Comparative use of dimethyl sulphoxide (DMSO) in different animal species G.M., Crivellenti L.Z., Borin-Crivellenti S., Cintra C.A., Gomes L.G., Spiller P.R. (2017): Comparative use of dimethyl sulphoxide (DMSO) in different animal species. Veterinarni Medicina, 62: 179-185.
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Dimethyl sulphoxide has a variety of biological effects that have made it the subject of numerous pharmacological studies. The first dimethyl sulphoxide therapeutic indication approved by the United States Food and Drug Administration (FDA) in 1978 was for intravesical instillation in cases of interstitial cystitis. Since then, due to its distinctive properties, it has been the subject of studies in several areas. This review describes indications, adverse effects and contraindications, as takes a critical approach to the main articles addressing the clinical use of dimethyl sulphoxide.

Bakar Bulent, Kose Emine Arzu, Sonal Sevilay, Alhan Aslıhan, Kilinc Kamer, Keskil Ismail Semih (2012): Evaluation of the neurotoxicity of DMSO infused into the carotid artery of rat. Injury, 43, 315-322
Baliga Radhakrishna, Zhang Zhiwei, Baliga Mithra, Ueda Norishi, Shah Sudhir V (1998): In vitro and in vivo evidence suggesting a role for iron in cisplatin-induced nephrotoxicity. Kidney International, 53, 394-401
Benekli M, Anderson B, Wentling D, Bernstein S, Czuczman M, McCarthy P (): Severe respiratory depression after dimethylsulphoxide-containing autologous stem cell infusion in a patient with AL amyloidosis. Bone Marrow Transplantation, 25, 1299-1301
Brayton CF (1986): Dimethyl sulfoxide (DMSO): a review. The Cornell Veterinarian 76, 76–90.
Capriotti K, Capriotti JA (2012): Dimethyl sulfoxide history, chemistry, and clinical utility in dermatology. The Journal of Clinical and Aesthetic Dermatology 5, 24–26.
Carpenter John F., Dawson Patti E. (1991): Quantitation of dimethyl sulfoxide in solutions and tissues by high-performance liquid chromatography. Cryobiology, 28, 210-215
Chaloupka JC, Vinuela F, Vinters HV, Robert J (1994): Technical feasibility and histopathologic studies of ethylene vinyl copolymer (EVAL) using a swine endovascular embolization model. American Journal of Neuroradiology 15, 1107.
Chen D, Song D, Wientjes MG, Au JL (2003): Effect of dimethyl sulfoxide on bladder tissue penetration of intravesical paclitaxel. Clinical Cancer Research 9, 363–369.
Crivellenti LZ (2015): Nephrology and urology (in Portuguese). In: Crivellenti LZ, Borin-Crivellenti S (eds): Routine Cases in Veterinary Medicine for Small Animals. 2nd edn. MedVet Ltda, Sao Paolo. 418–786.
Crivellenti Leandro Zuccolotto, Crivellenti Sofia Borin, Carvalho Marileda Bonafim (2013): Toxicidade do dimetilsulfóxido em cães hígidos e doentes renais crônicos. Ciência Rural, 43, 1831-1837
David N A (1972): The Pharmacology of Dimethyl Sulfoxide. Annual Review of Pharmacology, 12, 353-374
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Duimel-Peeters IGP, Houwing RH, Teunissen CP, Berger MPF, Snoeckx LHEH, Halfens RJG (2003): A systematic review of the efficacy of topical skin application of dimethyl sulfoxide on wound healing and as an anti-inflammatory drug. Wounds-A Compendium of Clinical Research and Practice 15, 361–370.
Egorin M J, Rosen D M, Sridhara R, Sensenbrenner L, Cottler-Fox M (1998): Plasma concentrations and pharmacokinetics of dimethylsulfoxide and its metabolites in patients undergoing peripheral-blood stem-cell transplants.. Journal of Clinical Oncology, 16, 610-615
Ferm VH (1966): Congenital malformations induced by dimethyl sulphoxide in the golden hamster. Journal of Embryology and Experimental Morphology 16, 49–54.
Garcia-Aguirre JG, Mercado HQ, Reyes AR, Sahd JL (2008): Histopathological analysis of the effect of dimethyl sulfoxide (DMSO) in an experimental model of retinal ischemia (in Spanish). Revista Mexicana de Oftalmologia 82, 1–4.
Gurtovenko Andrey A., Anwar Jamshed (2007): Modulating the Structure and Properties of Cell Membranes:  The Molecular Mechanism of Action of Dimethyl Sulfoxide. The Journal of Physical Chemistry B, 111, 10453-10460
Hanslick Jennifer L., Lau Karen, Noguchi Kevin K., Olney John W., Zorumski Charles F., Mennerick Steven, Farber Nuri B. (2009): Dimethyl sulfoxide (DMSO) produces widespread apoptosis in the developing central nervous system. Neurobiology of Disease, 34, 1-10
Hung Man-Jung, Chen Yi-Ting, Shen Pao-Sheng, Hsu Shih-Tien, Chen Gin-Den, Ho Esther Shih-Chu (2012): Risk factors that affect the treatment of interstitial cystitis using intravesical therapy with a dimethyl sulfoxide cocktail. International Urogynecology Journal, 23, 1533-1539
Jacob Stanley W., de la Torre Jack C. (2009): Pharmacology of dimethyl sulfoxide in cardiac and CNS damage. Pharmacological Reports, 61, 225-235
Jo S.-K. (2004): Delayed DMSO Administration Protects the Kidney from Mercuric Chloride-Induced Injury. Journal of the American Society of Nephrology, 15, 2648-2654
Kim R, Liu WJ, Chen X, Kreder KJ, Luo Y (2010): Intravesical dimethyl sulfoxide inhibits acute and chronic bladder inflammation in transgenic experimental autoimmune cystitis models. Journal of Biomedicine and Biotechnology 2011, 1–9.
