Successful management of feline CD4+ CD8+ T-cell mediastinal lymphoma with pericardial effusion

https://doi.org/10.17221/70/2021-VETMEDCitation:

Yu SJ, Kim HE, Han HJ, Kim JH (2022): Successful management of feline CD4+ CD8+ T-cell mediastinal lymphoma with pericardial effusion. Vet Med-Czech 67, 544–551.

download PDF

A 2-year-old, castrated, male Russian blue cat presented with acute dyspnoea, cyanosis, and lethargy. A thoracic radiography revealed a large cranial mediastinal mass; the computed tomography revealed caudal lobe atelectasis of the right lung with pericardial and pleural effusions. The cytodiagnostic tests revealed high-grade CD4+ CD8+ T-cell mediastinal lymphoma as clinical stage Vb; l-asparaginase-cyclophosphamide-doxorubicin-vincristine-prednisolone (l-CHOP)-based chemotherapy was initiated, following which the mass shrunk rapidly; 1 week after the initiation of chemotherapy, the appetite-related and respiratory symptoms improved dramatically, and the pleural and pericardial effusion resolved. The patient remains in complete remission three years after the initiation of the l-CHOP chemotherapy. Therefore, the accurate diagnosis and instantaneous initiation of chemotherapy may resolve life-threatening pleural and pericardial effusions in cats with high-grade aberrant T-cell mediastinal lymphoma.

References:
Aniolek O, Gajewski Z, Gizinski S. Application of flow cytometry in diagnosing lymphomas in dogs and cats. Cent Eur J Immunol. 2014;39(3):327-30. https://doi.org/10.5114/ceji.2014.45943
 
Bernardi S, Martini V, Perfetto S, Cozzi M, Comazzi S. Flow cytometric analysis of mediastinal masses in cats: A retrospective study. Front Vet Sci. 2020 Aug 7;7:444. https://doi.org/10.3389/fvets.2020.00444
 
Collette SA, Allstadt SD, Chon EM, Vernau W, Smith AN, Garrett LD, Choy K, Rebhun RB, Rodriguez CO Jr, Skorupski KA. Treatment of feline intermediate-to high-grade lymphoma with a modified university of Wisconsin-Madison protocol: 119 cases (2004–2012). Vet Com Oncol. 2016 Aug;14(Suppl_1):136-46. https://doi.org/10.1111/vco.12158
 
Court EA, Watson ADJ, Peaston AE. Retrospective study of 60 cases of feline lymphosarcoma. Aust Vet J. 1997 Jun;75(6):424-7. https://doi.org/10.1111/j.1751-0813.1997.tb14347.x
 
Fabrizio F, Calam AE, Dobson JM, Middleton SA, Murphy S, Taylor SS, Schwartz A, Stell AJ. Feline mediastinal lymphoma: A retrospective study of signalment, retroviral status, response to chemotherapy and prognostic indicators. J Feline Med Surg. 2014 Aug;16(8):637-44. https://doi.org/10.1177/1098612X13516621
 
Gabor LJ, Malik R, Canfield PJ. Clinical and anatomical features of lymphosarcoma in 118 cats. Aust Vet J. 1998 Nov;76(11):725-32. https://doi.org/10.1111/j.1751-0813.1998.tb12300.x
 
Gabor LJ, Canfield PJ, Malik R. Immunophenotypic and histological characterisation of 109 cases of feline lymphosarcoma. Aust Vet J. 1999 Jul;77(7):436-41. https://doi.org/10.1111/j.1751-0813.1999.tb12085.x
 
Hall DJ, Shofer F, Meier CK, Sleeper MM. Pericardial effusion in cats: A retrospective study of clinical findings and outcome in 146 cats. J Vet Intern Med. 2007 Sep-Oct;21(5):1002-7. https://doi.org/10.1111/j.1939-1676.2007.tb03056.x
 
Kristal O, Lana SE, Ogilvie GK, Rand WM, Cotter SM, Moore AS. Single agent chemotherapy with doxorubicin for feline lymphoma: A retrospective study of 19 cases (1994–1997). J Vet Intern Med. 2001 Mar-Apr;15(2):125-30. https://doi.org/10.1111/j.1939-1676.2001.tb01243.x
 
