Open Access CAAS Agricultural Journals Veterinární medicína

Metastatic mast cell tumour in African hedgehog: A case report

M Kandefer-Golaorcid , R Ciaputa, K Sulima, M Miszczak, S Lachowska, M Nowak

https://doi.org/10.17221/17/2020-VETMEDCitation:

Kandefer-Gola M, Ciaputa R, Sulima K, Miszczak M, Lachowska S, Nowak M (2020): Metastatic mast cell tumour in African hedgehog: A case report. Vet Med-Czech 65, 371–376.

download PDF

Neoplastic lesions are common in African hedgehogs (Atelerix albiventris). To our knowledge, so far mast cell tumour metastases have only been described in local lymph nodes. An African hedgehog was referred to the veterinary clinic. A nodule was located on the right part of the mandible. Based on the clinical trial, an abscess was suspected. Surgery was performed, but a histopathological examination was not undertaken. After few months, tumour recurrence was detected and, additionally, a second tumour was found on the metatarsal skin. Due to the deteriorating clinical condition of the patient, euthanasia was decided, and a post-mortem examination was performed. During the post-mortem examination, a spleen tumour was detected, and, furthermore, mesenteric lymph nodes, liver and lung sections were also collected. The histopathological examination confirmed mast cell tumour metastasis to the spleen and lymph nodes, additionally single mast cells were found in the liver. Interestingly, the histological picture of the tumour does not show high malignancy. To our knowledge, this is the first description of a mast cell tumour with metastases to the spleen and lymph in the African hedgehog.

Keywords:

neoplasm; MCT; metastases; mastocytosis

References:
Heathley JJ, Mauldin GE, Cho DY. A review of neoplasia in the captive African hedgehog (Atelerix albiventris). Semin Avian Exotic Pet Med. 2005 May 18;14(5):182-92. https://doi.org/10.1016/j.saep.2005.07.002
 
Juan-Salles C, Garner MM. Cytologic diagnosis of diseases of hedgehogs. Vet Clin Exot Anim. 2007 Jan;10(1):51-9. https://doi.org/10.1016/j.cvex.2006.10.003
 
Kiupel M, Webster JD, Bailey KL, Best S, DeLay J, Detrisac CJ, Fitzgerald SD, Gamble D, Ginn PE, Goldschmidt MH, Hendrick MJ, Howerth EW, Janovitz EB, Langohr I, Lenz SD, Lipscomb TP, Miller MA, Misdorp W, Moroff S, Mullaney TP, Neyens I, O’Toole D, Ramos-Vara J, Scase TJ, Schulman FY, Sledge D, Smedley RC, Smith K, W Snyder P, Southorn E, Stedman NL, Steficek BA, Stromberg PC, Valli VE, Weisbrode SE, Yager J, Heller J, Miller R. Proposal of a 2-tier histologic grading system for canine cutaneous mast cell tumors to more accurately predict biological behavior. Vet Pathol. 2011 Jan;48(1):147-55. https://doi.org/10.1177/0300985810386469
 
Lamm CG, Stern AW, Smith AJ, Cooper EJ, Ullom SW, Campbell GA. Disseminated cutaneous mast cell tumors with epitheliotropism and systemic mastocytosis in a domestic cat. J Vet Diagn Invest. 2009 Sep;21(5):710-5. https://doi.org/10.1177/104063870902100520
 
Patnaik AK, Ehler WJ, MacEwen EG. Canine cutaneous mast cell tumor: Morphologic grading and survival time in 83 dogs. Vet Pathol. 1984 Sep;21(5):469-74. https://doi.org/10.1177/030098588402100503
 
Raymond JT, White MR, Janovitz EB. Malignant mast cell tumor in an African hedgehog (Atelerix albiventris). J Wildl Dis. 1997 Jan;33(1):140-2. https://doi.org/10.7589/0090-3558-33.1.140
 
Raymond JT, Garner MM. Spontaneous tumours in captive African hedgehogs (Atelerix albiventris): A retrospective study. J Comp Path. 2001 Feb-Apr;124(2-3):128-33. https://doi.org/10.1053/jcpa.2000.0441
 
Stefanello D, Valenti P, Faverzani S, Bronzo V, Fiorbianco V, Pinto da Cunha N, Romussi S, Cantatore M, Caniatti M. Ultrasound-guided cytology of spleen and liver: A prognostic tool in canine cutaneous mast cell tumor. J Vet Intern Med. 2009 Sep-Oct;23(5):1051-7. https://doi.org/10.1111/j.1939-1676.2009.0354.x
 
Tamlin VS, Bottema CDK, Peaston AE. Comparative aspects of mast cell neoplasia in animals and the role of KIT in prognosis and treatment. Vet Med Sci. 2020 Feb;6(1):3-18. https://doi.org/10.1002/vms3.201
 
Valent P, Akin C, Metcalfe DD. Mastocytosis: 2016 updated WHO classification and novel emerging treatment concepts. Blood. 2017 Mar 16;129(11):1420-7. https://doi.org/10.1182/blood-2016-09-731893
 
Weishaar KM, Thamm DH, Worley DR, Kamstock DA. Correlation of nodal mast cells with clinical outcome in dogs with mast cell tumour and a proposed classification system for the evaluation of node metastasis. J Comp Pathol. 2014 Nov;151(4):329-38. https://doi.org/10.1016/j.jcpa.2014.07.004
 
Woldemeskel M, Merrill A, Brown C. Significance of cytological smear evaluation in diagnosis of splenic mast cell tumor-associated systemic mastocytosis in a cat (Felis catus). Can Vet J. 2017 Mar;58(3):293-5.
 
download PDF

Impact factor (WoS):

2019: 0.588
Q3  – Veterinary Sciences
5-Year Impact Factor: 0.877

SCImago Journal Rank (SCOPUS):

SCImago Journal & Country Rank

New Issue Alert

Join the journal on Facebook!
Ask for  email notification.

Similarity Check

All the submitted manuscripts are checked by the CrossRef Similarity Check.

Abstracted/Indexed in

Agrindex of AGRIS/FAO database
Animal Breeding Abstracts
CAB Abstracts
CNKI
CrossRef
Current Contents®/Agriculture, Biology and Environmental Sciences
Czech Agricultural and Food Bibliography
DOAJ (Directory of Open Access Journals)
EBSCO – Academic Search Ultimate
FSTA (formerly: Food Science and Technology Abstracts)
Google Scholar
J-GATE
Science Citation Index Expanded®
SCOPUS
TOXLINE PLUS
Web of KnowledgeSM
Web of Science®

Licence terms

All contents of the journal is freely available for non-commercial purposes, users are allowed to copy and redistribute the material, transform, and build upon the material as long as they cite the source.

Open Access Policy

This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge.

Contact

Ing. Helena Smolová, Ph.D.
Executive Editor
phone: + 420 227 010 352
e-mail: vetmed@cazv.cz

Address

Veterinární Medicína
Czech Academy of Agricultural Sciences
Slezská 7, 120 00 Praha 2, Czech Republic

© 2020 Czech Academy of Agricultural Sciences