Induction of atopic dermatitis by epicutaneous sensitisation with Dermatophagoides farinae in nongenetically predisposed Beagle dogs

https://doi.org/10.17221/58/2020-VETMEDCitation:

Jeong Y, Yun T, Kim H, Koo Y, Kang JH, Yang MP, Kang BT (2021): Induction of atopic dermatitis by epicutaneous sensitisation with Dermatophagoides farinae in nongenetically predisposed Beagle dogs. Vet Med-Czech 66, 413–422.

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This study was performed to induce atopic dermatitis (AD) using nongenetically predisposed Beagle dogs. Five healthy Beagle dogs were used. Twice weekly for 12 weeks, the dogs were painted on the axillae and groin with a solution of Dermatophagoides farinae (D. farinae). Each dog was thereafter placed in a cage where a house dust mite (HDM) solution was applied on the bottom of the cage. The dog remained in the cage for 3 h daily for 3 consecutive days for the environmental exposure to HDM. Serum samples were collected at 0 week and 6 weeks after sensitisation, and at 0 h and 72 h after the environmental exposure. During the environmental exposure, skin biopsies were obtained at 0 h, 36 h, and 72 hours. After the first environmental exposure, no dog had any marked clinical sign. An additional sensitisation was subsequently administered for 10–13 weeks. Three of the five dogs developed pruritic dermatitis with skin lesions after the second exposure. The histopathology of the lesions revealed severe infiltration of inflammatory cells and dermal oedema. The levels of D. farinae-specific IgE were also elevated. This study demonstrated that AD could be induced by epicutaneous sensitisation with HDM in nongenetically predisposed dogs.

References:
Akdis CA, Akdis M. Immunological differences between intrinsic and extrinsic types of atopic dermatitis. Clin Exp Allergy. 2003 Dec;33(12):1618-21. https://doi.org/10.1111/j.1365-2222.2003.01803.x
 
Bizikova P, Pucheu-Haston CM, Eisenschenk MN, Marsella R, Nuttall T, Santoro D. Review: Role of genetics and the environment in the pathogenesis of canine atopic dermatitis. Vet Dermatol. 2015 Apr;26(2):95-e26. https://doi.org/10.1111/vde.12198
 
de Weck AL, Mayer P, Stumper B, Schiessl B, Pickart L. Dog allergy, a model for allergy genetics. Int Arch Allergy Immunol. 1997 May-Jul;113(1-3):55-7. https://doi.org/10.1159/000237507
 
Egli KS, Schiessl B, Roosje PJ, Seewald W, Forster U, Peel JE, Welle MM. Evaluation of the usefulness of sensitization to aeroallergens as a model for canine atopic dermatitis in genetically predisposed Beagles. Am J Vet Res. 2002 Sep;63(9):1329-36. https://doi.org/10.2460/ajvr.2002.63.1329
 
Halliwell R. Revised nomenclature for veterinary allergy. Vet Immunol Immunopathol. 2006 Dec 15;114(3-4):207-8. https://doi.org/10.1016/j.vetimm.2006.08.013
 
Hill PB, Moriello KA, DeBoer DJ. Concentrations of total serum IgE, IgA, and IgG in atopic and parasitized dogs. Vet Immunol Immunopathol. 1995 Jan;44(2):105-13. https://doi.org/10.1016/0165-2427(94)05298-7
 
Hillier A, DeBoer DJ. The ACVD task force on canine atopic dermatitis (XVII): Intradermal testing. Vet Immunol Immunopathol. 2001 Sep 20;81(3-4):289-304. https://doi.org/10.1016/S0165-2427(01)00313-0
 
Hirshman CA, Malley A, Downes H. Basenji-Greyhound dog model of asthma: Reactivity to Ascaris suum, citric acid, and methacholine. J Appl Physiol Respir Environ Exerc Physiol. 1980 Dec;49(6):953-7. https://doi.org/10.1152/jappl.1980.49.6.953
 
Irvine AD, McLean WH, Leung DY. Filaggrin mutations associated with skin and allergic diseases. N Engl J Med. 2011 Oct 6;365(14):1315-27. https://doi.org/10.1056/NEJMra1011040
 
Leung DY, Jain N, Leo HL. New concepts in the pathogenesis of atopic dermatitis. Curr Opin Immunol. 2003 Dec;15(6):634-8. https://doi.org/10.1016/j.coi.2003.09.009
 
Marsella R, Girolomoni G. Canine models of atopic dermatitis: A useful tool with untapped potential. J Invest Dermatol. 2009 Oct;129(10):2351-7. https://doi.org/10.1038/jid.2009.98
 
Marsella R, Olivry T, Nicklin C, Lopez J. Pilot investigation of a model for canine atopic dermatitis: Environmental house dust mite challenge of high-IgE-producing Beagles, mite hypersensitive dogs with atopic dermatitis and normal dogs. Vet Dermatol. 2006a Feb;17(1):24-35. https://doi.org/10.1111/j.1365-3164.2005.00496.x
 
Marsella R, Nicklin C, Lopez J. Studies on the role of routes of allergen exposure in high IgE-producing Beagle dogs sensitized to house dust mites. Vet Dermatol. 2006b Oct;17(5):306-12. https://doi.org/10.1111/j.1365-3164.2006.00541.x
 
Marsella R, Olivry T. Animal models of atopic dermatitis. Clin Dermatol. 2003 Mar-Apr;21(2):122-33.
 
