Transient acquired Fanconi syndrome with unusual and rare aetiologies: A case study of two dogs

https://doi.org/10.17221/103/2019-VETMEDCitation:Park J., Park J., Han H., Kim J. (2020): Transient acquired Fanconi syndrome with unusual and rare aetiologies: A case study of two dogs. Veterinarni Medicina, 65: 41-47.
download PDF

The acquired form of Fanconi syndrome is seldom identified in dogs; those cases that have been reported have been secondary to hepatic copper toxicosis, primary hypoparathyroidism, ingestion of chicken jerky treats, exposure to ethylene glycol, or gentamicin toxicity. However, to the best of our knowledge, there have been no reports of acquired Fanconi syndrome secondary to Babesia infection or ingestion of cosmetics in dogs. We here report on two dogs presented with a history of marked polyuria, polydipsia, and lethargy. Laboratory examinations showed glucosuria with normoglycaemia and severe urinary loss of amino acids. One dog was infected with Babesia gibsoni and the other dog had a history of cosmetics ingestion. The first dog received treatment for Babesia infection and the second dog received aggressive care to correct metabolic acidosis, electrolyte imbalances, and other add-on deficiencies. In both dogs, the Fanconi syndrome was successfully managed following the treatment for the underlying causes. In conclusion, both Babesia infection and cosmetics ingestion should be considered as a possible aetiology for transient acquired Fanconi syndrome in canine patients.

References:
Appleman EH, Cianciolo R, Mosenco AS, Bounds ME, Al-Ghazlat S. Transient acquired Fanconi syndrome associated with copper storage hepatopathy in 3 dogs. J Vet Intern Med. 2008 Jul-Aug;22(4):1038-42.  https://doi.org/10.1111/j.1939-1676.2008.0140.x
 
Bommer NX, Brownlie SE, Morrison LR, Chandler ML, Simpson JW. Fanconi syndrome in Irish Wolfhound siblings. J Am Anim Hosp Assoc. 2018 May-Jun;54(3):173-8. https://doi.org/10.5326/JAAHA-MS-6439
 
Day MJ. The immunopathology of canine vector-borne diseases. Parasit Vectors. 2011 Apr;4(1):1-13. https://doi.org/10.1186/1756-3305-4-48
 
Freeman LM, Breitschwerdt EB, Keene BW, Hansen B. Fanconi’s Syndrome in a dog with primary hypoparathyroidism. J Vet Intern Med. 1994 Sep-Oct;8(5):349-54. https://doi.org/10.1111/j.1939-1676.1994.tb03249.x
 
Hall AM, Bass P, Unwin RJ. Drug-induced renal Fanconi syndrome. QJM. 2014 Apr;107(4):261-9. https://doi.org/10.1093/qjmed/hct258
 
Hooijberg EH, Furman E, Leidinger J, Brandstetter D, Hochleithner C, Sewell AC, Leidinger E, Giger U. Transient renal Fanconi syndrome in a Chihuahua exposed to Chinese chicken jerky treats. Tierarztl Prax Ausg K Kleintiere Heimtiere. 2015 May;43(3):188-92. https://doi.org/10.15654/TPK-140841
 
Izzedine H, Launay-Vacher V, Isnard-Bagnis C, Deray G. Drug-induced Fanconi’s syndrome. Am J Kidney Dis. 2003 Feb;41(2):292-309. https://doi.org/10.1053/ajkd.2003.50037
 
Jamieson PM, Chandler ML. Transient renal tubulopathy in a Labrador retriever. J Small Anim Pract. 2001 Nov;42(11):546-9. https://doi.org/10.1111/j.1748-5827.2001.tb06025.x
 
Tecklenborg J, Clayton D, Siebert S, Coley SM. The role of the immune system in kidney disease. Clin Exp Immunol. 2018 May;192(2):142-50.  https://doi.org/10.1111/cei.13119
 
Thompson MF, Fleeman LM, Kessell AE, Steenhard LA, Foster SF. Acquired proximal renal tubulopathy in dogs exposed to a common dried chicken treat: Retrospective study of 108 cases (2007–2009). Aust Vet J. 2013 Sep;91(9):368-73. https://doi.org/10.1111/avj.12100
 
Watanabe T, Yoshikawa H, Yamazaki S, Abe Y, Abe T. Secondary renal Fanconi syndrome caused by valproate therapy. Pediatr Nephrol. 2005 Jun;20(6):814-7. https://doi.org/10.1007/s00467-005-1827-7
 
Yearley JH, Hancock DD, Mealey KL. Survival time, lifespan, and quality of life in dogs with idiopathic Fanconi syndrome. J Am Vet Med Assoc. 2004 Aug 1;225(3):377-83. https://doi.org/10.2460/javma.2004.225.377
 
download PDF

© 2020 Czech Academy of Agricultural Sciences