Immunohistochemical localization of calbindin-D28k in the kidney and cerebellum of the porcupines (Hystrix cristata)
S. Timurkaan, A. Aydin, M. Kabanhttps://doi.org/10.17221/5792-VETMEDCitation:Timurkaan S., Aydin A., Kaban M. (2003): Immunohistochemical localization of calbindin-D28k in the kidney and cerebellum of the porcupines (Hystrix cristata). Veterinarni Medicina, 48: 369-372.
The localization of calbindin in the kidney and cerebellum of Hystrix cristata was investigated immunohistochemically using an antiserum against the 28k Da calbindin of chicken duodenum. Calbindin-D28k is an intracellular protein with a high affinity for calcium. This protein is exclusively localized in the distal convoluted tubules of the kidney and in Purkinje cells of the cerebellum. Functionaly, calbindin-D28k is supposed to be involved in the regulation of the reabsorption of calcium in the distal nephron, though the exact regulatory mechanisms are not yet known.Keywords:
calbindin-D28k; kidney; cerebellum; Hystrix cristata; immunohistochemist