Mannitol evaluated mineral absorption and bone retention in ovariectomized rats

https://doi.org/10.17221/420/2017-CJFSCitation:Xiao J., Sakaguchi E., Shi B. (2019): Mannitol evaluated mineral absorption and bone retention in ovariectomized rats. Czech J. Food Sci., 37: 319-324.
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Indigestible sugars are used in food production and pharmaceutical industry due to their desirable properties. The effects of mannitol on Ca and Mg absorption and retention in ovariectomized rats were evaluated. Five weeks old ovariectomized Wistar rats were given Ca, Mg-deficient diet for 28 days then fed a control diet or 8% mannitol diets for another 28 days. Feaces were collected twice for 72h to measure mineral absorption. On day 56, rats were slaughtered and cecal parameters were observed. Femurs were collected to measure mineral levels. Results were shown that mineral absorption and femoral mineral was significantly increased by mannitol feeding. Cecal parameters were significantly altered after mannitol consumption. In conclusion, Ca and Mg absorption and their retention were improved by cecal fermentation of mannitol in ovariectomized rats.

References:
Bar A. (1990): Factorial calculation model for the estimation of the physiological caloric value of polyols. In: Hosoya, N. (ed.), Proceedings of the International Symposium on Caloric Evaluation of Carbohydrates. The Japan Assco. Tokyo. Dietetic & Enriched Foods, 209–252.
 
Blottière H.M., Buecher B., Galmiche J.P., Cherbut C. (2003): Molecular analysis of the effect of short-chain fatty acids on intestinal cell proliferation. Proceedings of Nutrition Society, 62: 101–106. https://doi.org/10.1079/PNS2002215
 
Chakravorty M. (1964): Metabolism of mannitol and induction of mannitol 1-phosphate dehydrogenase in Lactobacillus plantarum. Journal of Bacteriology, 87:1246–1248.
 
Chonan O., Matsumoto K., Watanuki M. (1995): Effect of galactooligosaccharides on calcium absorption and preventing bone loss in ovariectomized rats. Bioscience Biotechnology and Biochemistry, 9: 236–239. https://doi.org/10.1271/bbb.59.236
 
Comalada M., Bailón E. (2007): The effects of short-chain fatty acids on colon epithelial proliferation and survival depend on the cellular phenotype. Journal of Cancer Research and Clinical Oncology, 132: 487–497. https://doi.org/10.1007/s00432-006-0172-y
 
De Vries W., Stouthamer A.H. (1968): Fermentation of glucose, lactose, galactose, mannitol, and xylose by bifidobacteria. Journal of Bacteriology, 96: 472–478.
 
Dwivedi B.K. (1991): Sorbitol and mannitol. In: Nabors L.O., Gelardi R.C. (eds): Alternative Sweeteners (2nd Ed.). Marcel Dekker, New York: 333–348.
 
Egermann M., Goldhahn J., Schneider E. (2005): Animal model for fracture treatment in osteoporosis. Osteoporosis International, 16: 129–138. https://doi.org/10.1007/s00198-005-1859-7
 
Freitas K.C., Amancio O.M., de Morais M.B. (2012): High-performance inulin and oligofructose prebiotics increase the intestinal absorption of iron in rats with iron deficiency anaemia during the growth phase. British Journal of Nutrition, 108: 1008–1016. https://doi.org/10.1017/S0007114511006301
 
Hongo R., Nakamura S., Oku T. (2010): Utilization of orally administered D-[14C]mannitol via fermentation by intestinal microbes in rats. Journal of Nutritional Science and Vitaminology, 56: 387–395. https://doi.org/10.3177/jnsv.56.387
 
Hoshi S. (1994): Nutritional and physiological effects of indigestible saccharides on digestive tract effect of the fermented products in the large intestine on the digestive tract size and their function in rats. [Doctoral Thesis]. Sendai, Tohoku University.
 
