Urocystitis, pyelonephritis, renal papillary necrosis and chronic tubulointerstitial disease causing chronic renal insufficiency in a Siberian tiger (Panthera tigris altaica): a case report

https://doi.org/10.17221/132/2017-VETMEDCitation:Lee S., Elfadl A., Chung M., Arif Ullah H., Yuh D., Lee S., Jeong K., Park J. (2018): Urocystitis, pyelonephritis, renal papillary necrosis and chronic tubulointerstitial disease causing chronic renal insufficiency in a Siberian tiger (Panthera tigris altaica): a case report. Veterinarni Medicina, 63: 482-487.
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The present case report describes a case of chronic renal failure characterised by renal medullary fibrosis and renal papillary necrosis in a male Siberian tiger (Panthera tigris altaica). A 12-year-old male Siberian tiger presented with depression, anorexia and weight loss. Blood urea nitrogen (> 50.4 mmol/l) and ammonia (71.7 µmol/l) were increased, suggesting chronic renal failure and uraemia. The tiger died secondary to gastric haemorrhage. At necropsy, the kidneys had yellow lesions in the medulla and renal papillae and petechiae in the cortex. The stomach had multiple mucosal ulcers and haemorrhage. Microscopically, marked renal medullary fibrosis and renal papillary necrosis were observed with tubular atrophy, degeneration, coagulative necrosis, calcification and chronic inflammatory cell infiltration. The renal cortex showed moderate interstitial inflammation. The urinary bladder exhibited epithelial desquamation and submucosal fibrosis. The tiger was diagnosed with chronic renal failure secondary to renal papillary necrosis and medullary fibrosis.

References:
Bartlett Paul C., Van Buren James W., Neterer Margaret, Zhou Chun (2010): Disease surveillance and referral bias in the veterinary medical database. Preventive Veterinary Medicine, 94, 264-271 https://doi.org/10.1016/j.prevetmed.2010.01.007
 
Breshears MA, Confer AW (2017): The urinary system. In: Zachary JF (ed.): Pathologic Basis of Veterinary Disease. 6th edn. Elsevier, St Louis. 661–662.
 
Brown C. A., Elliott J., Schmiedt C. W., Brown S. A. (2016): Chronic Kidney Disease in Aged Cats. Veterinary Pathology, 53, 309-326 https://doi.org/10.1177/0300985815622975
 
Chakrabarti S., Syme H. M., Brown C. A., Elliott J. (2012): Histomorphometry of Feline Chronic Kidney Disease and Correlation With Markers of Renal Dysfunction. Veterinary Pathology, 50, 147-155 https://doi.org/10.1177/0300985812453176
 
Corpa J. M., Marin S., Peris B., Bolea R., Ortega J., Martinez J., Segura P., Perez V. (2005): Renal papillary necrosis associated with dehydration in large cats. Veterinary Record, 157, 814-816 https://doi.org/10.1136/vr.157.25.814
 
Geller Stephen A., Campos Fernando P. F. de (2013): Renal papillary necrosis. Autopsy and Case Reports, 3, 69-71 https://doi.org/10.4322/acr.2013.042
 
JEE Hyang, PAKHRIN Bidur, BAE Il-Hong, SHIN Nam-Shik, LEE Su-In, YOO Han-Sang, KIM Dae-Yong (2007): Pyelonephritis Associated with Staphylococcus intermedius in a Siberian Tiger (Panthera tigris altaica). Journal of Veterinary Medical Science, 69, 851-852 https://doi.org/10.1292/jvms.69.851
 
Junginger Johannes, Hansmann Florian, Herder Vanessa, Lehmbecker Annika, Peters Martin, Beyerbach Martin, Wohlsein Peter, Baumgärtner Wolfgang, Thamm Douglas (2015): Pathology in Captive Wild Felids at German Zoological Gardens. PLOS ONE, 10, e0130573- https://doi.org/10.1371/journal.pone.0130573
 
Lawson Jack, Elliott Jonathan, Wheeler-Jones Caroline, Syme Harriet, Jepson Rosanne (2015): Renal fibrosis in feline chronic kidney disease: Known mediators and mechanisms of injury. The Veterinary Journal, 203, 18-26 https://doi.org/10.1016/j.tvjl.2014.10.009
 
Munson Linda, Terio Karen A., Worley Michael, Jago Mark, Bagot-Smith Arthur, Marker Laurie (2005): EXTRINSIC FACTORS SIGNIFICANTLY AFFECT PATTERNS OF DISEASE IN FREE-RANGING AND CAPTIVE CHEETAH (ACINONYX JUBATUS) POPULATIONS. Journal of Wildlife Diseases, 41, 542-548 https://doi.org/10.7589/0090-3558-41.3.542
 
Newkirk K. M., Newman S. J., White L. A., Rohrbach B. W., Ramsay E. C. (2011): Renal Lesions of Nondomestic Felids. Veterinary Pathology, 48, 698-705 https://doi.org/10.1177/0300985810382089
 
Polzin DJ, Osborne CA, Ross S (2005): Chronic kidney disease. In: Ettinger SJ, Feldman EC (eds): Textbook of Veterinary Internal Medicine Diseases of the Dog and Cat. 6th edn. Elsevier Saunders, St Louis. 1756–1786.
 
Segasothy Murugasu, Samad Sakijan Abdul, Zulfigar Annuar, Bennett William M. (1994): Chronic Renal Disease and Papillary Necrosis Associated With the Long-Term Use of Nonsteroidal Anti-inflammatory Drugs as the Sole or Predominant Analgesic. American Journal of Kidney Diseases, 24, 17-24 https://doi.org/10.1016/S0272-6386(12)80155-7
 
Stenvinkel Peter, Painer Johanna, Kuro-o Makoto, Lanaspa Miguel, Arnold Walter, Ruf Thomas, Shiels Paul G., Johnson Richard J. (2018): Novel treatment strategies for chronic kidney disease: insights from the animal kingdom. Nature Reviews Nephrology, 14, 265-284 https://doi.org/10.1038/nrneph.2017.169
 
Taugner F., Baatz G., Nobiling R. (1996): The renin-angiotensin system in cats withchronic renal failure. Journal of Comparative Pathology, 115, 239-252 https://doi.org/10.1016/S0021-9975(96)80082-X
 
Wolf D. C., Lenz S. D., Carlton W. W. (2016): Renal Papillary Necrosis in Two Domestic Cats and a Tiger. Veterinary Pathology, 28, 84-87 https://doi.org/10.1177/030098589102800113
 
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