Alterations of pancreatic functions and lipid profiles in dairy cows with left displacement of the abomasum

https://doi.org/10.17221/112/2018-VETMEDCitation:Ismail Z., Al-Majali A., Al-Rawashdeh O., Daradka M., Mohaffel M. (2019): Alterations of pancreatic functions and lipid profiles in dairy cows with left displacement of the abomasum. Veterinarni Medicina, 64: 204-208.
download PDF

The objectives of this study were to determine the serum activities of the pancreatic enzymes amylase, lipase, trypsinogen 1 and trypsinogen 2, serum concentrations of total cholesterol, high density lipoprotein, low-density lipoprotein and triglycerides and serum inflammatory indicators, namely C-reactive protein and procalcitonin, in Holstein-Friesian dairy cows with left displacement of the abomasum (LDA). A total of 60 cows (30 LDA-affected and 30 healthy) were included in the study. Laboratory analyses were performed using commercially available ELISA kits and chemical reagents according to the manufacturers’ recommendations. There was a significant increase (P ≤ 0.05) in the activities of lipase, trypsinogen 1 and trypsinogen 2 in LDA-affected cows compared to healthy cows. Amylase concentrations, however, remained unchanged. The serum concentrations of total cholesterol and high-density lipoprotein were significantly (P ≤ 0.05) increased in LDA-affected cows while the concentrations of low-density lipoprotein and triglycerides were significantly (P ≤ 0.05) decreased compared to healthy cows. Procalcitonin and C-reactive protein concentrations were significantly (P ≤ 0.05) increased in LDA-affected cows compared to healthy cows. This study indicates that displacement of the abomasum may be associated with significant pathological effects in the pancreas that may affect cows in the post-operative period.

References:
Al-Rawashdeh O., Ismail Z. Bani, Talafha A., Al-Momani A. (2017): Changes of hematological and biochemical parameters and levels of pepsinogen, histamine and prostaglandins in dairy cows affected with left displacement of the abomasum. Polish Journal of Veterinary Sciences, 20, 13-18  https://doi.org/10.1515/pjvs-2017-0002
 
Aly Mahmoud A., Saleh Nahed S., Allam Tamer S., Keshta Hany G. (2016): Evaluation of Clinical, Serum Biochemical and Oxidant-antioxidant Profiles in Dairy Cows with Left Abomasal Displacement. Asian Journal of Animal and Veterinary Advances, 11, 242-247  https://doi.org/10.3923/ajava.2016.242.247
 
Cameron R.E.B., Dyk P.B., Herdt T.H., Kaneene J.B., Miller R., Bucholtz H.F., Liesman J.S., Vandehaar M.J., Emery R.S. (1998): Dry Cow Diet, Management, and Energy Balance as Risk Factors for Displaced Abomasum in High Producing Dairy Herds. Journal of Dairy Science, 81, 132-139  https://doi.org/10.3168/jds.S0022-0302(98)75560-2
 
Mokhber Dezfouli M., Eftekhari Z., Sadeghian S., Bahounar A., Jeloudari M. (2013): Evaluation of hematological and biochemical profiles in dairy cows with left displacement of the abomasum. Comparative Clinical Pathology, 22, 175-179  https://doi.org/10.1007/s00580-011-1382-5
 
Doll Klaus, Sickinger Marlene, Seeger Torsten (2009): New aspects in the pathogenesis of abomasal displacement. The Veterinary Journal, 181, 90-96  https://doi.org/10.1016/j.tvjl.2008.01.013
 
Duffield T.F., Lissemore K.D., McBride B.W., Leslie K.E. (2009): Impact of hyperketonemia in early lactation dairy cows on health and production. Journal of Dairy Science, 92, 571-580  https://doi.org/10.3168/jds.2008-1507
 
Ramazan; SAGKAN OZTURK DURGUT (2016): Evaluation of oxidative stress, antioxidant status and lipid profile in cattle with displacement of the abomasum. Ankara Üniversitesi Veteriner Fakültesi Dergisi, 63, 137-141  https://doi.org/10.1501/Vetfak_0000002721
 
El-Attar HM, Yassein M, El-Raof A, Ghanem MM (2007): Alterations in the clinical, hematological and biochemical pictures in abomasal displacement in cows in Egypt. Journal of Veterinary Medicine 1, 102–109.
 
