Long-term evaluation of autologous lamellar corneal grafts for the treatment of deep corneal ulcer in four dogs: a case report

https://doi.org/10.17221/139/2017-VETMEDCitation:Kim S., Kim J., Jeong S. (2019): Long-term evaluation of autologous lamellar corneal grafts for the treatment of deep corneal ulcer in four dogs: a case report. Veterinarni Medicina, 64: 84-91.
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Autologous lamellar corneal grafts were performed on four dogs with two deep corneal ulcers and two corneal perforations to achieve better visual and aesthetic outcomes. The donor corneal graft was harvested from the relatively normal corneal region of the affected eye and used to cover the corneal defect. At the two-year follow-up examination, ultrasound biomicroscopy was performed to confirm the thickness and endothelial continuity of the transplanted grafts and donor site of the cornea. The evaluations revealed that the dogs had healed without incident and that their vision had been maintained. Furthermore, the owners were satisfied with the aesthetic outcomes in all cases. Our findings show that autologous lamellar corneal grafts are useful and effective in treating canine corneal ulcers and perforations.

Andrade , Laus , Figueiredo , Batista (1999): The use of preserved equine renal capsule to repair lamellar corneal lesions in normal dogs. Veterinary Ophthalmology, 2, 79-82  https://doi.org/10.1046/j.1463-5224.1999.00052.x
Andrew Stacy E., Tou Sandra, Brooks Dennis E. (2001): Corneoconjunctival transposition for the treatment of feline corneal sequestra: a retrospective study of 17 cases (1990-1998). Veterinary Ophthalmology, 4, 107-111  https://doi.org/10.1046/j.1463-5224.2001.00181.x
Barros Paulo S. M., Safatle Angelica M. V., Godoy Cintia A., Souza Mirian S. B., Barros Luiz F. M., Brooks Dennis E. (2005): Amniotic membrane transplantation for the reconstruction of the ocular surface in three cases. Veterinary Ophthalmology, 8, 189-192  https://doi.org/10.1111/j.1463-5224.2005.00391.x
Barut Selver O, Karaca I, Palamar M, Egrilmez S, Yagci A (2018): Graft failure and repeat penetrating keratoplasty. Experimental and Clinical Transplantation.
Bentley Ellison, Miller Paul E., Diehl Kathryn A. (2003): Use of high-resolution ultrasound as a diagnostic tool in veterinary ophthalmology. Journal of the American Veterinary Medical Association, 223, 1617-1622  https://doi.org/10.2460/javma.2003.223.1617
Brightman AH, McLaughlin SA, Brogdon JD (1989): Autogenous lamellar corneal grafting in dogs. Journal of the American Veterinary Medical Association 195, 469–475.
Brooks D. E., Plummer C. E., Kallberg M. E., Barrie K. P., Ollivier F. J., Hendrix D. V. H., Baker A., Scotty N. C., Utter M. E., Blackwood S. E., Nunnery C. M., Ben-Shlomo G., Gelatt K. N. (2008): Corneal transplantation for inflammatory keratopathies in the horse: Visual outcome in 206 cases (1993–2007). Veterinary Ophthalmology, 11, 123-133  https://doi.org/10.1111/j.1463-5224.2008.00611.x
COSTER D J (1997): Evaluation of corneal transplantation. British Journal of Ophthalmology, 81, 618-619  https://doi.org/10.1136/bjo.81.8.618
Dorbandt Daniel M., Moore Phillip A., Myrna Kathern E. (2015): Outcome of conjunctival flap repair for corneal defects with and without an acellular submucosa implant in 73 canine eyes. Veterinary Ophthalmology, 18, 116-122  https://doi.org/10.1111/vop.12193
Dulaurent Thomas, Azoulay Thierry, Goulle Frédéric, Dulaurent Alice, Mentek Marielle, Peiffer Robert L., Isard Pierre-François (2014): Use of bovine pericardium (Tutopatch ® ) graft for surgical repair of deep melting corneal ulcers in dogs and corneal sequestra in cats. Veterinary Ophthalmology, 17, 91-99  https://doi.org/10.1111/vop.12047
Gelatt KN, Brooks DE (2011): 8. Surgery of the cornea and sclera. In: Gelatt KN, Gelatt JP (eds): Veterinary Ophthalmic Surgery. Saunders. 191–236.
Gibson T, Roberts SM, Severin GA, Steyn PH, Wrigley RH (1998): Comparison of gonioscopy and ultrasound biomicroscopy for evaluating the iridocorneal angle in dogs. Journal of the American Veterinary Medical Association 213, 635–638.
Goulle F. (2012): Use of porcine small intestinal submucosa for corneal reconstruction in dogs and cats: 106 cases. Journal of Small Animal Practice, 53, 34-43  https://doi.org/10.1111/j.1748-5827.2011.01149.x
Hakanson NE, Merideth RE (1987): Conjunctival pedicle grafting in the treatment of corneal ulcers in the dog and cat. Journal of the American Animal Hospital Association 23, 641.
Hansen Philippe A., Guandalini Adolpho (1999): A retrospective study of 30 cases of frozen lamellar corneal graft in dogs and cats. Veterinary Ophthalmology, 2, 233-241  https://doi.org/10.1046/j.1463-5224.1999.00084.x
Jensen EC (1963): Experimental corneal transplantation in the dog. Journal of the American Veterinary Medical Association 142, 11–22.
Kim Soohyun, Kwak Ji Yoon, Jeong Manbok, Seo Kangmoon (2016): Deep anterior lamellar keratoplasty of dog eyes using the big-bubble technique. Journal of Veterinary Science, 17, 347-  https://doi.org/10.4142/jvs.2016.17.3.347
Lacerda Rodrigo P., Peña Gimenez Maria T., Laguna Fernando, Costa Daniel, Ríos Jose, Leiva Marta (2017): Corneal grafting for the treatment of full-thickness corneal defects in dogs: a review of 50 cases. Veterinary Ophthalmology, 20, 222-231  https://doi.org/10.1111/vop.12392
Laguna Fernando, Leiva Marta, Costa Daniel, Lacerda Rodrigo, Peña Gimenez Teresa (2015): Corneal grafting for the treatment of feline corneal sequestrum: a retrospective study of 18 eyes (13 cats). Veterinary Ophthalmology, 18, 291-296  https://doi.org/10.1111/vop.12228
Ledbetter EC, Gilger BC (2013): 18. Diseases and surgery of the canine cornea and sclera. In: Gelatt KN, Gilger BC, Kern TJ (eds): Veterinary Ophthalmology. 5th edn. Wiley-Blackwell. 976–1049.
Moffatt SL, Cartwright VA, Stumpf TH (2005): Centennial review of corneal transplantation. Clinical & Experimental Ophthalmology 33, 642–657.
Refojo M. F., Dohlman C. H., Ahmad B., Carroll J. M., Allen J. C. (1968): Evaluation of Adhesives for Corneal Surgery. Archives of Ophthalmology, 80, 645-656  https://doi.org/10.1001/archopht.1968.00980050647013
Tsuzuki Keiko, Yamashita Kazuto, Izumisawa Yasuharu, Kotani Tadao (2008): Microstructure and glycosaminoglycan ratio of canine cornea after reconstructive transplantation with glycerin-preserved porcine amniotic membranes. Veterinary Ophthalmology, 11, 222-227  https://doi.org/10.1111/j.1463-5224.2008.00629.x
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