Indirect markers of glomerular filtration rate in dogs and cats: a review

https://doi.org/10.17221/77/2017-VETMEDCitation:Kovarikova S. (2018): Indirect markers of glomerular filtration rate in dogs and cats: a review. Veterinarni Medicina, 63: 395-412.
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Early diagnosis of kidney disease continues to be a subject of intense interest. Direct measurement of glomerular filtration rate is too complicated for first-line practices; thus, indirect markers of renal function have also been evaluated. Creatinine, traditionally measured as a readout of renal function, has limitations in its sensitivity. In dogs and cats, cystatin C became popular approximately 15 years ago, but recent reports question its usefulness, especially in cats. Symmetric dimethylarginine seems to be very promising as a marker of glomerular filtration rate with the ability to detect renal impairment earlier than creatinine. This article presents current knowledge of qualities, limitations, advantages and availability of novel and traditionally used biomarkers of glomerular filtration rate in dogs and cats.

References:
Abrahamson M, Olafsson I, Palsdottir A, Ulvsbäck M, Lundwall Å, Jensson O, Grubb A (1990): Structure and expression of the human cystatin C gene. Biochemical Journal, 268, 287-294 https://doi.org/10.1042/bj2680287
 
Almy Frederic S., Christopher Mary M., King Don P., Brown Scott A. (2002): Evaluation of Cystatin C as an Endogenous Marker of Glomerular Filtration Rate in Dogs. Journal of Veterinary Internal Medicine, 16, 45-51 https://doi.org/10.1111/j.1939-1676.2002.tb01605.x
 
Antognoni M. T., Siepi D., Porciello F., Fruganti G. (2005): Use of Serum Cistatin C Determination as a Marker of Renal Function in the Dog. Veterinary Research Communications, 29, 265-267 https://doi.org/10.1007/s11259-005-0058-5
 
Atzler Dorothee, Schwedhelm Edzard, Nauck Matthias, Ittermann Till, Böger Rainer H., Friedrich Nele (2014): Serum reference intervals of homoarginine, ADMA, and SDMA in the Study of Health in Pomerania. Clinical Chemistry and Laboratory Medicine (CCLM), 52, - https://doi.org/10.1515/cclm-2014-0314
 
Balint P, Visy M (1965): True creatinine and pseudocreatinine in blood plasma of the dog. Acta Physiologica Academiae Scientiarum Hungaricae 28, 265–272.
 
Baral Randolph M, Dhand Navneet K, Freeman Kathleen P, Krockenberger Mark B, Govendir Merran (2013): Biological variation and reference change values of feline plasma biochemistry analytes. Journal of Feline Medicine and Surgery, 16, 317-325 https://doi.org/10.1177/1098612X13508770
 
Bedford MT, Richard S (2005): Arginine methylation an emerging regulator of protein function. Molecular Cell 18, 263–272.
 
Bobek Libuse A., Levine Michael J. (2016): Cystatins — Inhibitors of Cysteine Proteinases. Critical Reviews in Oral Biology & Medicine, 3, 307-332 https://doi.org/10.1177/10454411920030040101
 
Bode-Boger S. M. (2006): Symmetrical Dimethylarginine: A New Combined Parameter for Renal Function and Extent of Coronary Artery Disease. Journal of the American Society of Nephrology, 17, 1128-1134 https://doi.org/10.1681/ASN.2005101119
 
Bokenkamp A, van Wijk JA, Lentze MJ, Stoffel-Wagner B (2002): Effect of corticosteroid therapy on serum cystatin C and beta2-microglobulin concentrations. Clinical Chemistry 48, 1123–1126.
 
Bovee KC, Kronfeld DS, Ramberg C, Goldschmidt M (1979): Long-term measurement of renal function in partially nephrectomized dogs fed 56, 27 or 19% protein. Investigative Urology 16, 378–384.
 
Braff J., Obare E., Yerramilli M., Elliott J., Yerramilli M. (2014): Relationship between Serum Symmetric Dimethylarginine Concentration and Glomerular Filtration Rate in Cats. Journal of Veterinary Internal Medicine, 28, 1699-1701 https://doi.org/10.1111/jvim.12446
 
Braun J.-P., Perxachs A., Pe´CHEREAU D., De La Farge F. (2002): Plasma Cystatin C in the Dog: Reference Values and Variations with Renal Failure. Comparative Clinical Pathology, 11, 44-49 https://doi.org/10.1007/s580-002-8081-2
 
Braun J. P., Lefebvre H. P., Watson A. D. J. (2003): Creatinine in the Dog: A Review. Veterinary Clinical Pathology, 32, 162-179 https://doi.org/10.1111/j.1939-165X.2003.tb00332.x
 
Braun J.-P., Cabe E., Geffre A., Lefebvre H. P., Trumel C. (2008): Comparison of plasma creatinine values measured by different veterinary practices. Veterinary Record, 162, 215-216 https://doi.org/10.1136/vr.162.7.215
 
Brzin Jože, Popovič Tatjana, Turk Vito, Borchart Ursula, Machleidt Werner (1984): Human cystatin, a new protein inhibitor of cysteine proteinases. Biochemical and Biophysical Research Communications, 118, 103-109 https://doi.org/10.1016/0006-291X(84)91073-8
 
Butler E. A., Flynn F. V. (1961): The occurrence of post-gamma protein in urine: a new protein abnormality. Journal of Clinical Pathology, 14, 172-178 https://doi.org/10.1136/jcp.14.2.172
 
