33, 44–47. (in Chinese)
Zhang J. (2012): Effects of dietary immunostimulants on growth, non-specific immune response and stress resistance of juvenile pacific white shrimp, Litopenaeus vannamei. Ph.D. Thesis. Guang Zhou, Sun Yat-sen University. (in Chinese)
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