Therapeutics of neonatal asphyxia in production animals: a review J., Bonilla-Jaime H., Gonzalez-Lozano M., Hernandez-Arteaga S., Greenwell-Beare V., Vega-Manriquez X., Gonzalez-Hernandez M., Orozco-Gregorio H. (2019): Therapeutics of neonatal asphyxia in production animals: a review. Veterinarni Medicina, 64: 191-203.
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The aim of this review is to assess the different treatments and therapeutic protocols used for neonatal asphyxia in animal production. Perinatal asphyxia is considered to be one of the main non-infectious causes of neonatal mortality in the majority of domestic mammals. However, its incidence in intensive animal production is increasing because of a series of implemented strategies aimed at improving and increasing production. For example, through the application of genetics, an increase in size and weight in newly born animals has been achieved. Nevertheless, this has resulted in a larger incidence of dystocia associated with oxygen restriction to thefoetus, which elicits metabolic and respiratory acidosis. Furthermore, aside from immediate financial implications when it comes to production, it also has an impact on the welfare of mother and offspring. Regarding the field of animal perinatology, several therapeutic strategies using respiratory and hormonal stimulants, as well as energetic supplements have been evaluated with the aim of preventing perinatal asphyxia and treating neonates with the condition, and also to diminish the incidence of stillbirths associated with it. However, during the last decades this condition has persisted mainly in porcine, equine, ovine and bovine production; for this reason, it continues to be studied extensively.

Alonso-Spilsbury María, Mota-Rojas Daniel, Villanueva-García Dina, Martínez-Burnes Julio, Orozco Héctor, Ramírez-Necoechea Ramiro, Mayagoitia Alfonso López, Trujillo María Elena (2005): Perinatal asphyxia pathophysiology in pig and human: A review. Animal Reproduction Science, 90, 1-30
Arteaga Olatz, Álvarez Antonia, Revuelta Miren, Santaolalla Francisco, Urtasun Andoni, Hilario Enrique (2017): Role of Antioxidants in Neonatal Hypoxic–Ischemic Brain Injury: New Therapeutic Approaches. International Journal of Molecular Sciences, 18, 265-
Bajcsy Árpád Csaba, Szenci Ottó, Doornenbal Arie, Weijden Gijsbert C. van der, Csorba Csaba, Kocsis László, Szűcs Imre, Ostgard Stig, Taverne Marcel A.M. (2005): Characteristics of bovine early puerperal uterine contractility recorded under farm conditions. Theriogenology, 64, 99-111
Barkhuizen M, van den Hove DL, Vles JS, Steinbusch HW, Kramer BW, Gavilanes AW (2017): 25 years of research on global asphyxia in the immature rat brain. Neuroscience & Biobehavioral Reviews 75, 166–182.
Baxter Emma M., Jarvis Susan, Sherwood Lorna, Farish Marianne, Roehe Rainer, Lawrence Alistair B., Edwards Sandra A. (2011): Genetic and environmental effects on piglet survival and maternal behaviour of the farrowing sow. Applied Animal Behaviour Science, 130, 28-41
Bleul U., Bircher B., Jud R.S., Kutter A.P.N. (2010): Respiratory and cardiovascular effects of doxapram and theophylline for the treatment of asphyxia in neonatal calves. Theriogenology, 73, 612-619
Bleul U., Kähn W. (2008): Monitoring the bovine fetus during stage II of parturition using pulse oximetry. Theriogenology, 69, 302-311
Carluccio A., Contri A., Gloria A., Veronesi M.C., Sfirro M.P., Parrillo S., Robbe D. (2017): Correlation between some arterial and venous blood gas parameters in healthy newborn Martina Franca donkey foals from birth to 96 hours of age. Theriogenology, 87, 173-178
Colella Marina, Biran Valérie, Baud Olivier (2016): Melatonin and the newborn brain. Early Human Development, 102, 1-3
Cordoba R, Pkiyach S, Rooke JA, Edwards SA, Penny PC, Pike I (2000): The effect of feeding salmon oil during pregnancy on causes of piglet deaths prior to weaning. Proceedings of the British Society of Animal Science. Abstract 105.