CHANOIT G. P., CONCORDET D., LEFEBVRE H. P., ORCEL K., BRAUN J.-P. (2002): Exercise Does Not Induce Major Changes in Plasma Muscle Enzymes, Creatinine, Glucose and Total Proteins Concentrations in Untrained Beagle Dogs. Journal of Veterinary Medicine Series A, 49, 222-224 https://doi.org/10.1046/j.1439-0442.2002.00438.x
 
CHOI Bom-Sul, MOON Hyeong-Sun, SEO Sang-Hyuk, HYUN Changbaig (2017): Evaluation of serum cystatin-C and symmetric dimethylarginine concentrations in dogs with heart failure from chronic mitral valvular insufficiency. Journal of Veterinary Medical Science, 79, 41-46 https://doi.org/10.1292/jvms.16-0188
 
Clausen J. (1961): Proteins in Normal Cerebrospinal Fluid Not Found in Serum.. Experimental Biology and Medicine, 107, 170-172 https://doi.org/10.3181/00379727-107-26569
 
Craig AJ, Sequela J, Queau Y, Murgier P, Concordet D, Fleeman LM, Mimouni P, Braun JP, Germain C, Lefebvre HP (2006): Redefining the reference interval for plasma creatinine in dogs: effect of age, gender, body weight and breed. Journal of Veterinary Internal Medicine 20, 740.
 
Dahlem D.P., Neiger R., Schweighauser A., Francey T., Yerramilli M., Obare E., Steinbach S.M.L. (2017): Plasma Symmetric Dimethylarginine Concentration in Dogs with Acute Kidney Injury and Chronic Kidney Disease. Journal of Veterinary Internal Medicine, 31, 799-804 https://doi.org/10.1111/jvim.14694
 
Dharnidharka Vikas R., Kwon Charles, Stevens Gary (2002): Serum cystatin C is superior to serum creatinine as a marker of kidney function: A meta-analysis. American Journal of Kidney Diseases, 40, 221-226 https://doi.org/10.1053/ajkd.2002.34487
 
Diez M., Michaux C., Jeusette I., Baldwin P., Istasse L., Biourge V. (2004): Evolution of blood parameters during weight loss in experimental obese Beagle dogs. Journal of Animal Physiology and Animal Nutrition, 88, 166-171 https://doi.org/10.1111/j.1439-0396.2003.00474.x
 
Dixon JJ, Lane K, Dalton RN, MacPhee IA, Philips BJ (2013): Symmetrical dimethylarginine is a more sensitive biomarker of renal dysfunction than creatinine. Critical Care, 17, P423- https://doi.org/10.1186/cc12361
 
Dunlop M. M., Sanchez-Vazquez M. J., Freeman K. P., Gibson G., Sacchini F., Lewis F. (2011): Determination of serum biochemistry reference intervals in a large sample of adult greyhounds. Journal of Small Animal Practice, 52, 4-10 https://doi.org/10.1111/j.1748-5827.2010.01008.x
 
English P. B., Filippich L. J., Thompson H. L. (1980): CLINICAL ASSESSMENT OF RENAL FUNCTION IN THE DOG WITH A REDUCTION IN NEPHRON NUMBER. Australian Veterinary Journal, 56, 305-312 https://doi.org/10.1111/j.1751-0813.1980.tb05733.x
 
Epstein ME, Barsanti JA, Finco DR, Cowgill LM (1984): Postprandial changes in plasma urea nitrogen and plasma creatinine concentrations in dogs fed commercial diets. Journal of American Animal Hospital Association 20, 779–782.
 
Erlandsen E. J, Randers E, Kristensen J. H (2009): Evaluation of the Dade Behring N Latex Cystatin C assay on the Dade Behring Nephelometer II System. Scandinavian Journal of Clinical and Laboratory Investigation, 59, 1-8 https://doi.org/10.1080/00365519950185940
 
EVANS G. O. (1987): Post-prandial changes in canine plasma creatinine. Journal of Small Animal Practice, 28, 311-315 https://doi.org/10.1111/j.1748-5827.1987.tb03886.x
 
Farace G, Patch D, Yerramilli M (2015): Feline serum cystatin C does not differentiate healthy cats from those with chronic kidney disease. Journal of Veterinary Internal Medicine 29, 1215.
 
Finney H, Newman DJ, Gruber W, Merle P, Price CP (1997): Initial evaluation of cystatin C measurement by particle-enhanced immunonephelometry on the Behring nephelometer systems (BNA, BN II). Clinical Chemistry 43, 1016–1022.
 
Fontaine M, Hamelin N, Paradis M (1986): Effects of time, storage conditions and mailing on the stability of canine blood parameters (in French). Medicine Veterinaire Quebec 16, 157–164.
 
Feeman William E., Couto C. Guillermo, Gray Toni L. (2003): Serum Creatinine Concentrations in Retired Racing Greyhounds. Veterinary Clinical Pathology, 32, 40-42 https://doi.org/10.1111/j.1939-165X.2003.tb00312.x
 
Fricker Manuel, Wiesli Peter, Brändle Michael, Schwegler Beat, Schmid Christoph (2003): Impact of thyroid dysfunction on serum cystatin C. Kidney International, 63, 1944-1947 https://doi.org/10.1046/j.1523-1755.2003.00925.x
 
FUKUDA Satoshi, KAWASHIMA Naoyuki, IIDA Haruzo, AOKI Junji, TOKITA Kazumi (1989): Age dependency of hematological values and concentrations of serum biochemical constituents in normal beagles from 1 to 14 years of age.. The Japanese Journal of Veterinary Science, 51, 636-641 https://doi.org/10.1292/jvms1939.51.636
 
Ghys L, Paepe D, Smets P, Lefebvre H, Delanghe J, Daminet S (2014a): Cystatin C: a new renal marker and its potential use in small animal medicine. Journal of Veterinary Internal Medicine 28, 1152–1164.
 
