Tooth autotransplantations – lessons from animal models: a review

https://doi.org/10.17221/8243-VETMEDCitation:Langova P., Stembirek J., Matalova E., Buchtova M. (2015): Tooth autotransplantations – lessons from animal models: a review. Veterinarni Medicina, 60: 293-300.
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Autotransplantation of teeth is the most natural technique to for replacing missing teeth in exposed parts of the dental arch. Reports from human patients indicate great progress toward successful transplantations. However, complications such as inflammation and ankylosis still occur. To understand regenerative processes after autotransplantations, several animal models have been used (monkeys, rodents, rabbits, cats and dogs) and histological/molecular methods have been established. This review aims to summarise knowledge from animal models and discuss their advantages or disadvantages with respect to possible usage in research.
References:
Al-Majed AA, Neumann CM, Brushart TM, Gordon T (2000): Brief electrical stimulation promotes the speed and accuracy of motor axonal regeneration. Journal of Neurosciences 20, 2602–2608.
 
Altonen Mikko, Haavikko Kaarina, Malmström Maria (1978): Evaluation of autotransplantations of completely developed maxillary canines. International Journal of Oral Surgery, 7, 434-441  https://doi.org/10.1016/S0300-9785(78)80034-9
 
Andreasen JO (1981a): The effect of pulp extirpation or root canal treatment on periodontal healing after replantation of permanent incisors in monkeys. Journal of Endodontics 7, 245–252.
 
Andreasen JO (1981b): Relationship between surface and inflammatory resorption and changes in the pulp after replantation of permanent incisors in monkeys. Journal of Endodontics 7, 294–301.
 
Andreasen JO, Paulsen HU, Yu Z, Ahlquist R, Bayer T, Schwartz O (1990a): A long-term study of 370 autotransplanted premolars. Part I. Surgical procedures and standardized techniques for monitoring healing. European Journal of Orthodontics 12, 3–13.
 
Andreasen JO, Paulsen HU, Yu Z, Bayer T (1990b): A long-term study of 370 autotransplanted premolars. Part IV. Root development subsequent to transplantation. European Journal of Orthodontics 12, 38–50.
 
Andreasen JO, Paulsen HU, Yu Z, Bayer T, Schwartz O (1990c): A long-term study of 370 autotransplanted premolars. Part II. Tooth survival and pulp healing subsequent to transplantation. European Journal of Orthodontics 12, 14–24.
 
Andreasen JO, Paulsen HU, Yu Z, Schwartz O (1990d): A long-term study of 370 autotransplanted premolars. Part III. Periodontal healing subsequent to transplantation. European Journal of Orthodontics 12, 25–37.
 
Apfel H (1950): Autoplasty of enucleated prefunctional third molars. Jurnal Oral Surgery 8, 289–296.
 
Azevedo Paulo César, Moura Camilla Christian Gomes, Zanetta-Barbosa Darceny, Bernadineli Norberti (2007): Time of endodontic treatment in autogenic transplants of mature teeth: Histological study in dogs. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 104, 287-293  https://doi.org/10.1016/j.tripleo.2007.02.006
 
Birman E. G., Soares de Araujo N. (1975): Autotransplants and Allotransplants of Teeth in the Subcutaneous Tissue of Rabbits : A Histological Study. Journal of Dental Research, 54, 508-514  https://doi.org/10.1177/00220345750540031701
 
Byers Margaret R., Suzuki Hironobu, Maeda Takeyasu (2003): Dental neuroplasticity, neuro-pulpal interactions, and nerve regeneration. Microscopy Research and Technique, 60, 503-515  https://doi.org/10.1002/jemt.10291
 
Claus Inne, Laureys Wim, Cornelissen Ria, Dermaut Luc R (2004): Histologic analysis of pulpal revascularization of autotransplanted immature teeth after removal of the original pulp tissue. American Journal of Orthodontics and Dentofacial Orthopedics, 125, 93-99  https://doi.org/10.1016/S0889-5406(03)00619-X
 
COHEN A. SCOTT, SHEN T.C., POGREL M. ANTHONY (1995): TRANSPLANTING TEETH SUCCESSFULLY: AUTOGRAFTS AND ALLOGRAFTS THAT WORK. The Journal of the American Dental Association, 126, 481-485  https://doi.org/10.14219/jada.archive.1995.0211
 
Conklin William W. (1969): Autogenous dental transplants. Oral Surgery, Oral Medicine, Oral Pathology, 28, 17-25  https://doi.org/10.1016/0030-4220(69)90188-1
 