Cruz Raíssa K.S., Alfonso Angélica, Souza Fabiana F., Oba Eunice, Padovani Carlos R., Ramos Paulo R.R., Lourenço Maria Lúcia G., Chiacchio Simone B. (2017): Evaluation of neonatal vitality and blood glucose, lactate and cortisol concentrations in foals of the Paint Horse breed. Pesquisa Veterinária Brasileira, 37, 891-896
Ferraz Guilherme de Camargo, Teixeira-Neto Antônio Raphael, D’Angelis Flora Helena de Freitas, Lacerda-Neto José Corrêa de, Queiroz-Neto Antonio de (2006): Long-term creatine supplementation improves the aerobic capacity of horses. Ciência Rural, 36, 514-519
De Cramer K.G.M., Joubert K.E., Nöthling J.O. (2017): Puppy survival and vigor associated with the use of low dose medetomidine premedication, propofol induction and maintenance of anesthesia using sevoflurane gas-inhalation for cesarean section in the bitch. Theriogenology, 96, 10-15
Declerck I., Dewulf J., Decaluwé R., Maes D. (2016): Effects of energy supplementation to neonatal (very) low birth weight piglets on mortality, weaning weight, daily weight gain and colostrum intake. Livestock Science, 183, 48-53
Dickinson Hayley, Ellery Stacey, Ireland Zoe, LaRosa Domenic, Snow Rodney, Walker David W (2014): Creatine supplementation during pregnancy: summary of experimental studies suggesting a treatment to improve fetal and neonatal morbidity and reduce mortality in high-risk human pregnancy. BMC Pregnancy and Childbirth, 14, -
Dutra F., Banchero G. (2011): Polwarth and Texel ewe parturition duration and its association with lamb birth asphyxia12. Journal of Animal Science, 89, 3069-3078
Dwyer C.M. (2008): The welfare of the neonatal lamb. Small Ruminant Research, 76, 31-41
Ellery Stacey J., Dickinson Hayley, McKenzie Matthew, Walker David W. (2016): Dietary interventions designed to protect the perinatal brain from hypoxic-ischemic encephalopathy – Creatine prophylaxis and the need for multi-organ protection. Neurochemistry International, 95, 15-23
Endesfelder Stefanie, Weichelt Ulrike, Strauß Evelyn, Schlör Anja, Sifringer Marco, Scheuer Till, Bührer Christoph, Schmitz Thomas (2017): Neuroprotection by Caffeine in Hyperoxia-Induced Neonatal Brain Injury. International Journal of Molecular Sciences, 18, 187-
Figueira R.L., Gonçalves F.L., Simões A.L., Bernardino C.A., Lopes L.S., Castro e Silva O., Sbragia L. (2016): Brain caspase-3 and intestinal FABP responses in preterm and term rats submitted to birth asphyxia. Brazilian Journal of Medical and Biological Research, 49, -
Filippi Luca, Fiorini Patrizio, Daniotti Marta, Catarzi Serena, Savelli Sara, Fonda Claudio, Bartalena Laura, Boldrini Antonio, Giampietri Matteo, Scaramuzzo Rosa, Papoff Paola, Del Balzo Francesca, Spalice Alberto, la Marca Giancarlo, Malvagia Sabrina, Della Bona Maria Luisa, Donzelli Gianpaolo, Tinelli Francesca, Cioni Giovanni, Pisano Tiziana, Falchi Melania, Guerrini Renzo (2012): Safety and efficacy of topiramate in neonates with hypoxic ischemic encephalopathy treated with hypothermia (NeoNATI). BMC Pediatrics, 12, -
Fix J.S., Cassady J.P., Holl J.W., Herring W.O., Culbertson M.S., See M.T. (2010): Effect of piglet birth weight on survival and quality of commercial market swine. Livestock Science, 132, 98-106
Gonzalez-Bulnes A., Astiz S., Ovilo C., Lopez-Bote C.J., Torres-Rovira L., Barbero A., Ayuso M., Garcia-Contreras C., Vazquez-Gomez M. (2016): Developmental Origins of Health and Disease in swine: implications for animal production and biomedical research. Theriogenology, 86, 110-119
Gonzalez-Lozano M, Mota-Rojas D, Velazquez-Armenta EY, Nava-Ocampo AA, Hernandez-Gonzalez R, Becerril-Herrera M, Trujillo-Ortega ME, Alonso-Spilsbury M (2009a): Obstetric and fetal outcomes in dystocic and eutocic sows to an injection of exogenous oxytocin during farrowing. Canadian Veterinary Journal 50, 1273–1277.
