Primary splenic diffuse large B-cell lymphoma with multinucleated giant cells in a horseCitation:
Hananeh W, Al Rukibat R, Daradka M (2021): Primary splenic diffuse large B-cell lymphoma with multinucleated giant cells in a horse. Vet Med-Czech 66, 76–79.
A diagnosis of a diffuse splenic large B-cell lymphoma with multinucleated giant cells in a 5-year-old mare was made based upon the clinical, pathological, and immunohistochemical findings. The enormous primary splenic mass weighed 51.75 kg. To the best of our knowledge, this is the biggest reported splenic mass and the first case of an equine diffuse large B-cell lymphoma with multinucleated giant cells.
equine; immunohistochemistry; lymphoma; spleen
Durham AC, Pillitteri CA, San Myint M, Valli VE. Two hundred three cases of equine lymphoma classified according to the World Health Organization (WHO) classification criteria. Vet Pathol. 2013 Jan;50(1):86-93. https://doi.org/10.1177/0300985812451603
Meyer J, Delay J, Bienzle D. Clinical, laboratory, and histopathologic features of equine lymphoma. Vet Pathol. 2006 Nov;43(6):914-24. https://doi.org/10.1354/vp.43-6-914
Miglio A, Morelli C, Gialletti R, Lauteri E, Sforna M, Marenzoni ML, Antognoni MT. Clinical and immunophenotypic findings in 4 forms of equine lymphoma. Can Vet J. 2019 Jan;60(1):33-40.
Munoz A, Riber C, Trigo P, Castejon F. Hematopoietic neoplasias in horses: Myeloproliferative and lymphoproliferative disorders. J Equine Sci. 2009;20(4):59-72. https://doi.org/10.1294/jes.20.59
Ohshima M, Morita T, Sawada M, Shimada A, Kobayashi H, Sawashima K. B-cell immunoblastic lymphoma with multinucleated giant cells in a cat. J Vet Med Sci. 2004 Feb;66(2):189-91. https://doi.org/10.1292/jvms.66.189
Sprayberry KA, Robinson NE. Robinson’s current therapy in equine medicine. St. Louis, Missouri: Elsevier Health Sciences; 2014. 998 p.
Suvarna KS, Layton C, Bancroft JD. Bancroft’s theory and practice of histological techniques. Amsterdam: Elsevier Health Sciences; 2018. 672 p.
Taintor J, Schleis S. Equine lymphoma. Equine Vet Educ. 2011;23(4):205-13. https://doi.org/10.1111/j.2042-3292.2010.00200.x
Tanimoto T, Yamasaki S, Ohtsuki Y. Primary splenic lymphoma in a horse. J Vet Med Sci. 1994 Aug;56(4):767-9. https://doi.org/10.1292/jvms.56.767