Ichikawa H., Sakata T. (1998): Stimulation of epithelial cell proliferation of isolated distal colon of rats by continuous colonic infusion of ammonia or short chain fatty acids is nonadditive. Journal of Nutrition, 128: 843–847. https://doi.org/10.1093/jn/128.5.843
 
Johnson C.D., Lucas E.A., Hooshmand S., Campbell S., Akhter M.P., Arjmandi B.H. (2011): Addition of fructooligosaccharides and dried plum to soy-based diets reverses bone loss in the ovariectomized rat. Evidence-Based Complementary and Alternative Medicine, 2011:836267. doi: 10.1093/ecam/nen050 https://doi.org/10.1093/ecam/nen050
 
Kalu D.N., Orhii P.B. (1999): Calcium absorption and bone loss in ovariectomized rats fed varying levels of dietary calcium. Calcified Tissue International, 65: 73–77. https://doi.org/10.1007/s002239900660
 
Keighley M.R., Taylor E.W., Hares M.M., Arabi Y., Youngs D., Bentley S., Burdon D.W. (1981): Influence of oral mannitol bowel preparation on colonic microflora and the risk of explosion during endoscopic diathermy. British Journal of Surgery, 68: 554–556. https://doi.org/10.1002/bjs.1800680811
 
Kishino E., Norii M., Fujita K., Hara K., Teramoto F., Fukunaga M. (2006): Enhancement by lactosucrose of the calcium absorption from the intestine in growing rats. Bioscience Biotechnology and Biochemistry, 70: 1485–1488. https://doi.org/10.1271/bbb.50538
 
Lopez H.W., Coudray C., Levrat-Verny M.A., Feillet-Coudray C., Demigné C., Rémésy C. (2000): Fructooligosaccharides enhance mineral apparent absorption and counteract the deleterious effects of phytic acid on mineral homeostasis in rats. Journal of Nutritional Biochemistry, 11: 500–508. https://doi.org/10.1016/S0955-2863(00)00109-1
 
Lupton J.R., Coder D.M., Jacobs L.R. (1985): Influence of luminal pH on rat large bowel epithelial cell cycle. American Journal of Physiology, 249: 382–388. https://doi.org/10.1152/ajpgi.1985.249.3.G382
 
Lutz T., Scharrer E. (1991): Effect of short-chain fatty acids on calcium absorption by the rat colon. Experimental Physiology, 76: 615–618. https://doi.org/10.1113/expphysiol.1991.sp003530
 
Maekawa M., Ushida K., Hoshi S., Kashima N., Ajisaka K., Yajima T. (2005): Butyrate and propionate production from d-mannitol in the large intestine of pig and rat. Microbial Ecology in Health and Disease, 17: 169–176
 
Maryanski J.H., Wittenberger C.L. (1975): Mannitol transport in Streptococcus mutans. Journal of Bacteriology, 124: 1475–1481.
 
Mattila P.T., Svanberg M.J., Jämsä T., Knuuttila M.L. (2002): Improved bone biomechanical properties in xylitol-fed aged rats. Metabolism, 51: 92–96. https://doi.org/10.1053/meta.2002.28105
 
Morishita Y. (1994): The effect of dietary mannitol on caecal microflora and shortchain fatty acids in rats. Letters in Applied Microbiology, 18: 27–29.
 
Nakada H., Sakae T., Watanabe T., Takahashi T., Fujita K., Tanimoto Y. (2014): A new osteoporosis prevention supplements-diet improve bone mineral density in ovariectomized rats. Journal of Hard Tissue Biology, 23: 1–8. https://doi.org/10.2485/jhtb.23.1
 
Neves A.R., Ramos A., Shearman C., Gasson M.J., Santos H. (2002): Catabolism of mannitol in Lactococcus lactis MG1363 and a mutant defective in lactate dehydrogenase. Microbiology, 148: 3467–1376. https://doi.org/10.1099/00221287-148-11-3467
 
Nishiyama A., Nishioka S., Islam S.M., Sakaguchi E. (2009): Mannitol lowers fat digestibility and body fat accumulation in both normal and cecectomized rats. Journal of Nutritional Science and Vitaminology, 55: 242–251. https://doi.org/10.3177/jnsv.55.242
 