Marsella R, Saridomichelakis MN. Environmental and oral challenge with storage mites in Beagles experimentally sensitized to Dermatophagoides farinae. Vet Dermatol. 2010 Feb;21(1):105-11. https://doi.org/10.1111/j.1365-3164.2009.00859.x
 
Marsella R, Sousa CA, Gonzales AJ, Fadok VA. Current understanding of the pathophysiologic mechanisms of canine atopic dermatitis. J Am Vet Med Assoc. 2012 Jul 15;241(2):194-207. https://doi.org/10.2460/javma.241.2.194
 
Nuttall TJ, Knight PA, McAleese SM, Lamb JR, Hill PB. T-helper 1, T-helper 2 and immunosuppressive cytokines in canine atopic dermatitis. Vet Immunol Immunopathol. 2002 Sep 10;87(3-4):379-84. https://doi.org/10.1016/S0165-2427(02)00076-4
 
Olivry T, Baumer W. Atopic itch in dogs: Pharmacology and modeling. In: Cowan A, Yosipovitch G, editors. Pharmacology of itch. Berlin, Heidelberg: Springer; 2015. p. 357-69.
 
Olivry T, Hill PB. The ACVD task force on canine atopic dermatitis (IX): The controversy surrounding the route of allergen challenge in canine atopic dermatitis. Vet Immunol Immunopathol. 2001 Sep 20;81(3-4):219-25. https://doi.org/10.1016/S0165-2427(01)00311-7
 
Olivry T, Naydan DK, Moore PF. Characterization of the cutaneous inflammatory infiltrate in canine atopic dermatitis. Am J Dermatopathol. 1997 Oct;19(5):477-86. https://doi.org/10.1097/00000372-199710000-00008
 
Olivry T, Wofford J, Paps JS, Dunston SM. Stratum corneum removal facilitates experimental sensitization to mite allergens in atopic dogs. Vet Dermatol. 2011 Apr;22(2):188-96. https://doi.org/10.1111/j.1365-3164.2010.00938.x
 
Olivry T, Saridomichelakis M, Nuttall T, Bensignor E, Griffin CE, Hill PB, International Committe on Allergic Diseases of Animals (ICADA). Validation of the canine atopic dermatitis extent and severity index (CADESI)-4, A simplified severity scale for assessing skin lesions of atopic dermatitis in dogs. Vet Dermatol. 2014 Apr;25(2):77-85. https://doi.org/10.1111/vde.12107
 
Pucheu-Haston CM, Jackson HA, Olivry T, Dunston SM, Hammerberg B. Epicutaneous sensitization with Dermatophagoides farinae induces generalized allergic der-matitis and elevated mite-specific immunoglobulin E levels in a canine model of atopic dermatitis. Clin Exp Allergy. 2008 Apr;38(4):667-79. https://doi.org/10.1111/j.1365-2222.2008.02949.x
 
Redman TK, Rudolph K, Barr EB, Bowen LE, Muggenburg BA, Bice DE. Pulmonary immunity to ragweed in a Beagle dog model of allergic asthma. Exp Lung Res. 2001 Jul-Aug;27(5):433-51. https://doi.org/10.1080/019021401300317143
 
Rhodes KH, Kerdel F, Soter NA, Chinnici R. Investigation into the immunopathogenesis of canine atopy. Semin Vet Med Surg (Small Anim). 1987 Aug;2(3):199-201.
 
Santoro D, Marsella R. Animal models of allergic diseases. Vet Sci. 2014;1(3):192-212. https://doi.org/10.3390/vetsci1030192
 
Schwab-Richards R, Prost C, Steffan J, Seewald W, Nenci C, Roosje P. Use of activity monitors for assessment of pruritus in an acute model of canine atopic dermatitis. Vet Dermatol. 2014 Oct;25(5):441-e69. https://doi.org/10.1111/vde.12133
 
Schwartzman RM, Massicot JG, Sogn DD, Cohen SG. The atopic dog model: Report of an attempt to establish a colony. Int Arch Allergy Appl Immunol. 1983;72(2):97-101. https://doi.org/10.1159/000234849
 
Shiohara T, Hayakawa J, Mizukawa Y. Animal models for atopic dermatitis: Are they relevant to human disease? J Dermatol Sci. 2004 Oct;36(1):1-9. https://doi.org/10.1016/j.jdermsci.2004.02.013
 
van Smeden J, Bouwstra JA. Stratum corneum lipids: Their role for the skin barrier function in healthy subjects and atopic dermatitis patients. Curr Probl Dermatol. 2016;49:8-26.
 
Yamamoto M, Haruna T, Yasui K, Takahashi H, Iduhara M, Takaki S, Deguchi M, Arimura A. A novel atopic dermatitis model induced by topical application with Der-matophagoides farinae extract in NC/Nga mice. Allergol Int. 2007 Jun;56(2):139-48.  https://doi.org/10.2332/allergolint.O-06-458
 
Zosky GR, Sly PD. Animal models of asthma. Clin Exp Allergy. 2007;37(7):973-88. https://doi.org/10.1111/j.1365-2222.2007.02740.x
 
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