Changes in lymphocyte function and subset counts in cats with spontaneous chronic kidney disease

https://doi.org/10.17221/282/2015-VETMEDCitation:Kralova-Kovarikova S., Leva L., Knotek Z., Toman M. (2016): Changes in lymphocyte function and subset counts in cats with spontaneous chronic kidney disease. Veterinarni Medicina, 61: 553-559.
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Chronic kidney disease alters the immune response in humans and dogs and it is thought to be one of the causes of immunosuppression in cats. Haematological, biochemical, and immunological examinations were performed on blood samples obtained from 20 cats with chronic kidney disease, and were compared with the results of 18 healthy cats. In cats with chronic kidney disease, statistically significantly lower numbers of total lymphocytes (P < 0.01), especially T lymphocytes (P < 0.001), were observed. When the results were compared with the lymphocyte transformation test in healthy cats, decreased responses to phytohaemaglutinin, concanavalin A, and pokeweed mitogen were found in cats with chronic kidney disease. Our results document an alteration of counts and activity of lymphocytes in cats with chronic kidney disease. Thus, higher susceptibility to infection may be expected in these patients.
References:
Agrawal S., Gollapudi P., Elahimehr R., Pahl M. V., Vaziri N. D. (): Effects of end-stage renal disease and haemodialysis on dendritic cell subsets and basal and LPS-stimulated cytokine production. Nephrology Dialysis Transplantation, 25, 737-746  https://doi.org/10.1093/ndt/gfp580
 
Alvarez-Lara M. A., Carracedo J., Ramirez R., Martin-Malo A., Rodriguez M., Madueno J. A., Aljama P. (): The imbalance in the ratio of Th1 and Th2 helper lymphocytes in uraemia is mediated by an increased apoptosis of Th1 subset. Nephrology Dialysis Transplantation, 19, 3084-3090  https://doi.org/10.1093/ndt/gfh382
 
Campbell D.J, Rawlings J.M, Koelsch S, Wallace J, Strain J.J, Hannigan B.M (2004): Age-related differences in parameters of feline immune status. Veterinary Immunology and Immunopathology, 100, 73-80  https://doi.org/10.1016/j.vetimm.2004.03.002
 
Chew DJ, DiBartola SP, Boyce JT, Hayes Jr HM, Brace JJ (1983): Juvenile renal disease in Doberman Pinscher dogs. Journal of the American Veterinary Medical Association 182, 481–485.
 
Cohen Gerald, Hörl Walter (2012): Immune Dysfunction in Uremia—An Update. Toxins, 4, 962-990  https://doi.org/10.3390/toxins4110962
 
DiBartola SP, Rutgers HC, Zack PM, Tarr MJ (1987): Clinicopathological findings associated with chronic renal disease in cats: 74 cases (1973–1984). Journal of the American Veterinary Medical Association 190, 1196–1202.
 
DiBartola SP, Tarr MJ, Parker AT, Powers JD, Pultz JA (1989): Clinicopathologic findings in dogs with renal amyloidosis: 59 cases (1976–1986). Journal of the American Veterinary Medical Association 195, 358–364.
 
Elliott J., Barber P. J. (1998): Feline chronic renal failure: clinical findings in 80 cases diagnosed between 1992 and 1995. Journal of Small Animal Practice, 39, 78-85  https://doi.org/10.1111/j.1748-5827.1998.tb03598.x
 
Fernandez-Fresnedo G., Ramos M. A., Gonzalez-Pardo M. C., de Francisco A. L. M., Lopez-Hoyos M., Arias M. (2000): B lymphopenia in uraemia is related to an accelerated in vitro apoptosis and dysregulation of Bcl-2. Nephrology Dialysis Transplantation, 15, 502-510  https://doi.org/10.1093/ndt/15.4.502
 
Girndt M., Sester U., Sester M., Kaul H., Kohler H. (1999): Impaired cellular immune function in patients with end-stage renal failure. Nephrology Dialysis Transplantation, 14, 2807-2810  https://doi.org/10.1093/ndt/14.12.2807
 
Girndt M, Sester M, Sester U, Kaul H, Kohler H (2001): Molecular aspects of T- and B-cell function in uremia. Kidney International 78, S206–S211.
 
Hendrikx T. K., van Gurp E. A. F. J., Mol W. M., Schoordijk W., Sewgobind V. D. K. D., IJzermans J. N. M., Weimar W., Baan C. C. (): End-stage renal failure and regulatory activities of CD4+CD25bright+FoxP3+ T-cells. Nephrology Dialysis Transplantation, 24, 1969-1978  https://doi.org/10.1093/ndt/gfp005
 
Keegan R.F., Webb C.B. (2010): Oxidative Stress and Neutrophil Function in Cats with Chronic Renal Failure. Journal of Veterinary Internal Medicine, 24, 514-519  https://doi.org/10.1111/j.1939-1676.2010.0498.x
 
Kralova S, Leva L, Toman M (2009): Polymorphonuclear function in naturally occurring renal failure in dogs. Veterinarni Medicina 5, 236–243.
 