Ferreira Manuel Marques, Botelho Maria Filomena, Abrantes Margarida, Oliveiros Barbara, Carrilho Eunice Virgínia (2010): Quantitative scintigraphic analysis of pulp revascularization in autotransplanted teeth in dogs. Archives of Oral Biology, 55, 825-829  https://doi.org/10.1016/j.archoralbio.2010.07.005
 
Ferreira Manuel Marques, Botelho Maria Filomena Rabaça, Carvalho Lina, Silva Maria Reis, Oliveiros Barbara, Carrilho Eunice Virgínia Palmeirão (2012): Evaluation of dentin formed in autogenous tooth transplantation in the dog: a comparison between one- and two-stage surgical techniques. Dental Traumatology, 28, 97-100  https://doi.org/10.1111/j.1600-9657.2011.01040.x
 
Fleischmannova Jana, Matalova Eva, Tucker Abigail S., Sharpe Paul T. (2008): Mouse models of tooth abnormalities. European Journal of Oral Sciences, 116, 1-10  https://doi.org/10.1111/j.1600-0722.2007.00504.x
 
Groisman Mario, Schwartz Ole, Andreasen Jens Ove, Attstrom Rolf (1989): Supra-alveolar periodontal healing of auto- and allotransplanted teeth in monkeys. Dental Traumatology, 5, 227-233  https://doi.org/10.1111/j.1600-9657.1989.tb00366.x
 
Hale Merle L. (1954): Autogenous transplants. The Journal of the American Dental Association, 49, 193-198  https://doi.org/10.14219/jada.archive.1954.0147
 
Hasegawa Tomoko, Suzuki Hironobu, Yoshie Hiromasa, Ohshima Hayato (2007): Influence of extended operation time and of occlusal force on determination of pulpal healing pattern in replanted mouse molars. Cell and Tissue Research, 329, 259-272  https://doi.org/10.1007/s00441-007-0424-4
 
Holland G.R., Lau S., Truong P., Robinson P.P. (1991): Innervation of the Pulp-Predentin Border Zone of the Cat following Denervation and Reinnervation. Cells Tissues Organs, 142, 317-320  https://doi.org/10.1159/000147209
 
Holland GR, Robinson PP (1987a): A morphological study of the collateral reinnervation of the cat’s canine tooth. Experimental Neurology 98, 489–498.
 
Holland GR, Robinson PP (1987b): Pulp re-innervation in re-implanted canine teeth of the cat. Archives of Oral Biology 32, 593–597.
 
Hosoya A., Yukita A., Yoshiba K., Yoshiba N., Takahashi M., Nakamura H. (): Two Distinct Processes of Bone-like Tissue Formation by Dental Pulp Cells after Tooth Transplantation. Journal of Histochemistry & Cytochemistry, 60, 861-873  https://doi.org/10.1369/0022155412459741
 
Huebsch Raymond F., Hansen Louis S. (1969): A histopathologic study of extraction wounds in dogs. Oral Surgery, Oral Medicine, Oral Pathology, 28, 187-196  https://doi.org/10.1016/0030-4220(69)90286-2
 
Izumi N., Yoshizawa M., Ono Y., Kobayashi T., Hamamoto Y., Saito C. (2007): Periodontal regeneration of transplanted rat teeth subcutaneously after cryopreservation. International Journal of Oral and Maxillofacial Surgery, 36, 838-844  https://doi.org/10.1016/j.ijom.2007.06.003
 
Jonsson Teitur, Sigurdsson Thorarinn J (2004): Autotransplantation of premolars to premolar sites. A long-term follow-up study of 40 consecutive patients. American Journal of Orthodontics and Dentofacial Orthopedics, 125, 668-675  https://doi.org/10.1016/j.ajodo.2003.12.002
 
Katayama Akihiko, Ota Mikio, Sugito Hiroki, Shibukawa Yoshihiro, Yamada Satoru (2006): Effect of proliferating tissue on transplanted teeth in dogs. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 101, e110-e118  https://doi.org/10.1016/j.tripleo.2005.10.074
 
Kawasaki Naoko, Hamamoto Yoshioki, Nakajima Tamio, Irie Kazuharu, Ozawa Hidehiro (2004): Periodontal regeneration of transplanted rat molars after cryopreservation. Archives of Oral Biology, 49, 59-69  https://doi.org/10.1016/j.archoralbio.2003.07.002
 
