Cephalothoracopagus (monocephalic dithoracic) conjoined twins in a pig (Sus scrofa f. domestica): a case report

https://doi.org/10.17221/155/2016-VETMEDCitation:Kulawik M., Pluta K., Wojnowska M., Bartyzel B., Nabzdyk M., Bukowska D. (2017): Cephalothoracopagus (monocephalic dithoracic) conjoined twins in a pig (Sus scrofa f. domestica): a case report. Veterinarni Medicina, 62: 470-477.
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In this report, we present a rare case of cephalothoracopagus (monocephalic dithoracic) conjoined twins with anencephaly in pig. Conjoined Polish large white piglets were born at term after an uncomplicated birth. The litter consisted of 11 piglets. The conjoined twins were born alive, but died shortly after birth and were subjected to further investigation. Blood vessels of the heart were filled with LBS 3060 latex, and then the twins were fixed in 10% non-buffered formalin. Necropsy revealed the external and internal anatomy of the affected twins. Examinations demonstrated abnormalities of skeletal, digestive, cardiovascular, respiratory and nervous systems. The twins had a single head, neck and chest and were separated from the umbilicus caudally. They had four forelimbs and four hindlimbs. Examination of the skeleton revealed two complete vertebral columns connected with one skull. Two tongues and a cleft palate were present in the oral cavity. The conjoined twins had a single pharynx, oesophagus, stomach, duodenum, part of jejunum, spleen, liver and pancreas. The remaining part of the digestive system was doubled. Each piglet had a separate urogenital apparatus. The examination revealed only one heart with structural abnormalities. Two larynxes and tracheas were identified. The right twin had the right lung while the left twin had the left lung. To the authors’ knowledge, this is the first detailed report of this type of conjoined twins in the pig.
References:
Baumgartner W. J. (1928): A double monster pig?Cephalothoracopagus monosymmetros. The Anatomical Record, 37, 303-316  https://doi.org/10.1002/ar.1090370306
 
Binanti D., Riccaboni P. (2012): Thoraco-Omphalopagus Conjoined Twins in Chamois-Coloured Domestic Goat Kids. Anatomia, Histologia, Embryologia, 41, 159-162  https://doi.org/10.1111/j.1439-0264.2011.01118.x
 
Chen H (2012): Atlas of Genetic Diagnosis and Counselling. Springer-Verlag, New York. 495–505.
 
Deveer RD, Engin-Ustun Y, Kale I, Aktulay A, Danisman N, Mollamahmutoglu L (2010): Anencephalic conjoined twins with mirror-image cleft lip and palate. Clinical and Experimental Obstetrics and Gynaecology 37, 231–232.
 
Evans H. E., Sack W. O. (1973): Prenatal Development of Domestic and Laboratory Mammals: Growth Curves, External Features and Selected References. Anatomia, Histologia, Embryologia: Journal of Veterinary Medicine Series C, 2, 11-45  https://doi.org/10.1111/j.1439-0264.1973.tb00253.x
 
Gilbert SF (2006): Developmental Biology. Sinauer Associates Inc, Sunderland. 427–464.
 
Gilbert-Barness E (2007): Potter’s Pathology of the Fetus, Infant and Child. Elsevier, Philadelphia. 1281–1344.
 
Greene NDE, Copp AJ (2005): Mouse models of neural tube defects: investigating preventive mechanisms. American Journal of Medical Genetics Part C, Seminars in Medical Genetics 135C, 31–41.
 
Greene Nicholas D. E., Copp Andrew J. (2009): Development of the vertebrate central nervous system: formation of the neural tube. Prenatal Diagnosis, 29, 303-311  https://doi.org/10.1002/pd.2206
 
Grova Monica, Lo David D., Montoro Daniel, Hyun Jeong S., Chung Michael T., Wan Derrick C., Longaker Michael T. (2012): Models of Cranial Suture Biology. Journal of Craniofacial Surgery, 23, S12-S16  https://doi.org/10.1097/SCS.0b013e318258ba53
 
Hemm Roger D., Arslanoglou Leontios, Pollock John J. (1977): Cleft palate following prenatal food restriction in mice: Association with elevated maternal corticosteroids. Teratology, 15, 243-248  https://doi.org/10.1002/tera.1420150305
 
