Improvement of systemic lupus erythematosus in dogs with canine adipose-derived stem cells M., Kim T., Kim Y., Kim D., Ahn J., Kang B., Choi S., Park I., Choi J., Chung J. (2019): Improvement of systemic lupus erythematosus in dogs with canine adipose-derived stem cells. Veterinarni Medicina, 64: 462-466.
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A 6-year-old, intact female, Maltese presented with limited movement of the hind limbs and intermittent pruritus for three months. The patient was diagnosed with systemic lupus erythematosus. Conventional immunosuppressive therapy was attempted for 70 days; however, the patient still suffered from life-threatening pancreatitis and hepatopathy. Therefore, we tried canine adipose-derived mesenchymal stem cells for immunomodulation and liver protection. After 6-months of the stem cell therapy, the patient’s walking and hepatopathy improved. These findings indicate that stem cell therapy may be another option for systemic lupus erythematosus in dogs.

Bastida G, Nos P, Aguas M, Beltran B, Rubin A, Dasi F, Ponce J (2005): Incidence, risk factors and clinical course of thiopurine-induced liver injury in patients with inflammatory bowel disease. Alimentary Pharmacology and Therapeutics 22, 775–782.
Cheng K, Benten D, Bhargava K, Inada M, Joseph B, Palestro C, Gupta S (2009): Hepatic targeting and biodistribution of human fetal liver stem/progenitor cells and adult hepatocytes in mice. Hepatology 50, 1194–1203.
Costa O, Fournel C, Lotchouang E, Monier JC, Fontaine M (1984): Specificities of antinuclear antibodies detected in dogs with systemic lupus erythematosus. Veterinary Immunology and Immunopathology 7, 369–382.
Ettinger SJ, Feldman EC (2005): Textbook of Veterinary Internal Medicine: Diseases of the Dog and the Cat. 6th edn. Elsevier Saunders, St. Louis, Mo.
Fournel C, Chabanne L, Caux C, Faure JR, Rigal D, Magnol JP, Monier JC (1992): Canine systemic lupus erythematosus. I: A study of 75 cases. Lupus 1, 133–139.
Gisbert JP, Luna M, Gonzalez-Lama Y, Pousa ID, Velasco M, Moreno-Otero R, Mate J (2007): Liver injury in inflammatory bowel disease: long-term follow-up study of 786 patients. Inflammatory Bowel Diseases 13, 1106–1114.
Jones DR (1993): Canine systemic lupus erythematosus: new insights and their implications. Journal of Comparative Pathology 108, 215–228.
Kim SJ, Park KC, Lee JU, Kim KJ, Kim DG (2011): Therapeutic potential of adipose tissue-derived stem cells for liver failure according to the transplantation routes. Journal of the Korean Surgical Society 81, 176–186.
Ko M, Lee KY, Kim SH, Kim M, Choi JH, Im W, Chung JY (2018): Flow cytometric immunophenotyping of canine adipose-derived mesenchymal stem cells (ADMSCs) and feline ADMSCs using anti-human antibodies. Korean Journal of Veterinary Research 58, 33–37.
Mokbel A, El-Tookhy O, Shamaa AA, Sabry D, Rashed L, Mostafa A (2011): Homing and efficacy of intra-articular injection of autologous mesenchymal stem cells in experimental chondral defects in dogs. Clinical and Experimental Rheumatology 29, 275–284.
Phillips CD, Wongsaisri P, Htut T, Grossman T (2017): Purified umbilical cord derived mesenchymal stem cell treatment in a case of systemic lupus erythematosus. Clinical and Translational Medicine 6. doi: 10.1186/s40169-017-0161-6.
Quintanilha LF, Takami T, Hirose Y, Fujisawa K, Murata Y, Yamamoto N, Goldenberg RC, Terai S, Sakaida I (2014): Canine mesenchymal stem cells show antioxidant properties against thioacetamide-induced liver injury in vitro and in vivo. Hepatology Research 44, E206–E217.
Stewart MC, Stewart AA (2011): Mesenchymal stem cells: characteristics, sources, and mechanisms of action. Veterinary Clinics of North America: Equine Practice 27, 243–261.
Trzil JE, Masseau I, Webb TL, Chang CH, Dodam JR, Liu H, Quimby JM, Dow SW, Reinero CR (2016): Intravenous adipose-derived mesenchymal stem cell therapy for the treatment of feline asthma: A pilot study. Journal of Feline Medicine and Surgery 18, 981–990.
Villatoro AJ, Fernandez V, Claros S, Rico-Llanos GA, Becerra J, Andrades JA (2015): Use of adipose-derived mesenchymal stem cells in keratoconjunctivitis sicca in a canine model. Biomed Research International, 2015. doi: 10.1155/2015/527926.
Wallisch K, Trepanier LA (2015): Incidence, timing, and risk factors of azathioprine hepatotoxicosis in dogs. Journal of Veterinary Internal Medicine 29, 513–518.
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