Comparison of intraocular pressure, tear production and cardiorespiratory variables before and after induction of anaesthesia with either propofol or ketofol in dogs premedicated with midazolam

https://doi.org/10.17221/18/2017-VETMEDCitation:Imani Rastabi H, Baniadam A, Ronagh A, Khajeh A, Kamyabnia M (2018): Comparison of intraocular pressure, tear production and cardiorespiratory variables before and after induction of anaesthesia with either propofol or ketofol in dogs premedicated with midazolam. Veterinarni Medicina, 63: 271-278.
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The objective of the present study was to compare the effects of propofol and ketofol on intraocular pressure, tear production and cardiorespiratory variables in dogs premedicated with midazolam. Six castrated adult mixed-breed dogs were used in a cross-over design with a one-week interval. Twenty minutes after premedication with midazolam (0.2 mg/kg), animals were assigned randomly to two groups and received either propofol (6 mg/kg) or ketofol (3 mg/kg; 1 : 1 mg/ml ratio) treatments intravenously. Intraocular pressure, tear production, heart rate, respiratory rate, rectal temperature and direct mean arterial blood pressure were measured at base (before induction), and at 5, 10, 15, 20 and 30 min after induction of anaesthesia. Blood gas samples were obtained at base (before induction), and at 5, 15 and 30 min after administration of treatments. Intraocular pressure showed significantly higher values at 5 min after induction in ketofol compared with propofol (16.1 ± 4.5 mm Hg vs 8.2 ± 1.2 mm Hg, respectively). There were no significant changes in tear production in either group. Significantly higher heart rate and mean arterial blood pressure were detected in ketofol at several time points. Respiratory depression occurred in both groups with no significant differences between them. In conclusion, although ketofol improved heart rate and mean arterial blood pressure and did not elicit more pronounced respiratory depression than propofol, it resulted in significantly higher values of intraocular pressure at 5 min after administration in dogs. Despite the small number of dogs in this study, our results indicate that ketofol should not be recommended for ophthalmic surgical procedures in dogs. Appropriate oxygenation should be provided when propofol is used for ophthalmic surgeries.

References:
Aguiar Antonio JA, Luna Stelio PL, Oliva Valéria NLS, Eugênio Flávia R, Castro Gladys B (2001): Continuous infusion of propofol in dogs premedicated with methotrimeprazine. Veterinary Anaesthesia and Analgesia, 28, 220-224 https://doi.org/10.1046/j.1467-2987.2001.00048.x
 
Almeida Denise E., Nishimori Celina T., Oriá Arianne P., Paula Danielli P., Nunes Newton, Laus José L. (2008): Effects of nitrous oxide on IOP and pupillary diameter in dogs anesthetized with varying concentrations of desflurane. Veterinary Ophthalmology, 11, 170-176 https://doi.org/10.1111/j.1463-5224.2008.00616.x
 
Andolfatto Gary, Willman Elaine (2010): A Prospective Case Series of Pediatric Procedural Sedation and Analgesia in the Emergency Department Using Single-syringe Ketamine-Propofol Combination (Ketofol). Academic Emergency Medicine, 17, 194-201 https://doi.org/10.1111/j.1553-2712.2009.00646.x
 
Artigas Cristina, Redondo José I., López-Murcia María M. (2012): Effects of intravenous administration of dexmedetomidine on intraocular pressure and pupil size in clinically normal dogs. Veterinary Ophthalmology, 15, 79-82 https://doi.org/10.1111/j.1463-5224.2011.00966.x
 
Artru Alan A. (1991): Intraocular pressure in anaesthetized dogs given flumazenil with and without prior administration of midazolam. Canadian Journal of Anaesthesia, 38, 408-414 https://doi.org/10.1007/BF03007632
 
Batista C.M., Laus J.L., Nunes N., Patto dos Santos P.S., Costa J.L.O. (2000): Evaluation of intraocular and partial CO2 pressure in dogs anesthetized with propofol. Veterinary Ophthalmology, 3, 17-19 https://doi.org/10.1046/j.1463-5224.2000.00099.x
 
Costa D, Leiva M, Moll X, Aguilar A, Pena T, Andaluz A (2014): Alfaxalone versus propofol in dogs: a randomised trial to assess effects on peri-induction tear production, intraocular pressure and globe position. Veterinary Record 176, doi: 10.11136/vr.102621.
 
