Ultrasonographic characteristics of benign mammary lesions in bitches

https://doi.org/10.17221/87/2017-VETMEDCitation:Gasser B, Rodriguez MGK, Uscategui RAR, Silva PA, Maronezi MC, Pavan L, Feliciano MAR, Vicente WRR (2018): Ultrasonographic characteristics of benign mammary lesions in bitches. Veterinarni Medicina, 63: 216-224.
download PDF

The aim of this study was to evaluate the applicability of B-mode, Doppler, acoustic radiation force impulse elastography and contrast-enhanced ultrasound exams in the differentiation of neoplastic and non-neoplastic benign mammary lesions in bitches. This research was conducted as a prospective secondary observational cohort (2014–2016) study, which included 36 mammary lesions, evaluated physically and by ultrasound (B-mode, Doppler, contrast-enhanced ultrasound and acoustic radiation force impulse) exams prior to mastectomy and histopathological classification as neoplastic or non-neoplastic lesions. All ultrasonographic parameters studied were compared between histopathological classifications using Fisher’s or Student’s tests and differences were considered significant when P < 0.05. Out of 36 benign mammary lesions evaluated, 25 were classified as neoplastic and 11 as non-neoplastic. The qualitative and quantitative parameters evaluated using the different ultrasound methods were not effective (P > 0.05) in differentiating between neoplastic and non-neoplastic mammary masses in bitches. Nevertheless, some B-mode variables, such as longitudinal length (P = 0.0292), width/length ratio (P = 0.0001) and width/height ratio (P = 0.0001) showed limited efficacy in the differentiation of mammary lesions types. In conclusion, ultrasonographic evaluation of benign canine mammary lesions did not allow differentiation between neoplastic and non-neoplastic tissues and only a few B-mode variables may aid in the prediction of specific tumour types.

References:
Bastan A, Ozenc E, Pir Yagci I, Baki Acar D (2009): Ultrasonographic evaluation of mammary tumors in bitches. Kafkas Universitesi Veteriner Fakultesi Dergisi 1, 81–86.
 
Bostock D.E. (1986): Canine and feline mammary neoplasms. British Veterinary Journal, 142, 506-515 https://doi.org/10.1016/0007-1935(86)90107-7
 
Calas Maria Julia Gregorio, Koch Hilton Augusto, Dutra Maria Virginia Peixoto (2007): Ultra-sonografia mamária: avaliação dos critérios ecográficos na diferenciação das lesões mamárias. Radiologia Brasileira, 40, 1-7 https://doi.org/10.1590/S0100-39842007000100003
 
Cassali GD, Lavalle GE, Ferreira E, Estrela-Lima A, De Nardi B, Ghever C, Sobral RA, Amorim RL, Oliveira LO, Sueiro FAR, Beserra HEO, Bertagnolli AC, Gamba CO, Damasceno KA, Campos CB, Araujo MR, Campos LC, Monteiro LN, Nunes FC, Horta RS, Reis DC, Luvizotto MCR, Magalhaes GM, Raposo JB, Ferreira AMR, Tanaka NM, Grandi F, Ubukata R, Batschinski K, Terra EM, Salvador RCL, Jark PC, Delecrodi JER, Nascimento NA, Silva DN, Silva LP, Ferreira KCRS, Frehse MS, di Santis GW, Silva EO, Guim TN, Kerr B, Cintra PP, Silva FBF, Leite JS, Mello MFV, Ferreira MLG, Fukumasu H, Salgado BS, Torres R (2013): Consensus for the diagnosis, prognosis and treatment of canine mammary tumors. Brazilian Journal of Veterinary Pathology 7, 38–69.
 
Cassidy J, Bissett D, Roy AJ, Spence OBE, Payne M, Morris-Stiff G (eds) (2015): Oxford Handbook of Oncology. 4th edn. Oxford. Xxii + 873.
 