Gonzalez-Lozano M, Ortega MET, Becerril-Herrera M, Alonso-Spilsbury M, Ramirez-Necoechea R, Hernandez-Gonzalez R, Mota-Rojas D (2009b): Effects of oxytocin on critical blood variables from dystocic sows (in Spanish). Veterinaria México 40, 231–245.
González-Lozano M., Trujillo-Ortega M.E., Alonso-Spilsbury M., Rosales A.M., Ramírez-Necoechea R., González-Maciel A., Martínez-Rodríguez R., Becerril-Herrera M., Mota-Rojas D. (2012): Vetrabutine clorhydrate use in dystocic farrowings minimizes hemodynamic sequels in piglets. Theriogenology, 78, 455-461
Herpin P, Le Dividich J, Hulin J C, Fillaut M, De Marco F, Bertin R (1996): Effects of the level of asphyxia during delivery on viability at birth and early postnatal vitality of newborn pigs.. Journal of Animal Science, 74, 2067-
Herpin P, Hulin J C, Le Dividich J, Fillaut M (2001): Effect of oxygen inhalation at birth on the reduction of early postnatal mortality in pigs.. Journal of Animal Science, 79, 5-
Herrera-Marschitz Mario, Neira-Pena Tanya, Rojas-Mancilla Edgardo, Espina-Marchant Pablo, Esmar Daniela, Perez Ronald, Muñoz Valentina, Gutierrez-Hernandez Manuel, Rivera Benjamin, Simola Nicola, Bustamante Diego, Morales Paola, Gebicke-Haerter Peter J. (2014): Perinatal asphyxia: CNS development and deficits with delayed onset. Frontiers in Neuroscience, 8, -
IMSS-632-13 (n.d.): Clinical Practice Guideline (GPC): Diagnosis and treatment of neonatal asphyxia. Mexican Social Security Institute. Medical Benefits Direction (México D.F.), 1–21.
Ireland Z, Dickinson H, Snow R, Walker DW (2008): Maternal creatine: does it reach the fetus and improve survival after an acute hypoxic episode in the spiny mouse (Acomys cahirinus)? American Journal of Obstetrics & Gynecology 198, 431.e1–6.
Jiménez-Bravo M.A., Mota-Rojas D., Orozco-Gregorio H., Pérez-Guille B., Soriano-Rosales R., Roldan-Santiago P., Alonso-Spilsbury M., Arch-Tirado E., Mora-Medina P., Martínez-Burnes J. (2016): Evaluation of the protective effect of thiamine pyrophosphate based on the biochemical analysis of rabbit foetuses at 30 days of gestation. Reproductive Toxicology, 65, 359-364
Katz L (2006): Perinatal asphyxia syndrome in a quarter horse foal. Veterinary Clinics of North America: Equine Practice 22, 193–208.
Knottenbelt DC, Holdstock N, Madigan JE (2004): Equine Neonatology: Medicine and Surgery. Elsevier, Philadelphia. 508 pp.
Kreider Richard B., Kalman Douglas S., Antonio Jose, Ziegenfuss Tim N., Wildman Robert, Collins Rick, Candow Darren G., Kleiner Susan M., Almada Anthony L., Lopez Hector L. (2017): International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine. Journal of the International Society of Sports Nutrition, 14, -
Lee Moonhee, McGeer Edith G., McGeer Patrick L. (2016): Quercetin, not caffeine, is a major neuroprotective component in coffee. Neurobiology of Aging, 46, 113-123
Lu Kristina G., Barr Bonnie S., Embertson Rolf, Schaer Barbara Dallap (2006): Dystocia—A True Equine Emergency. Clinical Techniques in Equine Practice, 5, 145-153
Marseglia Lucia, D’Angelo Gabriella, Manti Sara, Reiter Russel J., Gitto Eloisa (2016): Potential Utility of Melatonin in Preeclampsia, Intrauterine Fetal Growth Retardation, and Perinatal Asphyxia. Reproductive Sciences, 23, 970-977
Martz P, Georgiev P, Wehrend A (2017): Prolonged second stage labour and consequences of hypoxia in the neonate: A review. Bulgarian Journal of Veterinary Medicine, doi: 10.15547/bjvm.2012.
