Transscleral ultrasonographic measurements of the optic nerve sheath diameter and a regression analysis with morphometric measures of the globe in dogs

https://doi.org/10.17221/39/2019-VETMEDCitation:Vinas M., Zeyen U., D'Anna N., Vignoli M. (2019): Transscleral ultrasonographic measurements of the optic nerve sheath diameter and a regression analysis with morphometric measures of the globe in dogs. Veterinarni Medicina, 64: 490-496.
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To describe transscleral ultrasonography as a novel alternative approach for visualising the optic nerve sheath and measuring its diameter and to analyse the linear regressions of the optic nerve sheath diameter value with the weights and morphometric measurements of the globe in dogs. Forty healthy dogs admitted for routine sterilisation were examined. Under general anaesthesia, a B-mode ultrasonography with a linear probe (9–18 MHz) was applied transscleral in the dorso-temporal quadrant. The optic nerve sheath diameter was measured 3 mm behind the caudal aspect of the globe. The morphometric measurements, including the axial globe, lens thickness and vitreous chamber, were estimated by two observers using the direct corneal approach. Univariate and multivariate multiple linear regression analyses were performed to explore the associations of the independent predictors with dependent variables. The optic nerve sheath diameter intraclass correlation coefficient (ICC) analyses revealed interobserver 0.91 (ICC = 0.83–0.95) and intraobserver 0.93 (ICC = 0.87–0.96) reliability. The multiple regression analysis revealed that the optic nerve sheath diameter was associated with the weight (R2 = 0.60, P < 0.0001) but not with the axial globe (P = 0.48), the lens thickness (P = 0.73) or the vitreous chamber (P = 0.99). The findings of this study suggest that transscleral ultrasonography may be a valid alternative approach for the optic nerve visualisation and optic nerve sheath diameter measurements with excellent intra- and interobserver repeatability. The optic nerve sheath diameter was associated with the body weight, but not with the morphometric measurements of the globe.

References:
Bauerle J, Schuchardt F, Schroeder L, Egger K, Weigel M, Harloff A (2013): Reproducibility and accuracy of optic nerve sheath diameter assessment using ultrasound compared to magnetic resonance imaging. BMC Neurology 13. https://doi.org/10.1186/1471-2377-13-187
 
Boroffka SA, Gorig C, Auriemma E, Passon-Vastenburg MH, Voorhout G, Barthez PY (2008): Magnetic resonance imaging of canine optic nerve. Veterinary Radiology and Ultrasound 49, 540–544.  https://doi.org/10.1111/j.1740-8261.2008.00427.x
 
Cavallotti C, Pacella E, Pescosolido N, Tranquilli-Leali FM, Feher J (2002): Age-related changes in the human optic nerve. Canadian Journal of Ophthalmology 37, 389–394. https://doi.org/10.1016/S0008-4182(02)80040-0
 
Cooley SD, Scrivani PV, Thompson MS, Irby NL, Divers TJ, Erb HN (2016): Correlations among ultrasonographic measurements of optic nerve sheath diameter, age, and body weight in clinically normal horses. Veterinary Radiology and Ultrasound 57, 49–57.  https://doi.org/10.1111/vru.12300
 
East L, Lyon M, Agrawal P, Islam Z, Newell M, Hockman T, Heger IM, Xu H, Kuchinski AM, Gibson RW (2019): Increased intracranial pressure damages optic nerve structural support. Journal of Neurotrauma. https://doi.org/10.1089/neu.2019.6490
 
Geeraerts T, Merceron S, Benhamou D, Vigue B, Duranteau J (2008): Non-invasive assessment of intracranial pressure using ocular sonography in neurocritical care patients. Intensive Care Medicine 34, 2062–2067. https://doi.org/10.1007/s00134-008-1149-x
 
Gonzalez EM, Rodriguez A, Garcia I (2001): Review of ocular ultrasonography. Veterinary Radiology and Ultrasound 42, 485–495. https://doi.org/10.1111/j.1740-8261.2001.tb00975.x
 
Ilie LA, Thomovsky EJ, Johnson PA, Bentley RT, Heng HG, Lee HC, Moore GE (2015): Relationship between intracranial pressure as measured by an epidural intracranial pressure monitoring system and optic nerve sheath diameter in healthy dogs. American Journal of Veterinary Research 76, 724–731. https://doi.org/10.2460/ajvr.76.8.724
 
Lee HC, Choi HJ, Choi MC, Yoon JH (2003): Ultrasonographic measurement of optic nerve sheath diameter in normal dogs. Journal of Veterinary Science 4, 265–268.  https://doi.org/10.4142/jvs.2003.4.3.265
 
Padayachy LC, Padayachy V, Galal U, Pollock T, Fieggen AG (2016): The relationship between transorbital ultrasound measurement of the optic nerve sheath diameter (ONSD) and invasively measured ICP in children. Child’s Nervous System 32, 1779–1785.  https://doi.org/10.1007/s00381-016-3068-4
 
Raboel PH, Bartek Jr J, Andresen M, Bellander BM, Romner B (2012): Intracranial pressure monitoring: Invasive versus non-invasive methods. Critical Care Research and Practice. doi: 10.1155/950393.
 
Raffiz M, Abdullah JM (2017): Optic nerve sheath diameter measurement: a means of detecting raised ICP in adult traumatic and non-traumatic neurosurgical patients. The American Journal of Emergency Medicine 35, 150–153. https://doi.org/10.1016/j.ajem.2016.09.044
 
Rajajee V, Vanaman M, Fletcher JJ, Jacobs TL (2011): Optic nerve ultrasound for the detection of raised intracranial pressure. Neurocritical Care 15, 506–515. https://doi.org/10.1007/s12028-011-9606-8
 
Smith JJ, Fletcher DJ, Cooley SD, Thompson MS (2018): Transpalpebral ultrasonographic measurement of the optic nerve sheath diameter in healthy dogs. Journal of Veterinary Emergency Critical Care 28, 31–38. https://doi.org/10.1111/vec.12677
 
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