Fluorescence biomodulation in the management of acute traumatic wounds in two aged dogs

https://doi.org/10.17221/131/2019-VETMEDCitation:Marchegiani A., Spaterna A., Palumbo Piccionello A., Meligrana M., Fruganti A., Tambella A. (2020): Fluorescence biomodulation in the management of acute traumatic wounds in two aged dogs. Veterinarni Medicina, 65: 215-220.
download PDF

Traumatic wounds represent a fairly common reason for the admission of dogs to a veterinary practice. In elderly patients, the management of wound healing can be challenging due to both the concurrent diseases and impaired physiological states, potentially resulting in delayed healing and chronic or non-healing wounds. The aim of this article is to describe an innovative therapy based on photobiomodulation (PBM) for the management of acute traumatic wounds with significant tissue loss in aged dogs. Two mixed breed dogs were presented with similar wounds in the cervical region and were managed with a fluorescence biomodulation system, a form of PBM, which consists of a photoconverter topical gel that is illuminated with a blue light-emitting diode lamp, applied on a weekly basis. Wound closure was achieved after 9 and 16 weekly treatments, respectively, with a complete re-epithelisation of the skin. This fluorescence-generating system is an innovative, non-invasive, wound care therapy and these results indicate it could be successfully applied in the management of acute traumatic wounds with tissue loss in dogs.