Mellor D.J., Stafford K.J. (2004): Animal welfare implications of neonatal mortality and morbidity in farm animals. The Veterinary Journal, 168, 118-133
Miller Suzanne L., Yan Edwin B., Castillo-Meléndez Margie, Jenkin Graham, Walker David W. (2005): Melatonin Provides Neuroprotection in the Late-Gestation Fetal Sheep Brain in Response to Umbilical Cord Occlusion. Developmental Neuroscience, 27, 200-210
Moallem U., Zachut M. (2012): Short communication: The effects of supplementation of various n-3 fatty acids to late-pregnant dairy cows on plasma fatty acid composition of the newborn calves. Journal of Dairy Science, 95, 4055-4058
Mota-Rojas Daniel, Martínez-Burnes Julio, Trujillo Ma. Elena, López Alfonso, Rosales Ana M., Ramírez Ramiro, Orozco Héctor, Merino Angeles, Alonso-Spilsbury María (2005): Uterine and fetal asphyxia monitoring in parturient sows treated with oxytocin. Animal Reproduction Science, 86, 131-141
Mota-Rojas D, Trujillo-Ortega Ma E, Villanueva-Garcia D, Gonzalez-Lozano M, Orozco-Gregorio H, Ramirez-Necoechea R, Olmos-Hernandez A, Alonso-Spilsbury M (2006): Can uterotonics reduce fetal and newborn piglet mortality by perinatal asphyxia and improve functional vitality? Journal of Medical Sciences 6, 884–893.
Muns R., Nuntapaitoon M., Tummaruk P. (2016): Non-infectious causes of pre-weaning mortality in piglets. Livestock Science, 184, 46-57
Murray Christine F., Leslie Ken E. (2013): Newborn calf vitality: Risk factors, characteristics, assessment, resulting outcomes and strategies for improvement. The Veterinary Journal, 198, 322-328
Murray CF, Veira DM, Nadalin AL, Haines DM, Jackson ML, Pearl DL, Leslie KE (2015): The effect of dystocia on physiological and behavioral characteristics related to vitality and passive transfer of immunoglobulins in newborn Holstein calves. Canadian Journal of Veterinary Research 79, 109–119.
Natarajan G., Lulic-Botica M., Aranda J.V. (2007): Pharmacology Review: Clinical Pharmacology of Caffeine in the Newborn. NeoReviews, 8, e214-e221
Nemeth J, Toth-Szuki V, Varga V, Kovacs V, Remzso G, Domoki F (2016): Molecular hydrogen affords neuroprotection in a translational piglet model of hypoxic-ischemic encephalopathy. Journal of Physiology and Pharmacology 67, 677–689.
Nogueira CEW, Lins LA (2010): Equine Neonatology and Pediatrics. Editora e Gráfica Universitária da UFPel, Rio Grande do Sul, Brazil.
Ohl F., van der Staay F.J. (2012): Animal welfare: At the interface between science and society. The Veterinary Journal, 192, 13-19
Olmos-Hernández A., Trujillo-Ortega M. E., Alonso-Spilsbury M., Sánchez-Aparicio P., Ramírez-Necoechea R., Mota-Rojas D. (2011): Foetal Monitoring, Uterine Dynamics and Reproductive Performance in Spontaneous Farrowings in Sows. Journal of Applied Animal Research, 33, 181-185
Oñatibia-Astibia Ainhoa, Martínez-Pinilla Eva, Franco Rafael (2016): The potential of methylxanthine-based therapies in pediatric respiratory tract diseases. Respiratory Medicine, 112, 1-9
Orozco-Gregorio H., Bonilla-Jaime H., Mota-Rojas D., Trujillo-Ortega M. E., Roldan-Santiago P., Martínez-Rodríguez R., Borderas-Tordesillas F., Flores-Peinado S., Mora-Medina P., Ramírez-Necoechea R. (2012): Effects of subcutaneous administration of caffeine on the physiometabolic profile of low-birthweight neonate piglets. Animal Production Science, 52, 981-
Orozco-Gregorio H., Mota-Rojas D., Alonso-Spilsbury M., Olmos-Hernandez A., Ramirez-Necoechea R., Velazquez-Armenta E. Y., Nava-Ocampo A. A., Hernandez-Gonzalez R., Trujillo-Ortega M. E., Villanueva-Garcia D. (2009): Short-Term Neurophysiologic Consequences of Intrapartum Asphyxia in Piglets Born by Spontaneous Parturition. International Journal of Neuroscience, 118, 1299-1315
Orozco-Gregorio Héctor, Mota-Rojas Daniel, Bonilla-Jaime Herlinda, Trujillo-Ortega María E., Becerril-Herrera Marcelino, Hernández-González Rafael, Villanueva-García Dina (2010): Effects of administration of caffeine on metabolic variables in neonatal pigs with peripartum asphyxia. American Journal of Veterinary Research, 71, 1214-1219
Orozco-Gregorio H, Mota-Rojas D, Villanueva D, Bonilla-Jaime H, Suarez-Bonilla X, Torres-Gonzalez L, Bolanos D, Hernandes-Gonzalez R, Martinez-Rodriguez R, Trujillo-Ortega ME (2011): Caffeine therapy for apnoea of prematurity: Pharmacological treatment. African Journal of Pharmacy and Pharmacology 5, 564–571.