Lind R (1997): Late Dimethyl Sulfoxide Administration Provides a Protective Action against Chemically Induced Injury in both the Liver and the Kidney. Toxicology and Applied Pharmacology, 142, 201-207
Lishner Michael, Lang Ruth, Kedar Igal, Ravid Mordchai (1985): Treatment of Diabetic Perforating Ulcers (Mal Perforant) with Local Dimethylsulfoxide. Journal of the American Geriatrics Society, 33, 41-43
Lotan Danny, Kaplan Bernard S, Fong Jack S C, Goodyer Paul R, de Chadarevian Jean-Pierre (1984): Reduction of protein excretion by dimethyl sulfoxide in rats with passive Heymann nephritis. Kidney International, 25, 778-788
Melchior D, Packer CS, Johnson TC, Kaefer M (2003): Dimethyl sulfoxide: Does it change the functional properties of the bladder wall? Journal of Urology 170, 253–258.
Notman Rebecca, den Otter Wouter K., Noro Massimo G., Briels W.J., Anwar Jamshed (2007): The Permeability Enhancing Mechanism of DMSO in Ceramide Bilayers Simulated by Molecular Dynamics. Biophysical Journal, 93, 2056-2068
Paes AC, Cortes JA (2008): Isoniazid potentiation of the dimethyl sulfoxide (DMSO) in the treatment of hamsters (Mesocricetus auratus) experimentally infected with Mycobacterium (AN5) (in Portuguese). Veterinary and Animal Sciences 15, 486–495.
Paulin H. J., Murphy J. B., Larson R. E. (1966): Determination of Dimethyl Sulfoxide in Plasma and Cerebrospinal Fluid by Gas-Liquid Chromatography.. Analytical Chemistry, 38, 651-652
Preisler Harvey D., Christoff Gregory, Reese Peter, Pavelic Paul, Rustum Youcef (1978): Friend leukemia cells: Relationship between differentiation, clonogenicity and malignancy. Cell Differentiation, 7, 1-10
Raskin Douglas J., Sullivan Kathleen H., Rappaport Norman H. (1983): THE ROLE OF TOPICAL DIMETHYL SULFOXIDE IN BURN WOUND INFECTION: EVALUATION IN THE RAT. Annals of the New York Academy of Sciences, 411, 105-109
Ravid M, Shapira J, Lang R, Kedar I (1982): Prolonged dimethylsulphoxide treatment in 13 patients with systemic amyloidosis.. Annals of the Rheumatic Diseases, 41, 587-592
Rijtema Mariette, Mosig Dolores, Drukker Alfred, Guignard Jean-Pierre (1999): The Effects of Dimethyl Sulfoxide on Renal Function of the Newborn Rabbit. Biology of the Neonate, 76, 355-361
Santos Nuno C., Figueira-Coelho J., Martins-Silva J., Saldanha Carlota (2003): Multidisciplinary utilization of dimethyl sulfoxide: pharmacological, cellular, and molecular aspects. Biochemical Pharmacology, 65, 1035-1041
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Senior D (2006): Feline lower urinary tract disease. The Latin American Veterinary Conference TLAVC, Lima, Peru, 29. September–2. October 2006. 7–12. Available at
Soto FRM, Viana WG, Mucciolo GCB, Hosomi FYM, Vannucchi CI, Mazzei CP, Eyherabide AR, de F��tima L��cio C, Dias RA, de Azevedo SS (2009): Evaluation of Efficacy and Safety of Zinc Gluconate Associated with Dimethyl Sulphoxide for Sexually Mature Canine Males Chemical Neutering. Reproduction in Domestic Animals, 44, 927-931
Stav Kobi, Beberashvili Ilia, Lindner Arie, Leibovici Dan (2012): Predictors of Response to Intravesical Dimethyl-sulfoxide Cocktail in Patients With Interstitial Cystitis. Urology, 80, 61-65
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Wang Chi-Chung, Lin Sheng-Yi, Lai Yi-Hua, Liu Ya-Jung, Hsu Yuan-Lin, Chen Jeremy J. W., Yang Pan-Chyr (2012): Dimethyl Sulfoxide Promotes the Multiple Functions of the Tumor Suppressor HLJ1 through Activator Protein-1 Activation in NSCLC Cells. PLoS ONE, 7, e33772-
Ware WA (2006): Glomerulopathy (in Portuguese). In: Nelson RW, Couto CG (eds): Small Animal Internal Medicine. 3rd edn. 575–582.
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Zenhäusern R., Tobler A., Leoncini L., Hess O. M., Ferrari P. (2000): Fatal cardiac arrhythmia after infusion of dimethyl sulfoxide-cryopreserved hematopoietic stem cells in a patient with severe primary cardiac amyloidosis and end-stage renal failure. Annals of Hematology, 79, 523-526
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