A simplified superovulation protocol using split-single administration of Folltropin®-V in hyaluronan: application to purebred sheep

https://doi.org/10.17221/52/2016-VETMEDCitation:Panyaboriban S., Suwimonteerabutr J., Swangchan-Uthai T., Tharasanit T., Suthikrai W., Suadsong S., Techakumphu M. (2018): A simplified superovulation protocol using split-single administration of Folltropin®-V in hyaluronan: application to purebred sheep. Veterinarni Medicina, 63: 321-328.
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Superovulation is an important step in assisted reproductive technology. Due to its short half-life, follicle stimulating hormone is usually given twice daily to ewes for three to five days, which is both time- and labour-intensive. However, dissolving follicle stimulating hormone in degradable polymers to delay absorbtion has been effective in ruminants. Experiment 1 was performed to compare a split-single follicle stimulating hormone dissolved in hyaluronan (S group; 150 mg follicle stimulating hormone on the first day and 30 mg 48 h later; n = 21) and six decreasing doses of follicle stimulating hormone (M group; 50, 50, 30, 30, 10 and 10 mg; n = 22) at 12-h intervals. Ovarian responses and numbers of recovered ova/embryos did not differ significantly between groups. However, there tended to be more Grade 1 and 2 embryos in S vs M groups (mean ± SEM, 5.1 ± 4.9 vs 2.9 ± 2.9, respectively; = 0.08). Experiment 2 tested the effectiveness of a simplified split-single follicle stimulating hormone in purebred sheep on a commercial farm. The numbers of recovered good-grade embryos (day 2) were 4.8 ± 5.0 and 4.0 ± 2.5 per donors in Corriedale and Bond sheep breeds, respectively. We conclude that this modified technique for ewe superovulation improved animal welfare, reduced animal handling and labour and yielded results similar to or better than conventional twice-daily follicle stimulating hormone treatments.

References:
Alvarez RH, Martinez AC, Pires RML (2010): Superovulatory Response of Zebu Cows Treated with pFSH in a Single Subcutaneous Injection Followed by an Additional Intramuscular Sub-Dose 48 h Later. Reproduction in Domestic Animals, 45, 421-424  https://doi.org/10.1111/j.1439-0531.2008.01209.x
 
Anakkul N, Suwimonteerabutr J, Tharasanit T, Panyaboriban S, Khunmanee S, Thanomsuksinchai N, Techakumphu M (2013): Production of black goat using laparoscopic artificial insemination and embryo transfer. The Thai Journal of Veterinary Medicine 43, 259–263.
 
Bo G.A., Hockley D.K., Nasser L.F., Mapletoft R.J. (1994): Superovulatory response to a single subcutaneous injection of Folltropin-V in beef cattle. Theriogenology, 42, 963-975  https://doi.org/10.1016/0093-691X(94)90119-4
 
Cascone M. G., Di Silvio L., Sim B., Downes S. (1994): Collagen and hyaluronic acid based polymeric blends as drug delivery systems for the release of physiological concentrations of growth hormone. Journal of Materials Science: Materials in Medicine, 5, 770-774  https://doi.org/10.1007/BF00120374
 
Catanzaro Joseph M., Smith J. Graham (1991): Propylene glycol dermatitis. Journal of the American Academy of Dermatology, 24, 90-95  https://doi.org/10.1016/0190-9622(91)70018-W
 
CHASOMBAT Jakkhaphan, SAKHONG Denpong, NAGAI Takashi, PARNPAI Rangsun, VONGPRALUB Thevin (2013): Superstimulation of Follicular Growth in Thai Native Heifers by a Single Administration of Follicle Stimulating Hormone Dissolved in Polyvinylpyrrolidone. Journal of Reproduction and Development, 59, 214-218  https://doi.org/10.1262/jrd.2012-119
 
Cho K (2003): Release of ciprofloxacin from poloxamer-graft-hyaluronic acid hydrogels in vitro. International Journal of Pharmaceutics, 260, 83-91  https://doi.org/10.1016/S0378-5173(03)00259-X
 
