SRY-negative XX sex reversal in an English Cocker Spaniel: a case report D., Gulten T., Karkucak M., Yilmaz R., Nak Y., Simsek G., Shahzad A. (2015): SRY-negative XX sex reversal in an English Cocker Spaniel: a case report. Veterinarni Medicina, 60: 170-173.
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A SRY-negative XX male describes a female karyotype with testicular tissue resulting from abnormal gonadal development. In such cases male gonad formation takes place in the absence of a Y chromosome which supports the hypothesis that some other genes are also responsible for testicular development. The present case report describes a one-year-old dog brought to the hospital with a complaint of no oestrus cycle. Apparently normal masculine bitch had an enlarged clitoris with an os on radiograph. A gonado-hysterectomy was performed. Instead of ovarian structures both testicular masses were present and a normal complete bicornuate uterus with a normal cervix was observed. The histology of both gonads showed two testes, each with its ductus deferens and the uterus with typical histological structure. Cytogenetic evaluation of peripheral blood lymphocytes revealed a female with a normal karyotype (78, XX). Polymerase chain reaction (PCR) analysis of genomic DNA showed that the SRY gene was absent.
Campos M, Moreno-Manzano V, García-Roselló M, García-Roselló E (2011): SRY-Negative XX Sex Reversal in a French Bulldog. Reproduction in Domestic Animals, 46, 185-188
Jakob Susanne, Lovell-Badge Robin (2011): Sex determination and the control of Sox9 expression in mammals. FEBS Journal, 278, 1002-1009
Meyers-Wallen VN, Bowman L, Acland GM, Palmer VL, Schlafer D, Fajt V (1995a): SRY-negative XX sex reversal in the German shorthaired pointer dog. Journal of Heredity 86, 369–374.
Meyers-Wallen VN, Palmer VL, Acland GM, Hershfield B (1995b): SRY-negative XXSR in the American spaniel dog. Molecular Reproduction and Development 41, 300–305.
Meyers-Wallen V.N., Schlafer D., Barr I., Lovell-Badge R., Keyzner A. (1999): Sry-negative XX sex reversal in purebred dogs. Molecular Reproduction and Development, 53, 266-273<266::AID-MRD2>3.0.CO;2-6
Pailhoux E., Pelliniemi L., Barbosa A., Parma P., Kuopio T., Cotinot C. (1997): Relevance of intersexuality to breeding and reproductive biotechnology programs; XX sex reversal in pigs. Theriogenology, 47, 93-102
Plumb DC (2011): Plumb’s Veterinary Drug Handbook. 7th ed. John Wiley and Sons, New York, USA. 1057 pp.
Silversides DW, Jean-Marc B, Collard F, Gilson C (2011): Disorder of sex development (XX male, SRY negative) in a French bulldog. Canadian Veterinary Journal 52, 670–672.
Swain A, Narvaez V, Burgoyne P, Camerino G, Lovell-Badge R (1998): Dax1 antagonizes Sry action in mammalian sex determination. Nature 391, 761–767.
Vaiman D., Pailhoux E., Schibler L., Oustry A., Chaffaux S., Cotinot C., Fellous M., Cribiu E.P. (1997): Genetic mapping of the polled/intersex locus (PIS) in goats. Theriogenology, 47, 103-109
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