Dandy-Walker malformation in Polish hunting dogs: long term prognosis and quality of life

Citation:Kwiatkowska M., Rose J., Pomianowski A. (2019): Dandy-Walker malformation in Polish hunting dogs: long term prognosis and quality of life. Veterinarni Medicina, 64: 37-43.
supplementary materialdownload PDF

In the last few years, it has become easier to diagnose congenital brain malformations in dog’s ante-mortem. This is probably due to the wider availability of advanced diagnostic imaging, in particular computed tomography or magnetic resonance imaging (MRI). Despite this, there is still not much literature available about potential treatments, outcome and overall prognosis with respect to the patient’s quality of life. We present three cases of Dandy-Walker malformation in Polish hunting dogs with up to five years follow up including assessment of their quality of life. A nine-week-old Polish hunting dog was presented with progressive signs of ataxia that had developed over the preceding few weeks. MRI revealed a Dandy-Walker malformation. The dog underwent MRI at the ages of 12 and 36 months, and his neurological condition was followed for five years. No other subsequent abnormities were found on further diagnostic tests. The dog showed transient behavioural problems which improved after castration and training. The ataxia seen at first visit improved with time and intensive physiotherapy, and the dog was considered to have a good quality of life in the owner’s eyes. A further two cases shared a similar disease course. Dandy-Walker malformation was confirmed with MRI, but diagnostic imaging could not be reported here because the owner did not consent to publication. The Dandy-Walker malformations described in these three Polish hunting dogs had a stable disease course and revealed that dogs suffering from this condition may have a good quality of life, providing no other abnormalities are detected and rehabilitation is performed.

References:
Bernardino Filipa, Rentmeister Kai, Schmidt Martin J., Bruehschwein Andreas, Matiasek Kaspar, Matiasek Lara A., Lauda Alexander, Schoon Heinz A., Fischer Andrea, de Castro Fernando (2015): Inferior Cerebellar Hypoplasia Resembling a Dandy-Walker-Like Malformation in Purebred Eurasier Dogs with Familial Non-Progressive Ataxia: A Retrospective and Prospective Clinical Cohort Study. PLOS ONE, 10, e0117670- https://doi.org/10.1371/journal.pone.0117670
 
Bindal Ajay K., Storrs Bruce B., McLone David G. (1990): Management of the Dandy-Walker Syndrome. Pediatric Neurosurgery, 16, 163-169 https://doi.org/10.1159/000120518
 
Boddaert N., Klein O., Ferguson N., Sonigo P., Parisot D., Hertz-Pannier L., Baraton J., Emond S., Simon I., Chigot V., Schmit P., Pierre-Kahn A., Brunelle F. (2003): Intellectual prognosis of the Dandy-Walker malformation in children: the importance of vermian lobulation. Neuroradiology, 45, 320-324 https://doi.org/10.1007/s00234-003-0980-6
 
BOLDUC MARIE-EVE, LIMPEROPOULOS CATHERINE (2009): Neurodevelopmental outcomes in children with cerebellar malformations: a systematic review. Developmental Medicine & Child Neurology, 51, 256-267 https://doi.org/10.1111/j.1469-8749.2008.03224.x
 
CHOI HOJUNG, KANG SANGKYU, JEONG SEONGMOK, CHO SUNGWHAN, LEE KICHANG, EOM KIDONG, LEE HEECHUN, CHANG DONGWOO, YOON JUNGHEE, LEE YOUNGWON (2007): IMAGING DIAGNOSIS?CEREBELLAR VERMIS HYPOPLASIA IN A MINIATURE SCHNAUZER. Veterinary Radiology & Ultrasound, 48, 129-131 https://doi.org/10.1111/j.1740-8261.2007.00217.x
 
Ecker Jeffrey L., Shipp Thomas D., Bromley Bryann, Benacerraf Beryl (2000): The sonographic diagnosis of Dandy-Walker and Dandy-Walker variant: associated findings and outcomes. Prenatal Diagnosis, 20, 328-332 https://doi.org/10.1002/(SICI)1097-0223(200004)20:4<328::AID-PD806>3.0.CO;2-O
 
Estey Chelsie M. (2016): Congenital Hydrocephalus. Veterinary Clinics of North America: Small Animal Practice, 46, 217-229 https://doi.org/10.1016/j.cvsm.2015.10.003
 