Cognie Y (1999): State of the art in sheep-goat embryo transfer. Theriogenology, 51, 105-116  https://doi.org/10.1016/S0093-691X(98)00235-0
 
D’Alessandro A.G, Martemucci G, Colonna M.A, Borghese A, Terzano M.G, Bellitti A (2001): Superovulation in ewes by a single injection of pFSH dissolved in polyvinylpyrrolidone (PVP): effects of PVP molecular weight, concentration and schedule of treatment. Animal Reproduction Science, 65, 255-264  https://doi.org/10.1016/S0378-4320(01)00080-X
 
Dattena M., Vespignani S., Branca A., Gallus M., Ledda S., Naitana S., Cappai P. (1994): Superovulatory response and quality of embryos recovered from anestrus ewes after a single injection of porcine FSH dissolved in polyvinylpyrrolidone. Theriogenology, 42, 235-239  https://doi.org/10.1016/0093-691X(94)90267-4
 
Evans G., Robinson T. J. (1980): The control of fertility in sheep: endocrine and ovarian responses to progestagen-PMSG treatment in the breeding season and in anoestrus. The Journal of Agricultural Science, 94, 69-  https://doi.org/10.1017/S002185960002791X
 
Ganaie B.A., Khan M.Z., Islam R., Makhdoomi D.M., Qureshi S., Wani G.M. (2009): Evaluation of different techniques for pregnancy diagnosis in sheep. Small Ruminant Research, 85, 135-141  https://doi.org/10.1016/j.smallrumres.2009.09.003
 
Gherardi R. K. (): Macrophagic myofasciitis lesions assess long-term persistence of vaccine-derived aluminium hydroxide in muscle. Brain, 124, 1821-1831  https://doi.org/10.1093/brain/124.9.1821
 
Gonzalo Ma, De Argila D, García Jm, Alvarado Mi (1999): Allergic contact dermatitis to propylene glycol. Allergy, 54, 82-83  https://doi.org/10.1034/j.1398-9995.1999.00047.x
 
Goto K., Ohkutsu S., Nakanishi Y., Ogawa K., Tasaki M., Ohta H., Inohae S., Tateyama S., Kawabata T., Ishii S., Miyamoto A., Furusawa T., Umezu M., Masaki J. (1988): Endocrine profiles and embryo quality in superovulated Japanese Black cattle. Theriogenology, 29, 615-629  https://doi.org/10.1016/S0093-691X(88)80009-8
 
Kamonpatana M, Luvira Y, Bodhipaksha P, Kunawongkrit A (1976): Serum progesterone, 17a-hydroxyprogesterone and 17-b oestradiol during oestrous cycle in swamp buffalo in thailand: A preliminary report. Proceedings of the International Symposium on Nuclear Techniques in Animal Production and Health as Related to the Soil Plant System International Atomic Energy Agency. 569–578.
 
Kim Mee Ryang, Park Tae Gwan (2002): Temperature-responsive and degradable hyaluronic acid/Pluronic composite hydrogels for controlled release of human growth hormone. Journal of Controlled Release, 80, 69-77  https://doi.org/10.1016/S0168-3659(01)00557-0
 
Kimura Koji, Hirako Makoto, Iwata Hisataka, Aoki Mari, Kawaguchi Mamoru, Seki Makoto (2007): Successful superovulation of cattle by a single administration of FSH in aluminum hydroxide gel. Theriogenology, 68, 633-639  https://doi.org/10.1016/j.theriogenology.2007.02.016
 
Lee Yuhan, Chung Hyun Jung, Yeo Sangho, Ahn Cheol-Hee, Lee Haeshin, Messersmith Phillip B., Park Tae Gwan (2010): Thermo-sensitive, injectable, and tissue adhesive sol–gel transition hyaluronic acid/pluronic composite hydrogels prepared from bio-inspired catechol-thiol reaction. Soft Matter, 6, 977-  https://doi.org/10.1039/b919944f
 
