Aortic thromboembolism. A different predisposing disease in four dogs: a case report
Four dogs had signs of pelvic limb lameness, pain, and collapse resulting from an occlusion of the distal aorta or the iliac arteries by thrombi. The diagnosis of an aortic thromboembolism was based on the absence or weakness of a femoral pulse, and the two-dimensional and Doppler ultrasonography of the abdominal aorta, iliac, and femoral arteries. Three dogs had a concurrent disease predisposing to thrombosis, including hyperadrenocorticism, protein losing nephropathy, neoplasia, and cardiac disease. Three dogs were treated with a tissue plasminogen activator (t-PA) in an attempt to lyse the thrombosis; two regained pelvic limb function. The other two dogs died shortly after the diagnosis of a thrombosis. A complete description of the history, clinical signs, laboratory analysis and imaging studies is included. Moreover, a review of the aortic thromboembolism, a diagnosis protocol and the options for its treatment are discussed.
arterial thrombosis; tissue plasminogen activator; pelvic weakness; hind-limb paresis
Boswood A, Lamb CR, White RN (2000): Aortic and iliac thrombosis in six dogs. Journal of Small Animal Practice 41, 109–114.
https://doi.org/10.1111/j.1748-5827.2000.tb03176.x
Carter A, Van Heerden J (1994): Aortic thrombosis in a dog with glomerulonephritis. Journal of the South African Veterinary Association 65, 189–192.
Felix N, Mouro S, Vilela CL, Peleteiro MC, Ferreira AJA, Niza MMRE (2008): Canine leishmaniasis with nephrotic syndrome and aortic and caudal vena cava thromboembolism. Journal of Veterinary Emergency and Critical Care 18, 526–531.
https://doi.org/10.1111/j.1476-4431.2008.00341.x
Lake-Bakaar GA, Johnson EG, Griffiths LG (2012): Aortic thrombosis in dogs: 31 cases (2000–2010). Journal of the American Veterinary Medical Association 241, 910–915.
https://doi.org/10.2460/javma.241.7.910
Rosenberg RD, Aird WC (1999): Vascular-bed-specific hemostasis and hypercoagulable states. New England Journal of Medicine 340, 1555–1564.
https://doi.org/10.1056/NEJM199905203402007
Schoeman JP (1999): Feline distal aortic thromboembolism: A review of 44 cases (1990–1998). Journal of Feline Medicine and Surgery 1, 221–231.
https://doi.org/10.1053/jfms.1999.0049
Smith SA (2012): Antithrombotic therapy. Topics in Companion Animal Medicine 27, 88–94.
https://doi.org/10.1053/j.tcam.2012.08.002
Smith SA, Tobias AH, Jacob KA, Fine DM, Grumbles PL (2003): Arterial thromboembolism in cats: Acute crisis in 127 cases (1992–2001) and long-term management with low-dose aspirin in 24 cases. Journal of Veterinary Internal Medicine 17, 73–83.
Van Winkle TJ, Liu SM, Hackner SG (1993): Clinical and pathological features of aortic thromboembolism in 36 dogs. Journal of Veterinary Emergency and Critical Care 3, 13–21.
https://doi.org/10.1111/j.1476-4431.1993.tb00099.x
Winter RL, Sedacca CD, Adams A, Orton EC (2012): Aortic thrombosis in dogs: Presentation, therapy, and outcome in 26 cases. Journal of Veterinary Cardiology 14, 333–342.
https://doi.org/10.1016/j.jvc.2012.02.008