Park Hye Won, Lim Gina, Chung Sung-Hoon, Chung Sochung, Kim Kyo Sun, Kim Soo-Nyung (2015): Early Caffeine Use in Very Low Birth Weight Infants and Neonatal Outcomes: A Systematic Review and Meta-Analysis. Journal of Korean Medical Science, 30, 1828-
Perez-de-Sa Valeria, Cunha-Goncalves Doris, Nordh Anders, Hansson Stefan, Larsson Anders, Ley David, Fellman Vineta, Werner Olof (2009): High Brain Tissue Oxygen Tension During Ventilation With 100% Oxygen After Fetal Asphyxia in Newborn Sheep. Pediatric Research, 65, 57-61
Perrone Serafina, Bracciali Carlotta, Di Virgilio Nicola, Buonocore Giuseppe (2017): Oxygen Use in Neonatal Care: A Two-edged Sword. Frontiers in Pediatrics, 4, -
Petzold M., Meyer U., Kersten S., Breves G., Dänicke S. (2014): Feeding conjugated linoleic acids and various concentrate proportions to late pregnant cows and its consequence on blood metabolites of calves. Livestock Science, 161, 95-100
Pirrone Alessandro, Panzani Sara, Govoni Nadia, Castagnetti Carolina, Veronesi Maria Cristina (2013): Thyroid hormone concentrations in foals affected by perinatal asphyxia syndrome. Theriogenology, 80, 624-629
Probo M., Giordano A., Moretti P., Opsomer G., Fiems L.O., Veronesi M.C. (2012): Mode of delivery is associated with different hematological profiles in the newborn calf. Theriogenology, 77, 865-872
Quiniou N, Dagorn J, Gaudré D (2002): Variation of piglets’ birth weight and consequences on subsequent performance. Livestock Production Science, 78, 63-70
Retes-Lopez R, Martin-Rivera M, Ibarra-Flores F, Moreno-Medina S, Denogean-Ballesteros FG (2013): Analysis of profitability of beef calves in Sonora (in Spanish). Revista Mexicana de Agronegocios 33, 588–598.
Robertson N. J., Faulkner S., Fleiss B., Bainbridge A., Andorka C., Price D., Powell E., Lecky-Thompson L., Thei L., Chandrasekaran M., Hristova M., Cady E. B., Gressens P., Golay X., Raivich G. (2013): Melatonin augments hypothermic neuroprotection in a perinatal asphyxia model. Brain, 136, 90-105
Robertson S. M., Friend M. A., Doran G. S., Edwards S. (2018): Caffeine supplementation of ewes during lambing may increase lamb survival. animal, 12, 376-382
Rooke J.A, SinclaiR A. G., Ewen M. (2001): Changes in piglet tissue composition at birth in response to increasing maternal intake of long-chain n -3 polyunsaturated fatty acids are non-linear. British Journal of Nutrition, 86, 461-470
Seddon Y.M., Cain P.J., Guy J.H., Edwards S.A. (2013): Development of a spreadsheet based financial model for pig producers considering high welfare farrowing systems. Livestock Science, 157, 317-321
Sicilia-Argumedo G, Martinez-Avila MA, Valenzuela-Peraza A, Gonzalez-Zavala MA, Granados-Rojas L, Barragan-Mejia MG (2007): Protective effect of thiamine pyrophosphate in the hippocampus of rats exposed to stress by forced immobilization. Veterinaria México 38, 429–438.
Skouroliakou Maria, Bacopoulou Flora, Markantonis Sophia L (2009): Caffeine versus theophylline for apnea of prematurity: A randomised controlled trial. Journal of Paediatrics and Child Health, 45, 587-592
Smith BP (2002): Large Animal Internal Medicine. 3rd edn. Manole, São Paulo. 1728 pp.