Ghys LF, Meyer E, Paepe D, Delanghe J, Daminet S (2014b): Analytical validation of a human particle-enhanced nephelometric assay for cystatin C measurement in feline serum an urine. Veterinary Clinical Pathology 43, 226–234.
 
Ghys LF, Paepe D, Lefebvre HP, Taffin ER, Hesta M, Delanghe JR, Smets P, Vandendriessche V, Daminet S (2015a): The effect of feeding, storage and anticoagulant on feline serum cystatin C. Veterinary Journal 206, 91–96.
 
Ghys LF, Paepe D, Duchateau L, Taffin ER, Marynissen S, Delanghe J, Daminet S (2015b): Biological validation of feline serum cystatin C: The effect of breed, age and sex and establishment of a reference interval. Veterinary Journal 204, 168–173.
 
Ghys LF, Paepe D, Lefebvre HP, Reynold BS, Croubels S, Meyer E, Delanghe JR, Daminet S (2016a): Evaluation of cystatin C for the detection of chronic kidney disease in cats. Journal of Veterinary Internal Medicine 30, 1074–1082.
 
Ghys LF, Paepe D, Taffin ER, Vandermeulen E, Duchateau L, Smets PM, Delanghe J, Daminet S (2016b): Serum and urinary cystatin C in cats with feline immunodeficiency virus infection and cats with feline hyperthyroidism. Journal of Feline Medicine and Surgery 18, 658–665.
 
Grubb A (1992): Diagnostic value of analysis of cystatin C and protein HC in biological fluids. Clinical Nephrology 38, S20–S27.
 
GRUBB A., SIMONSEN O., STURFELT G., TRUEDSSON L., THYSELL H. (1985): Serum Concentration of Cystatin C, Factor D and β2-Microglobulin as a Measure of Glomerular Filtration Rate. Acta Medica Scandinavica, 218, 499-503 https://doi.org/10.1111/j.0954-6820.1985.tb08880.x
 
Gunn-Moore DA, Dodkin SJ, Sparkes AH (2016): Letter to the Editor. Journal of Feline Medicine and Surgery, 4, 165-166 https://doi.org/10.1053/jfms.2002.0175
 
Hall JA, Yerramilli M, Obare E, Yerramilli M, Yu S, Jewell DE (2014a): Comparison of serum concentrations of symmetric dimethylarginine and creatinine as kidney function biomarkers in healthy geriatric cats fed reduced protein foods enriched with fish oil, L-carnitine, and medium-chain triglycerides. Veterinary Journal 202, 588–596.
 
Hall JA, Yerramilli M, Obare E, Yerramilli M, Jewell DE (2014b): Comparison of serum concentrations of symmetric dimethylarginine and creatinine as kidney function biomarkers in cats with chronic kidney disease. Journal of Veterinary Internal Medicine 28, 1676–1683.
 
Hall Jean A., Yerramilli Maha, Obare Edward, Yerramilli Murthy, Melendez Lynda D., Jewell Dennis E. (2015): Relationship between lean body mass and serum renal biomarkers in healthy dogs. Journal of Veterinary Internal Medicine, 29, 808-814 https://doi.org/10.1111/jvim.12607
 
Hall JA, Yerramilli M, Obare E, Yerramilli M, Almes K, Jewell DE (2016a): Serum concentrations of symmetric dimethylarginine and creatinine in dogs with naturally occurring chronic kidney disease. Journal of Veterinary Internal Medicine 30, 794–802.
 
Hall Jean A., MacLeay Jennifer, Yerramilli Maha, Obare Edward, Yerramilli Murthy, Schiefelbein Heidi, Paetau-Robinson Inke, Jewell Dennis E., Aguilera Abelardo I (2016): Positive Impact of Nutritional Interventions on Serum Symmetric Dimethylarginine and Creatinine Concentrations in Client-Owned Geriatric Cats. PLOS ONE, 11, e0153654- https://doi.org/10.1371/journal.pone.0153654
 
Hall Jean A., MacLeay Jennifer, Yerramilli Maha, Obare Edward, Yerramilli Murthy, Schiefelbein Heidi, Paetau-Robinson Inke, Jewell Dennis E., Aguilera Abelardo I (2016): Positive Impact of Nutritional Interventions on Serum Symmetric Dimethylarginine and Creatinine Concentrations in Client-Owned Geriatric Dogs. PLOS ONE, 11, e0153653- https://doi.org/10.1371/journal.pone.0153653
 
Hall Jean A., Yerramilli Maha, Obare Edward, Li Jun, Yerramilli Murthy, Jewell Dennis E., Aguilera Abelardo I (2017): Serum concentrations of symmetric dimethylarginine and creatinine in cats with kidney stones. PLOS ONE, 12, e0174854- https://doi.org/10.1371/journal.pone.0174854
 
Hammel E P, Kronfeld D S, Ganjam V K, Dunlap H L (1977): Metabolic responses to exhaustive exercise in racing sled dogs fed diets containing medium, low, or zero carbohydrate. The American Journal of Clinical Nutrition, 30, 409-418 https://doi.org/10.1093/ajcn/30.3.409
 
Hansen B, DiBartola SP, Chew DJ, Brownie C, Nagode L (1992): Clinical and metabolic findings in dogs with chronic renal failure fed two diets. American Journal of Veterinary Research 53, 326–334.
 