Kim E, Cho SW, Yang JY, Cai J, Lee SJ, Ohshima H, Jung HS (2006): Tooth survival and periodontal tissues healing of allogenic-transplanted teeth in the mice. Oral Diseases, 12, 395-401  https://doi.org/10.1111/j.1601-0825.2006.01213.x
 
Kristerson L., Andreasen J.O. (1984): Influence of root development on periodontal and pulpal healing after replantation of incisors in monkeys. International Journal of Oral Surgery, 13, 313-323  https://doi.org/10.1016/S0300-9785(84)80039-3
 
Laureysa Wim, Beeleb Hilde, Cornelissenc Ria, Dermauta Luc (2001): Revascularization after cryopreservation and autotransplantation of immature and mature apicoectomized teeth. American Journal of Orthodontics and Dentofacial Orthopedics, 119, 346-352  https://doi.org/10.1067/mod.2001.113259
 
Laureys Wim G.M., Cuvelier Claude A., Dermaut Luc R., De Pauw Guy A.M. (2013): The Critical Apical Diameter to Obtain Regeneration of the Pulp Tissue after Tooth Transplantation, Replantation, or Regenerative Endodontic Treatment. Journal of Endodontics, 39, 759-763  https://doi.org/10.1016/j.joen.2013.02.004
 
Lu Lu, Sun Hui-fang, Xue Han, Guo Jing, Chen Yang-xi (2013): Effects of orthodontic load on the periodontium of autogenously transplanted teeth in beagle dogs. Journal of Zhejiang University SCIENCE B, 14, 1025-1032  https://doi.org/10.1631/jzus.B1300062
 
Marques-Ferreira M., Rabaca-Botelho MF., Carvalho L., Oliveiros B., Palmeirao-Carrilho EV. (2009): Autogenous tooth transplantation: Evaluation of pulp tissue regeneration. Medicina Oral Patología Oral y Cirugia Bucal, , e984-e989  https://doi.org/10.4317/medoral.16926
 
Marques Ferreira Manuel, Filomena Botelho Maria, Lina Carvalho, Barbara Oliveiros, Palmeirão Carrilho Eunice Virgínia (2010): Histological evaluation of periodontal regeneration in autogenous tooth transplantation in the dog: a comparison between one and two-stage surgical techniques, a pilot study. Dental Traumatology, 26, 76-79  https://doi.org/10.1111/j.1600-9657.2009.00853.x
 
Miller HM (1951): Tooth transplantation; report of case. Jurnal Oral Surgery 9, 68–69.
 
Mirzabagi Mostafa H. (1978): Histologic study of tooth transplantation in the rabbit. Oral Surgery, Oral Medicine, Oral Pathology, 46, 618-627  https://doi.org/10.1016/0030-4220(78)90457-7
 
Mutoh Noriko, Nakatomi Mitsushiro, Ida-Yonemochi Hiroko, Nakagawa Eizo, Tani-Ishii Nobuyuki, Ohshima Hayato (2011): Responses of BrdU label-retaining dental pulp cells to allogenic tooth transplantation into mouse maxilla. Histochemistry and Cell Biology, 136, 649-661  https://doi.org/10.1007/s00418-011-0868-1
 
Nethander Gunnar, Skoglund Annika, Kahnberg Karl-Erik (2003): Experimental autogenous tooth transplantation in the dog: a comparison between one- and two-stage surgical techniques. Acta Odontologica Scandinavica, 61, 223-229  https://doi.org/10.1080/00016350310004098
 
Ogawa Ryoichiro, Saito Chikara, Jung Han-Sung, Ohshima Hayato (2006): Capacity of dental pulp differentiation after tooth transplantation. Cell and Tissue Research, 326, 715-724  https://doi.org/10.1007/s00441-006-0242-0
 
Ohazama A., Modino S.A.C., Miletich I., Sharpe P.T. (2004): Stem-cell-based Tissue Engineering of Murine Teeth. Journal of Dental Research, 83, 518-522  https://doi.org/10.1177/154405910408300702
 
Ohman A (1965): Healing and sensitivity to pain in young replanted human teeth: an experimental, clinical and histological study. Odontologisk Tidskrift 73, 166–227.
 