Cunningham Anthony J., Barry Peter (1986): Intraocular pressure -physiology and implications for anaesthetic management. Canadian Anaesthetists’ Society Journal, 33, 195-208 https://doi.org/10.1007/BF03010831
 
Frey K, Sukhani R, Pawlowski J, Pappas AL, Mikat-Stevens M, Slogoff S (1999): Propofol versus propofol-ketamine sedation for retrobulbar nerve block: comparison of sedation quality, intraocular pressure changes, and recovery profiles. Anesthesia and Analgesia 89, 317–321.
 
Gelatt K.N., MacKay E.O. (1998): Distribution of intraocular pressure in dogs. Veterinary Ophthalmology, 1, 109-114 https://doi.org/10.1046/j.1463-5224.1998.00024.x
 
Ghaffari Masoud Selk, Rezaei Mohammad Ali, Mirani Amir Hessam, Khorami Nargess (2010): The effects of ketamine-midazolam anesthesia on intraocular pressure in clinically normal dogs. Veterinary Ophthalmology, 13, 91-93 https://doi.org/10.1111/j.1463-5224.2010.00762.x
 
GOODCHILD C.S., SERRAO J.M. (1989): CARDIOVASCULAR EFFECTS OF PROPOFOL IN THE ANAESTHETIZED DOG. British Journal of Anaesthesia, 63, 87-92 https://doi.org/10.1093/bja/63.1.87
 
Gross ME, Pablo LS (2015): Ophthalmic patients. In: Grimm KA, Lamont LA, Tranquilli WJ, Greene SA, Robertson SA (eds): Veterinary Anesthesia and Analgesia: The Fifth Edition of Lumb and Jones. Wiley Blackwell, Pondicherry. 963–982.
 
Hamor Ralph E., Gerding Paul A., Ramsey David T., Whiteley Herbert E., Benson Gordon J., Schaeffer David J. (2000): Evaluation of short-term increased intraocular pressure on flash- and pattern-generated electroretinograms of dogs. American Journal of Veterinary Research, 61, 1087-1091 https://doi.org/10.2460/ajvr.2000.61.1087
 
Hasiuk Michelle M. M., Forde Nessa, Cooke Amy, Ramey Kelli, Pang Daniel S. J. (2014): A comparison of alfaxalone and propofol on intraocular pressure in healthy dogs. Veterinary Ophthalmology, 17, 411-416 https://doi.org/10.1111/vop.12119
 
Henao-Guerrero Natalia, Riccó Carolina H. (2014): Comparison of the cardiorespiratory effects of a combination of ketamine and propofol, propofol alone, or a combination of ketamine and diazepam before and after induction of anesthesia in dogs sedated with acepromazine and oxymorphone. American Journal of Veterinary Research, 75, 231-239 https://doi.org/10.2460/ajvr.75.3.231
 
Hofmeister Erik H., Mosunic Cory B., Torres Bryan T., Ralph Alan G., Moore Phillip Anthony, Read Matt R. (2006): Effects of ketamine, diazepam, and their combination on intraocular pressures in clinically normal dogs. American Journal of Veterinary Research, 67, 1136-1139 https://doi.org/10.2460/ajvr.67.7.1136
 
Hofmeister Erik H, Williams Clara O, Braun Christina, Moore Phillip Anthony (2008): Propofol versus thiopental: effects on peri-induction intraocular pressures in normal dogs. Veterinary Anaesthesia and Analgesia, 35, 275-281 https://doi.org/10.1111/j.1467-2995.2007.00385.x
 
Hofmeister Erik H, Weinstein William L, Burger Diana, Brainard Benjamin M, Accola Peter J, Moore Phillip Anthony (2009): Effects of graded doses of propofol for anesthesia induction on cardiovascular parameters and intraocular pressures in normal dogs. Veterinary Anaesthesia and Analgesia, 36, 442-448 https://doi.org/10.1111/j.1467-2995.2009.00482.x
 