Davoudi Yasmin, Borhani Barat, Rad Masoud Pezeshki, Matin Nassim (2014): The Role of Doppler Sonography in Distinguishing Malignant from Benign Breast Lesions. Journal of Medical Ultrasound, 22, 92-95 https://doi.org/10.1016/j.jmu.2013.12.001
 
Feliciano M. A. R., Vicente W. R. R., Silva M. A. M. (2012): Conventional and Doppler ultrasound for the differentiation of benign and malignant canine mammary tumours. Journal of Small Animal Practice, 53, 332-337 https://doi.org/10.1111/j.1748-5827.2012.01227.x
 
Feliciano M. A. R., Maronezi M. C., Pavan L., Castanheira T. L., Simões A. P. R., Carvalho C. F., Canola J. C., Vicente W. R. R. (2014): ARFI elastography as a complementary diagnostic method for mammary neoplasia in female dogs - preliminary results. Journal of Small Animal Practice, 55, 504-508 https://doi.org/10.1111/jsap.12256
 
Feliciano Marcus Antonio Rossi, Uscategui Ricardo Andrés Ramirez, Maronezi Marjury Cristina, Simões Ana Paula Rodrigues, Silva Priscila, Gasser Beatriz, Pavan Leticia, Carvalho Cibele Figueira, Canola Júlio Carlos, Vicente Wilter Ricardo Russiano, Thamm Douglas (2017): Ultrasonography methods for predicting malignancy in canine mammary tumors. PLOS ONE, 12, e0178143- https://doi.org/10.1371/journal.pone.0178143
 
Feliciano Marcus Antonio Rossi, Ramirez Ricardo Andrés Uscategui, Maronezi Marjury Cristina, Maciel Giovanna Serpa, Avante Michelle Lopes, Senhorello Igor Luiz Salardani, Mucédola Talita, Gasser Beatriz, Carvalho Cibele Figueira, Vicente Wilter Ricardo Russiano (): Accuracy of four ultrasonography techniques in predicting histopathological classification of canine mammary carcinomas. Veterinary Radiology & Ultrasound, , - https://doi.org/10.1111/vru.12606
 
Gokhale Sudheer (2009): Ultrasound characterization of breast masses. Indian Journal of Radiology and Imaging, 19, 242- https://doi.org/10.4103/0971-3026.54878
 
Gong JJ, Wan ZX, Yao MH, Zhao LX, Xu G, Liu H, Wu R (2016): Conventional ultrasound, ultrasound elasticity imaging, and acoustic radiation force impulse imaging for prediction of malignancy in breast masses. International Journal of Clinical and Experimental Medicine 9, 8108–8117.
 
Gonzales de Bulnes A, Garcia Fernandez P, Mayenco Aguirre AM, Sanchez de la Muela M (1998): Ultrasonographic imaging of canine mammary tumours. Veterinary Record 143, 687–689.
 
Li Guiling, Li De-Wei, Fang Yu-Xiao, Song Yi-Jiang, Deng Zhu-Jun, Gao Jian, Xie Yan, Yin Tian-Sheng, Ying Li, Tang Kai-Fu, Coleman William B. (2013): Performance of Shear Wave Elastography for Differentiation of Benign and Malignant Solid Breast Masses. PLoS ONE, 8, e76322- https://doi.org/10.1371/journal.pone.0076322
 
Guray M. (2006): Benign Breast Diseases: Classification, Diagnosis, and Management. The Oncologist, 11, 435-449 https://doi.org/10.1634/theoncologist.11-5-435
 
Liu He, Jiang Yu-Xin, Liu Ji-Bin, Zhu Qing-Li, Sun Qiang (2008): Evaluation of breast lesions with contrast-enhanced ultrasound using the microvascular imaging technique: Initial observations. The Breast, 17, 532-539 https://doi.org/10.1016/j.breast.2008.04.004
 
Liu BaoXian, Zheng YanLing, Shan QuanYuan, Lu Ying, Lin ManXia, Tian WenShuo, Xie XiaoYan (2016): Elastography by acoustic radiation force impulse technology for differentiation of benign and malignant breast lesions: a meta-analysis. Journal of Medical Ultrasonics, 43, 47-55 https://doi.org/10.1007/s10396-015-0658-9
 
Masciadri N., Ferranti C. (2011): Benign breast lesions: Ultrasound. Journal of Ultrasound, 14, 55-65 https://doi.org/10.1016/j.jus.2011.03.002
 
Misdorp W, Else RW, Hellmen E, Lipscomb TP (eds) (1999): Histological Classification of Mammary Tumors of the Dog and Cat. World Health Organization International Classification of Tumors of Domestic Animals. Armed Forces Institute of Pathology. 59 pp.
 