Amalsadvala T, Swaim SF. Management of hard-to-heal wounds. Vet Clin North Am Small Anim Pract. 2006 Jul 1;36(4):693-711. https://doi.org/10.1016/j.cvsm.2006.02.002
Balasch J, Ramio-Lluch L, Puigdemont A, Castro B, Bastida F. Case report on the treatment of surgically debrided deep wounds with a new antioxidant wound dressing in two dogs. Adv Anim Vet Sci. 2016;4(7):389-93. https://doi.org/10.14737/journal.aavs/2016/4.7.389.393
Campbell BG. Dressings, bandages, and splints for wound management in dogs and cats. Vet Clin North Am Small Anim Pract. 2006 Jul 1;36(4):759-91. https://doi.org/10.1016/j.cvsm.2006.03.002
de Freitas LF, Hamblin MR. Proposed mechanisms of photobiomodulation or low-level light therapy. IEEE J Sel Top Quantum Electron. 2016 May-Jun;22(3):348-64. https://doi.org/10.1109/JSTQE.2016.2561201
Dernell WS. Initial wound management. Vet Clin North Am Small Anim Pract. 2006 Jul;36(4):713-38. https://doi.org/10.1016/j.cvsm.2006.04.003
Devriendt N, de Rooster H. Initial management of traumatic wounds. Vet Clin North Am Small Anim Pract. 2017 Nov;47(6):1123-34. https://doi.org/10.1016/j.cvsm.2017.06.001
Edge D, Mellegaard M, Dam-Hansen C, Corell DD, Jaworska J, Scapagnini G, Nielsen MCE. Fluorescent light energy: The future for treating inflammatory skin conditions? J Clin Aesthet Dermatol. 2019 May;12(5):E61-E8.
Fahie MA, Shettko D. Evidence-based wound management: A systematic review of therapeutic agents to enhance granulation and epithelialization. Vet Clin North Am Small Anim Pract. 2007 May;37(3):559-77. https://doi.org/10.1016/j.cvsm.2007.02.001
Fogacci T, Cattin F, Semprini G, Frisoni G, Fabiocchi L, Samorani D. The use of chromophore gel-assisted blue light phototherapy (Lumiheal) for the treatment of surgical site infections in breast surgery. Breast J. 2018 Nov;24(6):1135. https://doi.org/10.1111/tbj.13138
Hanks J, Spodnick G. Wound healing in the veterinary rehabilitaton patient. Vet Clin North Am Small Anim Pract. 2005 Nov;35(6):1453-71. https://doi.org/10.1016/j.cvsm.2005.08.005
Hosgood G. Stages of wound healing and their clinical relevance. Vet Clin North Am Small Anim Pract. 2006 Jul;36(4):667-85. https://doi.org/10.1016/j.cvsm.2006.02.006
Krahwinkel DJ, Boothe HW. Topical and systemic medications for wounds. Vet Clin North Am Small Anim Pract. 2006 Jul 1;36(4):739-57. https://doi.org/10.1016/j.cvsm.2006.04.001
Langella LG, Casalechi HL, Tomazoni SS, Johnson DS, Albertini R, Pallotta RC, Marcos RL, de Carvalho P de TC, Leal-Junior ECP. Photobiomodulation therapy (PBMT) on acute pain and in-flammation in patients who underwent total hip arthroplasty – a randomized, triple-blind, placebo-controlled clinical trial. Lasers Med Sci. 2018 Dec 1;33(9):1933-40. https://doi.org/10.1007/s10103-018-2558-x
Luca-Pozner V, Dessena L, Teot L. [Interest of photobiomodulation in the management of acute second-degree burns] Intérêt de la photobiomodulation dans la prise en charge des brûlures aiguës du deuxième degré. Revue francophone de cicatrisation. 2019 Apr-Jun;3(2):51-4. French. https://doi.org/10.1016/j.refrac.2019.06.005
Marchegiani A, Spaterna A, Cerquetella M, Tambella AM, Fruganti A, Paterson S. Fluorescence biomodulation in the management of canine interdigital pyoderma cases: A prospective, single-blinded, randomised, controlled clinical study. Vet Derm. 2019 Oct;30(5):371-e109. https://doi.org/10.1111/vde.12785
Nikolis A, Grimard D, Pesant Y, Scapagnini G, Vezina D. A prospective case series evaluating the safety and efficacy of the Klox BioPhotonic System in venous leg ulcers. Chronic Wound Care Manag Res. 2016 Sep;3:101-11. https://doi.org/10.2147/CWCMR.S104391
Nolff MC, Albert R, Reese S, Meyer-Lindenberg A. Comparison of negative pressure wound therapy and silver-coated foam dressing in open wound treatment in dogs: A prospective controlled clinical trial. Vet Comp Orthop Traumatol. 2018 Jul;31(4):229-38. https://doi.org/10.1055/s-0038-1639579
Pavletic MM. Atlas of small animal wound management and reconstructive surgery. 4th ed. Hoboken, New Jersey, USA: Wiley Blackwell; 2018. p. 866.
Percival NJ. Classification of wounds and their management. Surgery. 2002 May 1;20(5):114-7. https://doi.org/10.1383/surg.
Pitt KA, Stanley BJ. Negative pressure wound therapy: Experience in 45 dogs. Vet Surg. 2014 May;43(4):380-7. https://doi.org/10.1111/j.1532-950X.2014.12155.x
Ramos RM, Burland M, Silva JB, Burman LM, Gelain MS, Debom LM, Bec JM, Alirezai M, Uebel CO, Valmier J. Photobiomodulation improved the first stages of wound healing process after abdominoplasty: An experimental, double-blinded, non-randomized clinical trial. Aesthetic Plast Surg. 2019 Feb 15;43(1):147-54. https://doi.org/10.1007/s00266-018-1271-2
Romanelli M, Piaggesi A, Scapagnini G, Dini V, Janowska A, Iacopi E, Scarpa C, Fauverghe S, Bas-setto F, EUREKA Study Group. Evaluation of fluorescence biomodulation in the real-life manage-ment of chronic wounds: The EUREKA trial. J Wound Care. J Wound Care. 2018 Nov 2;27(11):744-53. https://doi.org/10.12968/jowc.2018.27.11.744
Salvaggio A, Magi GE, Rossi G, Garvao R, Tambella AM, Vullo C, Marchegiani A, Spaterna A, Pa-lumbo Piccionello A. Effect of the topical Klox Fluorescence Biomodulation system (PHOVIA™) on the healing of canine cutaneous incisional wounds. Vet Surg. Forthcoming 2020. https://doi.org/10.1111/vsu.13415
Scapagnini G, Marchegiani A, Rossi G, Zago M, Jowarska J, Wael M, Campbell SE, Schiffman Z, Buonamici E, Garvao R, et al. Management of all three phases of wound healing through the induction of fluorescence biomodulation using fluorescence light energy, Proc. SPIE 10863, Photonic Diagnosis and Treatment of Infections and Inflammatory Diseases II, 108630W, San Francisco, California, United States, 7 March 2019. Bellingham, WA, USA: International Society for Optics and Photonics; 2019.
Shnitkind E, Yaping E, Geen S, Shalita AR, Lee WL. Anti-inflammatory properties of narrow-band blue light. J Drugs Dermatol. 2006 Jul-Aug;5(7):605-10.
Tambella AM, Attili AR, Dini F, Palumbo Piccionello A, Vullo C, Serri E, Scrollavezza P, Dupre G. Autologous platelet gel to treat chronic decubital ulcers: A randomized, blind controlled clinical trial in dogs. Vet Surg. 2014 Aug;43(6):726-33. https://doi.org/10.1111/j.1532-950X.2014.12148.x
Tambella AM, Attili AR, Dupre G, Cantalamessa A, Martin S, Cuteri V, Marcazzan S, Del Fabbro M. Platelet-rich plasma to treat experimentally-induced skin wounds in animals: A systematic review and meta-analysis. PLoS One. 2018 Jan 11;13(1):e0191093. https://doi.org/10.1371/journal.pone.0191093
Tambella AM, Attili AR, Beribe F, Marchegiani A, Cerquetella M, Palumbo Piccionello A, Vullo C, Spaterna A, Fruganti A. Management of otitis externa with an led-illuminated gel: A randomized controlled clinical trial in dogs. BMC Vet Res. 2020 Mar 20;16(1):91. https://doi.org/10.1186/s12917-020-02311-9
download PDF

© 2022 Czech Academy of Agricultural Sciences | Prohlášení o přístupnosti