Different outcomes of multiple sialadenitis involving the submandibular and zygomatic salivary glands in a Welsh Corgi dog

https://doi.org/10.17221/174/2020-VETMEDCitation:

Park SY, Lee JS, Yoon HY, Kim HE, Kim JH (2022): Different outcomes of multiple sialadenitis involving the submandibular and zygomatic salivary glands in a Welsh Corgi dog. Vet Med-Czech 67, 447–453.

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A ten-year-old indoor, castrated male Cardigan Welsh Corgi (Canis familiaris) presented with the chief complaints of chronic vomiting, retching, hypersalivation, and bilateral submandibular masses for two months. The systemic examinations, including serum chemistry, radiography, ultrasonography, and fluoroscopy, were unremarkable. A fine-needle aspiration revealed bilateral submandibular sialadenitis. Broad-spectrum antibiotics with phenobarbital were prescribed to alleviate the ptyalism. Thereafter, the left submandibular glands were normalised, and the right submandibular glands decreased to half their size. Three weeks later, the animal had an emergency visit because of a sudden left exophthalmos. Computed tomography and magnetic resonance imaging revealed enlarged left zygomatic and right mandibular salivary glands. The affected glands were surgically removed; the histopathologic examination confirmed non-septic sialadenitis, and the patient was finally diagnosed with idiopathic sialadenitis. Vomiting continued after the gland removal and the dog required a gradual increase in the phenobarbital dosage and an additional antiepileptic drug (potassium bromide) to manage the symptoms. The patient died eight months later from an unknown cause. This case report of bilateral submandibular sialadenitis concurrent with unilateral zygomatic sialadenitis in a Welsh Corgi dog suggests that when multiple salivary glands are involved, the response to anti-epileptic drugs and the prognosis is poor compared to that involving a single salivary gland.

References:
Alcoverro E, Tabar MD, Lloret A, Roura X, Pastor J, Planellas M. Phenobarbital-responsive sialadenosis in dogs: Case series. Top Companion Anim Med. 2014 Dec;29(4):109-12. https://doi.org/10.1053/j.tcam.2015.01.003
 
Boland L, Gomes E, Payen G, Bouvy B, Poncet C. Zygomatic salivary gland diseases in the dog: Three cases diagnosed by MRI. J Am Anim Hosp Assoc. 2013 Sep-Oct;49(5):333-7. https://doi.org/10.5326/JAAHA-MS-5882
 
Breit S, Kupferberg A, Rogler G, Hasler G. Vagus nerve as modulator of the brain-gut axis in psychiatric and inflammatory disorders. Front Psychiatry. 2018 Mar 13;9:44. https://doi.org/10.3389/fpsyt.2018.00044
 
Dagan A. Sialadenosis in a dog. Israel J Vet Med. 2011 Jan;66(1):32-5.
 
Gibbon KJ, Trepanier LA, Delaney FA. Phenobarbital-responsive ptyalism, dysphagia, and apparent esophageal spasm in a German Shepherd puppy. J Am Anim Hosp Assoc. 2004 May-Jun;40(3):230-7. https://doi.org/10.5326/0400230
 
Gilor C, Gilor S, Graves TK. Phenobarbital-responsive sialadenosis associated with an esophageal foreign body in a dog. J Am Anim Hosp Assoc. 2010 Mar-Apr;46(2):115-20. https://doi.org/10.5326/0460115
 
Kalayanakoul K, Yongsiri S, Sukanan P. A case report: Phenobarbital-responsive sialadenosis in a dog. Thai J Vet Med. 2019 June;49(2):197-201.
 
Martinez PS, Carter R, Gaschen L, Ryan K. Phenobarbital-responsive bilateral zygomatic sialadenitis following an enterotomy in a Cavalier King Charles Spaniel. Res J Vet Pract. 2018 Aug;6(2):14-9. https://doi.org/10.17582/journal.rjvp/2018/6.2.14.19
 
Mason DR, Lamb CR, McLellan GJ. Ultrasonographic findings in 50 dogs with retrobulbar disease. J Am Anim Hosp Assoc. 2001 Nov-Dec;37(6):557-62. https://doi.org/10.5326/15473317-37-6-557
 
Mawby DI, Bauer MS, Lloyd-Bauer PM, Clark EG. Vasculitis and necrosis of the mandibular salivary glands and chronic vomiting in a dog. Can Vet J. 1991 Sep;32(9):562-4.
 
McGill S, Lester N, McLachlan A, Mansfield C. Concurrent sialocoele and necrotising sialadenitis in a dog. J Small Anim Pract. 2009 Mar;50(3):151-6. https://doi.org/10.1111/j.1748-5827.2009.00706.x
 
Nabeta R, Kambe N, Nakagawa Y, Chiba S, Xiantao H, Furuya T, Kishimoto M, Uchide T. Sjögren’s-like syndrome in a dog. J Vet Med Sci. 2019 Jun 21;81(6):886-9. https://doi.org/10.1292/jvms.18-0387
 
Nam YS, Kang MH, Kim SG, Park HM. Idiopathic phenobarbital-responsive sialadenosis in a Maltese dog: Clinical findings and outcomes. Pak Vet J. 2014 Jan;34(3):410-3.
 
Schroeder H, Berry WL. Salivary gland necrosis in dogs: A retrospective study of 19 cases. J Small Anim Pract. 1998 Mar;39(3):121-5. https://doi.org/10.1111/j.1748-5827.1998.tb03615.x
 
Spangler WL, Culbertson MR. Salivary gland disease in dogs and cats: 245 cases (1985–1988). J Am Vet Med Assoc. 1991 Feb;198(3):465-9.
 
Stonehewer J, Mackin AJ, Tasker S, Simpson JW, Mayhew IG. Idiopathic phenobarbital-responsive hypersialosis in the dog: An unusual form of limbic epilepsy? J Small Anim Pract. 2000 Sep;41(9):416-21. https://doi.org/10.1111/j.1748-5827.2000.tb03236.x
 
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