Nyman Helena T., Nielsen Ole L., McEvoy Fintan J., Lee Marcel H., Martinussen Torben, Hellmén Eva, Kristensen Annemarie T. (2006): Comparison of B-mode and Doppler ultrasonographic findings with histologic features of benign and malignant mammary tumors in dogs. American Journal of Veterinary Research, 67, 985-991 https://doi.org/10.2460/ajvr.67.6.985
 
Oliveira JC, Kommers GD, Masuda EK, Marques BMFPP, Fighera RA, Irigoyen LF, Barros CSL (2010): A retrospective study of 1.647 mammary tumors in bitches (in Portuguese). Pesquisa Veterinaria Brasileira 30, 177–185.
 
Ricci Paolo, Maggini Elena, Mancuso Ester, Lodise Pietro, Cantisani Vito, Catalano Carlo (2014): Clinical application of breast elastography: State of the art. European Journal of Radiology, 83, 429-437 https://doi.org/10.1016/j.ejrad.2013.05.007
 
Schmillevitch Joel, Guimarães Filho Hélio Antonio, De Nicola Harley, Gorski Ana Cheila (2009): Utilização do índice de resistência vascular na diferenciação entre nódulos mamários benignos e malignos. Radiologia Brasileira, 42, 241-244 https://doi.org/10.1590/S0100-39842009000400010
 
Soler Marta, Dominguez Elisabet, Lucas Xiomara, Novellas Rosa, Gomes-Coelho Kassia Valeria, Espada Yvonne, Agut Amalia (2016): Comparison between ultrasonographic findings of benign and malignant canine mammary gland tumours using B-mode, colour Doppler, power Doppler and spectral Doppler. Research in Veterinary Science, 107, 141-146 https://doi.org/10.1016/j.rvsc.2016.05.015
 
TAGAWA Michihito, KANAI Eiichi, SHIMBO Genya, KANO Mikiya, KAYANUMA Hideki (2016): Ultrasonographic evaluation of depth–width ratio (D/W) of benign and malignant mammary tumors in dogs. Journal of Veterinary Medical Science, 78, 521-524 https://doi.org/10.1292/jvms.15-0456
 
Tang L, Xu HX, Bo XW, Liu BJ, Li XL, Wu R, Dan-Dan L, Lin F, Xiao-Hong X (2015): A novel two-dimensional quantitative shear wave elastography for differentiating malignant from benign breast lesions. International Journal of Clinical and Experimental Medicine 8, 10920–10928.
 
Tozaki M, Isobe S, Fukuma E (2011a): Preliminary study of ultrasonographic tissue quantification of the breast using the acoustic radiation force impulse (ARFI) technology. European Journal of Radiology 80, e182–e187.
 
Tozaki M, Isobe S, Yamaguchi M, Ogawa Y, Homma K, Saito M, Joo C, Fukuma E (2011b): Ultrasonographic elastography of the breast using acoustic radiation force impulse technology: preliminary study. Japanese Journal of Radiology 29, 452–456.
 
Wan Caifeng, Du Jing, Fang Hua, Li Fenghua, Wang Lin (2012): Evaluation of breast lesions by contrast enhanced ultrasound: Qualitative and quantitative analysis. European Journal of Radiology, 81, e444-e450 https://doi.org/10.1016/j.ejrad.2011.03.094
 
Wang YongMei, Fan Wei, Zhao Song, Zhang Kai, Zhang Li, Zhang Ping, Ma Rong (2016): Qualitative, quantitative and combination score systems in differential diagnosis of breast lesions by contrast-enhanced ultrasound. European Journal of Radiology, 85, 48-54 https://doi.org/10.1016/j.ejrad.2015.10.017
 
Xia Han-Sheng, Wang Xi, Ding Hong, Wen Jie-Xian, Fan Pei-Li, Wang Wen-Ping (2014): Papillary breast lesions on contrast-enhanced ultrasound: morphological enhancement patterns and diagnostic strategy. European Radiology, 24, 3178-3190 https://doi.org/10.1007/s00330-014-3375-7
 
Zhou JianQiao, Zhan WeiWei, Dong YiJie, Yang ZhiFang, Zhou Chun (2014): Stiffness of the surrounding tissue of breast lesions evaluated by ultrasound elastography. European Radiology, 24, 1659-1667 https://doi.org/10.1007/s00330-014-3152-7
 
download PDF

© 2018 Czech Academy of Agricultural Sciences