Kralova S, Leva L, Toman M (2010): Changes in lymphocyte function and subsets in dogs with naturally occurring chronic renal failure. Canadian Journal of Veterinary Research 74, 124–129.
 
Massry S, Smogorzewski M (2001): Dysfunction of polymorphonuclear leukocytes in uremia: role of parathyroid hormone. Kidney International 78, S195–S196.
 
Matsumoto Y., Shinzato T., Amano I., Takai I., Kimura Y., Morita H., Miwa M., Nakane K., Yoshikai Y., Maeda K. (1995): Relationship Between Susceptibility to Apoptosis and Fas Expression in Peripheral Blood T Cells from Uremic Patients: A Possible Mechanism for Lymphopenia in Chronic Renal Failure. Biochemical and Biophysical Research Communications, 215, 98-105  https://doi.org/10.1006/bbrc.1995.2438
 
Meier P, Dayer E, Blanc E, Wauters JP (2002): Early T cell activation correlates with expression of apoptosis markers in patients with end-stage renal disease. Journal of the American Society of Nephrology 13, 204–212.
 
Moser Bernhard, Roth Georg, Brunner Markus, Lilaj Tatjana, Deicher Robert, Wolner Ernst, Kovarik Josef, Boltz-Nitulescu George, Vychytil Andreas, Ankersmit Hendrik Jan (2003): Aberrant T cell activation and heightened apoptotic turnover in end-stage renal failure patients: a comparative evaluation between non-dialysis, haemodialysis, and peritoneal dialysis. Biochemical and Biophysical Research Communications, 308, 581-585  https://doi.org/10.1016/S0006-291X(03)01389-5
 
Nakhla LS, Goggin MJ (1973): Lymphocyte transformation in chronic renal failure. Immunology 24, 229–235.
 
Pahl M. V., Gollapudi S., Sepassi L., Gollapudi P., Elahimehr R., Vaziri N. D. (): Effect of end-stage renal disease on B-lymphocyte subpopulations, IL-7, BAFF and BAFF receptor expression. Nephrology Dialysis Transplantation, 25, 205-212  https://doi.org/10.1093/ndt/gfp397
 
Raska Karel, Raskova Jana, Shea Stephen M., Frankel Richard M., Wood Robert H., Lifter John, Ghobrial Ibrahim, Eisinger Robert P., Homer Leroy (1983): T cell subsets and cellular immunity in end-stage renal disease. The American Journal of Medicine, 75, 734-740  https://doi.org/10.1016/0002-9343(83)90401-1
 
Raskin RE, Latimer KS, Tvedten H (2004): Leukocyte disorders. In: Willard MD, Tvedten H (eds): Small Animal Clinical Diagnosis by Laboratory Methods. 4th edn. Saunders, St Louis. 63–91.
 
Sarnak Mark J., Jaber Bertrand L. (2000): Mortality caused by sepsis in patients with end-stage renal disease compared with the general population. Kidney International, 58, 1758-1764  https://doi.org/10.1111/j.1523-1755.2000.00337.x
 
Silva AC, de Almeida BF, Soeiro CS, Ferreira WL, de Lima VM, Ciarlini PC (2013): Oxidative stress, superoxide production, and apoptosis of neutrophils in dogs with chronic kidney disease. Canadian Journal of Veterinary Research 77, 136–141.
 
Smogorzewski M, Massry SG (2001): Defects in B-cell function and metabolism in uremia: role of parathyroid hormone. Kidney International 78, S186–S189.
 
Soriano Sagrario, Mart&iacute;n-Malo Alejandro, Carracedo Julia, Ram&iacute;rez Rafael, Rodr&iacute;guez Mariano, Aljama Pedro (2005): Lymphocyte Apoptosis: Role of Uremia and Permeability of Dialysis Membrane. Nephron Clinical Practice, 100, c71-c77  https://doi.org/10.1159/000085051
 
Torrance A (2000): Overview of haematological diagnostic techniques. In: Day M, Mackin A, Littlewood J (eds): Manual of Canine and Feline Haematology and Transfusion Medicine. 1st edn. British Small Animal Veterinary Association, Gloucester. 3–17.
 
Vaziri Nosratola D., Pahl Madeleine V., Crum Albert, Norris Keith (2012): Effect of Uremia on Structure and Function of Immune System. Journal of Renal Nutrition, 22, 149-156  https://doi.org/10.1053/j.jrn.2011.10.020
 
Yoon J-W, Gollapudi S, Pahl M V, Vaziri N D (): Naïve and central memory T-cell lymphopenia in end-stage renal disease. Kidney International, 70, 371-376  https://doi.org/10.1038/sj.ki.5001550
 
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