Appraisal of antioxidant potential and biological studies of bogan bail (Bougainvillea glabra) leaf extracts using different solvents

Riaz M., Fatima H., Misbah ur Rehman M., Qadir R., Hussain S., Hafeez A., Siddique A.B. (2021): Appraisal of antioxidant potential and biological studies of bogan bail (Bougainvillea glabra) leaf extracts using different solvents. Czech J. Food Sci., 39: 176–180.

download PDF

Current research work was performed to evaluate the antioxidant, antidiabetic, thrombolytic, and cytotoxic potential of Bougainvillea glabra leaf extracts with different solvents. Extraction of leaves was carried out by maceration using solvents of various polarity such as n-hexane, chloroform, ethyl acetate, n-butanol, and methanol. The highest values of total phenolic and flavonoid contents were assessed in methanolic extract, such as 58.57% and 29.41%, respectively. Antioxidant potential was measured by DPPH free radical, showing 65.16% scavenging activity in methanolic extract. Similarly, the reducing power of methanolic extract was also measured. Hemolytic activity of B. glabra leaf extracts was evaluated, and maximum percentage lysis was found as 6.86% in chloroform extract. The thrombolytic activity of B. glabra leaf extracts was evaluated against human red blood cells, and the maximum percentage of clot lysis was 59.10% in chloroform extract. Maximum antidiabetic activity (16.20%) was observed in methanolic extract. Overall, the presented results reveal that bogan bail extract is capable of being employed in nutra-pharmaceutical industry.

Akhtar M.T., Qadir R., Bukhari I., Ashraf R.A., Malik Z., Zahoor S., Murtaza M.A., Siddique F., Shah S.N.H., Saadia M. (2020): Antidiabetic potential of Nigella sativa L seed oil in alloxaninduced diabetic rabbits. Tropical Journal of Pharmaceutical Research, 19: 283–289.
Ali M.S., Faruq K.O., Islam A., Nurullah A., Chowdhury K.A.A., Sayeed M.A. (2015): Thrombolytic and cytotoxic activities of Terminalia bellerica Roxb. Bangladesh Journal of Pharmacology, 16: 131–135.
Carlson C., Hussain S.M., Schrand A.M., Braydich-Stolle L.K., Hess K.L., Jones R.L., Schlager J.J. (2008): Unique cellular interaction of silver nanoparticles: Size-dependent generation of reactive oxygen species. The Journal of Physical Chemistry, 112: 13608–13619.
Chaovanalikit A., Wrolstad R. (2004): Total anthocyanins and total phenolics of fresh and processed cherries and their antioxidant properties. Journal of Food Science, 69: 67–72.
Devasagayam T., Sainis K. (2002): Immune system and antioxidants, especially those derived from Indian medicinal plants. Indian Journal of Experimental Biology, 40: 639–655.
Dewanto V., Wu X., Adom K.K., Liu R.H. (2002): Thermal processing enhances the nutritional value of tomatoes by increasing total antioxidant activity. Journal of Agriculture and Food Chemistry, 50: 3010–3014.
Iqbal S., Bhanger M.I., Anwar F. (2005): Antioxidant properties and component of some commercially available vari-eties of rice bran in Pakistan. Food Chemistry, 93: 265–272.
Kumar H.K., Navyashree S., Rakshitha H., Chauhan J.B. (2012): Studies on the free radical scavenging activity of Syagrus romanzoffiana. International Journal of Pharmacy, 3: 81–84.
Nostro A., Germano M., Dangelo V., Marino A., Cannatelli M. (2000). Extraction methods and bioautography for evaluation of medicinal plant antimicrobial activity. Letters in Applied Microbiology, 30: 379–384.
Powell W., Catranis C., Maynard C. (2000): Design of self-processing antimicrobial peptides for plant protection. Letters in Applied Microbiology, 31: 163–168.
Prasad S., Kashyap R.S., Deopujari J.Y., Purohit H.J., Taori G.M., Daginawala H.F. (2007): Effect of Fagonia arabica (Dhamasa) on in vitro thrombolysis. BMC Complementary Medicine and Therapy, 7: 1–6.
Qadir R., Anwar F., Gilani M.A., Zahoor S., Misbah ur Rehman M., Mustaqeem M. (2019): RSM/ANN based optimized recovery of phenolics from mulberry leaves by enzyme-assisted extraction. Czech Journal of Food Sciences., 37: 99–105.
Qadir R., Anwar F., Mehmood T., Zahoor S., Mehmood N. (2020): Variations in biological attributes and phenolics of enzymatically hydrolysed medicinal plant extracts. Bangladesh Journal of Botany, 49: 163–169.
Riaz M., Rasool N., Bukhari I.H., Shahid M., Zubair M., Rizwan K., Rashid U. (2012): In vitro antimicrobial, antioxidant, cytotoxicity and GC-MS analysis of Mazus goodenifolius. Molecules, 17: 14275–14287.
Rizwan K., Zubair M., Rasool N., Riaz M., Zia-Ul-Haq M., Feo D.V. (2012): Phytochemical and biological studies of Agave attenuata. International Journal of Molecular Science, 13: 6440–6451.
Samad A., Sultana Y., Aqi M. (2007): Liposomal drug delivery systems: An update review. Current Drug Delivery, 4: 297–305.
Siddhuraju P., Becker K. (2003): Antioxidant properties of various solvent extracts of total phenolic constituents from three different agroclimatic origins of drumstick tree (Moringa oleifera Lam.) leaves. Journal of Agricultural and Food Chemistry, 51: 2144–2155.
Yen G.C., Duh P.D., Chuang D.Y. (2000): Antioxidant activity of anthraquinones and anthrone. Food Chemistry, 70: 437–441.
download PDF

© 2021 Czech Academy of Agricultural Sciences | Prohlášení o přístupnosti