Canine adipose tissue-derived mesenchymal stem cell therapy in a dog with renal Fanconi syndrome

https://doi.org/10.17221/213/2020-VETMEDCitation:

An JH, Kim KB, Kwon SC, Kim HJ, Ryu MO, Oh YI, Ahn JO, Youn HY (2022): Canine adipose tissue-derived mesenchymal stem cell therapy in a dog with renal Fanconi syndrome. Vet Med-Czech 67, 206–211.

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Renal Fanconi syndrome (RFS) affects the proximal tubular resorption in the nephrons. This causes excessive loss of key solutes through the urine. In a canine patient, we successfully managed the renal tubular acidosis and proteinuria caused by RFS via transplantation of canine adipose tissue-derived mesenchymal stem cells (cAT-MSCs). cAT-MSCs were administered ten times at intervals of 2–4 weeks. The post-therapy check-up revealed that the cAT-MSC treatment improved the renal tubular acidosis and proteinuria. Hence, a cAT-MSC transplant may be considered as an adjuvant therapy in veterinary medicine to initiate and maintain relief of RFS-induced acidosis and proteinuria.

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