Canine adipose tissue-derived mesenchymal stem cell therapy in a dog with renal Fanconi syndrome

An JH, Kim KB, Kwon SC, Kim HJ, Ryu MO, Oh YI, Ahn JO, Youn HY (2022): Canine adipose tissue-derived mesenchymal stem cell therapy in a dog with renal Fanconi syndrome. Vet Med-Czech 67, 206–211.

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Renal Fanconi syndrome (RFS) affects the proximal tubular resorption in the nephrons. This causes excessive loss of key solutes through the urine. In a canine patient, we successfully managed the renal tubular acidosis and proteinuria caused by RFS via transplantation of canine adipose tissue-derived mesenchymal stem cells (cAT-MSCs). cAT-MSCs were administered ten times at intervals of 2–4 weeks. The post-therapy check-up revealed that the cAT-MSC treatment improved the renal tubular acidosis and proteinuria. Hence, a cAT-MSC transplant may be considered as an adjuvant therapy in veterinary medicine to initiate and maintain relief of RFS-induced acidosis and proteinuria.

Ali SA, Tariq M. Successful treatment of proximal renal tubular acidosis and Fanconi syndrome with vitamin D replacement. Saudi J Kidney Dis Transpl. 2016 Jul-Aug;27(4):812-5.
Beerts C, Brondeel C, Pauwelyn G, Depuydt E, Tack L, Duchateau L, Xu Y, Saunders JH, Peremans K, Spaas JH. Scintigraphic tracking of 99mTechnetium-labelled equine peripheral blood-derived mesenchymal stem cells after intravenous, intramuscular, and subcutaneous injection in healthy dogs. Stem Cell Res Ther. 2021 Jul 13;12(1): [11].
de Almeida DC, Donizetti-Oliveira C, Barbosa-Costa P, Origassa CS, Camara NO. In search of mechanisms associated with mesenchymal stem cell-based therapies for acute kidney injury. Clin Biochem Rev. 2013 Nov;34(3):131-44.
Easley JR, Breitschwerdt DB. Glucosuria associated with renal tubular dysfunction in three Basenji dogs. J Am Vet Med Assoc. 1976 May 15;168(10):938-43.
Evans RDR, Antonelou M, Sathiananthamoorthy S, Rega M, Henderson S, Ceron-Gutierrez L, Barcenas-Morales G, Muller CA, Doffinger R, Walsh SB, Salama AD. Inherited salt-losing tubulopathies are associated with immunodeficiency due to impaired IL-17 responses. Nat Commun. 2020 Aug;11(1):1-19.
Gonto S. Fanconi syndrome protocol – Fanconi disease management protocol for veterinarians [Internet]. Savannah, Georgia; 2003 [cited 2020 Nov 1]. Available from:
Hostutler RA, DiBartola SP, Eaton KA. Transient proximal renal tubular acidosis and Fanconi syndrome in a dog. J Am Vet Med Assoc. 2004 May 15;224(10):1611-4.
Hu MK, Witham MD, Soiza RL. Oral bicarbonate therapy in non-haemodialysis dependent chronic kidney disease patients: A systematic review and meta-analysis of randomised controlled trials. J Clin Med. 2019 Feb 7;8(2): [12].
Karatzas A, Paridis D, Kozyrakis D, Tzortzis V, Samarinas M, Dailiana Z, Karachalios T. Fanconi syndrome in the adulthood. The role of early diagnosis and treatment. J Musculoskelet Neuronal Interact. 2017 Dec 1;17(4):303-6.
Lange C, Togel F, Ittrich H, Clayton F, Nolte-Ernsting C, Zander AR, Westenfelder C. Administered mesenchymal stem cells enhance recovery from ischemia/reperfusion-induced acute renal failure in rats. Kidney Int. 2005 Oct;68(4):1613-7.
Nakhoul N, Batuman V. Role of proximal tubules in the pathogenesis of kidney disease. Herrera GA, Ronco C, editors. Experimental models for renal diseases. Basel: Karger Publishers; 2011. p. 37-50.
Norden AG, Lapsley M, Lee PJ, Pusey CD, Scheinman SJ, Tam FW, Thakker RV, Unwin RJ, Wrong O. Glomerular protein sieving and implications for renal failure in Fanconi syndrome. Kidney Int. 2001 Nov;60(5):1885-92.
Perez-Merino EM, Uson-Casaus JM, Duque-Carrasco J, Zaragoza-Bayle C, Marinas-Pardo L, Hermida-Prieto M, Vilafranca-Compte M, Barrera-Chacon R, Gualtieri M. Safety and efficacy of allogeneic adipose tissue-derived mesenchymal stem cells for treatment of dogs with inflammatory bowel disease: Endoscopic and histological outcomes. Vet J. 2015 Dec;206(3):391-7.
Rabelink TJ, van Kooten C. Stem cell therapy for glomerular disease. J Am Soc Nephrol. 2006 Aug;17(8):2086-8.
Sharma R, Kinsey GR. Regulatory T-cells in acute and chronic kidney diseases. Am J Physiol Renal Physiol. 2018 May 1;314(5):F679-F98.
Soleymaninejadian E, Pramanik K, Samadian E. Immunomodulatory properties of mesenchymal stem cells: Cytokines and factors. Am J Reprod Immunol. 2012 Jan;67(1):1-8.
Wilson DR, Yendt ER. Treatment of the adult Fanconi syndrome with oral phosphate supplements and alkali: Report of two cases associated with nephrolithiasis. Am J Med. 1963 Oct;35(4):487-511.
Yabuki A, Iwanaga T, Giger U, Sawa M, Kohyama M, Yamato O. Acquired Fanconi syndrome in two dogs following long-term consumption of pet jerky treats in Japan: Case report. J Vet Med Sci. 2017 Apr;79(5):818-21.
Yang HM, Song WJ, Li Q, Kim SY, Kim HJ, Ryu MO, Ahn JO, Youn HY. Canine mesenchymal stem cells treated with TNF-α and IFN-γ enhance anti-inflammatory effects through the COX-2/PGE2 pathway. Res Vet Sci. 2018 Aug;119:19-26.
Yearley JH, Hancock DD, Mealey KL. Survival time, lifespan, and quality of life in dogs with idiopathic Fanconi syndrome. J Am Vet Med Assoc. 2004 Aug 1;225(3):377-83.
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