Effects of Neospora caninum on reproductive performance and the efficacy of treatment with a combination of sulphadiazine-trimethoprim and toltrazuril: a longitudinal field study

https://doi.org/10.17221/7241-VETMEDCitation:Canatan H., Polat I., Bayramoglu R., Kuplulu S., Vural M., Aktug E. (2014): Effects of Neospora caninum on reproductive performance and the efficacy of treatment with a combination of sulphadiazine-trimethoprim and toltrazuril: a longitudinal field study. Veterinarni Medicina, 59: 22-28.
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 This study was designed to determine the prevalence of Neospora caninum, the effect of infection on abortion and fertility parameters and the efficacy and outcomes with combination treatment in a dairy farm with high abortion rates and low fertility parameters. Four hundred and eighty-six cows were tested using the immunofluorescence antibody test (IFAT). The seroprevalence of N. caninum was 19%. Sulphadiazine-trimethoprim and toltrazuril were administered to the seropositive animals. The risk of abortion increased 19-fold in animals infected with N. caninum (P < 0.05), and N. caninum-induced abortions occurred more often between the fourth and the sixth months of gestation. N. caninum infection also had an adverse influence on the number of inseminations to conception (P < 0.05) and calving to conception interval (P < 0.05). The treatment protocol improved the fertility parameters. Although, it is not a radical approach, this combination therapy may be recommended as the primary treatment in neosporosis.  
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