Imaging findings of renal telangiectasia in a Maltese dog

https://doi.org/10.17221/87/2020-VETMEDCitation:

Noh D, Lee SW, Jung D, Park JK, Lee K (2020): Imaging findings of renal telangiectasia in a Maltese dog. Vet Med-Czech 65, 457–463.

download PDF

A 13-year-old neutered male Maltese dog presented with a three-month history of haematuria. The abdominal ultrasound and computed tomography revealed a large, multifocally-calcified left renal mass that was disrupting most of the renal parenchyma. Most of the areas of this mass did not show any contrast enhancement on the CT. After a nephrectomy, renal telangiectasia was diagnosed on the histopathology. Renal telangiectasia is a hereditary dysplastic blood vessel disease only previously reported in Pembroke Welsh Corgi. This is the first diagnostic imaging report of renal telangiectasia and the first report in a Maltese. Renal telangiectasia should be considered for the differential diagnosis of destructive renal masses with faint or no contrast enhancement on a CT, even in cases of unilateral renal involvement in Maltese dogs or those in non-corgi breeds.

References:
Ardelean DS, Letarte M. Anti-angiogenic therapeutic strategies in hereditary hemorrhagic telangiectasia. Front Genet. 2015 Feb 11;6:35.
 
Bryan JN, Henry CJ, Turnquist SE, Tyler JW, Liptak JM, Rizzo SA, Sfiligoi G, Steinberg SJ, Smith AN, Jackson T. Primary renal neoplasia of dogs. J Vet Intern Med. 2006 Sep-Oct;20(5):1155-60.
 
Cnossen WR, Drenth JP. Polycystic liver disease: An overview of pathogenesis, clinical manifestations and management. Orphanet J Rare Dis. 2014 May 1;9:1-13.
 
Diters RW, Wells M. Renal interstitial cell tumors in the dog. Vet Pathol. 1986 Jan;23(1):74-6. https://doi.org/10.1177/030098588602300112
 
Gajanayake I, Priestnall SL, Benigni L, English K, Summers BA, Garden OA. Paraneoplastic hypercalcemia in a dog with benign renal angiomyxoma. J Vet Diagn Invest. 2010 Sep;22(5):775-80. https://doi.org/10.1177/104063871002200523
 
Herman S. Computed tomography contrast enhancement principles and the use of high-concentration contrast media. J Comput Assist Tomogr. 2004 Jul-Aug;28:S7-11.
 
Jain RK, Kozak KR. Molecular pathophysiology of tumors. In: Halperin EC, Parez CA, Brady LW, editors. Principles and practice of radiation encology. Philadelphia, USA: Lippincott Williams & Wilkins; 2008. p. 126-41.
 
Katabathina VS, Vikram R, Nagar AM, Tamboli P, Menias CO, Prasad SR. Mesenchymal neoplasms of the kidney in adults: Imaging spectrum with radiologic-pathologic correlation. Radiographics. 2010 Oct;30(6):1525-40. https://doi.org/10.1148/rg.306105517
 
Konde LJ, Wrigley RH, Park RD, Lebel JL. Sonographic appearance of renal neoplasia in the dog. Vet Radiol. 1985 May;26(3):74-81. https://doi.org/10.1111/j.1740-8261.1985.tb01387.x
 
Moore FM, Thorton GW. Telangiectasia of Pembroke welsh corgi dogs. Vet Pathol. 1983 Mar;20(2):203-8. https://doi.org/10.1177/030098588302000207
 
Na X, Wu G, Ryan CK, Schoen SR, di’Santagnese PA, Messing EM. Overproduction of vascular endothelial growth factor related to von Hippel-Lindau tumor suppressor gene mutations and hypoxia-inducible factor-1 alpha expression in renal cell carcinomas. J Urol. 2003 Aug;170:588-92. https://doi.org/10.1097/01.ju.0000074870.54671.98
 
Nyland TG, Widmer WR, Mattoon JS. Urinary tract. In: Mattoon JS. Nyland TG, editors. Small animal diagnostic ultrasound. St. Louis, USA: Elsevier Health Sciences; 2002. p. 557-607.
 
Park HA, Jeong CW, Kim GS, Kim HJ, Do SH, Park HM. Primary renal fibrosarcoma with local invasion into the mesenteric membrane of a mongrel dog. Korean J Vet Res. 2015 Mar;55(1):65-9.
 
Sadick H, Naim R, Gossler U, Hormann K, Riedel F. Angiogenesis in hereditary hemorrhagic telangiectasia: VEGF165 plasma concentration in correlation to the VEGF expression and microvessel density. Int J Mol Med. 2005 Jan;15(1):15-9. https://doi.org/10.3892/ijmm.15.1.15
 
Seiler GS. Kidneys and ureters. In: Thrall DE, editor. Textbook of veterinary diagnostic radiology. St. Louis, US: Elsevier Health Sciences; 2018. p. 823-45.
 
Sheth S, Scatarige JC, Horton KM, Corl FM, Fishman EK. Current concepts in the diagnosis and management of renal cell carcinoma: Role of multidetector CT and three-dimensional CT. Radiographics.2001 Oct;21:S237-54.
 
Weyman PJ, McClennan BL, Lee JK, Stanley RJ. CT of calcified renal masses. AJR Am J Roentgenol. 1982 Jun;138(6):1095-9. https://doi.org/10.2214/ajr.138.6.1095
 
Zini E, Bovero A, Nigrisoli E, Ratto A, Rampazzo A, Zatelli A. Sarcomatoid renal cell carcinoma with osteogenic differentiation and paraneoplastic hepatopathy in a dog, possibly related to human Stauffer’s syndrome. J Comp Pathol. 2003 Nov;129(4):303-7. https://doi.org/10.1016/S0021-9975(03)00038-0
 
download PDF

© 2020 Czech Academy of Agricultural Sciences | Prohlášení o přístupnosti