Lehr Claus-Michael, Haas Jochen (2005): Developments in the area of bioadhesive drug delivery systems. Expert Opinion on Biological Therapy, 2, 287-298  https://doi.org/10.1517/14712598.2.3.287
 
Lopez-Sebastian A., Gomez-Brunet A., Lishman A. W., Johnson S. K., Inskeep E. K. (1993): Modification by propylene glycol of ovulation rate in ewes in response to a single injection of FSH. Reproduction, 99, 437-442  https://doi.org/10.1530/jrf.0.0990437
 
Luo Yi, Kirker Kelly R, Prestwich Glenn D (2000): Cross-linked hyaluronic acid hydrogel films: new biomaterials for drug delivery. Journal of Controlled Release, 69, 169-184  https://doi.org/10.1016/S0168-3659(00)00300-X
 
Bacelar MARQUES Igor Denizarde, PINHEIRO Karina França, de Freitas do CARMO Lílian Pires, COSTA Maristela Carvalho, ABENSUR Hugo (2011): Anaphylactic reaction induced by a polysulfone/polyvinylpyrrolidone membrane in the 10th session of hemodialysis with the same dialyzer. Hemodialysis International, 15, 399-403  https://doi.org/10.1111/j.1542-4758.2011.00553.x
 
Mayorga I., Mara L., Sanna D., Stelletta C., Morgante M., Casu S., Dattena M. (2011): Good quality sheep embryos produced by superovulation treatment without the use of progesterone devices. Theriogenology, 75, 1661-1668  https://doi.org/10.1016/j.theriogenology.2010.12.029
 
Oh Eun Ju, Park Kitae, Kim Ki Su, Kim Jiseok, Yang Jeong-A, Kong Ji-Hyun, Lee Min Young, Hoffman Allan S., Hahn Sei Kwang (2010): Target specific and long-acting delivery of protein, peptide, and nucleotide therapeutics using hyaluronic acid derivatives. Journal of Controlled Release, 141, 2-12  https://doi.org/10.1016/j.jconrel.2009.09.010
 
Panyaboriban S, Suwimonteerabutr J, Phutikanit N, Swangchan-Uthai T, Tharasanit T, Techakumphu M (2015): Effect of various combinations of sugar supplementation in the extender on frozen-thawed ram semen quality and fertility. The Thai Journal of Veterinary Medicine 45, 229.
 
Radice M., Brun P., Cortivo R., Scapinelli R., Battaliard C., Abatangelo G. (2000): Hyaluronan-based biopolymers as delivery vehicles for bone-marrow-derived mesenchymal progenitors. Journal of Biomedical Materials Research, 50, 101-109  https://doi.org/10.1002/(SICI)1097-4636(200005)50:2<101::AID-JBM2>3.0.CO;2-M
 
Satoh H., Numabe T., Takada T., Oikawa T., Kifune A., Watanabe G., Taya K. (1996): Superovulation in Japanese beef cows using polyvinylpyrolidone(PVP) as the vehicle for porcine FSH(pFSH). Theriogenology, 45, 332-  https://doi.org/10.1016/0093-691X(96)84805-9
 
Sharma V.K., Gupta R.C., Khar S.K., Khurana N.K. (1993): Plasma progesterone profiles, ovarian response and embryo recovery in crossbred ewes superovulated during breeding and non-breeding seasons. Animal Reproduction Science, 34, 119-126  https://doi.org/10.1016/0378-4320(93)90070-8
 
Shaw Christopher A., Petrik Michael S. (2009): Aluminum hydroxide injections lead to motor deficits and motor neuron degeneration. Journal of Inorganic Biochemistry, 103, 1555-1562  https://doi.org/10.1016/j.jinorgbio.2009.05.019
 
