Distribution and aetiology of valvular endocarditis in suckling and weaned piglets in Serbia


Savic B, Radanovic O, Milicevic V, Kureljusic B, Zdravkovic N, Nesic K, Stevancevic O (2020): Distribution and aetiology of valvular endocarditis in suckling and weaned piglets in Serbia. Vet Med-Czech 65, 480–486.

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There are limited data available in the literature about the frequency and distribution of endocarditis in suckling and weaned piglets. The goal of this study was to investigate the frequency and distribution of lesions from cases of spontaneous valvular endocarditis in young piglets and to determine the bacterial agents involved in those lesions. Valvular endocarditis lesions in suckling piglets were detected in 21/454 cases (4.62%) and in 20/306 cases (6.53%) in weaned piglets. Streptococci were the dominant bacterial species isolated in 68% of the cases; S. suis was identified in 48.7% of the cases, S. pyogenes in 7.3% and S. spp., which could not be further identified, were cultured in 12.1% of the cases. E. rhusiopathiae was identified as the causal agent of endocarditis in four cases in the weaned piglets. In three cases, A. suis and S. aureus were isolated, and, in two cases, A. pleuropneumoniae was identified. Y. enterocolitica was isolated form one case of valvular endocarditis in a weaned pig. The finding of valvular endocarditis caused by Y. enterocolitica is an uncommon finding in pigs, and to the authors’ knowledge, there are no other reports of this agent being the cause of endocarditis in pigs. The involvement of Y. enterocolitica in endocarditis might have been assisted by the predisposing role of immunosuppressive viruses, such as porcine reproductive and respiratory syndrome.