OHSHIMA Hayato, NAKAKURA-OHSHIMA Kuniko, YAMAMOTO Hitoshi, MAEDA Takeyasu (2001): Alteration in the Expression of Heat Shock Protein (Hsp) 25-Immunoreactivity in the Dental Pulp of Rat Molars Following Tooth Replantation.. Archives of Histology and Cytology, 64, 425-437  https://doi.org/10.1679/aohc.64.425
 
Robinson P.P. (1983): An electrophysiological study of the reinnervation of reimplanted and autotransplanted teeth in the cat. Archives of Oral Biology, 28, 1139-1147  https://doi.org/10.1016/0003-9969(83)90172-3
 
Rungvechvuttivittaya Seree, Okiji Takashi, Suda Hideaki (1998): Responses of macrophage-associated antigen-expressing cells in the dental pulp of rat molars to experimental tooth replantation. Archives of Oral Biology, 43, 701-710  https://doi.org/10.1016/S0003-9969(98)00044-2
 
Saito Kotaro, Ishikawa Yuko, Nakakura-Ohshima Kuniko, Ida-Yonemochi Hiroko, Nakatomi Mitsushiro, Kenmotsu Shin-ichi, Ohshima Hayato (2011): Differentiation capacity of BrdU label-retaining dental pulp cells during pulpal healing following allogenic transplantation in mice. Biomedical Research, 32, 247-257  https://doi.org/10.2220/biomedres.32.247
 
Schendel Klaus Ursus, Schwartz Ole, Andreasen Jens Ove, Hoffmeister Bodo (1990): Reinnervation of autotransplanted teeth. A histological investigation in monkeys. International Journal of Oral and Maxillofacial Surgery, 19, 247-249  https://doi.org/10.1016/S0901-5027(05)80403-5
 
Schwartz O., Andreasen J.O. (1988): Allotransplantation and autotransplantation of mature teeth in monkeys: The influence of endodontic treatment. Journal of Oral and Maxillofacial Surgery, 46, 672-681  https://doi.org/10.1016/0278-2391(88)90110-3
 
Schwartz O., Andreasen J. O. (2002): Allo- and autotransplantation of mature teeth in monkeys: a sequential time-related histoquantitative study of periodontal and pulpal healing. Dental Traumatology, 18, 246-261  https://doi.org/10.1034/j.1600-9657.2002.00085.x
 
Schwartz Ole, Groisman Mario, Attstrom Rolf, Andreasen Jens Ove (1990): Transmission electron microscopy of supraalveolar periodontal healing of auto- and allotransplanted teeth in monkeys. Dental Traumatology, 6, 26-32  https://doi.org/10.1111/j.1600-9657.1990.tb00383.x
 
Schwartz Ole, Rank Christian P. (1986): Autotransplantation of cryopreserved tooth in connection with orthodontic treatment. American Journal of Orthodontics and Dentofacial Orthopedics, 90, 67-72  https://doi.org/10.1016/0889-5406(86)90029-6
 
Skoglund Annika (1981): Vascular changes in replanted and autotransplanted apicoectomized mature teeth of dogs. International Journal of Oral Surgery, 10, 100-110  https://doi.org/10.1016/S0300-9785(81)80019-1
 
Skoglund A., Tronstad L., Wallenius K. (1978): A microangiographic study of vascular changes in replanted and autotransplanted teeth of young dogs. Oral Surgery, Oral Medicine, Oral Pathology, 45, 17-28  https://doi.org/10.1016/0030-4220(78)90217-7
 
Sun HF, Liu Y, Guo J, Chen YX (2011): Histological study about the effect of orthodontic loading time and duration on the periodontal repair in autologous tooth transplantation. West China Journal of Stomatology 29, 237–241.
 
Takamori Y., Suzuki H., Nakakura-Ohshima K., Cai J., Cho S.-W., Jung H.-S., Ohshima H. (2008): Capacity of Dental Pulp Differentiation in Mouse Molars as Demonstrated by Allogenic Tooth Transplantation. Journal of Histochemistry and Cytochemistry, 56, 1075-1086  https://doi.org/10.1369/jhc.2008.951558
 
Tsukamoto-Tanaka Hiroko, Ikegame Mika, Takagi Ritsuo, Harada Hidemitsu, Ohshima Hayato (2006): Histochemical and immunocytochemical study of hard tissue formation in dental pulp during the healing process in rat molars after tooth replantation. Cell and Tissue Research, 325, 219-229  https://doi.org/10.1007/s00441-005-0138-4
 
Wolfe-Coote S (2005): The Laboratory Primate. Academic Press. Elsevier (London), 650 pp.
 
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