Shin Sang Tae, Jang Sung Keun, Yang Hong Suk, Lee Ok Keun, Shim Yhong Hee, Choi Won Il, Lee Doo Soo, Lee Gwan Sun, Cho Jong Ki, Lee Young Won (2008): Laparoscopy vs. laparotomy for embryo transfer to produce transgenic goats (Capra hircus). Journal of Veterinary Science, 9, 103-  https://doi.org/10.4142/jvs.2008.9.1.103
 
Sugano Mikio, Shinogi Tadashi (1999): Superovulation induction in Japanese Black cattle by a single intramuscular injection of hMG or FSH dissolved in polyvinylpyrrolidone. Animal Reproduction Science, 55, 175-181  https://doi.org/10.1016/S0378-4320(99)00019-6
 
Takedomi T., Aoyagi Y., Konishi M., Kishi H., Taya K., Watanabe G., Sasamoto S. (1995): Superovulation of holstein heifers by a single subcutaneous injection of FSH dissolved in polyvinylpyrrolidone. Theriogenology, 43, 1259-1268  https://doi.org/10.1016/0093-691X(95)00097-R
 
Thomas F. H., Walters K. A., Telfer E. E. (2003): How to make a good oocyte: an update on in-vitro models to study follicle regulation. Human Reproduction Update, 9, 541-555  https://doi.org/10.1093/humupd/dmg042
 
Tríbulo Andrés, Rogan Dragan, Tribulo Humberto, Tribulo Ricardo, Alasino Roxana V., Beltramo Dante, Bianco Ismael, Mapletoft Reuben J., Bó Gabriel A. (2011): Superstimulation of ovarian follicular development in beef cattle with a single intramuscular injection of Folltropin-V. Animal Reproduction Science, 129, 7-13  https://doi.org/10.1016/j.anireprosci.2011.10.013
 
Tríbulo Andrés, Rogan Dragan, Tríbulo Humberto, Tríbulo Ricardo, Mapletoft Reuben J., Bó Gabriel A. (2012): Superovulation of beef cattle with a split-single intramuscular administration of Folltropin-V in two concentrations of hyaluronan. Theriogenology, 77, 1679-1685  https://doi.org/10.1016/j.theriogenology.2011.12.013
 
Upadhyay Kamal K., Bhatt Anant N., Mishra Anil K., Dwarakanath Bilikere S., Jain Sanyog, Schatz Christophe, Le Meins Jean-François, Farooque Abdullah, Chandraiah Godugu, Jain Amit K., Misra Ambikanandan, Lecommandoux Sébastien (2010): The intracellular drug delivery and anti tumor activity of doxorubicin loaded poly(γ-benzyl l-glutamate)-b-hyaluronan polymersomes. Biomaterials, 31, 2882-2892  https://doi.org/10.1016/j.biomaterials.2009.12.043
 
Wright J (1998): Photographic illustrations of embryo developmental stage and quality codes. Manual of the International Embryo Transfer Society 3, 167–170.
 
Yamamoto M., Ooe M., Kawaguchi M., Suzuki T. (1994): Superovulation in the cow with a single intramuscular injection of FSH dissolved in polyvinylpyrrolidone. Theriogenology, 41, 747-755  https://doi.org/10.1016/0093-691X(94)90184-K
 
YAMAMOTO Masao, OOE Masato, KAWAGUCHI Mamoru, SUZUKI Tatsuyuki (): Dose Response to a Single Intramuscular Injection of FSH Dissolved in Polyvinylpyrrolidone for Superovulation in Cows.. Journal of Reproduction and Development, 41, 93-96  https://doi.org/10.1262/jrd.41.93
 
Yoshida Koichi, Sakurai Yoshihiko, Kawahara Shingo, Takeda Tomohiro, Ishikawa Tomoaki, Murakami Tomohiko, Yoshioka Akira (2008): Anaphylaxis to Polyvinylpyrrolidone in Povidone-Iodine for Impetigo Contagiosum in a Boy with Atopic Dermatitis. International Archives of Allergy and Immunology, 146, 169-173  https://doi.org/10.1159/000113522
 
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