Effect of different dietary oil sources on the growth performance, blood characteristics, fatty acid profiles, and expression of lipogenic genes in the liver of broiler chickens

https://doi.org/10.17221/8557-CJASCitation:Yan B.X., Zhao R., Wang J.P., Chen W., Huang Y.Q., Wang Z.X., Zhang J.S., Liu L.L., Qi D.F. (2015): Effect of different dietary oil sources on the growth performance, blood characteristics, fatty acid profiles, and expression of lipogenic genes in the liver of broiler chickens. Czech J. Anim. Sci., 60: 487-497.
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The effect of different levels of corn oil (CO) and flaxseed oil (FO) on growth performance, blood characteristics, fatty acid composition, and expression of lipogenic genes in the liver of broiler chickens was studied. Two hundred forty female Cobb-500 broiler chickens at the age of one day (body weight (BW) = 46 ± 4 g) were fed a corn soybean meal based diet containing 5% CO (LC), 3.75% CO + 1.25% FO (FO1), 2.5% CO + 2.5% FO (FO2) or 5% FO (FC). Chickens fed FO1 diet had better BW gain (P = 0.049) and gain/feed ratio (P = 0.006) than those fed LC and FC diets during days 1–21 of age. However, for the whole experimental period (1–42 days of age), the dietary lipid source had no effect on the growth performance. On day 42 of age, the hepatic percentages of 18:3n-3 (P = 0.001) and 20:5n-3 (P < 0.001) were higher in FC than in LC group, which led to a higher content of total n-3 PUFA and lower n-6/n-3 PUFA ratio. The contents of 18:2n-6 (P < 0.05) and Σ n-6 PUFA (P = 0.009) were lower in FC than in LC group. Chickens fed FO1 and FO2 diets had higher Ca2+-ATPase activity and lower lipoprotein lipase activity than those fed LC and FC diets, whereas activities of lactate dehydrogenase and Na+,K+-ATPase were increased by FO2 than by LC diet (P < 0.05). The relative mRNA expression level of lipin 1 in chickens fed FO2 and FC was higher (P < 0.01) than in those fed LC and FO1 diets. Our results demonstrated that higher levels of FO led to hepatic enrichment of n-3 PUFA content and lower n-6/n-3 PUFA ratios in liver and increased the expression of lipin 1 whereas the expression of lipin 2, NADH dehydrogenase subunit 2, Δ-6 fatty acid desaturase, WD and tetratricopeptide repeats 1, and glyceraldehyde-3-phosphate dehydrogenase was not affected.
Bell J.G., McEvoy J., Tocher D.R., McGhee F., Campbell P.J., Sargent J.R. (2001): Replacement of fish oil with rapeseed oil in diets of Atlantic salmon (Salmo salar) affects tissue lipid compositions and hepatocyte fatty acid metabolism. The Journal of Nutrition, 131, 1535–1543.
Benatmane F., Kouba M., Youyou A., Mourot J. (2011): Effect of a linseed diet on lipogenesis, fatty acid composition and stearoyl-CoA-desaturase in rabbits. animal, 5, 1993-2000 https://doi.org/10.1017/S1751731111001145
Blackinton Jeff, Kumaran Ravindran, van der Brug Marcel P., Ahmad Rili, Olson Lars, Galter Dagmar, Lees Andrew, Bandopadhyay Rina, Cookson Mark R. (2009): Post-transcriptional regulation of mRNA associated with DJ-1 in sporadic Parkinson disease. Neuroscience Letters, 452, 8-11 https://doi.org/10.1016/j.neulet.2008.12.053
Brunzell John D., Zambon Alberto, Deeb Samir S. (2012): The effect of hepatic lipase on coronary artery disease in humans is influenced by the underlying lipoprotein phenotype. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1821, 365-372 https://doi.org/10.1016/j.bbalip.2011.09.008
. Saban Celebi, . Necati Utlu (2006): Influence of Animal and Vegetable Oil in Layer Diets on Performance and Serum Lipid Profile. International Journal of Poultry Science, 5, 370-373 https://doi.org/10.3923/ijps.2006.370.373
Chen W., Zhao R., Yan B., Zhang J., Huang Y., Wang Z., Guo Y. (2014): Effects of the replacement of corn oil with linseed oil on fatty acid composition and the expression of lipogenic genes in broiler chickens. Czech Journal of Animal Science, 59, 353–364.