Herring Susan W., Rowlatt Ursula F. (1981): Anatomy and embryology in cephalothoracopagus twins. Teratology, 23, 159-173  https://doi.org/10.1002/tera.1420230202
 
Huisinga M., Reinacher M., Nagel S., Herden C. (): Anencephaly in a German Shepherd Dog. Veterinary Pathology, 47, 948-951  https://doi.org/10.1177/0300985810371306
 
Hyatt Brian A., Lohr Jamie L., Yost H. Joseph (1996): Initiation of vertebrate left–right axis formation by maternal Vg1. Nature, 384, 62-65  https://doi.org/10.1038/384062a0
 
Hyatt Brian A, Yost H.Joseph (1998): The Left-Right Coordinator: The Role of Vg1 in Organizing Left-Right Axis Formation. Cell, 93, 37-46  https://doi.org/10.1016/S0092-8674(00)81144-7
 
Hynd Thomas E., Buckley Cadie L., Lozanoff Scott (2013): Case of cephalothoracopagus conjoined twinning in an embryonic mouse. Birth Defects Research Part A: Clinical and Molecular Teratology, 97, 421-424  https://doi.org/10.1002/bdra.23151
 
Kompanje EJO (2005): Two cases of asymmetrical conjoined twins in wild mammals from the Netherlands. Deinsea 11, 139–145.
 
Kompanje Erwin J. O., Hermans John J. (2008): Cephalopagus Conjoined Twins in a Leopard Cat (Prionailurus bengalensis). Journal of Wildlife Diseases, 44, 177-180  https://doi.org/10.7589/0090-3558-44.1.177
 
Levin Michael, Roberts Drucilla J., Holmes Lewis B., Tabin Cliff (1996): Laterality defects in conjoined twins. Nature, 384, 321-321  https://doi.org/10.1038/384321a0
 
Mazzullo G., Montalbano G., Augello A., Germanà A., Macrì B. (2007): A Case of Conjoined Cephalopagus Twinning in an Ostrich (Struthio camelus). Anatomia, Histologia, Embryologia: Journal of Veterinary Medicine Series C, 36, 263-265  https://doi.org/10.1111/j.1439-0264.2006.00748.x
 
Mazzullo G., Macrì F., Rapisarda G., Marino F. (2009): Deradelphous Cephalothoracopagus in Kittens. Anatomia, Histologia, Embryologia, 38, 327-329  https://doi.org/10.1111/j.1439-0264.2009.00944.x
 
McMahon C. J., Spencer R. (2006): Congenital Heart Defects in Conjoined Twins: Outcome After Surgical Separation of Thoracopagus. Pediatric Cardiology, 27, 1-12  https://doi.org/10.1007/s00246-005-0835-5
 
McManus Cheryl A., Partlow Gary D., Fisher Kenneth R. S. (1994): Conjoined twin piglets with duplicated cranial and caudal axes. The Anatomical Record, 239, 224-229  https://doi.org/10.1002/ar.1092390213
 
Monfared AL, Sahar HN, Mohammad TS (2013): Case report of a congenital defect (dicephalus) in a lamb. Global Veterinaria 10, 90–92.
 
Mostafa M. B., Koma K. L. M. K., Acon J. (2005): Conjoined twin piglets. Veterinary Record, 156, 779-780  https://doi.org/10.1136/vr.156.24.779
 
Nottidge H. O., Omobowale T. O., Olopade J. O., Oladiran O. O., Ajala O. O. (2007): A Case of Craniothoracopagus (Monocephalus Thoracopagus Tetrabrachius) in a Dog. Anatomia, Histologia, Embryologia: Journal of Veterinary Medicine Series C, 36, 179-181  https://doi.org/10.1111/j.1439-0264.2006.00731.x
 
Ozkur A, Karaca M, Gocmen A, Bayram M, Sirikci A (2006): Cephalopagus conjoined twins presented with encephalocele: diagnostic role of ultrafast MR imaging. Diagnostic and Interventional Radiology 12, 90–92.
 