Klevenhusen Fenja, Humer Elke, Metzler-Zebeli Barbara, Podstatzky-Lichtenstein Leopold, Wittek Thomas, Zebeli Qendrim (2015): Metabolic Profile and Inflammatory Responses in Dairy Cows with Left Displaced Abomasum Kept under Small-Scaled Farm Conditions. Animals, 5, 1021-1033  https://doi.org/10.3390/ani5040396
 
Holtenius K, Sternbauer K, Holtenius P (2000): The effect of the plasma glucose level on the abomasal function in dairy cows.. Journal of Animal Science, 78, 1930-  https://doi.org/10.2527/2000.7871930x
 
KAYA Semra, KAÇAR Cihan, ÖĞÜN Metin, KURU Mushap, ÖZEN Hasan, DEMİR Murat Can, ŞAHİN Levent, ZONTURLU Abuzer Kaffar (2016): Endometritisli İneklerde Serum C-Reaktif Protein ve Doğal Antikor Düzeylerinin Değerlendirilmesi. Kafkas Universitesi Veteriner Fakultesi Dergisi, , -  https://doi.org/10.9775/kvfd.2016.15226
 
LEBLANC Stephen (2010): Monitoring Metabolic Health of Dairy Cattle in the Transition Period. Journal of Reproduction and Development, 56, S29-S35  https://doi.org/10.1262/jrd.1056S29
 
Lee WC, Hsiao HC, Wu YL, Lin JH, Lee YP, Fung HP, Chen HH, Chen YH, Chu RM (2003): Serum C-reactive protein in dairy herds. Canadian Journal of Veterinary Research 67, 102–107.
 
Maruna P, Frasko R, Gurlich R (2008): Plasma procalcitonin in patients with ileus relations to other inflammatory parameters. Physiology Research 57, 481–486.
 
Radostits OM, Gay CC, Hinchcliff KW, Constable PD (2007): Veterinary Medicine – A Textbook of the Diseases of Cattle, Horses, Sheep, Pigs and Goats. 10th edn. Elsevier Health Sciences, Philadelphia. 2156 pp.
 
Rau Bettina M., Kemppainen Esko A., Gumbs Andrew A., B??chler Markus W., Wegscheider Karl, Bassi Claudio, Puolakkainen Pauli A., Beger Hans G. (2007): Early Assessment of Pancreatic Infections and Overall Prognosis in Severe Acute Pancreatitis by Procalcitonin (PCT). Annals of Surgery, 245, 745-754  https://doi.org/10.1097/01.sla.0000252443.22360.46
 
Ricciotti Emanuela, FitzGerald Garret A. (2011): Prostaglandins and Inflammation. Arteriosclerosis, Thrombosis, and Vascular Biology, 31, 986-1000  https://doi.org/10.1161/ATVBAHA.110.207449
 
Sevinc M, Ok M, Basoglu A (2002): Liver function in dairy cows with abomasal displacement. Revue de Médecine Vétérinaire 153, 477–480.
 
Simon L., Gauvin F., Amre D. K., Saint-Louis P., Lacroix J. (2004): Serum Procalcitonin and C-Reactive Protein Levels as Markers of Bacterial Infection: A Systematic Review and Meta-analysis. Clinical Infectious Diseases, 39, 206-217  https://doi.org/10.1086/421997
 
Steiner A (2006): Surgical treatment of the left displacement of the abomasum an update. Nice, France: XXIV World Buiatrics Congress. 165−169 p.
 
Stengärde L., Holtenius K., Tråvén M., Hultgren J., Niskanen R., Emanuelson U. (2010): Blood profiles in dairy cows with displaced abomasum. Journal of Dairy Science, 93, 4691-4699  https://doi.org/10.3168/jds.2010-3295
 
TANI Chikako, PRATAKPIRIYA Watanyoo, TANI Mineto, YAMAUCHI Takenori, HIRAI Takuya, YAMAGUCHI Ryoji, ANO Hitoshi, KATAMOTO Hiromu (2017): Histopathological changes in the pancreas of cattle with abdominal fat necrosis. Journal of Veterinary Medical Science, 79, 52-59  https://doi.org/10.1292/jvms.16-0282
 
Van Winden S.C.L., Jorritsma R., Müller K.E., Noordhuizen J.P.T.M. (2003): Feed Intake, Milk Yield, and Metabolic Parameters Prior to Left Displaced Abomasum in Dairy Cows. Journal of Dairy Science, 86, 1465-1471  https://doi.org/10.3168/jds.S0022-0302(03)73730-8
 
download PDF

© 2019 Czech Academy of Agricultural Sciences