Baumann B, Bilkei G. Emergency-culling and mortality in growing/fattening pigs in a large Hungarian “farrow-to-finish” production unit. Dtsch Tierarztl Wochenschr. 2002 Jan;109(1):26-33.
Butts CL, Sternberg EM. Neuroendocrine factors alter host defense by modulating immune function. Cell Immunol. 2008 Mar-Apr;252(1-2):7-15.  https://doi.org/10.1016/j.cellimm.2007.09.009
Esgleas M, Lacouture S, Gottschalk M. Streptococcus suis serotype 2 binding to extracellular matrix proteins. FEMS Microbiol Lett. 2005 Mar 1;244(1):33-40. https://doi.org/10.1016/j.femsle.2005.01.017
Guarda F, Negro M. Beitrag zur Pathomorphologie der Endokardiose des Schweines [The pathomorphology of endocardiosis in swine]. Dtsch Tierarztl Wochenschr. 1989 Jul-Aug;96(7):377-9. German.
Hookey JV, Richardson JF, Cookson BD. Molecular typing of Staphylococcus aureus based on PCR restriction fragment length polymorphism and DNA sequence analysis of the coagulase gene. J Clin Microbiol. 1998 Apr;36(4):1083-9.
Jarplid B, Brennius E, Nilsson NG. Observations of apparent early valvular endocarditis in swine. J Vet Diagn Invest. 1997 Oct;9(4):449-51.
Jensen HE, Gyllensten J, Hofman C, Leifsson PS, Agerholm JS, Boye M, Aalbæk B. Histologic and bacteriologic findings in valvular endocarditis of slaughter-age pigs. J Vet Diagn Invest. 2010 Nov;22(6):921-7.
Johnson CM, Bahn RC, Fass DN. Experimental porcine infective endocarditis: Description of a clinical model. Vet Pathol. 1986 Nov;23(6):780-2. https://doi.org/10.1177/030098588602300620
Jones JET. Bacterial endocarditis in the pig with special reference to streptococcal endocarditis. J Comp Pathol. 1980 Jan;90(1):11-28. https://doi.org/10.1016/0021-9975(80)90024-9
Jones JET. Experimental streptococcal endocarditis in the pig: The development of lesions 18 to 48 hours after inoculation. J Comp Pathol. 1982 Apr;92(2):301-8.
Kariyawasam S, Strait E, Jordan D, Kroll J. Development of a real-time polymerase chain reaction assay for detection of Actinobacillus suis in porcine lung. J Vet Diagn Invest. 2011 Sep;23(5):885-9. https://doi.org/10.1177/1040638711416854
Katsumi M, Kataoka Y, Takahashi T, Kikuchi N, Hiramune T. Bacterial isolation from slaughtered pigs associated with endocarditis, especially the isolation of Streptococcus suis. J Vet Med Sci. 1997;59(1):75-8. https://doi.org/10.1292/jvms.59.75
Krajinovic V, Tambic Andrasevic A, Barsic B. Tricuspidal valve endocarditis due to Yersinia enterocolitica. Infection. 2007 Jun;35(3):203-5.
Kumar V, Cotran RS, Robbins SL. Heart. In: Kumar V, Cotran RS, Robbins SL, editors. Basic pathology. 5th ed. Phil-adephia, Pennsylvania: W.B. Saunders Company; 1992. p. 1-784.
Liu D, Hollingshead S, Swiatlo E, Lawrence ML, Austin FW. Rapid identification of Streptococcus pyogenes with PCR primers from a putative transcriptional regulator gene. Res Microbiol. 2005 May;156(4):564-7. https://doi.org/10.1016/j.resmic.2005.01.010
Loynachan AT. Cardiovascular and hematopoietic system. In: Zimmerman J, Karriker L, Ramirez A, Schwartz K, Stevenson G, editors. Diseases of swine. 10th ed. Chichester: Wiley-Blackwell; 2012. p. 89-198.
Makino S, Okada Y, Maruyama T, Ishikawa K, Takahashi T, Nakamura M, Ezaki T, Morita H. Direct and rapid detection of Erysipelothrix rhusiopathiae DNA in animals by PCR. J Clin Microbiol. 1994 Jun;32(6):1526-31. https://doi.org/10.1128/JCM.32.6.1526-1531.1994
Marois C, Bougeard S, Gottschalk M, Kobisch M. Multiplex PCR assay for detection of Streptococcus suis species and serotypes 2 and 1/2 in tonsils of live and dead pigs. J Clin Microbiol. 2004 Jul;42(7):3169-75.
Pedersen KB, Henrichsen J, Perch B. The bacteriology of endocarditis in slaughter pigs. Acta Pathol Microbiol Immunol Scand B. 1984 Aug;92(4):237-8. https://doi.org/10.1111/j.1699-0463.1984.tb02827.x
Schaller A, Djordjevic SP, Eamens GJ, Forbes WA, Kuhn R, Kuhnert P, Gottschalk M, Nicolet J, Frey J. Identification and detection of Actinobacillus pleuropneumoniae by PCR based on the gene apxIVA. Vet Microbiol. 2001 Mar 2;79(1):47-62.
Schultze-Koops H, Burkhardt H, Heesemann T, Kirsch J, Swoboda B, Bull C, Goodman S, Emmrich F. Outer membrane protein YadA of enteropathogenic Yersinia mediates specific binding to cellular but not plasma fibronectin. Infect Immun.1993 Jun;61(6):2513-9.
Thomson JR, Smith WJ, Murray BP, Murray D, Dick JE, Sumption KJ. Porcine enteric spirochete infections in the UK: Surveillance data and preliminary investigation of atypical isolates. Anim Health Res Rev. 2001 Jun;2(1):31-6. https://doi.org/10.1079/AHRR200123
VanVleet JF, Ferrans VJ. Cardiovascular system. In: McGavin MD, Zachary JF, editors. Pathologic basis of veterinary diseases. 4th ed. St. Louis, MO: Mosby Elsevier; 2007. p. 559-611.
Wannet WJ, Reessink M, Brunings HA, Maas HM. Detection of pathogenic Yersinia enterocolitica by a rapid and sensitive duplex PCR assay. J Clin Microbiol. 2001 Dec;39(12):4483-6. https://doi.org/10.1128/JCM.39.12.4483-4486.2001
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