Lana S, Plaza S, Hampe K, Burnett R, Avery AC. Diagnosis of mediastinal masses in dogs by flow cytometry. J Vet Intern Med. 2006 Sep-Oct;20(5):1161-5. https://doi.org/10.1111/j.1939-1676.2006.tb00716.x
 
Lara-Garcia A, Wellman M, Burkhard MJ, Machado-Parrula C, Valli VE, Stromberg PC, Couto CG. Cervical thymoma originating in ectopic thymic tissue in a cat. Vet Clin Pathol. 2008 Dec;37(4):397-402. https://doi.org/10.1111/j.1939-165X.2008.00061.x
 
Limmer S, Eberle N, Nerschbach V, Nolte I, Betz D. Treatment of feline lymphoma using a 12-week, maintenance-free combination chemotherapy protocol in 26 cats. Vet Comp Oncol. 2016 Aug;14(Suppl_1):21-31. https://doi.org/10.1111/vco.12082
 
Malik R, Gabor LJ, Foster SF, McCorkell BE, Canfield PJ. Therapy for Australian cats with lymphosarcoma. Aust Vet J. 2001 Dec;79(12):808-17. https://doi.org/10.1111/j.1751-0813.2001.tb10923.x
 
Sapierzynski R. Practical aspects of immunocytochemistry in canine lymphomas. Pol J Vet Sci. 2010;13(4):661-8. https://doi.org/10.2478/v10181-010-0016-1
 
Sato H, Fujino Y, Chino J, Takahashi M, Fukushima K, Goto-Koshino Y, Uchida K, Ohno K, Tsujimoto H. Prognostic analyses on anatomical and morphological classification of feline lymphoma. J Vet Med Sci. 2014 Jun;76(6):807-11. https://doi.org/10.1292/jvms.13-0260
 
Shih JL, Brenn S, Schrope DP. Cardiac involvement secondary to mediastinal lymphoma in a cat: Regression with chemotherapy. J Vet Cardiol. 2014 Jun;16(2):115-20. https://doi.org/10.1016/j.jvc.2014.01.002
 
Simon D, Eberle N, Laacke-Singer L, Nolte I. Combination chemotherapy in feline lymphoma: Treatment outcome, tolerability, and duration in 23 cats. J Vet Intern Med. 2008 Mar-Apr;22(2):394-400. https://doi.org/10.1111/j.1939-1676.2008.0057.x
 
Stein TJ, Pellin M, Steinberg H, Chun R. Treatment of feline gastrointestinal small-cell lymphoma with chlorambucil and glucocorticoids. J Am Anim Hosp Assoc. 2010 Nov-Dec;46(6):413-7. https://doi.org/10.5326/0460413
 
Tompkins MB, Gebhard DH, Bingham HR, Hamilton MJ, Davis WC, Tompkins WA. Characterization of monoclonal antibodies to feline T lymphocytes and their use in the analysis of lymphocyte tissue distribution in the cat. Vet Immunol Immunopathol. 1990 Dec;26(4):305-17. https://doi.org/10.1016/0165-2427(90)90115-9
 
Twomey LN, Alleman AR. Cytodiagnosis of feline lymphoma. Compendium. 2005 Jan;27:17-31.
 
Waite AH, Jackson K, Gregor TP, Krick EL. Lymphoma in cats treated with a weekly cyclophosphamide-, vincristine-, and prednisone-based protocol: 114 cases (1998–2008). J Am Vet Med Assoc. 2013 Apr 15;242(8):1104-9. https://doi.org/10.2460/javma.242.8.1104
 
Zoia A, Hughes D, Connolly DJ. Pericardial effusion and cardiac tamponade in a cat with extra-nodal lymphoma. J Small Anim Pract. 2004 Sep 1;45(9):467-71. https://doi.org/10.1111/j.1748-5827.2004.tb00266.x
 
download PDF

© 2022 Czech Academy of Agricultural Sciences | Prohlášení o přístupnosti