Harris R.C, Lowe J.A, Warnes K, Orme C.E (1997): The concentration of creatine in meat, offal and commercial dog food. Research in Veterinary Science, 62, 58-62 https://doi.org/10.1016/S0034-5288(97)90181-8
 
Hinchcliff KW, Olson J, Crusberg C, Kenyon J, Long R, Royle W, Weber W, Burr J (1993): Serum biochemical changes in dogs competing in a long-distance sled race. Journal of American Veterinary Medical Association 202, 401–405.
 
ISHIGURO HIROSHI, OHKUBO IWAO, MIZOKAMI MASASHI, TITANI KOITI, SASAKI MAKOTO (1989): The Use of Monoclonal Antibodies to Define Levels of Cystatin C in Normal Human Serum. Hybridoma, 8, 303-313 https://doi.org/10.1089/hyb.1989.8.303
 
Jacobs RM, Lumsden JH, Taylor JA, Grift E (1991): Effects of interferents on the kinetic Jaffe reaction and an enzymatic colorimetric test for serum creatinine concentration determination in cats, cows, dogs and horses. Canadian Journal of Veterinary Research 55, 150–154.
 
Jacobs RM, Lumsden JH, Grift E (1992): Effects of bilirubinemia, hemolysis, and lipemia on clinical chemistry analytes in bovine, canine, equine, and feline sera. Canadian Veterinary Journal 33, 605–608.
 
Jensen A.L., Wenck A., Koch J., Poulsen J.S.D. (1994): Comparison of results of haematological and clinical chemical analyses of blood samples obtained from the cephalic and external jugular veins in dogs. Research in Veterinary Science, 56, 24-29 https://doi.org/10.1016/0034-5288(94)90191-0
 
Jensen Asger L., Bomholt Mads, Moe Lars (2001): Preliminary Evaluation of a Particle-enhanced Turbidimetric Immunoassay (PETIA) for the Determination of Serum Cystatin C-Like Immunoreactivity in Dogs. Veterinary Clinical Pathology, 30, 86-90 https://doi.org/10.1111/j.1939-165X.2001.tb00263.x
 
Jepson RE, Slater L, Nashi S, Neiger R, Church D, Elliott J, Syme HM (2006): Evaluation of cystatin C as a marker of GFR in hyperthyroid cats. Journal of Veterinary Internal Medicine 20, 740.
 
Jepson R.E., Syme H.M., Vallance C., Elliott J. (2008): Plasma Asymmetric Dimethylarginine, Symmetric Dimethylarginine, l-Arginine, and Nitrite/Nitrate Concentrations in Cats with Chronic Kidney Disease and Hypertension. Journal of Veterinary Internal Medicine, 22, 317-324 https://doi.org/10.1111/j.1939-1676.2008.0075.x
 
Jewell DE, Yu S, Yerramilli M, Obare E, Yerramilli M, Hall JA (2014a): In geriatric cats symmetric dimethylarginine (SDMA) responds to changes in GFR whereas serum creatinine responds to changes in lean body mass. Journal of Veterinary Internal Medicine 28, 1080.
 
Jewell DE, Fritsch D, Yerramilli M, Obare E, Yerramilli M, Hall JA (2014b): Feeding reduced protein and phosphorus food to dogs with naturally occurring renal disease reduces serum concentrations of creatinine and symmetric dimethylarginine (SDMA). Journal of Veterinary Internal Medicine 28, 1079–1080.
 
Jonkisz Paweł, Kungl Krisztina, Sikorska Agnieszka, Kurosad Agnieszka, Nicpoń Józef (2010): Cystatin C analysis in the dog: A comparison of turbidimetric and nephelometric assay results. Acta Veterinaria Hungarica, 58, 59-67 https://doi.org/10.1556/AVet.58.2010.1.6
 
Kakimoto Y, Akazawa S (1970): Isolation and identification of NG, NG- nad NG,N'G-dimethylarginine, Nε-mono-, di-, and trimethyllysine, and glucosylgalactosyl- and galactosyl-δ-hydroxylysine from human urine. Journal of Biological Chemistry 245, 5751–5758.
 
Kaseda Ryohei, Iino Noriaki, Hosojima Michihiro, Takeda Tetsuro, Hosaka Kiyoko, Kobayashi Asako, Yamamoto Keiko, Suzuki Akiyo, Kasai Ayaka, Suzuki Yoshiki, Gejyo Fumitake, Saito Akihiko (2007): Megalin-mediated endocytosis of cystatin C in proximal tubule cells. Biochemical and Biophysical Research Communications, 357, 1130-1134 https://doi.org/10.1016/j.bbrc.2007.04.072
 
Kielstein Jan T., Salpeter Shelley R., Bode-Boeger Stefanie M., Cooke John P., Fliser Danilo (2006): Symmetric dimethylarginine (SDMA) as endogenous marker of renal function—a meta-analysis. Nephrology Dialysis Transplantation, 21, 2446-2451 https://doi.org/10.1093/ndt/gfl292
 
Kielstein JT, Fliser D, Veldink H (2009): Assymetric dimethylarginine and symmetric dimethylarginine: axis of evil or useful alliance? Seminars in Dialysis 22, 346–350.
 