Padmanabhan Rengasamy (2006): Etiology, pathogenesis and prevention of neural tube defects. Congenital Anomalies, 46, 55-67  https://doi.org/10.1111/j.1741-4520.2006.00104.x
 
Partlow Gary D., Barrales Dorothy E., Fisher Kenneth R. S. (1981): Morphology of a two-headed piglet. The Anatomical Record, 199, 441-448  https://doi.org/10.1002/ar.1091990312
 
Al Rabeeah Abdullah (2006): Conjoined twins—past, present, and future. Journal of Pediatric Surgery, 41, 1000-1004  https://doi.org/10.1016/j.jpedsurg.2005.12.045
 
Sachan V, Kumar B, Sonkar V, Saxena A (2016): Monocephalic thoracopagus tetrabrachius monster in murrach buffalo – a case report. Buffalo Bulletin 35, 23–26.
 
Samuel M. O., Wachida N., Abenga J. H., Kisani A. I., Adamu S. S., Hambesha P., Gyang E., Oyedipe E. O. (2014): A Case of Omphalo-Ischiopagus (Dicephalic Dithoracic Abdominopagus Tetrascelus Tetrabrachius) in Lambs. Anatomia, Histologia, Embryologia, 43, 320-323  https://doi.org/10.1111/ahe.12070
 
Senarath-Yapa Kshemendra, Chung Michael T., McArdle Adrian, Wong Victor W., Quarto Natalina, Longaker Michael T., Wan Derrick C. (2012): Craniosynostosis: Molecular pathways and future pharmacologic therapy. Organogenesis, 8, 103-113  https://doi.org/10.4161/org.23307
 
Sharma Dinesh, Jhobta Anupam, Azad J. R., Dhiman D. S., Pandith Mansa, Sharma Sanjiv (2013): Cephalothoracopagus janiceps asymmetros twins: Antenatal sonographic diagnosis. Journal of Clinical Ultrasound, 41, 199-202  https://doi.org/10.1002/jcu.22021
 
Singh Mandavi, Singh K.P., Shaligram Pragya (2003): Conjoined twins cephalopagus Janiceps monosymmetros: A case report. Birth Defects Research Part A: Clinical and Molecular Teratology, 67, 268-272  https://doi.org/10.1002/bdra.10042
 
Smolec O, Kos J, Vnuk D, Stejskal M, Bottegaro NB (2010a): Multiple congenital malformation in Simental female calf: a case report. Veterinarni Medicina 55, 194–198.
 
Smolec O, Vnuk D, Kos J, Bottegaro NB, Pirkic B (2010b): Repair of cleft palate in a calf using polypropylene mesh and palatal mucosal flap: a case report. Veterinarni Medicina 55, 566–570.
 
Sonfada ML, Sivachelvan MN, Haruna Y, Wiam IM, Yahaya A (2010): Incidence of congenital malformations in ruminants in the North Eastern region of Nigeria. International Journal of Animal and Veterinary Advances 2, 1–4.
 
Spencer R (2000a): Theoretical and analytical embryology of conjoined twins: Part I: Embryogenesis. Clinical Anatomy 13, 36–53.
 
Spencer R (2000b): Theoretical and analytical embryology of conjoined twins: Part II: Adjustments to union. Clinical Anatomy 13, 97–120.
 
Szulc Karolina, Knecht Damian, Jankowska-Mąkosa Anna, Skrzypczak Ewa, Nowaczewski Sebastian (2013): The influence of fattening and slaughter traits on reproduction in Polish Large White sows. Italian Journal of Animal Science, 12, -  https://doi.org/10.4081/ijas.2013.e3
 
Vanderzon D.M., Partlow G.D., Fisher K.R.S., Halina W.G. (1998): Parapagus conjoined twin holstein calf. The Anatomical Record, 251, 60-65  https://doi.org/10.1002/(SICI)1097-0185(199805)251:1<60::AID-AR10>3.0.CO;2-9
 
Willhite CC, Rossi NL, Frakes RA, Sharma RP (1985): Cranioschisis aperta with encephaloschisis in cephalothoracopagus hamster twins. Canadian Journal of Comparative Medicine 49, 195–201.
 
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