Djemli-Shipkolye A., Raccah D., Pieroni G., Vague P., Coste T.C., Gerbi A. (2003): Differential Effect of w3 PUFA Supplementations on Na,K-ATPase and Mg-ATPase Activities: Possible Role of the Membrane w6/w3 Ratio. Journal of Membrane Biology, 191, 37-47 https://doi.org/10.1007/s00232-002-1039-z
Enser M., Richardson R.I., Wood J.D., Gill B.P., Sheard P.R. (2000): Feeding linseed to increase the n-3 PUFA of pork: fatty acid composition of muscle, adipose tissue, liver and sausages. Meat Science, 55, 201-212 https://doi.org/10.1016/S0309-1740(99)00144-8
Esterbauer H. (1993): Cytotoxicity and genotoxicity of lipid-oxidation products. The American Journal of Clinical Nutrition, 57, 779S–785S.
Ferrini G., Manzanilla E.G., Menoyo D., Esteve-Garcia E., Baucells M.D., Barroeta A.C. (2010): Effects of dietary n-3 fatty acids in fat metabolism and thyroid hormone levels when compared to dietary saturated fatty acids in chickens. Livestock Science, 131, 287-291 https://doi.org/10.1016/j.livsci.2010.03.017
Folch J., Lees M., Sloane-Stanley G. (1957): A simple method for the isolation and purification of total lipids from animal tissues. Journal of Biological Chemistry, 226, 497–509.
Gingrich J. R., Pelkey K. A., Fam S. R., Huang Y., Petralia R. S., Wenthold R. J., Salter M. W. (): Unique domain anchoring of Src to synaptic NMDA receptors via the mitochondrial protein NADH dehydrogenase subunit 2. Proceedings of the National Academy of Sciences, 101, 6237-6242 https://doi.org/10.1073/pnas.0401413101
Herdmann A., Nuernberg K., Martin J., Nuernberg G., Doran O. (2010): Effect of dietary fatty acids on expression of lipogenic enzymes and fatty acid profile in tissues of bulls. animal, 4, 755- https://doi.org/10.1017/S1751731110000431
Kamal-Eldin Afaf, Yanishlieva Nedyalka V. (2002): N-3 fatty acids for human nutrition: stability considerations. European Journal of Lipid Science and Technology, 104, 825-836 https://doi.org/10.1002/1438-9312(200212)104:12<825::AID-EJLT825>3.0.CO;2-N
KASIM SIDIKA E., STERN BRIGITTE, KHILNANI SHEILA, MCLIN PATRICIA, BACIOROWSKI SHERRY, JEN K.-L. CATHERINE (1988): Effects of Omega-3 Fish Oils on Lipid Metabolism, Glycemic Control, and Blood Pressure in Type II Diabetic Patients*. The Journal of Clinical Endocrinology & Metabolism, 67, 1-5 https://doi.org/10.1210/jcem-67-1-1
Kaur G., Sinclair A. (2010): Regulation of gene expression in brain and liver by marine n-3 polyunsaturated fatty acids. Progress in Nutrition, 12, 24–28.
