Mutagenic effects of selected trichothecene mycotoxins and their combinations with aflatoxin B1
P. Šmerák, I. Bárta, Z. Polívková, J. Bártová, M. Sedmíkováhttps://doi.org/10.17221/6583-CJFSCitation:Šmerák P., Bárta I., Polívková Z., Bártová J., Sedmíková M. (2001): Mutagenic effects of selected trichothecene mycotoxins and their combinations with aflatoxin B1. Czech J. Food Sci., 19: 90-96.
The authors focused on the amplification of data on the mutagenicity of selected trichothecene mycotoxins (T-2 toxin, vomitoxin) and their combination with aflatoxin B1,which is known to be a strong mutagen. Mutagenic activity was investigated using the Ames test in a prokaryote model at low doses (close to 0.1 LD50). Whereas the individual trichothecene mycotoxins (T-2 toxin, vomitoxin) did not show any mutagenic activity in the test systems mentioned, in combination with AFB1, or as a combination of all three mycotoxins, they showed a mutagenic effect significantly greater than AFB1 alone in the Ames test (in strain TA98 at all concentrations) as well as in the micronucleus test (combination of T-2 toxin with AFB1).Keywords:
mutagenic activity; Ames test; micronucleus test; mycotoxins; aflatoxin B1; T-2 toxin; vomitoxin