Acute toxicity of praziquantel to fish Danio rerio and planktonic crustacean Daphnia magna

Zuskova E, Piackova V, Valentova O, Zalohova K, Velisek J (2022): Acute toxicity of praziquantel to fish Danio rerio and planktonic crustacean Daphnia magna. Vet Med-Czech 67, 579–584.

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This study evaluated the toxicity of the pyrazino isoquinoline anthelmintic praziquantel (PZQ) to the Danio rerio zebrafish and Daphnia magna water flea. The estimated 24 h and 96 h LC50 of PZQ to the zebrafish was 39.9 mg/l and 30.4 mg/l, respectively. The highest 24 h and 96 h non-lethal concentration (LC0) was 21.7 mg/l and 21.2 mg/l, respectively. The mobility inhibition test of the juvenile Daphnia magna revealed a 48 h EC50 of 42.7 mg/l.

Bader C, Starling DE, Jones DE, Brewer MT. Use of praziquantel to control platyhelminth parasites of fish. J Vet Pharmacol Ther. 2019 Mar;42(2):139-53.
Bjorklund H, Bylund G. Absorption, distribution and excretion of the anthelmintic praziquantel (Droncit) in rainbow trout (Salmo gairdneri R.). Parasitol Res. 1987;73(3):240-4.
Cupit PM, Cunningham C. What is the mechanism of action of praziquantel and how might resistance strike? Future Med Chem. 2015;7(6):701-5.
Forwood JM, Bubner EJ, Landos M, D’Antignana T, Deveney MR. Praziquantel treatment for yellowtail kingfish (Seriola lalandi): Dose and duration safety study. Fish Physiol Biochem. 2016 Feb;42(1):103-9.
Hirazawa N, Akiyama K, Umeda N. Differences in sensitivity to the anthelmintic praziquantel by the skin-parasitic monogeneans Benedenia seriolae and Neobenedenia girellae. Aquaculture. 2013 Aug;404-405:59-64.
Hoai T, Van K. Efficacy of praziquantel against external parasites infecting freshwater fish. J Sci Dev. 2014;12(5):711-9.
Ishimaru K, Mine R, Shirakashi S, Kaneko E, Kubono K, Okada T, Sawada Y, Ogawa K. Praziquantel treatment against Cardicola blood flukes: Determination of the minimal effective dose and pharmacokinetics in juvenile Pacific bluefin tuna. Aquaculture. 2013 Jul;402-403:24-7.
Kim KH, Kim CS, Kim JW. Depletion of praziquantel in plasma and muscle tissue of cultured rockfish Sebastes schlegeli after oral and bath treatment. Dis Aquat Organ. 2001 Aug 2;45(3):203-7.
Kim CS, Cho JB, Ahn KJ, Lee JI, Kim KH. Depletion of praziquantel in muscle tissue and skin of cultured rockfish (Sebastes schlegeli) under the commercial culture conditions. Aquaculture. 2003 Apr;219(1-4):1-7.
Kim KH, Cho JB. Treatment of Microcotyle sebastis (Monogenea: Polyopisthocotylea) infestation with praziquantel in an experimental cage simulating commercial rockfish Sebastes schlegeli culture conditions. Dis Aquat Organ. 2000 Apr 20;40(3):229-31.
Maciel PO, Affonso EG. Praziquantel against monogeneans of tambaqui (Colossoma macropomum). Aquacult Int. 2021 Oct;29(5):2369-86.
Mitchell A, Darwish A. Efficacy of 6-, 12-, and 24-h praziquantel bath treatments against Asian tapeworms Bothriocephalus acheilognathi in grass carp. N Am J Aquac. 2009 Jan;71(1):30-4.
Mitchell AJ, Hobbs MS. The acute toxicity of praziquantel to grass carp and golden shiners. N Am J Aquac. 2007 Jan;69(3):203-6.
Mitchell AJ. Effectiveness of praziquantel bath treatments against Bothriocephalus acheilognathi in grass carp. J Aquat Anim Health. 2004 Jan;16(3):130-6.
Morales-Serna FN, Chapa-Lopez M, Martinez-Brown JM, Ibarra-Castro L, Medina-Guerrero RM, Fajer-Avila EJ. Efficacy of praziquantel and a combination anthelmintic (Adecto®) in bath treatments against Tagia ecuadori and Neobenedenia melleni (Monogenea), parasites of bullseye puffer fish. Aquaculture. 2018 Jun;492:361-8.