Kopke M.A., Burchell R.K., Ruaux C.G., Burton S.E., Lopez-Villalobos N., Gal A. (2018): Variability of Symmetric Dimethylarginine in Apparently Healthy Dogs. Journal of Veterinary Internal Medicine, 32, 736-742 https://doi.org/10.1111/jvim.15050
 
Kos J, Stabuc B, Cimerman N, Brunner N (1998): Serum cystatin C, a new marker of glomerular filtration rate, is increased during malignant progression. Clinical Chemistry 44, 2556–2557.
 
Kyhse-Andersen J, Schmidt C, Nordin G, Andersson B, Nilsson-Ehle P, Lindstrom V, Grubb A (1994): Serum cystatin C, determined by a rapid, automated particle-enhanced turbidimetric method, is a better marker than serum creatinine for glomerular filtration rate. Clinical Chemistry 40, 1921–1926.
 
Levy Julie K., Crawford P. Cynda, Werner Linda L. (2006): Effect of age on reference intervals of serum biochemical values in kittens. Journal of the American Veterinary Medical Association, 228, 1033-1037 https://doi.org/10.2460/javma.228.7.1033
 
Lowseth Lisa A., Gillett Nancy A., Gerlach Robert F., Muggenburg Bruce A. (1990): The Effects of Aging on Hematology and Serum Chemistry Values in the Beagle Dog. Veterinary Clinical Pathology, 19, 13-19 https://doi.org/10.1111/j.1939-165X.1990.tb00535.x
 
Marliss E. B., Chevalier S., Gougeon R., Morais J. A., Lamarche M., Adegoke O. A. J., Wu G. (2006): Elevations of plasma methylarginines in obesity and ageing are related to insulin sensitivity and rates of protein turnover. Diabetologia, 49, 351-359 https://doi.org/10.1007/s00125-005-0066-6
 
Martin C, Pecherau D, de la Farge, Braun JP (2002): Plasma cystatin C in the cat: current techniques do not allow to use it for the diagnosis of renal failure (in French). Revue Medecine Veterinaire 153, 305–310.
 
Martinez J., Kellogg C., Iazbik M.C., Couto C.G., Pressler B.M., Hoepf T.M., Radin M.J. (2017): The Renin-Angiotensin-Aldosterone System in Greyhounds and Non-Greyhound Dogs. Journal of Veterinary Internal Medicine, 31, 988-993 https://doi.org/10.1111/jvim.14720
 
Marynissen Sofie J. J., Smets Pascale M. Y., Ghys Liesbeth F. E., Paepe Dominique, Delanghe Joris, Galac Sara, Meyer Evelyne, Lefebvre Hervé P., Daminet Sylvie (2016): Long-term follow-up of renal function assessing serum cystatin C in dogs with diabetes mellitus or hyperadrenocorticism. Veterinary Clinical Pathology, 45, 320-329 https://doi.org/10.1111/vcp.12365
 
MATSUZAWA Toshiaki, NOMURA Mamoru, UNNO Takashi (1993): Clinical Pathology Reference Ranges of Laboratory Animals.. The Journal of Veterinary Medical Science, 55, 351-362 https://doi.org/10.1292/jvms.55.351
 
McDermott J R (1976): Studies on the catabolism of NG -methylarginine, NG , NG -dimethylarginine and NG , NG -dimethylarginine in the rabbit. Biochemical Journal, 154, 179-184 https://doi.org/10.1042/bj1540179
 
Misbach Charlotte, Chetboul Valérie, Concordet Didier, Médaille Christine, Gruet Philippe, Speranza Cindy, Hoffmann Anne-Cécile, Rocha Adriana, Balouka David, Petit Amandine M.P., Trehiou-Sechi Emilie, Pouchelon Jean-Louis, Lefebvre Hervé P. (2014): Basal plasma concentrations of routine variables and packed cell volume in clinically healthy adult small-sized dogs: effect of breed, body weight, age, and gender, and establishment of reference intervals. Veterinary Clinical Pathology, 43, 371-380 https://doi.org/10.1111/vcp.12162
 
MIYAGAWA Yuichi, TAKEMURA Naoyuki, HIROSE Hisashi (2009): Evaluation of the Measurement of Serum Cystatin C by an Enzyme-Linked Immunosorbent Assay for Humans as a Marker of the Glomerular Filtration Rate in Dogs. Journal of Veterinary Medical Science, 71, 1169-1176 https://doi.org/10.1292/jvms.71.1169
 
MIYAGAWA Yuichi, TAKEMURA Naoyuki, HIROSE Hisashi (2010): Assessments of Factors that Affect Glomerular Filtration Rate and Indirect Markers of Renal Function in Dogs and Cats. Journal of Veterinary Medical Science, 72, 1129-1136 https://doi.org/10.1292/jvms.09-0443
 
Moesgaard S.G., Holte A.V., Mogensen T., Mølbak J., Kristensen A.T., Jensen A.L., Teerlink T., Reynolds A.J., Olsen L.H. (2007): Effects of breed, gender, exercise and white-coat effect on markers of endothelial function in dogs. Research in Veterinary Science, 82, 409-415 https://doi.org/10.1016/j.rvsc.2006.09.003
 
Mundim Antonio Vicente, Coelho Aline Oliveira, Hortêncio Sirley Manzan, Guimarães Ednaldo Carvalho, Espindola Foued Salmen (2007): Influence of age and sex on the serum biochemical profile of Doberman dogs in the growth phase. Comparative Clinical Pathology, 16, 41-46 https://doi.org/10.1007/s00580-006-0653-z
 
Munoz J, Soblechero P, Duque FJ, Ruiz P, Barrera R (2016): Increase of canine serum cystatin C produced by oral administration of prednisone. Journal of Veterinary Internal Medicine 30, 381.
 