Lodhi Irfan J., Wei Xiaochao, Semenkovich Clay F. (2011): Lipoexpediency: de novo lipogenesis as a metabolic signal transmitter. Trends in Endocrinology & Metabolism, 22, 1-8 https://doi.org/10.1016/j.tem.2010.09.002
Lu Wei-Wei, Hou Ling-Ling, Zhang Wen-Wen, Zhang Peng-Fei, Chen Wen, Kang Xiangtao, Huang Yanqun (2014): Study on heteroplasmic variation and the effect of chicken mitochondrial ND2. Mitochondrial DNA, , 1-7 https://doi.org/10.3109/19401736.2014.971022
Luo He-Feng, Wei Hong-Kui, Huang Fei-Ruo, Zhou Zheng, Jiang Si-Wen, Peng Jian (2009): The Effect of Linseed on Intramuscular Fat Content and Adipogenesis Related Genes in Skeletal Muscle of Pigs. Lipids, 44, 999-1010 https://doi.org/10.1007/s11745-009-3346-y
Maillet D., Weber J.-M. (2007): Relationship between n-3 PUFA content and energy metabolism in the flight muscles of a migrating shorebird: evidence for natural doping. Journal of Experimental Biology, 210, 413-420 https://doi.org/10.1242/jeb.02660
Martin Pascal G. P., Guillou Hervé, Lasserre Frédéric, Déjean Sébastien, Lan Annaig, Pascussi Jean-Marc, SanCristobal Magali, Legrand Philippe, Besse Philippe, Pineau Thierry (2007): Novel aspects of PPARα-mediated regulation of lipid and xenobiotic metabolism revealed through a nutrigenomic study. Hepatology, 45, 767-777 https://doi.org/10.1002/hep.21510
Niki Etsuo, Yoshida Yasukazu, Saito Yoshiro, Noguchi Noriko (2005): Lipid peroxidation: Mechanisms, inhibition, and biological effects. Biochemical and Biophysical Research Communications, 338, 668-676 https://doi.org/10.1016/j.bbrc.2005.08.072
Oliveira D. D., Baiao N. C., Cancado S. V., Grimaldi R., Souza M. R., Lara L. J. C., Lana A. M. Q. (): Effects of lipid sources in the diet of laying hens on the fatty acid profiles of egg yolks. Poultry Science, 89, 2484-2490 https://doi.org/10.3382/ps.2009-00522
OLOMU J. M., BARACOS V. E. (1991): Influence of Dietary Flaxseed Oil on the Performance, Muscle Protein Deposition, and Fatty Acid Composition of Broiler Chicks. Poultry Science, 70, 1403-1411 https://doi.org/10.3382/ps.0701403
Patsch J R, Prasad S, Gotto A M, Patsch W (1987): High density lipoprotein2. Relationship of the plasma levels of this lipoprotein species to its composition, to the magnitude of postprandial lipemia, and to the activities of lipoprotein lipase and hepatic lipase.. Journal of Clinical Investigation, 80, 341-347 https://doi.org/10.1172/JCI113078
Puthpongsiriporn U., Scheideler S. E. (2005): Effects of dietary ratio of linoleic to linolenic acid on performance, antibody production, and in vitro lymphocyte proliferation in two strains of leghorn pullet chicks. Poultry Science, 84, 846-857 https://doi.org/10.1093/ps/84.6.846
Raes K., De Smet S., Demeyer D. (2004): Effect of dietary fatty acids on incorporation of long chain polyunsaturated fatty acids and conjugated linoleic acid in lamb, beef and pork meat: a review. Animal Feed Science and Technology, 113, 199-221 https://doi.org/10.1016/j.anifeedsci.2003.09.001
Rahimi S., Kamran Azad S., Torshizi K. (2011): Omega-3 enrichment of broiler meat by using two oil seeds. Journal of Agricultural Science and Technology, 13, 353–365.