Morley NJ. Environmental risk and toxicology of human and veterinary waste pharmaceutical exposure to wild aquatic host-parasite relationships. Environ Toxicol Pharmacol. 2009 Mar;27(2):161-75.
Norbury LJ, Shirakashi S, Power C, Nowak BF, Bott NJ. Praziquantel use in aquaculture – Current status and emerging issues. Int J Parasitol Drugs Drug Resist. 2022 Apr;18:87-102.
Nwani CD, Nnaji MC, Oluah SN, Echi PC, Nwamba HO, Ikwuagwu OE, Ajima MN. Mutagenic and physiological responses in the juveniles of African catfish, Clarias gariepinus (Burchell 1822) following short term exposure to praziquantel. Tissue Cell. 2014 Aug;46(4):264-73.
Obiekezie A, Okafor N. Toxicity of four commonly used chemotherapeutic compounds to fry of the African catfish, Clarias gariepinus (Burchell). Aquacult Res. 1995 Jun;26(6):441-5.
OECD – Organisation for Economic Cooperation and Development. Guideline for testing of chemicals 203. Fish, acute toxicity test. Paris: OECD; 1992. 9 p.
OECD – Organisation for Economic Cooperation and Development. Guideline for testing of chemicals 202. Daphnia sp. acute immobilisation test. Paris: OECD; 2004. 12 p.
Ogawa K. Diseases of cultured marine fishes caused by Platyhelminthes (Monogenea, Digenea, Cestoda). Parasitology. 2015 Jan;142(1):178-95.
Samuelsen OB, Lunestad BT. Bath treatment, an alternative method for the administration of the quinolones flumequine and oxolinic acid to halibut Hippoglossus hippoglossus, and in vitro antibacterial activity of the drugs against some Vibrio sp. Dis Aquat Org. 1996 Oct;27(1):13-8.
Schmahl G, Mehlhorn H. Treatment of fish parasites. 1. Praziquantel effective against Monogenea (Dactylogyrus vastator, Dactylogyrus extensus, Diplozoon paradoxum). Z Parasitenkd. 1985;71(6):727-37.
Shirakashi S, Andrews M, Kishimoto Y, Ishimary K, Okada T, Swasa Y, Ogawa K. Oral treatment of praziquantel as an effective control measure against blood fluke infection in Pacific bluefin tuna (Thunnus orientalis). Aquaculture. 2012 Jan;326-329:15-9.
Sudova E, Piackova V, Velisek J, Pijacek M, Svobodova Z. Efficacy testing of orally administered praziquantel to common carp naturally infected by caryophyllidean tapeworms (Platyhelminthes: Eucestoda). Acta Vet Brno. 2010;79(9):73-8.
Szekely C, Molnar K. Praziquantel (Droncit) is effective against diplostomosis of grass carp Ctenopharyngodon idella and silver carp Hypophthalmichthys molitrix. Dis Aquat Org. 1991 Aug;11(2):147-50.
Thoney DA, Hargis Jr WJ. Monogenea (Platyhelminthes) as hazards for fish in confinement. Annu Rev Fish Dis. 1991;1:133-53.
Treves-Brown KM. Anthelmintics. In: Poxton MG, editor. Applied fish pharmacology. Dordrecht, the Netherlands: Kluwer Academic Publishers; 2000. p. 200-5.
Xie X, Zhao Y, Yang X, Hu K. Comparison of praziquantel pharmacokinetics and tissue distribution in fresh and brackish water cultured grass carp (Ctenopharyngodon idellus) after oral administration of single bolus. BMC Vet Res. 2015 Apr 1;11:84.
Zhang XP, Li WX, Ai TS, Zou H, Wu SG, Wang GT. The efficacy of four common anthelmintic drugs and traditional Chinese medicinal plant extracts to control Dactylogyrus vastator (Monogenea). Aquaculture. 2014 Jan;420-421:302-7.
Zrncic M, Gros M, Babic S, Kastelan-Macan M, Barcelo D, Petrovic M. Analysis of anthelmintics in surface water by ultra high performance liquid chromatography coupled to quadrupole linear ion trap tandem mass spectrometry. Chemosphere. 2014 Mar;99:224-32.
Zuskova E, Piackova V, Machova J, Chupani L, Steinbach C, Stara A, Velisek J. Efficacy and toxicity of praziquantel in helminth-infected barbel (Barbus barbus L.). J Fish Dis. 2018 Apr;41(4):643-9.
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