Nabity MB, Lees GE, Bogges M, Yerramilli M, Obare E, Yerramilli M, Aguiar J, Relford R (2013a): Correlation of symmetric dimethylarginine with glomerular filtration rate in dogs with chronic progressive renal disease. Journal of Veterinary Internal Medicine 27, 733.
 
Nabity MB, Lees GE, Bogges M, Yerramilli M, Obare E, Yerramilli M, Aguiar J, Relford R (2013b): Week-to-week variability of iohexol clearance, serum creatinine, and symmetric dimethylarginine in dogs with stable chronic renal disease. Journal of Veterinary Internal Medicine 27, 734.
 
Nabity M.B., Lees G.E., Boggess M.M., Yerramilli M., Obare E., Yerramilli M., Rakitin A., Aguiar J., Relford R. (2015): Symmetric Dimethylarginine Assay Validation, Stability, and Evaluation as a Marker for the Early Detection of Chronic Kidney Disease in Dogs. Journal of Veterinary Internal Medicine, 29, 1036-1044 https://doi.org/10.1111/jvim.12835
 
Nakata Junya, Nakahari Aiko, Takahashi Chika, Chikazawa Seishiro, Hori Yasutomo, Kanai Kazutaka, Ito Naoyuki, Higuchi Seiichi, Hoshi Fumio (2010): Molecular cloning, expression in Escherichia coli, and development of monoclonal antibodies to feline cystatin C. Veterinary Immunology and Immunopathology, 138, 231-234 https://doi.org/10.1016/j.vetimm.2010.07.016
 
O'Connor W J, Summerill R A (1976): The effect of a meal of meat on glomerular filtration rate in dogs at normal urine flows.. The Journal of Physiology, 256, 81-91 https://doi.org/10.1113/jphysiol.1976.sp011312
 
Padmanabhan M, Obare E, Yerramilli M (2013): LCMS method development and validation for a potential chronic kidney disease marker symmetric dimethylarginine. Journal of Veterinary Internal Medicine 27, 750.
 
Pagitz Maximilian, Frommlet Florian, Schwendenwein Ilse (2007): Evaluation of Biological Variance of Cystatin C in Comparison With Other Endogenous Markers of Glomerular Filtration Rate in Healthy Dogs. Journal of Veterinary Internal Medicine, 21, 936-942 https://doi.org/10.1111/j.1939-1676.2007.tb03046.x
 
Paltrinieri Saverio, Ibba Fabrizio, Rossi Gabriele (2013): Haematological and biochemical reference intervals of four feline breeds. Journal of Feline Medicine and Surgery, 16, 125-136 https://doi.org/10.1177/1098612X13499337
 
Pedersen L.G., Tarnow I., Olsen L.H., Teerlink T., Pedersen H.D. (2006): Body size, but neither age nor asymptomatic mitral regurgitation, influences plasma concentrations of dimethylarginines in dogs. Research in Veterinary Science, 80, 336-342 https://doi.org/10.1016/j.rvsc.2005.07.005
 
Peterson M.E., Varela F.V., Rishniw M., Polzin D.J. (2018): Evaluation of Serum Symmetric Dimethylarginine Concentration as a Marker for Masked Chronic Kidney Disease in Cats With Hyperthyroidism. Journal of Veterinary Internal Medicine, 32, 295-304 https://doi.org/10.1111/jvim.15036
 
Polzin D. J., Osborne C A., Lulich J. P. (1991): Effects of dietary protein/phosphate restriction in normal dogs and dogs with chronic renal failure. Journal of Small Animal Practice, 32, 289-295 https://doi.org/10.1111/j.1748-5827.1991.tb00933.x
 
Poświatowska-Kaszczyszyn Iwona (2012): Usefulness of Serum Cystatin C Measurement for Assessing Renal Function in Cats. Bulletin of the Veterinary Institute in Pulawy, 56, 235-239 https://doi.org/10.2478/v10213-012-0042-0
 
Poulik M.D., Shinnick C.S., Smithies O. (1981): Partial amino acid sequences of human and dog post-gamma globulins. Molecular Immunology, 18, 569-572 https://doi.org/10.1016/0161-5890(81)90136-X
 
Relford Roberta, Robertson Jane, Clements Celeste (2016): Symmetric Dimethylarginine. Veterinary Clinics of North America: Small Animal Practice, 46, 941-960 https://doi.org/10.1016/j.cvsm.2016.06.010
 
Rentko V, Nabity M, Yerramilli M, Obare E, Yerramilli M, Aguiar J, Relford R (2013): Determination of serum symmetric dimethylarginine reference limit in clinically healthy dogs. Journal of Veterinary Internal Medicine 27, 750.
 
