Sodium cholate sorption on N-octadecylpectinamide in comparison with cholestyramine
A. Synytsya, L. Fesslová, M. Marounek, J. Čopíkováhttps://doi.org/10.17221/739-CJFSCitation:Synytsya A., Fesslová L., Marounek M., Čopíková J. (2007): Sodium cholate sorption on N-octadecylpectinamide in comparison with cholestyramine. Czech J. Food Sci., 25: 32-38.
N-Octadecylpectinamide is hydrophobically modified HM citrus pectin. Previously, it had been prepared by heterogeneous amino-de-alkoxylation of initial pectin with n-octadecylamine in dimethylsulphoxide and characterised as potential hydrophobic sorbent and cholesterol lowering agent. The sorption properties of N-octadecylpectinamide were analysed in comparison with cholestyramine, an effective bile acid sequestrant. Sorption experiments were carried out using sodium cholate as a model bile acid. Cholate concentration was estimated by enzymatic spectroscopic method. Sorption kinetics curves and sorption isotherms of both sorbents were constructed and analysed.Keywords:N-octadecylpctinamide; cholestyramine; sodium cholate; sorption kinetics; sorption isotherm