Guinea pigs are common patients in veterinary clinics. Knowledge of the urine composition is necessary for the evaluation of their health. We, therefore, analysed the urine of fifty guinea pigs, thirty-two males, and eighteen females, aged between four months and seven years. None of these guinea pigs showed clinical signs of urinary tract diseases. The urine samples were obtained as part of a preventive check-up, during a regular dental check-up or another minor procedure. The urine was acquired by spontaneous micturition after inducing a short-term, light isoflurane anaesthesia. A macroscopic evaluation of the urine samples and a urine dipstick test were used for the preliminary examination. The average pH was determined to be 8.5 ± 0.5, and in three animals, moderate glycosuria was detected using the urine dipsticks. No urobilinogen, ketone bodies, haemoglobin, or blood traces were present in any of the samples. Severe proteinuria was detected in all the samples. The samples were subsequently evaluated in a laboratory for the following values: specific gravity 1 024.40 ± 1.83 kg/m3, osmolality 601.14 ± 52.28 mOsm/kg, total protein 290.16 ± 34.73 mg/l, albumin 12.04 ± 1.92 mg/l, glucose 0.77 ± 0.20 mmol/l, urea 217.60 ± 24.23 mmol/l, creatinine 3.98 ± 0.48 mmol/l, bilirubin 9.63 ± 1.73 μmol/l, calcium 6.14 ± 0.40 mmol/l, phosphorus 4.95 ± 1.30 mmol/l, magnesium 9.86 ± 0.57 mmol/l, sodium 49.15 ± 6.67 mmol/l, potassium 152.21 ± 10.62 mmol/l, chloride 51.14 ± 5.81 mmol/l, activity of gamma-glutamyltransferase 0.72 ± 0.14 μkat/l, alkaline phosphatase 0.56 ± 0.11 μkat/l and lactate dehydrogenase 0.68 ± 0.14 μkat/l. The descriptive values of the urine biochemical parameters of guinea pigs were determined for the first time in this study.
Ardiaca M, Montesinos A, Bonveho C. Urinary calcium excretion and urine turbidity does not affect the urine specific gravity readings by refractometry in rabbits (Oryctolagus cuniculus). Proceedings of the 1st International Conference on Avian, Herpetological and Exotic Mammal Medicine; 2013 Apr 20-26; Wiesbaden, Germany. Germany: VVB Laufersweiler Verlag; 2013. p. 456-8.
Bishop CR, Fischer J, Brossoit A, Pierson CH. Standardization of renal physiology parameters in guinea pigs via urinalysis. Proceedings of the 31st Annual AAV Conference & Expo with AEMV; 2010 Aug 1; San Diego, California, USA. San Diego, CA, USA: Association of Exotic Mammal Veterinarians; 2010. p. 49-52.
DeCubellis J. Common emergencies in rabbits, guinea pigs, and chinchillas. Vet Clin North Am Exot Anim Pract. 2016 May;19(2):411-29. https://doi.org/10.1016/j.cvex.2016.01.003
DiBartola SP, Westropp JL. Urinary tract disorders. In: Nelson RW, Couto CG, editors. Small animal internal medicine. 5th ed. St. Louis, USA: Elsevier-Mosby; 2014. p. 629-712.
Doss GA, Mans C, Houseright RA, Webb JL. Urinalysis in chinchillas (Chinchilla lanigera). J Am Vet Med Assoc. 2016 Apr 15;248(8):901-7. https://doi.org/10.2460/javma.248.8.901
Fisher PG. Exotic mammal renal disease: Diagnosis and treatment. Vet Clin North Am Exot Anim Pract. 2006 Jan;9(1):69-96. https://doi.org/10.1016/j.cvex.2005.10.002
Hesse A, Neiger R. Urinary stones in rabbits a guinea pigs. In: Hesse A, Neiger R, editors. Urinary stones in small animal medicine – A colour handbook. London, UK: Manson Publishing; 2009. p. 133-40.
Jenkins JR. Evaluation of the rabbit urinary tract. J Exot Pet Med. 2010 Oct;19(4):271-9. https://doi.org/10.1053/j.jepm.2010.10.006
Kawasaki K, Min X, Li X, Hasegawa E, Sakaguchi E. Transfer of blood urea nitrogen to cecal microbial nitrogen is increased by fructo-oligosaccharide feeding in guinea pigs. Anim Sci J. 2015 Jan;86(1):77-82.
Mancinelli E, Shaw DJ, Meredith AL. γ-Glutamyl-transferase (GGT) activity in the urine of clinically healthy domestic rabbits (Oryctolagus cuniculus). Vet Rec. 2012 Nov 10;171(19):475.
Melillo A. Rabbit clinical pathology. J Exot Pet Med. 2007 Jul;16(3):135-45. https://doi.org/10.1053/j.jepm.2007.06.002
Nabity MB. Re-evaluating urine dipstick protein in dogs: When should you be concerned? Adv Small Anim Med Surg. 2011 Nov;24(11):1-3. https://doi.org/10.1016/j.asams.2011.10.001
Ness RD. Clinical pathology and sample collection of exotic small mammals. Vet Clin North Am ExotAnimPract. 1999 Sep;2(3):591-620.
Ozkan C, Kaya A, Akgul Y. Normal values of haematological and some biochemical parameters in serum and urine of New Zealand white rabbits. World Rabbit Sci. 2012 Jun;20(4):253-9.
Parrah JD, Moulvi BA, Gazi MA, Makhdoomi DM, Athar H, Din MU, Dar S, Mir AQ. Importance of urinalysis in veterinary practice – A review. Vet World. 2013;6(9):640-6. https://doi.org/10.14202/vetworld.2013.640-646
Piech TL, Wycislo KL. Importance of urinalysis. Vet Clin North Am Small Anim Pract. 2019 Mar;49(2):233-45.
Quesenberry KE, Donnelly TM, Mans CH. Biology, husbandry, and clinical techniques of guinea pigs and chinchillas. In: Quesenberry KE, Carpenter JW, editors. Ferrets, rabbits and rodents: Clinical medicine and surgery. 3rd ed. St. Louis, USA: Elsevier; 2012. p. 279-94.
Reavill DR, Lennox AM. Disease overview of the urinary tract in exotic companion mammals and tips on clinical management. Vet Clin North Am Exot Anim Pract. 2020 Jan;23(1):169-93. https://doi.org/10.1016/j.cvex.2019.09.003
Riggs SM. Guinea pig. In: Mitchell MA, Tully TN, editors. Manual of exotic pet practice. St. Louis, USA: Elsevier; 2009. p. 456-73.
Rueloekke ML, Spangsberg R, Koch J. Establishment of normal values of urine protein/creatinine ratio in pet guinea pigs (Cavia porcellus). Proceedings of BSAVA Congress; 2016 Apr 7-10; Birmingham, UK. Quedgeley, Gloucester, England: British Small Animal Veterinary Association; 2016. p. 554.
Thornton PC, Wright PA, Sacra PJ, Goodier TE. The ferret, Mustela putorius furo, as a new species in toxicology. Lab Anim. 1979 Apr;13(2):119-24.
Wesche P. Rodents: Clinical pathology. In: Keeble E, Meredith A, editors. BSAVA manual of rodents and ferrets. Gloucester, UK: British Small Animal Veterinary Association; 2009. p. 42-51.
Williams BH. Non-infectious diseases. In: Suckow MA, Stevens KA, Wilson RP, editors. The laboratory rabbit, guinea pig, hamster and other rodents. Waltham, USA: Academic Press; 2012. p. 686-704.