Reynolds Brice S., Boudet Karine G., Germain Claude A., Braun Jean-Pierre D., Lefebvre Herve P. (2008): Determination of reference intervals for plasma biochemical values in clinically normal adult domestic shorthair cats by use of a dry-slide biochemical analyzer. American Journal of Veterinary Research, 69, 471-477 https://doi.org/10.2460/ajvr.69.4.471
 
Reynolds B.S., Concordet D., Germain C.A., Daste T., Boudet K.G., Lefebvre H.P. (2010): Breed Dependency of Reference Intervals for Plasma Biochemical Values in Cats. Journal of Veterinary Internal Medicine, 24, 809-818 https://doi.org/10.1111/j.1939-1676.2010.0541.x
 
Reynolds Brice S, Brosse Claire, Jeunesse Elisabeth, Concordet Didier, Lefebvre Hervé P (2014): Routine plasma biochemistry analytes in clinically healthy cats: within-day variations and effects of a standard meal. Journal of Feline Medicine and Surgery, 17, 468-475 https://doi.org/10.1177/1098612X14546920
 
Risch Lorenz, Huber Andreas R. (2002): Glucocorticoids and increased serum cystatin C concentrations. Clinica Chimica Acta, 320, 133-134 https://doi.org/10.1016/S0009-8981(02)00044-X
 
Roos Juliana F., Doust Jenny, Tett Susan E., Kirkpatrick Carl M.J. (2007): Diagnostic accuracy of cystatin C compared to serum creatinine for the estimation of renal dysfunction in adults and children—A meta-analysis. Clinical Biochemistry, 40, 383-391 https://doi.org/10.1016/j.clinbiochem.2006.10.026
 
Rørtveit Runa, Saevik Bente K., Eggertsdóttir Anna V., Skancke Ellen, Lingaas Frode, Thoresen Stein I., Jansen Johan H. (2015): Age-related changes in hematologic and serum biochemical variables in dogs aged 16-60 days. Veterinary Clinical Pathology, 44, 47-57 https://doi.org/10.1111/vcp.12220
 
ROSE R.J., BLOOMBERG M.S. (1989): Responses to sprint exercise in the greyhound: effects on haematology, serum biochemistry and muscle metabolites. Research in Veterinary Science, 47, 212-218 https://doi.org/10.1016/S0034-5288(18)31208-6
 
Ross Sheri J., Osborne Carl A., Kirk Claudia A., Lowry Stephen R., Koehler Lori A., Polzin David J. (2006): Clinical evaluation of dietary modification for treatment of spontaneous chronic kidney disease in cats. Journal of the American Veterinary Medical Association, 229, 949-957 https://doi.org/10.2460/javma.229.6.949
 
Rosset Emilie, Rannou Benoit, Casseleux Grégory, Chalvet-Monfray Karine, Buff Samuel (2012): Age-related changes in biochemical and hematologic variables in Borzoi and Beagle puppies from birth to 8 weeks. Veterinary Clinical Pathology, 41, 272-282 https://doi.org/10.1111/j.1939-165X.2012.00415.x
 
Ruaux Craig G., Carney Patrick C., Suchodolski Jan S., Steiner Jörg M. (2012): Estimates of biological variation in routinely measured biochemical analytes in clinically healthy dogs. Veterinary Clinical Pathology, 41, 541-547 https://doi.org/10.1111/j.1939-165x.2012.00473.x
 
Schwedhelm E, Boger RH (2011): The role of asymmetric and symmetric dimethylarginines in renal disease. Nature Reviews. Nephrology 7, 275–285.
 
Séronie-Vivien Sophie, Delanaye Pierre, Piéroni Laurence, Mariat Christophe, Froissart Marc, Cristol Jean-Paul (2008): Cystatin C: current position and future prospects. Clinical Chemistry and Laboratory Medicine, 46, - https://doi.org/10.1515/CCLM.2008.336
 
Simon A (): Renal haemodynamic responses to a chicken or beef meal in normal individuals. Nephrology Dialysis Transplantation, 13, 2261-2264 https://doi.org/10.1093/ndt/13.9.2261
 
Simonsen O., Grubb A., Thysell H. (2009): The blood serum concentration of cystatin C (γ-trace) as a measure of the glomerular filtration rate. Scandinavian Journal of Clinical and Laboratory Investigation, 45, 97-101 https://doi.org/10.3109/00365518509160980
 
Singer U, Kraft H (1989): Biological rhythms in the dog (in German). Kleintierpraxis 36, 167–174.
 
Siroen Michiel P.C., van der Sijp Joost R. M., Teerlink Tom, van Schaik Cors, Nijveldt Robert J., van Leeuwen Paul A. M. (2005): The human liver clears both asymmetric and symmetric dimethylarginine. Hepatology, 41, 559-565 https://doi.org/10.1002/hep.20579
 
Strasser A, Seiser M, Heizmann V, Niedermuller H (2001): The influence of season on hematologic and clinical parameters in a Beagle dog colony (in German). Kleintierpraxis 46, 798–804.
 
Sunde Kathrin, Nilsen Tom, Flodin Mats (2009): Performance Characteristics of a Cystatin C Immunoassay with Avian Antibodies. Upsala Journal of Medical Sciences, 112, 21-37 https://doi.org/10.3109/2000-1967-092
 
Tenstad O., Roald A. B., Grubb A., Aukland K. (2009): Renal handling of radiolabelled human cystatin C in the rat. Scandinavian Journal of Clinical and Laboratory Investigation, 56, 409-414 https://doi.org/10.3109/00365519609088795
 
Thoen ME, Kerl ME (2011): Characterization of acute kidney injury in hospitalized dogs and evaluation of a veterinary acute kidney injury staging system. Journal of Veterinary Emergency and Critical Care (San Antonio) 21, 648–657.
 