Sullivan Patrick G., Geiger Jonathan D., Mattson Mark P., Scheff Stephen W. (2000): Dietary supplement creatine protects against traumatic brain injury. Annals of Neurology, 48, 723-729<723::AID-ANA5>3.0.CO;2-W
Superchi Paola, Mazzoni Claudio, Zanardelli Paola, Piancastelli Chiara, Zambini Ernesto Mario, Beretti Valentino, Sabbioni Alberto (2013): Effects of oral caffeine administration to sows with induced parturition on hypoxia in piglets. Livestock Science, 157, 372-377
Superchi Paola, Saleri Roberta, Farina Elena, Cavalli Valeria, Riccardi Enzo, Sabbioni Alberto (2016): Effects of oral administration of caffeine on some physiological parameters and maternal behaviour of sows at farrowing. Research in Veterinary Science, 105, 121-123
Tølløfsrud Per Arne, Medbø Sverre, SolÅs Anne Beate, Drevon Christian A, Saugstad Ola Didrik (2002): Albumin Mixed with Meconium Attenuates Pulmonary Dysfunction in a Newborn Piglet Model with Meconium Aspiration. Pediatric Research, 52, 545-553
Tønnessen R., Borge K. Sverdrup, Nødtvedt A., Indrebø A. (2012): Canine perinatal mortality: A cohort study of 224 breeds. Theriogenology, 77, 1788-1801
Trujillo-Ortega ME, Mota-Rojas D, Olmos-Hernandez A, Alonso-Spilsbury M, Gonzalez M, Orozco H, Ramirez-Necoechea R, Nava-Ocampo AA (2007): A study of piglets born by spontaneous parturition under uncontrolled conditions: could this be a naturalistic model for the study of intrapartum asphyxia? Acta Biomedica 78, 29–35.
Valenzuela-Peraza A, Martinez-Avila MA, Jimenez Bravo-Luna MA, Granados-Rojas L, Mendoza-Torreblanca JG, Barragan-Mejia MG (2014): Thiamine pyrophosphate reduces hypoxia-induced cellular damage in neonatal rat brain. International Journal of Morphology 32, 531–536.
Vanderhaeghe C., Dewulf J., de Kruif A., Maes D. (2013): Non-infectious factors associated with stillbirth in pigs: A review. Animal Reproduction Science, 139, 76-88
Vento Máximo, Sastre Juan, Asensi Miguel A., Viña José (2005): Room-Air Resuscitation Causes Less Damage to Heart and Kidney than 100% Oxygen. American Journal of Respiratory and Critical Care Medicine, 172, 1393-1398
Veronesi M.C., Panzani S., Faustini M., Rota A. (2009): An Apgar scoring system for routine assessment of newborn puppy viability and short-term survival prognosis. Theriogenology, 72, 401-407
Welin Anne-Karin, Svedin Pernilla, Lapatto Risto, Sultan Bo, Hagberg Henrik, Gressens Pierre, Kjellmer Ingemar, Mallard Carina (2007): Melatonin Reduces Inflammation and Cell Death in White Matter in the Mid-Gestation Fetal Sheep Following Umbilical Cord Occlusion. Pediatric Research, 61, 153-158
WHO – World Health Organization (2017): Reduce the mortality of newborns. Descriptive Note, October 2017. Available at (Accessed: January 22, 2018).
Wilkins Pamela A. (2003): Acute respiratory failure: Diagnosis, monitoring techniques, and therapeutics. Clinical Techniques in Equine Practice, 2, 56-66
Xu Linlin, Dong Wenhong, Zhao Jie, Xu Yajun (2015): Effect of Marine Collagen Peptides on Physiological and Neurobehavioral Development of Male Rats with Perinatal Asphyxia. Marine Drugs, 13, 3653-3671
Yadegari M, Khazaei M, Anvari M, Eskandari M (2016): Prenatal caffeine exposure impairs pregnancy in rats. International Journal of Fertility & Sterility 9, 558–562.
Yeates J.W., Main D.C.J. (2008): Assessment of positive welfare: A review. The Veterinary Journal, 175, 293-300
Yli BM, Kjellmer I (2016): Pathophysiology of foetal oxygenation and cell damage during labour. Best Practice & Research Clinical Obstetrics & Gynaecology 30, 9–21.
Zaleski HM, Hacker RR (1993): Variables related to the progress of parturition and probability of stillbirth in swine. Canadian Veterinary Journal 34, 109–113.
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