Nuti R., Bonucci E., Brancaccio D., Gallagher J.C., Gennari C., Mazzuoli G., Passeri M., Sambrook P. (2000): The role of calcitriol in the treatment of osteoporosis. Calcified Tissue International, 66: 239–240. https://doi.org/10.1007/PL00005840
 
Peck W.A. (1984): Concensus Conference: Osteoporosis. Journal of the American Medical Association, 252: 799–802. https://doi.org/10.1001/jama.1984.03350060043028
 
Raschka L., Daniel H. (2005): Mechanisms underlying the effects of inulin-type fructans on calcium absorption in the large intestine of rats. Bone, 37: 728–735. https://doi.org/10.1016/j.bone.2005.05.015
 
Reeves P.G., Nielsen F.H., Fahey G.C. Jr. (1993): AIN-93 purified diets for laboratory rodents: final report of the American Institution of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. Journal of Nutrition, 123: 1939–1951. https://doi.org/10.1093/jn/123.11.1939
 
Rémésy C., Levrat M.A., Gamet L., Demigné C. (1993): Cecal fermentations in rats fed oligosaccharides (inulin) are modulated by dietary calcium level. American Journal of Physiology, 264: 855–862.
 
Roediger W.E. (1980): Role of anaerobic bacteria in the metabolic welfare of colonic mucosa in man. Gut, 21: 793–798. https://doi.org/10.1136/gut.21.9.793
 
Sakata T. (1986): Effects of indigestible dietary bulk and short chain fatty acids on the tissue weight and epithelial cell proliferation rate of the digestive tract in rats. Journal of Nutritional Science and Vitaminology, 32: 355–362. https://doi.org/10.3177/jnsv.32.355
 
Sakata T. (1987): Stimulatory effect of short-chain fatty acids on epithelial cell proliferation in the rat intestine: a possible explanation for trophic effects of fermentable fibre, gut microbes and luminal trophic factors. British Journal of Nutrition, 58: 95–103. https://doi.org/10.1079/BJN19870073
 
Sakata T., Ichikawa H., Inagaki A. (1999): Influences of lactic acid, succinic acid and ammonia on epithelial cell proliferation and motility of the large bowel. Asia Pacific Journal of Clinical Nutrition, 8: 9–13.
 
Song S.H., Vieille C. (2009): Recent advance in the biological production of mannitol. Applied Microbiology and Biotechnology, 84: 55–62. https://doi.org/10.1007/s00253-009-2086-5
 
Tahiri M., Tressol J.C., Arnaud J., Bornet F., Bouteloup-Demange C., Feillet-Coudray C., Ducros V., Pepin D., Brouns F., Rayssiguier A.M., Coudray C. (2001): Five week intake of short-chain fructo-oligosaccharides increases intestinal absorption and status of magnesium in post-menopausal women. Journal of Bone and Mineral Research, 16: 2152–2160. https://doi.org/10.1359/jbmr.2001.16.11.2152
 
Takasugi S., Ashida K., Maruyama S., Matsukiyo Y., Kaneko T., Yamaji T. (2013): A combination of a dairy product fermented by lactobacilli and galactooligosaccharides shows additive effects on mineral balances in growing rats with hypochlorhydria induced by a proton pump inhibitor. Biological Trace Elements Research, 153: 309–318. https://doi.org/10.1007/s12011-013-9681-0
 
Toba Y., Kajita Y., Masuyama R., Takada Y., Suzuki K., Aoe S. (2000): Dietary magnesium supplementation affects bone metabolism and dynamic strength of bone in ovariectomized rats. Journal of Nutrition, 130: 216–220. https://doi.org/10.1093/jn/130.2.216
 
Topping D.L., Clifton P.M. (2001): Short-chain fatty acids and human colonic function: roles of resistant starch and nonstarch polysaccharides. Physiological Reviews, 81: 1031–1064. https://doi.org/10.1152/physrev.2001.81.3.1031
 
Zafar T.A., Weaver C.M., Zhao Y., Martin B.R., Wastney M.E. (2004): Nondigestible oligosaccharides increase calcium absorption and suppress bone resorption in ovariectomized rats. Journal of Nutrition, 134: 399–402. https://doi.org/10.1093/jn/134.2.399
 
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