Ralston Jessica C., Matravadia Sarthak, Gaudio Nicholas, Holloway Graham P., Mutch David M. (2015): Polyunsaturated fatty acid regulation of adipocyte FADS1 and FADS2 expression and function. Obesity, 23, 725-728 https://doi.org/10.1002/oby.21035
Rodrigo Ramón, Miranda-Merchak Andres, Valenzuela Grau Rodrigo, Bachler Juan P., Vergara Leonardo (): Modulation of (Na,K)-ATPase activity by membrane fatty acid composition: therapeutic implications in human hypertension. Clinical and Experimental Hypertension, 36, 17-26 https://doi.org/10.3109/10641963.2013.783048
Schmitz Gerd, Ecker Josef (2008): The opposing effects of n−3 and n−6 fatty acids. Progress in Lipid Research, 47, 147-155 https://doi.org/10.1016/j.plipres.2007.12.004
Schweitzer George G., Chen Zhouji, Gan Connie, McCommis Kyle S., Soufi Nisreen, Chrast Roman, Mitra Mayurranjan S., Yang Kui, Gross Richard W., Finck Brian N. (): Liver-specific loss of lipin-1-mediated phosphatidic acid phosphatase activity does not mitigate intrahepatic TG accumulation in mice. Journal of Lipid Research, 56, 848-858 https://doi.org/10.1194/jlr.M055962
Stuglin C. (2005): Effect of Flaxseed Consumption on Blood Pressure, Serum Lipids, Hemopoietic System and Liver and Kidney Enzymes in Healthy Humans. Journal of Cardiovascular Pharmacology and Therapeutics, 10, 23-27 https://doi.org/10.1177/107424840501000103
Suh Jae Myoung, Zeve Daniel, McKay Renee, Seo Jin, Salo Zack, Li Robert, Wang Michael, Graff Jonathan M. (2007): Adipose Is a Conserved Dosage-Sensitive Antiobesity Gene. Cell Metabolism, 6, 195-207 https://doi.org/10.1016/j.cmet.2007.08.001
Thering B.J., Graugnard D.E., Piantoni P., Loor J.J. (2009): Adipose tissue lipogenic gene networks due to lipid feeding and milk fat depression in lactating cows. Journal of Dairy Science, 92, 4290-4300 https://doi.org/10.3168/jds.2008-2000
Vajreswari A., Narayanareddy K. (1992a): Effect of dietary fats on erythrocyte membrane lipid composition and membrane-bound enzyme activities. Metabolism, 41, 352–358.
Vajreswari A., Narayanareddy K. (1992b): Effect of dietary fats on some membrane-bound enzyme activities, membrane lipid composition and fatty acid profiles of rat heart sarcolemma. Lipids, 27, 339–343.
Yang Yong, Zhao Chunjiang, Xiao Shan, Zhan He, Du Min, Wu Changxin, Ma Changwei (2010): Lipids deposition, composition and oxidative stability of subcutaneous adipose tissue and Longissimus dorsi muscle in Guizhou mini-pig at different developmental stages. Meat Science, 84, 684-690 https://doi.org/10.1016/j.meatsci.2009.11.003
Yilmaz H.Ramazan, Songur Ahmet, Özyurt Birsen, Zararsiz İsmail, Sarsilmaz Mustafa (2004): The effects of n-3 polyunsaturated fatty acids by gavage on some metabolic enzymes of rat liver. Prostaglandins, Leukotrienes and Essential Fatty Acids, 71, 131-135 https://doi.org/10.1016/j.plefa.2004.03.002
Yu Kaifan, Shu Gang, yuan Fangfang, Zhu Xiaotong, Gao Ping, Wang Songbo, Wang Lina, Xi Qianyun, Zhang Shouquan, Zhang Yongliang, Li Yan, Wu Tongshan, Yuan Li, Jiang Qingyan (2013): Fatty Acid and Transcriptome Profiling of Longissimus Dorsi Muscles between Pig Breeds Differing in Meat Quality. International Journal of Biological Sciences, 9, 108-118 https://doi.org/10.7150/ijbs.5306
Zhou Ran, Li Shufen (2009): In vitro antioxidant analysis and characterisation of antler velvet extract. Food Chemistry, 114, 1321-1327 https://doi.org/10.1016/j.foodchem.2008.11.010
Zhu S.K., Tian Y.D., Zhang S., Chen Q.X., Wang Q.Y., Han R.L., Kang X.T. (2014): Adjacent SNPs in the transcriptional regulatory region of the FADS2 gene associated with fatty acid and growth traits in chickens. Genetics and Molecular Research, 13, 3329-3336 https://doi.org/10.4238/2014.April.29.11
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