Thoresen Stein Istre, Havre Gustav N., Morberg Hanne, Mowinckel Petter (1992): Effects of Storage Time on Chemistry Results from Canine Whole Blood, Heparinized Whole Blood, Serum and Heparinized Plasma. Veterinary Clinical Pathology, 21, 88-94 https://doi.org/10.1111/j.1939-165X.1992.tb00591.x
 
Thoresen S.I., Tverdal A., Havre G., Morberg H. (1995): Effects of Storage Time and Freezing Temperature on Clinical Chemical Parameters From Canine Serum and Heparinized Plasma. Veterinary Clinical Pathology, 24, 129-133 https://doi.org/10.1111/j.1939-165X.1995.tb00954.x
 
Turk Vito, Bode Wolfram (1991): The cystatins: Protein inhibitors of cysteine proteinases. FEBS Letters, 285, 213-219 https://doi.org/10.1016/0014-5793(91)80804-C
 
Tvarijonaviciute A., Ceron J.J., Holden S.L., Biourge V., Morris P.J., German A.J. (2013): Effect of Weight Loss in Obese Dogs on Indicators of Renal Function or Disease. Journal of Veterinary Internal Medicine, 27, 31-38 https://doi.org/10.1111/jvim.12029
 
Uhríková I, Lačňáková A, Tandlerová K, Kuchařová V, Řeháková K, Jánová E, Doubek J (2013): Haematological and biochemical variations among eight sighthound breeds. Australian Veterinary Journal, 91, 452-459 https://doi.org/10.1111/avj.12117
 
Ulleberg Tina, Robben Joris, Nordahl Kathrine M, Ulleberg Thomas, Heiene Reidun (2011): Plasma creatinine in dogs: intra- and inter-laboratory variation in 10 European veterinary laboratories. Acta Veterinaria Scandinavica, 53, 25- https://doi.org/10.1186/1751-0147-53-25
 
Vajdovich P, Gaal T, Szilagyi A, Harnos A (1997): Changes in some red blood cell and clinical laboratory parameters in young and old Beagle dogs. Veterinary Research Communications 21, 463–470.https://doi.org/10.1023/A:1005929801735
 
Vaske H, Armbrust L, Zicker S, Jewell D, Grauer G (2015): Assessment of renal function in hyperthyroid cats managed with Hill’s® Prescription Diet® y/d® feline. Journal of Veterinary Internal Medicine 29, 1170.
 
Von Hendy-Willson Vanessa E., Pressler Barrak M. (2011): An overview of glomerular filtration rate testing in dogs and cats. The Veterinary Journal, 188, 156-165 https://doi.org/10.1016/j.tvjl.2010.05.006
 
Warfel A. H. (1987): Constitutive secretion of cystatin C (gamma-trace) by monocytes and macrophages and its downregulation after stimulation. Journal of Experimental Medicine, 166, 1912-1917 https://doi.org/10.1084/jem.166.6.1912
 
WATSON A. D. J., CHURCH D. B. (1980): POSTPRANDIAL INCREASE IN PLASMA CREATININE CONCENTRATION IN DOGS FED COOKED MEAT. Australian Veterinary Journal, 56, 463-463 https://doi.org/10.1111/j.1751-0813.1980.tb02656.x
 
Watson AD, Church DB, Fairburn AJ (1981): Postprandial changes in plasma urea and creatinine concentrations in dogs. American Journal of Veterinary Research 42, 1878–1880.
 
Wehner Astrid, Hartmann Katrin, Hirschberger Johannes (2008): Utility of Serum Cystatin C as a Clinical Measure of Renal Function in Dogs. Journal of the American Animal Hospital Association, 44, 131-138 https://doi.org/10.5326/0440131
 
Wolfordd S.T., Schroer R.A., Gohs F.X., Gallo P.P., Falk H.B., Dente A.R. (1988): Effect of Age on Serum Chemistry Profile, Electrophoresis and Thyroid Hormones in Beagle Dogs Two Weeks to One Year of Age. Veterinary Clinical Pathology, 17, 35-42 https://doi.org/10.1111/j.1939-165X.1988.tb00488.x
 
Woods Lori L. (1993): Mechanisms of renal hemodynamic regulation in response to protein feeding. Kidney International, 44, 659-675 https://doi.org/10.1038/ki.1993.299
 
Wyss Markus, Kaddurah-Daouk Rima (2000): Creatine and Creatinine Metabolism. Physiological Reviews, 80, 1107-1213 https://doi.org/10.1152/physrev.2000.80.3.1107
 
Yerramilli M, Obare E, Relford R, Beall M, Yerramilli M (2013): Stability of SDMA (symmetrical dimethylarginine) in canine and feline serum and plasma. Journal of Veterinary Internal Medicine 27, 737.
 
Yerramilli M, Yerramilli M, Obare E, Jewell DE, Hall JA (2015): Prognostic value of symmetric dimethylarginine (SDMA) to creatinine ratio in dogs and cats with chronic kidney disease. Journal of Veterinary Internal Medicine 29, 1274.
 
Zaldívar-López S., Marín L.M., Iazbik M.C., Westendorf-Stingle N., Hensley S., Couto C.G. (2011): Clinical pathology of Greyhounds and other sighthounds. Veterinary Clinical Pathology, 40, 414-425 https://doi.org/10.1111/j.1939-165X.2011.00360.x
 
Zhai Jian-Long, Ge Ning, Zhen Yuzhi, Zhao Qingzhen, Liu Chao (2016): Corticosteroids Significantly Increase Serum Cystatin C Concentration without Affecting Renal Function in Symptomatic Heart Failure. Clinical Laboratory, 62, - https://doi.org/10.7754/Clin.Lab.2015.150701
 
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