Golden Jeffrey A., Rorke Lucy B., Bruce Derek A. (2004): Dandy-Walker Syndrome and Associated Anomalies. Pediatric Neurosurgery, 13, 38-44 https://doi.org/10.1159/000120299
 
Hart M. N., Malamud N., Ellis W. G. (1972): The Dandy-Walker syndrome: A clinicopathological study based on 28 cases. Neurology, 22, 771-771 https://doi.org/10.1212/WNL.22.8.771
 
Hirsch Jean-François, Pierre-Kahn Alain, Renier Dominique, Sainte-Rose Christian, Hoppe-Hirsch Elizabeth (1984): The Dandy-Walker malformation. Journal of Neurosurgery, , 515-522 https://doi.org/10.3171/jns.1984.61.3.0515
 
Klein O., Pierre-Kahn A., Boddaert N., Parisot D., Brunelle F. (2003): Dandy-Walker malformation: prenatal diagnosis and prognosis. Child's Nervous System, 19, 484-489 https://doi.org/10.1007/s00381-003-0782-5
 
Kornegay J. N. (2016): Cerebellar Vermian Hypoplasia in Dogs. Veterinary Pathology, 23, 374-379 https://doi.org/10.1177/030098588602300405
 
Lazzerini K., Gutierrez-Quintana R., José-López R., McConnell F., Gonçalves R., McMurrough J., De Decker S., Muir C., Priestnall S.L., Mari L., Stabile F., De Risio L., Loeffler C., Tauro A., Rusbridge C., Rodenas S., Añor S., de la Fuente C., Fischer A., Bruehschwein A., Penderis J., Guevar J. (2017): Clinical Features, Imaging Characteristics, and Long-term Outcome of Dogs with Cranial Meningocele or Meningoencephalocele. Journal of Veterinary Internal Medicine, 31, 505-512 https://doi.org/10.1111/jvim.14638
 
Lim Ji-Hey, Kim Dae-Yong, Yoon Jung-hee, Kim Wan Hee, Kweon Oh-kyeong (2008): Cerebellar vermian hypoplasia in a Cocker Spaniel. Journal of Veterinary Science, 9, 215- https://doi.org/10.4142/jvs.2008.9.2.215
 
Limperopoulos Catherine, du Plessis Adré J (2006): Disorders of cerebellar growth and development. Current Opinion in Pediatrics, 18, 621-627 https://doi.org/10.1097/MOP.0b013e32801080e8
 
MacKillop E (2011): Magnetic resonance imaging of intracranial malformations in dogs and cats Veterinary Radiology and Ultrasound 52, S42–S51.
 
Murray Jeffrey C., Johnson Jennifer A., Bird Thomas D. (1985): Dandy-Walker malformation: etiologic heterogeneity and empiric recurrence risks. Clinical Genetics, 28, 272-283 https://doi.org/10.1111/j.1399-0004.1985.tb00401.x
 
Patek KJ, Kline-Fath BM, Hopkin RJ, Pilipenko W, Crombleholme TM, Spaeth CG (2012): Posterior fossa anomalies diagnosed with fetal MRI: Associated anomalies and neurodevelopmental outcomes Prenatal Diagnosis 32, 75–82.
 
Sawaya Raymond, McLaurin Robert L. (1981): Dandy-Walker syndrome. Journal of Neurosurgery, , 89-98 https://doi.org/10.3171/jns.1981.55.1.0089
 
Schmid V, Lang J, Wolf M (1992): Dandy-Walker-like syndrome in four dogs: cisternography as a diagnostic aid. Journal of American Animal Hospital Association 28, 355–360.
 
SCHMIDT MARTIN JÜRGEN, JAWINSKI SEBASTIAN, WIGGER ANTJE, KRAMER MARTIN (2008): IMAGING DIAGNOSIS—DANDY WALKER MALFORMATION. Veterinary Radiology & Ultrasound, 49, 264-266 https://doi.org/10.1111/j.1740-8261.2008.00362.x
 
Summers BA, Cummings JF, deLahunta A (1995): Malformations of the central nervous system. In: Summers BA, Cummings JF, deLahunta A (eds): Veterinary Neuropathology. Mosby, St Louis. 86.
 
supplementary materialdownload PDF

© 2019 Czech Academy of Agricultural Sciences