Hubanova Ralitsa, Aptel Florent, Zhou Thierry, Arnol Nathalie, Romanet Jean-Paul, Chiquet Christophe (2015): Comparison of Intraocular Pressure Measurements With the Reichert Pt100, the Keeler Pulsair Intellipuff Portable Noncontact Tonometers, and Goldmann Applanation Tonometry. Journal of Glaucoma, 24, 356-363 https://doi.org/10.1097/01.ijg.0000435776.99193.41
 
Jang Min, Park Sangwan, Son Won-gyun, Jo Sang-min, Hwang Hyeshin, Seo Kangmoon, Lee Inhyung (2015): Effect of tiletamine-zolazepam on the intraocular pressure of the dog. Veterinary Ophthalmology, 18, 481-484 https://doi.org/10.1111/vop.12237
 
Kennedy Martin J, Smith Lesley J (2015): A comparison of cardiopulmonary function, recovery quality, and total dosages required for induction and total intravenous anesthesia with propofol versus a propofol-ketamine combination in healthy Beagle dogs. Veterinary Anaesthesia and Analgesia, 42, 350-359 https://doi.org/10.1111/vaa.12218
 
Kovalcuka Liga, Birgele Edite, Bandere Dace, Williams David L. (2013): The effects of ketamine hydrochloride and diazepam on the intraocular pressure and pupil diameter of the dog’s eye. Veterinary Ophthalmology, 16, 29-34 https://doi.org/10.1111/j.1463-5224.2012.01015.x
 
Lerche P., Reid J., Nolan A. M. (2000): Comparative study of propofol or propofol and ketamine for the induction of anaesthesia in dogs. Veterinary Record, 146, 571-574 https://doi.org/10.1136/vr.146.20.571
 
Martinez-Taboada Fernando, Leece Elizabeth A (2014): Comparison of propofol with ketofol, a propofol-ketamine admixture, for induction of anaesthesia in healthy dogs. Veterinary Anaesthesia and Analgesia, 41, 575-582 https://doi.org/10.1111/vaa.12171
 
Miller PE (2013): The glaucomas. In: Maggs DJ, Miller PE, Ofri R (eds): Slatter’s Fundamentals of Veterinary Ophthalmology. 5th edn. Saunders Elsevier. 247–271.
 
Pagel Paul S., Warltier David C. (1993): Negative Inotropic Effects of Propofol as Evaluated by the Regional Preload Recruitable Stroke Work Relationship in Chronically Instrumented Dogs. Anesthesiology, 78, 100-108 https://doi.org/10.1097/00000542-199301000-00015
 
Rankin DC (2015): Sedatives and tranquilizers. In: Grimm KA, Lamont LA, Tranquilli WJ, Greene SA, Robertson SA (eds): Veterinary Anesthesia and Analgesia: The Fifth Edition of Lumb and Jones. Wiley Blackwell, Pondicherry. 196–206.
 
Shepard Molly K., Accola Peter J., Lopez Luis A., Shaughnessy Michael R., Hofmeister Erik H. (2011): Effect of duration and type of anesthetic on tear production in dogs. American Journal of Veterinary Research, 72, 608-612 https://doi.org/10.2460/ajvr.72.5.608
 
Thomson S (2007): Ophthalmic surgery. In: Seymour C, Duke-Novakovski T (eds): BSAVA Manual of Canine and Feline Anesthesia and Analgesia. British Small Animal Veterinary Association, Gloucester. 183–193.
 
Verbruggen A‐M.J., Akkerdaas L.C., Hellebrekers L.J., Stades F.C. (2000): The effect of intravenous medetomidine on pupil size and intraocular pressure in normotensive dogs. Veterinary Quarterly, 22, 179-180 https://doi.org/10.1080/01652176.2000.9695052
 
Wallin-Hakanson Nils, Wallin-Hakanson Berit (2001): The effects of topical tropicamide and systemic medetomidine, followed by atipamezole reversal, on pupil size and intraocular pressure in normal dogs. Veterinary Ophthalmology, 4, 3-6 https://doi.org/10.1046/j.1463-5224.2001.00114.x
 
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